MX2021005808A - Complejos macrociclicos de radionucleidos alfa-emisores y su uso en radioterapia focalizada de cancer. - Google Patents
Complejos macrociclicos de radionucleidos alfa-emisores y su uso en radioterapia focalizada de cancer.Info
- Publication number
- MX2021005808A MX2021005808A MX2021005808A MX2021005808A MX2021005808A MX 2021005808 A MX2021005808 A MX 2021005808A MX 2021005808 A MX2021005808 A MX 2021005808A MX 2021005808 A MX2021005808 A MX 2021005808A MX 2021005808 A MX2021005808 A MX 2021005808A
- Authority
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- Prior art keywords
- compounds
- cancer
- pharmaceutically acceptable
- acceptable salt
- radiotherapy
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente tecnología proporciona compuestos, así como composiciones que incluyen estos compuestos útiles en radioterapia focalizada de cáncer y/o tejido de mamífero que sobreexpresa antígeno de membrana específico de próstata ("PSMA") donde los compuestos están representados por las siguientes fórmulas (ver Fórmula) (I) o una sal farmacéuticamente aceptable del mismo, (ver Fórmula) (IA) o una sal farmacéuticamente aceptable del mismo, (ver Fórmula) (II) o una sal farmacéuticamente aceptable del mismo, en donde M1 es independientemente en cada aparición un radionucleido alfa-emisor. También se describen equivalentes de estos compuestos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862769989P | 2018-11-20 | 2018-11-20 | |
US201962788700P | 2019-01-04 | 2019-01-04 | |
US201962792835P | 2019-01-15 | 2019-01-15 | |
PCT/US2019/062479 WO2020106886A1 (en) | 2018-11-20 | 2019-11-20 | Macrocyclic complexes of radionuclides and their use in radiotherapy of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021005808A true MX2021005808A (es) | 2021-07-02 |
Family
ID=70726247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021005808A MX2021005808A (es) | 2018-11-20 | 2019-11-20 | Complejos macrociclicos de radionucleidos alfa-emisores y su uso en radioterapia focalizada de cancer. |
Country Status (11)
Country | Link |
---|---|
US (5) | US11279698B2 (es) |
EP (1) | EP3883610A4 (es) |
JP (1) | JP2022507718A (es) |
KR (1) | KR20210116437A (es) |
CN (1) | CN113056288A (es) |
AU (1) | AU2019385497A1 (es) |
CA (1) | CA3119467A1 (es) |
IL (1) | IL283225A (es) |
MX (1) | MX2021005808A (es) |
SG (1) | SG11202104900SA (es) |
WO (1) | WO2020106886A1 (es) |
Families Citing this family (18)
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AU2020273654A1 (en) * | 2019-05-10 | 2021-11-25 | Janssen Biotech, Inc. | Macrocyclic chelators and methods of use thereof |
WO2021250240A1 (en) | 2020-06-12 | 2021-12-16 | Orano | Diaza-18-crown-6 derivative useful for chelating radium, conjugate and radium chelate comprising the same, and uses thereof |
US20220143231A1 (en) * | 2020-11-10 | 2022-05-12 | Janssen Biotech, Inc. | Macrocyclic compounds and methods of use thereof |
MX2023008803A (es) | 2021-01-27 | 2023-08-04 | Janssen Biotech Inc | Inmunoconjugados que comprenden dominios de union al antigeno de la peptidasa 2 relacionada con la calicreina y sus usos. |
TW202241526A (zh) * | 2021-02-01 | 2022-11-01 | 德商拜耳廠股份有限公司 | 用於靶向放射療法之多聚體螯合劑化合物 |
CA3210294A1 (en) * | 2021-03-04 | 2022-09-09 | Yoshifumi Maya | Compound and radioactive labeling compound |
JP2024514528A (ja) * | 2021-04-02 | 2024-04-02 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 線維芽細胞活性化タンパク質アルファおよび/または前立腺特異的膜抗原を標的とするヘテロ二価およびホモ二価薬剤 |
WO2022251496A1 (en) * | 2021-05-26 | 2022-12-01 | Cornell University | Rigidified macrocycles, complexes with radionuclides, and use in targeted radiotherapy of cancer |
CA3219934A1 (en) | 2021-05-27 | 2022-12-01 | Rhys Salter | Compositions and methods for the treatment of prostate cancer |
IL311070A (en) | 2021-08-27 | 2024-04-01 | Janssen Biotech Inc | Anti-PSMA antibodies and uses thereof |
CA3233458A1 (en) * | 2021-09-29 | 2023-04-06 | Katherine Anne MORGAN | Macrocycle containing compounds and radiolabelled complexes thereof, as ligands in targeted radiotherapy applications |
WO2023144723A1 (en) | 2022-01-26 | 2023-08-03 | Janssen Biotech, Inc. | Immunoconjugates comprising kallikrein related peptidase 2 antigen binding domains and their uses |
US20230346862A1 (en) | 2022-05-02 | 2023-11-02 | Athanor Biosciences, Inc. | Cancer eradicating - bio-nanoparticles (ce-bnp) |
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WO2023222557A1 (en) * | 2022-05-17 | 2023-11-23 | Bayer Aktiengesellschaft | Radiopharmaceutical complexes targeting prostate-specific membrane antigen and its combinations |
EP4279092A1 (en) * | 2022-05-17 | 2023-11-22 | Bayer AG | Radiopharmaceutical complexes targeting prostate-specific membrane antigen |
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2019
- 2019-11-20 WO PCT/US2019/062479 patent/WO2020106886A1/en unknown
- 2019-11-20 AU AU2019385497A patent/AU2019385497A1/en active Pending
- 2019-11-20 CA CA3119467A patent/CA3119467A1/en active Pending
- 2019-11-20 US US16/689,856 patent/US11279698B2/en active Active
- 2019-11-20 SG SG11202104900SA patent/SG11202104900SA/en unknown
- 2019-11-20 MX MX2021005808A patent/MX2021005808A/es unknown
- 2019-11-20 EP EP19887504.9A patent/EP3883610A4/en active Pending
- 2019-11-20 US US17/294,375 patent/US20220016277A1/en active Pending
- 2019-11-20 CN CN201980075936.1A patent/CN113056288A/zh active Pending
- 2019-11-20 KR KR1020217017495A patent/KR20210116437A/ko active Search and Examination
- 2019-11-20 JP JP2021527161A patent/JP2022507718A/ja active Pending
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2021
- 2021-05-18 IL IL283225A patent/IL283225A/en unknown
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2022
- 2022-02-23 US US17/678,803 patent/US20220274974A1/en active Pending
- 2022-02-23 US US17/678,793 patent/US20220177461A1/en active Pending
- 2022-02-23 US US17/678,782 patent/US20220185803A1/en active Pending
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US11279698B2 (en) | 2022-03-22 |
SG11202104900SA (en) | 2021-06-29 |
CN113056288A (zh) | 2021-06-29 |
US20200157087A1 (en) | 2020-05-21 |
AU2019385497A1 (en) | 2021-06-17 |
EP3883610A1 (en) | 2021-09-29 |
EP3883610A4 (en) | 2022-11-02 |
CA3119467A1 (en) | 2020-05-28 |
JP2022507718A (ja) | 2022-01-18 |
US20220016277A1 (en) | 2022-01-20 |
US20220185803A1 (en) | 2022-06-16 |
US20220177461A1 (en) | 2022-06-09 |
KR20210116437A (ko) | 2021-09-27 |
IL283225A (en) | 2021-07-29 |
US20220274974A1 (en) | 2022-09-01 |
WO2020106886A1 (en) | 2020-05-28 |
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