DE69739187D1 - Menschliche monoklonale antikörper spezifisch für antigen e2 des hepatitis c virus - Google Patents
Menschliche monoklonale antikörper spezifisch für antigen e2 des hepatitis c virusInfo
- Publication number
- DE69739187D1 DE69739187D1 DE69739187T DE69739187T DE69739187D1 DE 69739187 D1 DE69739187 D1 DE 69739187D1 DE 69739187 T DE69739187 T DE 69739187T DE 69739187 T DE69739187 T DE 69739187T DE 69739187 D1 DE69739187 D1 DE 69739187D1
- Authority
- DE
- Germany
- Prior art keywords
- antigen
- hcv
- molecules
- hepatitis
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000711549 Hepacivirus C Species 0.000 title abstract 6
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 102000008482 12E7 Antigen Human genes 0.000 abstract 2
- 108010020567 12E7 Antigen Proteins 0.000 abstract 2
- 230000027455 binding Effects 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 238000001261 affinity purification Methods 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000000159 protein binding assay Methods 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
- C07K16/109—Hepatitis C virus; Hepatitis G virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/635,109 US6538114B1 (en) | 1996-04-19 | 1996-04-19 | Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen |
| US08/844,215 US6747136B2 (en) | 1996-04-19 | 1997-04-17 | Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen |
| PCT/EP1997/001977 WO1997040176A1 (en) | 1996-04-19 | 1997-04-18 | Human monoclonal antibodies specific for hepatitis c virus (hcv) e2 antigen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69739187D1 true DE69739187D1 (de) | 2009-02-12 |
Family
ID=27092301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69739187T Expired - Lifetime DE69739187D1 (de) | 1996-04-19 | 1997-04-18 | Menschliche monoklonale antikörper spezifisch für antigen e2 des hepatitis c virus |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6747136B2 (de) |
| EP (1) | EP0937153B1 (de) |
| AT (1) | ATE419361T1 (de) |
| CA (1) | CA2262423C (de) |
| DE (1) | DE69739187D1 (de) |
| DK (1) | DK0937153T3 (de) |
| ES (1) | ES2320051T3 (de) |
| WO (1) | WO1997040176A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5285899A (en) | 1998-07-21 | 2000-02-14 | Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh | Anti hepatitis c virus antibody and uses thereof |
| US7091324B2 (en) * | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
| JP2002528140A (ja) | 1998-11-05 | 2002-09-03 | ザ ボード オブ トラスティーズ オブ リーランド スタンフォード ジュニア ユニバーシティ | ヒトｐａｎ−ｈｃｖヒトモノクローナル抗体 |
| DE19919585A1 (de) | 1999-04-29 | 2000-12-07 | Cmi Ag | Verwendung von Phyllanthus zur Behandlung von oxidativem Streß und anderen Symptomen |
| US6815160B1 (en) | 1999-07-28 | 2004-11-09 | Chiron Corporation | Hepatitis C viral antigen immunoassay detection systems |
| DK1295126T3 (da) * | 1999-07-28 | 2007-04-10 | Novartis Vaccines & Diagnostic | Immunoanalysesystemer til påvisning af hepatitis C-virusantigen |
| IL137522A (en) * | 2000-07-26 | 2007-06-17 | Drk Blutspendediendst Baden Wu | HCV human monoclonal antibody E2 glycoprotein antibody |
| US6924362B2 (en) | 2000-12-01 | 2005-08-02 | The United States Of America As Represented By The Department Of Health & Human Services | Monoclonal antibodies specific for the E2 glycoprotein of hepatitic C virus and their use in the diagnosis, treatment, and prevention of hepatitis C |
| JP4860098B2 (ja) | 2000-12-18 | 2012-01-25 | ダイアックス、コープ | 遺伝的パッケージの焦点を合わせたライブラリー |
| DE60231475D1 (de) * | 2001-01-12 | 2009-04-23 | Molecules Of Man Ab | Materialien und methoden zur behandlung von hepatitis c |
| WO2002059340A1 (en) * | 2001-01-26 | 2002-08-01 | The Scripps Research Institute | Immunopolypeptides to hepatitis c virus |
| US20070178065A1 (en) * | 2002-05-03 | 2007-08-02 | Lattime Edmund C | Neutralizing factors as vaccine adjuvants |
| AU2003272491B2 (en) * | 2002-09-18 | 2008-10-02 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits for detection of an antigen on a cell and in a biological mixture |
| CA2678888C (en) | 2007-02-21 | 2015-04-14 | University Of Massachusetts | Human antibodies against hepatitis c virus (hcv) and uses thereof |
| US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
| CN103429265A (zh) | 2010-05-25 | 2013-12-04 | 国家医疗保健研究所 | 用于治疗和预防hcv感染的抗包膜抗体和抗受体抗体组合物 |
| CN115124617B (zh) * | 2021-05-08 | 2024-02-09 | 南昌大学 | 一种高亲和力抗丙型肝炎病毒的全人源单克隆抗体及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308750A (en) | 1989-12-22 | 1994-05-03 | Abbott Laboratories | Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same |
| EP0447984A1 (de) | 1990-03-20 | 1991-09-25 | Abbott Laboratories | Hyperimmunglobulin gegen Hepatitis-C-Virus und Verfahren zur Herstellung |
| DK0585287T3 (da) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
| FR2677372B1 (fr) * | 1991-06-06 | 1994-11-10 | Pasteur Institut | Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques. |
| DK0605522T3 (da) | 1991-09-23 | 2000-01-17 | Medical Res Council | Fremgangsmåde til fremstilling af humaniserede antistoffer |
-
1997
- 1997-04-17 US US08/844,215 patent/US6747136B2/en not_active Expired - Fee Related
- 1997-04-18 AT AT97920721T patent/ATE419361T1/de not_active IP Right Cessation
- 1997-04-18 ES ES97920721T patent/ES2320051T3/es not_active Expired - Lifetime
- 1997-04-18 WO PCT/EP1997/001977 patent/WO1997040176A1/en active Application Filing
- 1997-04-18 EP EP97920721A patent/EP0937153B1/de not_active Expired - Lifetime
- 1997-04-18 DK DK97920721T patent/DK0937153T3/da active
- 1997-04-18 CA CA2262423A patent/CA2262423C/en not_active Expired - Lifetime
- 1997-04-18 DE DE69739187T patent/DE69739187D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20020016445A1 (en) | 2002-02-07 |
| EP0937153B1 (de) | 2008-12-31 |
| WO1997040176A1 (en) | 1997-10-30 |
| CA2262423A1 (en) | 1997-10-30 |
| ATE419361T1 (de) | 2009-01-15 |
| CA2262423C (en) | 2010-08-03 |
| DK0937153T3 (da) | 2009-05-04 |
| ES2320051T3 (es) | 2009-05-18 |
| US6747136B2 (en) | 2004-06-08 |
| EP0937153A1 (de) | 1999-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |