ATE419361T1 - Menschliche monoklonale antikörper spezifisch für antigen e2 des hepatitis c virus - Google Patents

Menschliche monoklonale antikörper spezifisch für antigen e2 des hepatitis c virus

Info

Publication number
ATE419361T1
ATE419361T1 AT97920721T AT97920721T ATE419361T1 AT E419361 T1 ATE419361 T1 AT E419361T1 AT 97920721 T AT97920721 T AT 97920721T AT 97920721 T AT97920721 T AT 97920721T AT E419361 T1 ATE419361 T1 AT E419361T1
Authority
AT
Austria
Prior art keywords
antigen
monoclonal antibodies
hcv
molecules
hepatitis
Prior art date
Application number
AT97920721T
Other languages
English (en)
Inventor
Mats Axel Atterdag Persson
Tobias Erik Allander
Original Assignee
Molecules Of Man Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/635,109 external-priority patent/US6538114B1/en
Application filed by Molecules Of Man Ab filed Critical Molecules Of Man Ab
Application granted granted Critical
Publication of ATE419361T1 publication Critical patent/ATE419361T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT97920721T 1996-04-19 1997-04-18 Menschliche monoklonale antikörper spezifisch für antigen e2 des hepatitis c virus ATE419361T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/635,109 US6538114B1 (en) 1996-04-19 1996-04-19 Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen
US08/844,215 US6747136B2 (en) 1996-04-19 1997-04-17 Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen

Publications (1)

Publication Number Publication Date
ATE419361T1 true ATE419361T1 (de) 2009-01-15

Family

ID=27092301

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97920721T ATE419361T1 (de) 1996-04-19 1997-04-18 Menschliche monoklonale antikörper spezifisch für antigen e2 des hepatitis c virus

Country Status (8)

Country Link
US (1) US6747136B2 (de)
EP (1) EP0937153B1 (de)
AT (1) ATE419361T1 (de)
CA (1) CA2262423C (de)
DE (1) DE69739187D1 (de)
DK (1) DK0937153T3 (de)
ES (1) ES2320051T3 (de)
WO (1) WO1997040176A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005266A1 (en) * 1998-07-21 2000-02-03 Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh Anti hepatitis c virus antibody and uses thereof
US7091324B2 (en) * 1998-11-05 2006-08-15 Board Of Trustees Of Leland Stanford Junior University Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes
WO2000026418A1 (en) * 1998-11-05 2000-05-11 The Board Of Trustees Of Leland Stanford Junior University Human pan-hcv human monoclonal antibodies
DE19919585A1 (de) 1999-04-29 2000-12-07 Cmi Ag Verwendung von Phyllanthus zur Behandlung von oxidativem Streß und anderen Symptomen
JP5498637B2 (ja) * 1999-07-28 2014-05-21 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Ｃ型肝炎ウイルス抗原免疫アッセイ検出システム
US6815160B1 (en) 1999-07-28 2004-11-09 Chiron Corporation Hepatitis C viral antigen immunoassay detection systems
IL137522A (en) * 2000-07-26 2007-06-17 Drk Blutspendediendst Baden Wu HCV human monoclonal antibody E2 glycoprotein antibody
WO2002055560A2 (en) * 2000-12-01 2002-07-18 The Gouvernment Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services Monoclonal antibodies specific for the e2 glycoprotein of hepatitis c virus and their use in the diagnosis, treatment, and prevention of hepatitis c
JP4860098B2 (ja) 2000-12-18 2012-01-25 ダイアックス、コープ 遺伝的パッケージの焦点を合わせたライブラリー
EP1355948B1 (de) * 2001-01-12 2009-03-11 Molecules of Man AB Materialien und methoden zur behandlung von hepatitis c
WO2002059340A1 (en) * 2001-01-26 2002-08-01 The Scripps Research Institute Immunopolypeptides to hepatitis c virus
US20070178065A1 (en) * 2002-05-03 2007-08-02 Lattime Edmund C Neutralizing factors as vaccine adjuvants
JP4601427B2 (ja) * 2002-09-18 2010-12-22 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 細胞上および生物学的混合物中の抗原の検出のための組成物、方法およびキット
AU2008223561B2 (en) 2007-02-21 2013-10-03 University Of Massachusetts Human antibodies against hepatitis C virus (HCV) uses thereof
US20100104555A1 (en) * 2008-10-24 2010-04-29 The Scripps Research Institute HCV neutralizing epitopes
WO2011147863A1 (en) 2010-05-25 2011-12-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Combination of anti-envelope antibodies and anti-receptor antibodies for the treatment and prevention of hcv infection
CN115028711B (zh) * 2021-05-08 2024-02-09 南昌大学 一种高亲和力抗丙型肝炎病毒的全人源单克隆抗体及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308750A (en) 1989-12-22 1994-05-03 Abbott Laboratories Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same
EP0447984A1 (de) 1990-03-20 1991-09-25 Abbott Laboratories Hyperimmunglobulin gegen Hepatitis-C-Virus und Verfahren zur Herstellung
EP0585287B1 (de) 1990-07-10 1999-10-13 Cambridge Antibody Technology Limited Verfahren zur herstellung von spezifischen bindungspaargliedern
FR2677372B1 (fr) * 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
WO1993006213A1 (en) 1991-09-23 1993-04-01 Medical Research Council Production of chimeric antibodies - a combinatorial approach

