SG11201907769XA - Cd80 variant immunomodulatory proteins and uses thereof - Google Patents

Cd80 variant immunomodulatory proteins and uses thereof

Info

Publication number
SG11201907769XA
SG11201907769XA SG11201907769XA SG11201907769XA SG11201907769XA SG 11201907769X A SG11201907769X A SG 11201907769XA SG 11201907769X A SG11201907769X A SG 11201907769XA SG 11201907769X A SG11201907769X A SG 11201907769XA SG 11201907769X A SG11201907769X A SG 11201907769XA
Authority
SG
Singapore
Prior art keywords
suite
washington
march
international
seattle
Prior art date
Application number
SG11201907769XA
Inventor
Ryan Swanson
Michael Kornacker
Mark F Maurer
Dan Ardourel
Daniel William Demonte
Joseph L Kuijper
Original Assignee
Alpine Immune Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpine Immune Sciences Inc filed Critical Alpine Immune Sciences Inc
Publication of SG11201907769XA publication Critical patent/SG11201907769XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

WO 18/ 17 00 26 A3 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT ill~~~~~~~~ 011101010VIIIOH olo olo monliolom (10) International Publication Number WO 2018/170026 A3 (51) International Patent Classification: C07K 14/705 (2006.01) (21) International Application Number: PCT/US2018/022270 (22) International Filing Date: 13 March 2018 (13.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/472,554 16 March 2017 (16.03.2017) US 62/472,558 16 March 2017 (16.03.2017) US 62/472,569 16 March 2017 (16.03.2017) US 62/472,572 16 March 2017 (16.03.2017) US 62/472,573 17 March 2017 (17.03.2017) US 62/475,204 22 March 2017 (22.03.2017) US 62/537,939 27 July 2017 (27.07.2017) US 62/574,165 18 October 2017 (18.10.2017) US 62/582,266 06 November 2017 (06.11.2017) US (71) Applicant: ALPINE IMMUNE SCIENCES, INC. [US/US]; 201 Elliott Avenue West, Suite 230, Seattle, Washington 98119 (US). (72) Inventors: SWANSON, Ryan; 201 Elliott Avenue West, Suite 230, Seattle, Washington 98119 (US). KORNACK- ER, Michael; 201 Elliott Avenue West, Suite 230, Seat- tle, Washington 98119 (US). MAURER, Mark F.; 201 El- liott Avenue West, Suite 230, Seattle, Washington 98119 (US). ARDOUREL, Dan; 201 Elliott Avenue West, Suite 230, Seattle, Washington 98119 (US). DEMONTE, Daniel William; 201 Elliott Avenue West, Suite 230, Seattle, Washington 98119 (US). KUIJPER, Joseph L.; 201 Elliott Avenue West, Suite 230, Seattle, Washington 98119 (US). (74) Agent: AIKEN, Charity et al.; 12531 High Bluff Drive, Suite 100, San Diego, California 92130-2040 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (54) Title: CD80 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF FIG. 3A Ci 4 (57) : Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided. [Continued on next page] WO 2018/170026 A3 IMEDIMO DOI 01011MENOMMENIMMEO111EEN KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 18 October 2018 (18.10.2018)
SG11201907769XA 2017-03-16 2018-03-13 Cd80 variant immunomodulatory proteins and uses thereof SG11201907769XA (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201762472554P 2017-03-16 2017-03-16
US201762472572P 2017-03-16 2017-03-16
US201762472569P 2017-03-16 2017-03-16
US201762472558P 2017-03-16 2017-03-16
US201762472573P 2017-03-17 2017-03-17
US201762475204P 2017-03-22 2017-03-22
US201762537939P 2017-07-27 2017-07-27
US201762574165P 2017-10-18 2017-10-18
US201762582266P 2017-11-06 2017-11-06
PCT/US2018/022270 WO2018170026A2 (en) 2017-03-16 2018-03-13 Cd80 variant immunomodulatory proteins and uses thereof

Publications (1)

Publication Number Publication Date
SG11201907769XA true SG11201907769XA (en) 2019-09-27

Family

ID=61832601

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201907769XA SG11201907769XA (en) 2017-03-16 2018-03-13 Cd80 variant immunomodulatory proteins and uses thereof

Country Status (12)

Country Link
US (7) US11639375B2 (en)
EP (1) EP3596114A2 (en)
JP (2) JP7386083B2 (en)
KR (1) KR20190140924A (en)
CN (1) CN110662758A (en)
AU (2) AU2018235838B2 (en)
BR (1) BR112019018747A2 (en)
CA (1) CA3054068A1 (en)
IL (1) IL268781A (en)
MX (1) MX2019010887A (en)
SG (1) SG11201907769XA (en)
WO (1) WO2018170026A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3283508T3 (en) 2015-04-17 2021-05-31 Alpine Immune Sciences Inc Immunomodulatory Proteins with Tunable Affinities
SG11201808783XA (en) 2016-04-15 2018-11-29 Alpine Immune Sciences Inc Cd80 variant immunomodulatory proteins and uses thereof
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
SG11201907769XA (en) 2017-03-16 2019-09-27 Alpine Immune Sciences Inc Cd80 variant immunomodulatory proteins and uses thereof
CN110809581A (en) 2017-03-16 2020-02-18 高山免疫科学股份有限公司 PD-L2 variant immunomodulatory proteins and uses thereof
EP3694870A1 (en) 2017-10-10 2020-08-19 Alpine Immune Sciences, Inc. Ctla-4 variant immunomodulatory proteins and uses thereof
US12065476B2 (en) 2018-06-15 2024-08-20 Alpine Immune Sciences, Inc. PD-1 variant immunomodulatory proteins and uses thereof
KR20210089146A (en) * 2018-09-19 2021-07-15 알파인 이뮨 사이언시즈, 인코포레이티드 Methods and uses of variant CD80 proteins and related constructs
KR20210135987A (en) * 2018-11-30 2021-11-16 알파인 이뮨 사이언시즈, 인코포레이티드 CD86 variant immunomodulatory protein and uses thereof
RU2706554C1 (en) * 2018-12-13 2019-11-19 Российская Федерация, от имени которой выступает ФОНД ПЕРСПЕКТИВНЫХ ИССЛЕДОВАНИЙ Method for creating anti-infectious immunological protection against salmonella typhimurium and listeria monocytogenes using transgenesis of t-lymphocytes
CN111423512B (en) * 2019-01-10 2024-01-05 北京比洋生物技术有限公司 Multi-targeting fusion protein for blocking vascular endothelial cell growth and activating T cells and pharmaceutical composition comprising same
CA3175457A1 (en) * 2020-03-18 2021-09-23 Gi Innovation, Inc. Pharmaceutical composition for treating cancer, comprising fusion protein comprising il-2 protein and cd80 protein and anticancer drug
WO2021226553A2 (en) 2020-05-08 2021-11-11 Alpine Immune Sciences, Inc. April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof
CA3185332A1 (en) * 2020-06-03 2021-12-09 Boehringer Ingelheim International Gmbh Recombinant rhabdovirus encoding for a cd80 extracellular domain fc-fusion protein
WO2023172883A1 (en) * 2022-03-07 2023-09-14 Alpine Immune Sciences, Inc. Immunomodulatory proteins of variant cd80 polypeptides, cell therapies thereof and related methods and uses
WO2024006721A1 (en) 2022-06-30 2024-01-04 The Procter & Gamble Company Absorbent articles with frangible pathways with simultaneously propagating tear zones
WO2024007872A1 (en) * 2022-07-05 2024-01-11 杭州阿诺生物医药科技有限公司 Cd80 mutant polypeptide and use thereof

Family Cites Families (188)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7045313B1 (en) 1982-11-30 2006-05-16 The United States Of America As Represented By The Department Of Health And Human Services Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US5443964A (en) 1987-08-10 1995-08-22 Duke University Poxvirus insertion/expression vector
US6218525B1 (en) 1988-02-25 2001-04-17 The General Hospital Corporation Nucleic acid encoding CD28
US5716826A (en) 1988-03-21 1998-02-10 Chiron Viagene, Inc. Recombinant retroviruses
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5580756A (en) 1990-03-26 1996-12-03 Bristol-Myers Squibb Co. B7Ig fusion protein
US6410010B1 (en) 1992-10-13 2002-06-25 Board Of Regents, The University Of Texas System Recombinant P53 adenovirus compositions
ES2206446T3 (en) 1991-05-06 2004-05-16 The Government Of The Usa As Represented By The Secretary Of Department Of Health And Human Services RECOMBINANT VIRUS EXPRESSING AN ANCIENT CARCINOEMBRIONICO AND METHODS OF USE OF THE SAME.
JP4124480B2 (en) 1991-06-14 2008-07-23 ジェネンテック・インコーポレーテッド Immunoglobulin variants
US6887471B1 (en) 1991-06-27 2005-05-03 Bristol-Myers Squibb Company Method to inhibit T cell interactions with soluble B7
US5262522A (en) 1991-11-22 1993-11-16 Immunex Corporation Receptor for oncostatin M and leukemia inhibitory factor
PT752248E (en) 1992-11-13 2001-01-31 Idec Pharma Corp THERAPEUTIC APPLICATION OF QUIMERIC ANTIBODIES AND RADIOACTIVELY MARKING OF ANTIGENES OF RESTRICTED DIFFERENTIATION OF HUMAN LYMPHOCYTE B FOR THE TREATMENT OF B-CELL LYMPHOMA
US5773253A (en) 1993-01-22 1998-06-30 Bristol-Myers Squibb Company MYPPPY variants of CTL A4 and uses thereof
CA2163345A1 (en) 1993-06-16 1994-12-22 Susan Adrienne Morgan Antibodies
US5457035A (en) 1993-07-23 1995-10-10 Immunex Corporation Cytokine which is a ligand for OX40
US6130316A (en) 1993-07-26 2000-10-10 Dana Farber Cancer Institute Fusion proteins of novel CTLA4/CD28 ligands and uses therefore
US6218510B1 (en) 1994-03-02 2001-04-17 Brigham & Woman's Hospital B7-1 and B7-2 polypeptides
US20020159979A1 (en) 1994-06-06 2002-10-31 Children's Hospital, Inc. Adeno-associated virus materials and methods
JP4418965B2 (en) 1994-09-23 2010-02-24 タップイミューン・インコーポレイテッド Method for enhancing the expression of MHC class I molecules with endogenous peptides
EP1016418B1 (en) 1994-10-03 2009-12-30 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Host cell comprising a recombinant virus expressing an antigen and a recombinant virus expressing an immunostimulatory molecule
US5998205A (en) 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US7153510B1 (en) 1995-05-04 2006-12-26 Yale University Recombinant vesiculoviruses and their uses
US5780426A (en) 1995-06-07 1998-07-14 Ixsys, Incorporated Fivemer cyclic peptide inhibitors of diseases involving αv β3
US5767071A (en) 1995-06-07 1998-06-16 Ixsys Incorporated Sevenmer cyclic peptide inhibitors of diseases involving αv β3
FR2735789B1 (en) 1995-06-23 1997-07-25 Centre Nat Rech Scient RECOMBINANT ADENOVIRUSES, THEIR USE FOR PREPARING AVA, COMPLEMENTARY CELL LINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP0850313B8 (en) 1995-09-08 2009-07-29 Genzyme Corporation Improved aav vectors for gene therapy
US7001765B2 (en) 1996-03-06 2006-02-21 Medigene Ag Adeno-associated virus vector for boosting immunogenicity of cells
US20030171551A1 (en) 1997-01-31 2003-09-11 Joseph D. Rosenblatt Chimeric antibody fusion proteins for the recruitment and stimulation of an antitumor immune response
US6294170B1 (en) 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
IL132560A0 (en) 1997-05-02 2001-03-19 Genentech Inc A method for making multispecific antibodies having heteromultimeric and common components
US6165476A (en) 1997-07-10 2000-12-26 Beth Israel Deaconess Medical Center Fusion proteins with an immunoglobulin hinge region linker
US5891432A (en) 1997-07-29 1999-04-06 The Immune Response Corporation Membrane-bound cytokine compositions comprising GM=CSF and methods of modulating an immune response using same
WO1999009139A1 (en) 1997-08-15 1999-02-25 Rubicon Laboratory, Inc. Retrovirus and viral vectors
AU9397098A (en) 1997-09-19 1999-04-12 Trustees Of The University Of Pennsylvania, The Methods and cell line useful for production of recombinant adeno-associated viruses
GB9801930D0 (en) 1998-01-29 1998-03-25 Univ London Mutant herpes simplex viruses and uses thereof
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
ES2292236T3 (en) 1998-04-02 2008-03-01 Genentech, Inc. VARIATIONS OF ANTIBODIES AND THEIR FRAGMENTS.
US6436392B1 (en) 1998-05-20 2002-08-20 University Of Iowa Research Foundation Adeno-associated virus vectors
US20040063094A1 (en) 1998-05-20 2004-04-01 Biovex Limited Mutant herpes simplex viruses and uses thereof
GB2337755B (en) 1998-05-29 2003-10-29 Secr Defence Virus vaccine
JP2002522451A (en) 1998-08-07 2002-07-23 ユニバーシティ オブ ワシントン Immunological herpes simplex virus antigens and their use
JP2002538770A (en) 1998-11-10 2002-11-19 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル Viral vectors and methods for their production and administration
NZ539776A (en) 1999-01-15 2006-12-22 Genentech Inc Polypeptide variants with altered effector function
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
GB9904582D0 (en) 1999-02-26 1999-04-21 Nycomed Imaging As Process
US6428968B1 (en) 1999-03-15 2002-08-06 The Trustees Of The University Of Pennsylvania Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject
BR0010155A (en) 1999-04-30 2002-01-15 Univ Pennsylvania Isolated and chimeric proteins, composition, nucleic acid molecule, plasmid, recombinant vaccine or attenuated vaccine, recombinant vaccine composition or attenuated vaccine composition, pharmaceutical composition, methods of immunizing an individual against an immunogen, isolated non-cd80 protein, molecule nucleic acid, and, method of immunosuppressing an individual
DE19933288A1 (en) 1999-07-15 2001-01-18 Medigene Ag Structural protein of adeno-associated virus with altered antigenicity, its production and use
US6365619B1 (en) 1999-07-22 2002-04-02 Novartis Ag Treatment of arteriosclerosis
ES2478635T3 (en) 1999-08-09 2014-07-22 Targeted Genetics Corporation Increased expression of a single stranded heterologous nucleotide sequence of recombinant viral vectors by designing the sequence so that it forms intracatenary base pairs
US7241447B1 (en) 1999-10-07 2007-07-10 University Of Iowa Research Foundation Adeno-associated virus vectors and uses thereof
US7329728B1 (en) 1999-10-25 2008-02-12 The Scripps Research Institute Ligand activated transcriptional regulator proteins
EP1242116A2 (en) 1999-12-22 2002-09-25 Onyx Pharmaceuticals, Inc. Herpes simplex virus-1 glycoprotein c mutants for treating unwanted hyperproliferative cell growth
KR100768408B1 (en) 2000-01-21 2007-10-18 바이오벡스 리미티드 Herpes Virus Strains
US7306902B2 (en) 2002-06-28 2007-12-11 Oncolyties Biotech Inc. Oncolytic viruses as phenotyping agents for neoplasms
US7094875B2 (en) 2000-06-23 2006-08-22 Maxygen, Inc. Co-stimulatory polypeptides
US7183376B2 (en) 2000-06-23 2007-02-27 Maxygen, Inc. Variant B7 co-stimulatory molecules
US7011972B2 (en) 2000-07-18 2006-03-14 The Scripps Research Institute Fusion polypeptide comprising two ligand binding domains
GB0021976D0 (en) 2000-09-07 2000-10-25 Optomed As Multi-parameter fiber optic probes
US6653103B2 (en) 2001-03-30 2003-11-25 Wisconsin Alumni Research Foundation Inhibition of nucleocytoplasmic transport by vesicular stomatitis virus M protein-like polypeptides
IL157504A0 (en) 2001-05-11 2004-03-28 Wellstat Biologics Corp Oncolytic virus therapy
EP1497426A2 (en) * 2001-06-22 2005-01-19 Maxygen, Inc. Co-stimulatory molecules
EP1411880B1 (en) 2001-07-11 2018-04-25 University of Miami Recombinant vsv for the treatment of tumor cells
CN1304559C (en) 2001-10-09 2007-03-14 杭州康科生物技术有限公司 Oncolytic microorganism expressing heat shock protein and its application
EP1456652A4 (en) 2001-11-13 2005-11-02 Dana Farber Cancer Inst Inc Agents that modulate immune cell activation and methods of use thereof
CA2468258C (en) 2001-11-30 2011-10-11 Jeffrey Schlom Peptide agonists of prostate-specific antigen, and uses therefor
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
EP1494613A4 (en) 2002-03-27 2008-06-18 Baylor College Medicine Potent oncolytic herpes simplex virus for cancer therapy
US20030225260A1 (en) 2002-04-30 2003-12-04 Snyder Richard O. Production of recombinant AAV virions
CA2489523A1 (en) 2002-06-21 2003-12-31 Wellstat Biologics Corporation Administration of therapeutic viruses
EP1391213A1 (en) 2002-08-21 2004-02-25 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
JP2005537802A (en) 2002-09-09 2005-12-15 ユニバーシティ・オブ・テネシー・リサーチ・ファウンデーション Rhabdovirus recombinant mutant and method of use thereof
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
BRPI0316779B8 (en) 2002-12-16 2023-02-28 Genentech Inc HUMAN ANTI-CD20 ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, ITS USES, COMPOSITION, MANUFACTURED ARTICLE AND LIQUID FORMULATION
ATE417115T1 (en) 2003-03-27 2008-12-15 Ottawa Health Research Inst MUTANT VESICULAR STOMATITIS VIRUSES AND THEIR USES
US7731974B2 (en) 2003-03-27 2010-06-08 Ottawa Hospital Research Institute Mutant vesicular stomatitis viruses and uses thereof
ATE420160T1 (en) 2003-06-18 2009-01-15 Genelux Corp MODIFIED RECOMBINANT VACCINIA VIRUSES, USES THEREOF
CA3072423A1 (en) 2003-09-30 2005-04-14 The Trustees Of The University Of Pennsylvania Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor
US7897146B2 (en) 2003-11-17 2011-03-01 Crusade Laboratories Limited Treatment using herpes simplex virus
US20070003520A1 (en) 2003-11-17 2007-01-04 Brown Susanne M Mutant viruses
GB0326798D0 (en) 2003-11-17 2003-12-24 Crusade Lab Ltd Methods for generating mutant virus
BRPI0417107A (en) 2003-12-19 2007-02-06 Genentech Inc antibody fragment, antibody fragment preparation methods, isolated nucleic acid, compositions, host cell, and antibody fragment manufacture and generation methods
WO2005100402A1 (en) 2004-04-13 2005-10-27 F.Hoffmann-La Roche Ag Anti-p-selectin antibodies
WO2005116224A2 (en) 2004-05-18 2005-12-08 Children's Memorial Hospital Tetracycline-regulated adeno-associated viral (aav) vectors for gene delivery to the nervous system
US7427396B2 (en) 2004-06-03 2008-09-23 Genzyme Corporation AAV vectors for gene delivery to the lung
US7731952B2 (en) 2004-06-24 2010-06-08 New York University Avirulent oncolytic herpes simplex virus strains engineered to counter the innate host response
ES2530340T3 (en) 2004-07-15 2015-03-02 Xencor Inc Optimized Fc variants
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
EP1810979B1 (en) 2004-09-22 2012-06-20 Kyowa Hakko Kirin Co., Ltd. STABILIZED HUMAN IgG4 ANTIBODIES
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
US20090208924A1 (en) 2004-12-01 2009-08-20 Bayer Schering Pharma Aktiengesellschaft Generation of Replication Competent Viruses for Therapeutic Use
TWI544076B (en) 2005-03-31 2016-08-01 Chugai Pharmaceutical Co Ltd A method of manufacturing a polypeptide that controls assembly
EP2963118B1 (en) 2005-06-01 2017-08-09 California Institute of Technology Method of targeted gene delivery using viral vectors
CN105483093A (en) 2005-06-23 2016-04-13 休斯顿大学 Use of mutant herpes simplex virus-2 for cancer therapy
US7943374B2 (en) 2005-08-21 2011-05-17 Markus Hildinger Super-size adeno-associated viral vector harboring a recombinant genome larger than 5.7 kb
GB0522476D0 (en) 2005-11-03 2005-12-14 Biovex Ltd Oncolytic herpes virus vectors
WO2008011636A2 (en) 2006-07-21 2008-01-24 California Institute Of Technology Targeted gene delivery for dendritic cell vaccination
US8052968B2 (en) 2006-10-16 2011-11-08 Genelux Corporation Modified vaccinia virus strains for use in diagnostic and therapeutic methods
WO2008140621A2 (en) 2006-12-21 2008-11-20 Mount Sinai School Of Medicine Of New York University Transgenic oncolytic viruses and uses thereof
WO2008092117A2 (en) 2007-01-25 2008-07-31 Xencor, Inc. Immunoglobulins with modifications in the fcr binding region
WO2008099189A2 (en) 2007-02-16 2008-08-21 Crusade Laboratories Limited Herpes simplex viruses and methods of viral replication
DK2537416T3 (en) 2007-03-30 2015-01-05 Sloan Kettering Inst Cancer Constitutive expression of costimulatory ligands ON adoptively transferred T-LYMPHOCYTES
EP2171071B1 (en) 2007-06-15 2015-08-05 Genelux Corporation Vaccinia virus vectors encoding a sodium-dependent transporter protein for imaging and/or treatment of tumors
DE602008005596D1 (en) 2007-06-21 2011-04-28 Univ Muenchen Tech BIOLOGICALLY ACTIVE PROTEINS WITH INCREASED IN VIVO AND / OR IN VITRO STABILITY
AU2008293885A1 (en) 2007-07-13 2009-03-05 The John Hopkins University B7-DC variants
JP2010533718A (en) 2007-07-18 2010-10-28 ジェネラックス・コーポレイション Use of chemotherapeutic agents in the manufacture of a medicament for the treatment or amelioration of side effects associated with oncolytic virus therapy
US20090136917A1 (en) 2007-10-25 2009-05-28 Szalay Aladar A Systems and methods for viral therapy
CN101925612A (en) 2007-11-27 2010-12-22 维文蒂阿生物技术公司 At antibody of the epi-position of the relevant NFKBIB variant of cancer and uses thereof
LT2222861T (en) 2007-12-11 2018-03-26 The University Of North Carolina At Chapel Hill Polypurine tract modified retroviral vectors
US8313896B2 (en) 2008-04-04 2012-11-20 The General Hospital Corporation Oncolytic herpes simplex virus immunotherapy in the treatment of brain cancer
US20120052003A9 (en) 2008-05-16 2012-03-01 Szalay Aladar A Microorganisms for preventing and treating neoplasms accompanying cellular therapy
