DE69434413D1 - Fusionsproteine zwischen antigene aminosäuresequenzen und beta - 2- mikroglobulin - Google Patents

Fusionsproteine zwischen antigene aminosäuresequenzen und beta - 2- mikroglobulin

Info

Publication number
DE69434413D1
DE69434413D1 DE69434413T DE69434413T DE69434413D1 DE 69434413 D1 DE69434413 D1 DE 69434413D1 DE 69434413 T DE69434413 T DE 69434413T DE 69434413 T DE69434413 T DE 69434413T DE 69434413 D1 DE69434413 D1 DE 69434413D1
Authority
DE
Germany
Prior art keywords
amino acid
microglobulin
beta
acid sequences
fusion proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69434413T
Other languages
English (en)
Other versions
DE69434413T2 (de
Inventor
Richard Mark Edwards
Michael George Hunter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Publication of DE69434413D1 publication Critical patent/DE69434413D1/de
Application granted granted Critical
Publication of DE69434413T2 publication Critical patent/DE69434413T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18822—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69434413T 1993-04-08 1994-04-08 Fusionsproteine zwischen antigene aminosäuresequenzen und beta - 2- mikroglobulin Expired - Fee Related DE69434413T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9307371 1993-04-08
GB939307371A GB9307371D0 (en) 1993-04-08 1993-04-08 Fusion proteins
PCT/GB1994/000755 WO1994024290A1 (en) 1993-04-08 1994-04-08 Fusion proteins between antigenic amino acid sequences and beta-2-microglobulin

Publications (2)

Publication Number Publication Date
DE69434413D1 true DE69434413D1 (de) 2005-08-04
DE69434413T2 DE69434413T2 (de) 2006-05-18

Family

ID=10733574

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69433845T Expired - Fee Related DE69433845T2 (de) 1993-04-08 1994-04-08 Expression von beta-2-mikroglobulin in pichia pastoris
DE69434413T Expired - Fee Related DE69434413T2 (de) 1993-04-08 1994-04-08 Fusionsproteine zwischen antigene aminosäuresequenzen und beta - 2- mikroglobulin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69433845T Expired - Fee Related DE69433845T2 (de) 1993-04-08 1994-04-08 Expression von beta-2-mikroglobulin in pichia pastoris

Country Status (8)

Country Link
US (1) US6881828B2 (de)
EP (2) EP0692027B1 (de)
AT (2) ATE269406T1 (de)
AU (2) AU6435394A (de)
DE (2) DE69433845T2 (de)
ES (1) ES2242183T3 (de)
GB (1) GB9307371D0 (de)
WO (2) WO1994024280A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2224205A1 (en) * 1995-06-07 1996-12-19 Zymogenetics, Inc. Fused soluble mhc heterodimer-peptide complexes and their uses
FR2735984B1 (fr) * 1995-06-30 1997-09-19 Inst Nat Sante Rech Med Vaccin contre des agents infectieux ayant une phase intracellulaire, composition pour le traitement et la prevention des infections a hiv, anticorps et procede de diagnostic
WO1997024446A2 (en) * 1995-12-29 1997-07-10 Chiron Corporation Gene delivery vehicle-targeting ligands
US6458354B1 (en) 1996-03-28 2002-10-01 The Johns Hopkins University Molecular complexes which modify immune responses
US6015884A (en) 1996-03-28 2000-01-18 The Johns Hopkins University Soluble divalent and multivalent heterodimeric analogs of proteins
US6268411B1 (en) 1997-09-11 2001-07-31 The Johns Hopkins University Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
US6682741B1 (en) 1998-06-10 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services β2 microglobulin fusion proteins and high affinity variants
DE69930630T2 (de) * 1998-06-10 2007-01-18 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services B2-Mikroglobulin-Fusionsproteine und Varianten mit hoher Affinität
EP1447451A4 (de) * 2001-09-28 2006-06-07 Dnavec Research Inc SÄUGERZELLEN INFIZIERENDER, EPITOPGEBUNDENES BETA2m CODIERENDER VIRUSVEKTOR UND DESSEN VERWENDUNG
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
JPWO2004031380A1 (ja) * 2002-10-01 2006-02-02 株式会社ディナベック研究所 ＴＡＰ活性の阻害によりＭＨＣｃｌａｓｓＩによる外来エピトープの提示を増強する方法
WO2004087058A2 (en) * 2003-03-28 2004-10-14 Vaccinex, Inc. Targeted mhc class i alpha3 vaccine delivery systems
WO2005099361A2 (en) * 2003-07-10 2005-10-27 Vaccinex, Inc. MHC CLASS I - PEPTIDE-ANTIBODY CONJUGATES WITH MODIFIED β2-MICROGLOBULIN
EP1989326A4 (de) 2006-01-17 2009-09-30 Health Research Inc Heteroduplex-verfolgungstest
EP2476432B1 (de) 2006-03-07 2015-08-19 Vaxinnate Corporation Zusammensetzungen mit Hämagglutinin, Verfahren zu ihrer Herstellung und Verfahren zu ihrer Verwendung
US9603922B2 (en) * 2007-02-21 2017-03-28 Vaccinex, Inc. Modulation of NKT cell activity with antigen-loaded CD1d molecules
WO2010053636A1 (en) 2008-11-06 2010-05-14 Tate & Lyle Technology Ltd Enhanced production and purification of a natural high intensity sweetener
PT2385980T (pt) 2009-01-08 2018-06-26 Albert Einstein College Medicine Inc Vacinas bacterianas com glicolípidos do tipo ceramida associados à parede celular e utilização dos mesmos
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
CN114958862B (zh) * 2022-05-23 2023-12-08 郑州伊美诺生物技术有限公司 检测慢性间质性肾炎的重组抗原的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05506447A (ja) * 1990-05-10 1993-09-22 ザ　ダナーファーバー　キャンサー　インスチチュート β↓２―ミクログロブリンを伴い抗原供給細胞表面上で外来ペプチッドのクラスＩＭＨＣ分子との会合を増進させる方法
US5733550A (en) * 1990-05-10 1998-03-31 Dana-Farber Cancer Institute, Inc. Method for enhancing the association of exogenous peptides with class I MHC molecules on the surface of antigen presenting cells with β-microglobulin
US5268273A (en) * 1990-12-14 1993-12-07 Phillips Petroleum Company Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same

Also Published As

Publication number Publication date
ATE269406T1 (de) 2004-07-15
DE69433845D1 (de) 2004-07-22
WO1994024280A1 (en) 1994-10-27
ATE298798T1 (de) 2005-07-15
US20020123108A1 (en) 2002-09-05
WO1994024290A1 (en) 1994-10-27
DE69433845T2 (de) 2005-06-23
EP0693125A1 (de) 1996-01-24
AU6435294A (en) 1994-11-08
EP0692027B1 (de) 2004-06-16
AU6435394A (en) 1994-11-08
EP0693125B1 (de) 2005-06-29
EP0692027A1 (de) 1996-01-17
DE69434413T2 (de) 2006-05-18
ES2242183T3 (es) 2005-11-01
GB9307371D0 (en) 1993-06-02
US6881828B2 (en) 2005-04-19

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee