MX2023008803A - Inmunoconjugados que comprenden dominios de union al antigeno de la peptidasa 2 relacionada con la calicreina y sus usos. - Google Patents
Inmunoconjugados que comprenden dominios de union al antigeno de la peptidasa 2 relacionada con la calicreina y sus usos.Info
- Publication number
- MX2023008803A MX2023008803A MX2023008803A MX2023008803A MX2023008803A MX 2023008803 A MX2023008803 A MX 2023008803A MX 2023008803 A MX2023008803 A MX 2023008803A MX 2023008803 A MX2023008803 A MX 2023008803A MX 2023008803 A MX2023008803 A MX 2023008803A
- Authority
- MX
- Mexico
- Prior art keywords
- immunoconjugates
- antigen binding
- binding domains
- related peptidase
- kallikrein related
- Prior art date
Links
- 229940127121 immunoconjugate Drugs 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 101000605528 Homo sapiens Kallikrein-2 Proteins 0.000 title 1
- 102100038356 Kallikrein-2 Human genes 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940051022 radioimmunoconjugate Drugs 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1075—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against an enzyme
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
En la presente descripción se proporcionan inmunoconjugados, tales como radioinmunoconjugados, que comprenden una entidad terapéutica conjugado con un anticuerpo o dominio de unión al antígeno con especificidad de unión para hK2. En ciertas modalidades, el inmunoconjugado específico de hK2 demuestra una vida media corta. También se proporcionan en la presente descripción métodos para usar los inmunoconjugados para dirigirse selectivamente a células cancerosas y para tratar enfermedades tales como cáncer de próstata.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163142147P | 2021-01-27 | 2021-01-27 | |
US202163144586P | 2021-02-02 | 2021-02-02 | |
PCT/IB2022/050673 WO2022162549A2 (en) | 2021-01-27 | 2022-01-26 | Immunoconjugates comprising kallikrein related peptidase 2 antigen binding domains and their uses |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023008803A true MX2023008803A (es) | 2023-08-04 |
Family
ID=80447388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023008803A MX2023008803A (es) | 2021-01-27 | 2022-01-26 | Inmunoconjugados que comprenden dominios de union al antigeno de la peptidasa 2 relacionada con la calicreina y sus usos. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP4284446A2 (es) |
JP (1) | JP2024503924A (es) |
KR (1) | KR20230142482A (es) |
AU (1) | AU2022213825A1 (es) |
CA (1) | CA3205707A1 (es) |
IL (1) | IL304656A (es) |
MX (1) | MX2023008803A (es) |
WO (1) | WO2022162549A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112022001368A2 (pt) | 2019-07-26 | 2022-05-24 | Janssen Biotech Inc | Proteínas que compreendem domínios de ligação ao antígeno de peptidase 2 relacionada à calicreína e seus usos |
CA3240194A1 (en) * | 2021-11-09 | 2023-05-19 | Edward Cleator | Macrocyclic compounds and methods of making the same |
CN118613288A (zh) * | 2022-01-26 | 2024-09-06 | 詹森生物科技公司 | 包含激肽释放酶相关肽酶2抗原结合结构域的免疫缀合物及其用途 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
ES2564523T3 (es) | 2007-12-19 | 2016-03-23 | Janssen Biotech, Inc. | Diseño y generación de bibliotecas de presentación en fago por pIX de novo humanas mediante fusión con pIX o pVII, vectores, anticuerpos y métodos |
CA3006800C (en) | 2010-03-31 | 2022-10-04 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
LT2931030T (lt) | 2012-12-14 | 2020-11-10 | Open Monoclonal Technology, Inc. | Polinukleotidai, koduojantys graužikų antikūnus su žmogaus idiotipais, ir juos apimantys gyvūnai |
HUE043875T2 (hu) | 2013-11-19 | 2019-09-30 | Fredax Ab | Humanizált, kallikrein-2 elleni antitest |
US20180326102A1 (en) | 2015-11-18 | 2018-11-15 | Memorial Sloan Kettering Cancer Center | Systems, methods, and compositions for imaging androgen receptor axis activity in carcinoma, and related therapeutic compositions and methods |
US11554182B2 (en) | 2017-03-30 | 2023-01-17 | Cornell University | Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer |
CN113056288A (zh) | 2018-11-20 | 2021-06-29 | 康奈尔大学 | 放射性核素的大环配合物及其在癌症的放射治疗中的应用 |
MX2021013667A (es) | 2019-05-10 | 2022-01-31 | Janssen Biotech Inc | Quelantes macrocíclicos y métodos de uso de estos. |
BR112022001368A2 (pt) * | 2019-07-26 | 2022-05-24 | Janssen Biotech Inc | Proteínas que compreendem domínios de ligação ao antígeno de peptidase 2 relacionada à calicreína e seus usos |
WO2021060350A1 (ja) | 2019-09-27 | 2021-04-01 | 株式会社J-オイルミルズ | 食肉加工品の製造方法 |
-
2022
- 2022-01-26 EP EP22703710.8A patent/EP4284446A2/en active Pending
- 2022-01-26 WO PCT/IB2022/050673 patent/WO2022162549A2/en active Application Filing
- 2022-01-26 JP JP2023545254A patent/JP2024503924A/ja active Pending
- 2022-01-26 KR KR1020237026179A patent/KR20230142482A/ko unknown
- 2022-01-26 CA CA3205707A patent/CA3205707A1/en active Pending
- 2022-01-26 AU AU2022213825A patent/AU2022213825A1/en active Pending
- 2022-01-26 MX MX2023008803A patent/MX2023008803A/es unknown
-
2023
- 2023-07-23 IL IL304656A patent/IL304656A/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20230142482A (ko) | 2023-10-11 |
EP4284446A2 (en) | 2023-12-06 |
IL304656A (en) | 2023-09-01 |
WO2022162549A2 (en) | 2022-08-04 |
WO2022162549A3 (en) | 2022-09-29 |
JP2024503924A (ja) | 2024-01-29 |
AU2022213825A1 (en) | 2023-09-14 |
CA3205707A1 (en) | 2022-08-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2023008803A (es) | Inmunoconjugados que comprenden dominios de union al antigeno de la peptidasa 2 relacionada con la calicreina y sus usos. | |
PH12020550741A1 (en) | Anti-cd79b antibodies and immunoconjugates and methods of use | |
MX2023013118A (es) | Derivados del exatecan y sus conjugados anticuerpo-farmaco. | |
MX2021014094A (es) | Conjugados de anticuerpo-farmaco inhibidores de mcl-1 y sus metodos de uso. | |
NZ595574A (en) | Anti-fcrh5 antibodies and immunoconjugates and methods of use | |
PE20170517A1 (es) | Conjugados de anticuerpo-farmaco-anti-ptk7 | |
DK1594542T3 (da) | Anti-CD70 antistof-lægemiddelkonjugater og deres anvendelse ved behandling af cancer | |
NZ599045A (en) | New maytansinoids and the use of said maytansinoids to prepare conjugates with an antibody | |
WO2004018000A3 (en) | Compositions and methods for treating cancer using maytansinoid cd44 antibody immonoconjugates and chemotherapeutic agents | |
WO2010019702A3 (en) | Ddr1-binding agents and methods of use thereof | |
NZ596490A (en) | Monoclonal antibodies that bind GT468 for the treatment of cancer | |
WO2002100326A3 (en) | Photoimmunotherapies for cancer using photosensitizer immunoconjugates and combination therapies | |
NZ587132A (en) | Anti-cd79b antibodies and immunoconjugates and methods of use | |
MX2010005830A (es) | Conjugado de anticuerpo monoclonal anti-b7h4 - farmaco y metodos de uso del mismo. | |
WO2006099141A3 (en) | Anti-mesothelin antibodies | |
MA31662B1 (fr) | Anticorps chimeres et humanises anti-cd44 influencant la cytotoxicite des cellules cancereuses | |
MX2021009138A (es) | Anticuerpos anti-cd228 y conjugados de anticuerpo-farmaco. | |
MX2022010599A (es) | Moleculas biespecificas de union al antigeno que se unen a her2, y metodos de uso de los mismos. | |
MX2021010003A (es) | Anticuerpos anti-mertk de alta afinidad y usos de los mismos. | |
GEP20135826B (en) | Novel antibodies used to treat cancer | |
MX2023009761A (es) | Inmunoconjugados para terapia dirigida con radioisotopos. | |
MX2021015533A (es) | Anticuerpos anti-mesotelina e inmunoconjugados de los mismos. | |
MX2009010269A (es) | Metodos de tratamiento del cancer mediante administracion de combinaciones de interleucina-18 humana. | |
FR3096259B1 (fr) | conjugués anticorps-médicament et leur utilisation en thérapie | |
MX2023014282A (es) | Conjugados de neodegradador-anticuerpo anti-cumulo de diferenciación 33 (cd33). |