EP2307033A4 (en) 2008-05-29 2012-06-13 Gen Hospital Corp Use of oncolytic herpes viruses for killing cancer stem cells
PE20110435A1 (en) 2008-08-25 2011-07-20 Amplimmune Inc ANTAGONIST COMPOSITIONS OF PD-1
EP2662383A1 (en) 2008-08-25 2013-11-13 Amplimmune, Inc. PD-I antagonists and methods for treating infectious disease
CN102165489B (en) 2008-09-16 2015-11-25 赫斯托克斯公司 The reproducible quantification of biomarker expression
EP2398466B1 (en) 2008-11-24 2021-02-17 Massachusetts Institute of Technology Methods and compositions for localized nanoparticle delivery to a tumor
US8481297B2 (en) 2009-01-08 2013-07-09 Yale University Compositions and methods of use of an oncolytic vesicular stomatitis virus
EP2283810A1 (en) 2009-07-16 2011-02-16 University College Cork-National University of Ireland, Cork Orally administered bacteria as vehicles for systemic delivery of agents
US20150359909A1 (en) 2009-07-16 2015-12-17 University College Cork-National University Of Ireland, Cork Orally administered bacteria as vehicles for systemic delivery of agents
RS58042B1 (en) 2009-07-24 2019-02-28 Immune Design Corp Non-integrating lentiviral vectors
WO2011066342A2 (en) 2009-11-24 2011-06-03 Amplimmune, Inc. Simultaneous inhibition of pd-l1/pd-l2
PT3053932T (en) * 2010-02-19 2020-10-21 Xencor Inc Novel ctla4-ig immunoadhesins
WO2011113019A2 (en) * 2010-03-12 2011-09-15 Abbott Biotherapeutics Corp. Ctla4 proteins and their uses
ES2617777T5 (en) 2010-04-23 2022-10-13 Hoffmann La Roche Production of heteromultimeric proteins
DK2649086T3 (en) 2010-12-09 2017-09-18 Univ Pennsylvania USING CHEMICAL ANTIGEN RECEPTOR-MODIFIED T-CELLS TO TREAT CANCER
CA2824997C (en) 2011-01-18 2023-01-17 The Trustees Of The University Of Pennsylvania Compositions and methods for treating cancer
ES2668895T3 (en) 2011-03-16 2018-05-23 Amgen Inc. Fc variants
EA027236B1 (en) 2011-04-08 2017-07-31 Иммьюн Дизайн Корп. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
PL2697257T3 (en) * 2011-04-13 2017-04-28 Bristol-Myers Squibb Company Fc fusion proteins comprising novel linkers or arrangements
WO2012149364A1 (en) 2011-04-28 2012-11-01 Diamond Don J Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy
CN102836441B (en) 2011-06-24 2019-06-11 台北荣民总医院 The method of immune response is promoted in the infectious treatment with malignant disease
DK2726101T3 (en) 2011-06-30 2018-12-03 Genzyme Corp T-CELL ACTIVATION INHIBITORS
EA201490636A1 (en) 2011-09-16 2014-08-29 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания T-CELLS DESIGNED WITH THE HELP OF RNA FOR THE TREATMENT OF MALIGNOUS NON-FORMATIONS
US8956619B2 (en) * 2011-10-25 2015-02-17 University Of Maryland, Baltimore County Soluble CD80 as a therapeutic to reverse immune supression in cancer patients
AU2013226090B2 (en) 2012-02-27 2018-03-08 Amunix Operating Inc. XTEN conjugate compositions and methods of making same
JP2015512263A (en) 2012-03-30 2015-04-27 イミューン デザイン コーポレイション Lentiviral vector particles with improved transduction efficacy for cells expressing DC-SIGN
MX355234B (en) 2012-05-11 2018-04-11 Medimmune Ltd Ctla-4 variants.