Also Published As

Publication number Publication date
CA2262423A1 (en) 1997-10-30
US20020016445A1 (en) 2002-02-07
DK0937153T3 (da) 2009-05-04
US6747136B2 (en) 2004-06-08
ES2320051T3 (es) 2009-05-18
EP0937153A1 (de) 1999-08-25
DE69739187D1 (de) 2009-02-12
EP0937153B1 (de) 2008-12-31
CA2262423C (en) 2010-08-03
WO1997040176A1 (en) 1997-10-30

Similar Documents

Publication Publication Date Title
ATE419361T1 (de) Menschliche monoklonale antikörper spezifisch für antigen e2 des hepatitis c virus
ATE425989T1 (de) Proteinreinigungsverfahren
Tissot et al. Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated peptide
DK1129190T3 (da) Human TSLP DNA og polypeptider
NO20025354L (no) Pattedyr-reseptorproteiner; beslektede reagenser og fremgangsmåter
ATE318309T1 (de) Hcv-spezifische peptide, mittel dazu und ihre verwendung
MX9603637A (es) Purificacion de anticuerpo.
AU2001294541A1 (en) Mammalian genes; related reagents and methods
HUP0003513A2 (hu) Apoptózist indukáló monoklonális antitest
HUP0004639A2 (hu) Chlamydia fehérje, génszekvencia és ezek alkalmazása
RU2008100239A (ru) Терапевтические связывающие молекулы в виде химерного антитела
MX347175B (es) Anticuerpos igm humanos con la capacidad de inducir remielinacion, y usos diagnosticos y terapeuticos de los mismos particularmente en el sistema nervioso central.
ATE380867T1 (de) Lactoferrinrezeptorgen von moraxella
ATE148168T1 (de) Monoklonale antikörper
DE69735207D1 (de) Neuartiges, fibrinogen-bindendes protein, welches von einem koagulase-negativen staphylokokkus abstammt
ATE370235T1 (de) Rekombinantpeptide hergeleitet vom mc3 antikörper gegen ba46, verfahren zu deren verwendung und verfahren zur humanisierung von antikörperpeptiden
EA201001190A1 (ru) Выделенное антитело, специфически связанное с полипептидом, состоящее из последовательности аминокислотных остатков
KR960705038A (ko) 자기 면역 질환에 관련된 프로토콜에서 미엘린 올리고덴드로시트 당 단백질 및 그의 펩타이드 부분들의 용도(users of myelin oligodendrocyte glycoprotein and peptide portions thereof in protocols related to autoimmune desease)
DE69435059D1 (de) Immunoreaktive antigene des hepatitis e viruses
DE60041697D1 (de) Säugetier-rezeptorproteine; ähnliche reagentien und methoden
FR2560212B1 (fr) Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps
ATE191568T1 (de) Spezifische bindungssubstanzen für antikörper und deren verwendung für immunoassays oder vakzine
DE69736158D1 (de) Glutamine: Fructose-6-Phosphat Amidotransferase (GFAT), ihre Herstellung und Verwendung
ATE190491T1 (de) Peptide als diagnose- und therapiemittel für spondyloarthropathien
SE9704141D0 (sv) New protein and nucleotide sequence, encoding said protein

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties