WO2000006736A3 - Nucleic acids and proteins from group b streptococcus - Google Patents

Nucleic acids and proteins from group b streptococcus Download PDF

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Publication number
WO2000006736A3
WO2000006736A3 PCT/GB1999/002444 GB9902444W WO0006736A3 WO 2000006736 A3 WO2000006736 A3 WO 2000006736A3 GB 9902444 W GB9902444 W GB 9902444W WO 0006736 A3 WO0006736 A3 WO 0006736A3
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WO
WIPO (PCT)
Prior art keywords
streptococcus
group
proteins
nucleic acids
vaccines
Prior art date
Application number
PCT/GB1999/002444
Other languages
French (fr)
Other versions
WO2000006736A2 (en
Inventor
Page Richard William Falla Le
Jeremy Mark Wells
Sean Bosco Hanniffy
Original Assignee
Microbial Technics Limited
Page Richard William Falla Le
Jeremy Mark Wells
Sean Bosco Hanniffy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9816335.5A external-priority patent/GB9816335D0/en
Application filed by Microbial Technics Limited, Page Richard William Falla Le, Jeremy Mark Wells, Sean Bosco Hanniffy filed Critical Microbial Technics Limited
Priority to EP99934984A priority Critical patent/EP1100920A2/en
Priority to JP2000562518A priority patent/JP2002531054A/en
Priority to CA002337102A priority patent/CA2337102A1/en
Publication of WO2000006736A2 publication Critical patent/WO2000006736A2/en
Publication of WO2000006736A3 publication Critical patent/WO2000006736A3/en
Priority to US09/769,736 priority patent/US7098182B2/en
Priority to US11/123,241 priority patent/US20060078565A1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56944—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/315—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Streptococcus (G), e.g. Enterococci

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)

Abstract

Novel protein antigens from Group B Streptococcus are described, together with nucleic acid sequences encoding them. Their use in vaccines and screening methods is also described.
PCT/GB1999/002444 1998-07-27 1999-07-27 Nucleic acids and proteins from group b streptococcus WO2000006736A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP99934984A EP1100920A2 (en) 1998-07-27 1999-07-27 Nucleic acids and proteins from group b streptococcus
JP2000562518A JP2002531054A (en) 1998-07-27 1999-07-27 Nucleic acids and proteins from group B streptococci
CA002337102A CA2337102A1 (en) 1998-07-27 1999-07-27 Nucleic acids and proteins from group b streptococcus
US09/769,736 US7098182B2 (en) 1998-07-27 2001-01-26 Nucleic acids and proteins from group B streptococcus
US11/123,241 US20060078565A1 (en) 1998-07-27 2005-05-06 Nucleic acids and proteins from Group B Streptococcus

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9816335.5A GB9816335D0 (en) 1998-07-27 1998-07-27 Proteins
GB9816335.5 1998-07-27
US12516399P 1999-03-19 1999-03-19
US60/125,163 1999-03-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/769,736 Continuation US7098182B2 (en) 1998-07-27 2001-01-26 Nucleic acids and proteins from group B streptococcus

Publications (2)

Publication Number Publication Date
WO2000006736A2 WO2000006736A2 (en) 2000-02-10
WO2000006736A3 true WO2000006736A3 (en) 2000-06-22

Family

ID=26314123

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/002444 WO2000006736A2 (en) 1998-07-27 1999-07-27 Nucleic acids and proteins from group b streptococcus

Country Status (4)

Country Link
EP (1) EP1100920A2 (en)
JP (1) JP2002531054A (en)
CA (1) CA2337102A1 (en)
WO (1) WO2000006736A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8858957B2 (en) 2007-09-12 2014-10-14 Novartis Ag GAS57 mutant antigens and GAS57 antibodies

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ301056B6 (en) 1998-02-20 2009-10-29 Id Biomedical Corporation Antigens of group B streptococci
GB0105922D0 (en) * 2001-03-09 2001-04-25 Microscience Ltd Genes and proteins, and their use
NZ512297A (en) 1998-12-22 2003-12-19 Microscience Ltd Genes and proteins of group a strep, and their use
US6890539B2 (en) 1998-12-22 2005-05-10 Microscience, Ltd. Genes and proteins, and their use
DK1206556T3 (en) * 1999-08-06 2007-05-21 Bioneer As Signal peptides isolated from LACTOCOCCUS LACTIS
US6833356B1 (en) 1999-08-25 2004-12-21 Medimmune, Inc. Pneumococcal protein homologs and fragments for vaccines
CA2382795A1 (en) * 1999-08-25 2001-03-01 Medimmune, Inc. Homologs of a pneumococcal protein and fragments for vaccines
US7892552B2 (en) 2001-08-08 2011-02-22 University Of Utah Research Foundation Group B Streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof
ATE360640T1 (en) 2000-08-08 2007-05-15 St Jude Childrens Res Hospital GROUP-B STREPTOCOCCUS POLYPEPTIDES, NUCLEIC ACIDS, THERAPEUTIC COMPOSITIONS AND VACCINES THEREOF
EP2277895B1 (en) 2000-10-27 2013-08-14 Novartis Vaccines and Diagnostics S.r.l. Nucleic acids and proteins from streptococcus groups A & B
ES2307564T3 (en) 2000-12-21 2008-12-01 Id Biomedical Corporation ANTIGENS OF STREPTOCOCCUS PYROGENS AND CORRESPONDING DNA FRAGMENTS.
US7348161B2 (en) 2001-03-23 2008-03-25 Emory University Macrolide efflux genetic assembly
GB0108079D0 (en) 2001-03-30 2001-05-23 Microbial Technics Ltd Protein
CA2502414A1 (en) 2002-10-15 2004-04-29 Intercell Ag Nucleic acids coding for adhesion factor of group b streptococcus, adhesion factors of group b streptococcus and further uses thereof
EP1648500B1 (en) 2003-07-31 2014-07-09 Novartis Vaccines and Diagnostics, Inc. Immunogenic compositions for streptococcus pyogenes
US8945589B2 (en) 2003-09-15 2015-02-03 Novartis Vaccines And Diagnostics, Srl Immunogenic compositions for Streptococcus agalactiae
EP1784211A4 (en) 2004-07-29 2010-06-30 Novartis Vaccines & Diagnostic Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae
EP1828231A2 (en) * 2004-12-22 2007-09-05 Novartis Vaccines and Diagnostics, Inc. Group b streptococcus
GB0522303D0 (en) * 2005-11-01 2005-12-07 Chiron Srl Culture method

Citations (6)

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Publication number Priority date Publication date Assignee Title
WO1994010317A2 (en) * 1992-11-02 1994-05-11 The General Hospital Corporation Conjugate vaccine against group b streptococcus
WO1995006732A2 (en) * 1993-09-01 1995-03-09 The Rockefeller University Bacterial exported proteins and acellular vaccines based thereon
WO1998018931A2 (en) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae polynucleotides and sequences
WO1998023631A1 (en) * 1996-11-27 1998-06-04 Smithkline Beecham Corporation Novel bacterial polypeptides and polynucleotides
WO1999016882A1 (en) * 1997-09-26 1999-04-08 Medimmune, Inc. LMB GENE OF $i(STREPTOCOCCUS AGALACTIAE)
WO1999042588A2 (en) * 1998-02-20 1999-08-26 Biochem Pharma Inc. Group b streptococcus antigens

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010317A2 (en) * 1992-11-02 1994-05-11 The General Hospital Corporation Conjugate vaccine against group b streptococcus
WO1995006732A2 (en) * 1993-09-01 1995-03-09 The Rockefeller University Bacterial exported proteins and acellular vaccines based thereon
WO1998018931A2 (en) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae polynucleotides and sequences
WO1998018930A2 (en) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae antigens and vaccines
WO1998023631A1 (en) * 1996-11-27 1998-06-04 Smithkline Beecham Corporation Novel bacterial polypeptides and polynucleotides
WO1999016882A1 (en) * 1997-09-26 1999-04-08 Medimmune, Inc. LMB GENE OF $i(STREPTOCOCCUS AGALACTIAE)
WO1999042588A2 (en) * 1998-02-20 1999-08-26 Biochem Pharma Inc. Group b streptococcus antigens

Non-Patent Citations (12)

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Title
DATABASE GENESEQ E.M.B.L. Databases; 2 October 1998 (1998-10-02), CHOI G ET AL: "Streptococcus pneumoniae SP0020 protein", XP002133369 *
DATABASE GENESEQ E.M.B.L. Databases; 7 May 1998 (1998-05-07), BARASH S ET AL: "Streptococcus pneumoniae genome fragment SEQ ID NO:54", XP002133371 *
DATABASE GENESEQ E.M.B.L. Databases; 8 April 1999 (1999-04-08), LUTTICKEN R ET AL: "Streptococcal adhesion mediator protein Lmb", XP002133343 *
DATABASE GENESEQ E.M.B.L. Databases; 9 November 1998 (1998-11-09), BLACK M ET AL: "Streptococcus pneumoniae polypeptide", XP002133370 *
DATABASE SWISSPROT E.M.B.L. Databases; 1 April 1993 (1993-04-01), PUYET A ET AL: "MALTOSE/MALTODEXTRIN-BINDING PROTEIN PRECURSOR", XP002125784 *
DATABASE SWISSPROT E.M.B.L. Databases; 1 February 1995 (1995-02-01), TOGNONI A ET AL: "Peptide Synthetase 1", XP002133345 *
DATABASE SWISSPROT E.M.B.L. Databases; 1 November 1995 (1995-11-01), YOSHIDA K ET AL: "Hypothetical sensor-like Histidine Kinase in IDH 3' region", XP002133344 *
DATABASE TREMBL E.M.B.L. databases; 1 May 1997 (1997-05-01), YOSHIDA K ET AL: "HOMOLOGOUS TO MANY ATP-BINDING TRANSPORT PROTEINS", XP002133346 *
DATABASE TREMBL E.M.B.L. Databases; 1 November 1996 (1996-11-01), PODBIELSKI A ET AL: "ORF 1 AND ORF2 5' REGION", XP002133342 *
LACHENAUER C S ET AL: "Cloning and expression in Escherichia coli of a protective surface protein from type V group B Streptococci", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY,US,SPRING ST., NY, vol. 418, no. 418, 9 December 1997 (1997-12-09), pages 615-618-618, XP002107261, ISSN: 0065-2598 *
LARSSON C ET AL: "Experimental vaccination against group B streptococcus, an encapsulated bacterium, with highly purified preparations of cell surface proteins Rib and alpha", INFECT. IMMUN., vol. 64, no. 9, September 1996 (1996-09-01), pages 3518 - 3523, XP002125783 *
MICHEL J L ET AL: "Cloned alpha and beta C-protein antigens of group B Streptococci elicit protective immunity", INFECTION AND IMMUNITY,US,AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, vol. 59, no. 6, June 1991 (1991-06-01), pages 2023-2028-2028, XP002107260, ISSN: 0019-9567 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8858957B2 (en) 2007-09-12 2014-10-14 Novartis Ag GAS57 mutant antigens and GAS57 antibodies

Also Published As

Publication number Publication date
EP1100920A2 (en) 2001-05-23
WO2000006736A2 (en) 2000-02-10
JP2002531054A (en) 2002-09-24
CA2337102A1 (en) 2000-02-10

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