JP5857896B2 (en) 2012-07-06 2016-02-10 東京エレクトロン株式会社 Method of operating film forming apparatus and film forming apparatus
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
CN104902913A (en) 2012-12-04 2015-09-09 昂科梅德制药有限公司 Immunotherapy with binding agents
US9562099B2 (en) 2013-03-14 2017-02-07 Genentech, Inc. Anti-B7-H4 antibodies and immunoconjugates
US20160017041A1 (en) 2013-03-15 2016-01-21 Biogen Ma Inc. Treatment and prevention of acute kidney injury using anti-alpha v beta 5 antibodies
WO2014198002A1 (en) 2013-06-14 2014-12-18 Ottawa Hospital Research Institute A bacterium producing an interferon binding protein and uses thereof
GB201311475D0 (en) 2013-06-27 2013-08-14 Alligator Bioscience Ab Polypeptides
WO2015103438A2 (en) 2014-01-02 2015-07-09 Genelux Corporation Oncolytic virus adjunct therapy with agents that increase virus infectivity
MX2016008539A (en) 2014-01-15 2016-09-26 Hoffmann La Roche Fc-region variants with modified fcrn- and maintained protein a-binding properties.
US10323077B2 (en) 2014-02-10 2019-06-18 Emory University Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer
WO2015181343A2 (en) 2014-05-30 2015-12-03 Ventana Medical Systems, Inc. Multiplex assay for improved scoring of tumor tissues stained for pd-l1
EP3166974A1 (en) 2014-07-11 2017-05-17 Genentech, Inc. Anti-pd-l1 antibodies and diagnostic uses thereof
AU2015289773A1 (en) 2014-07-15 2017-02-02 Immune Design Corp. Prime-boost regimens with a TLR4 agonist adjuvant and a lentiviral vector
HUE050406T2 (en) 2014-08-08 2020-12-28 Univ Leland Stanford Junior High affinity pd-1 agents and methods of use
KR20160021586A (en) 2014-08-18 2016-02-26 지경민 Filter for vision correction and vision correction method using the same
SG10201901735XA (en) 2014-09-03 2019-03-28 Bavarian Nordic As Recombinant modified vaccinia virus ankara (mva) filovirus vaccine
US20190119353A1 (en) 2014-11-06 2019-04-25 Children's Research Institute, Children's National Medical Center Immunotherapeutics for cancer and autoimmune diseases
EP3020816A1 (en) 2014-11-11 2016-05-18 University College Cork Bacterial mediated gene therapy
WO2016118577A1 (en) 2015-01-22 2016-07-28 Medimmune, Llc Thymosin-beta-four fusion proteins
AU2016240411A1 (en) 2015-04-02 2017-10-12 Cancure Limited Agents and compositions for eliciting an immune response
WO2016164428A1 (en) 2015-04-06 2016-10-13 The Board Of Trustees Of The Leland Stanford Junior University Receptor-based antagonists of the programmed cell death 1 (pd-1) pathway
DK3283508T3 (en) 2015-04-17 2021-05-31 Alpine Immune Sciences Inc Immunomodulatory Proteins with Tunable Affinities
TWI715587B (en) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Tigit-binding agents and uses thereof
WO2016196228A1 (en) * 2015-05-29 2016-12-08 Bristol-Myers Squibb Company Antibodies against ox40 and uses thereof
TWI833183B (en) 2015-07-30 2024-02-21 美商宏觀基因股份有限公司 Pd-1-binding molecules and methods of use thereof
CA2995987C (en) 2015-08-20 2023-10-24 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. B7-h1 fusion polypeptides for treating and preventing organ failure
CA2997217A1 (en) 2015-09-14 2017-03-23 Alpine Immune Sciences, Inc. Tunable variant immunoglobulin superfamily domains and engineered cell therapy
HUE059788T2 (en) 2015-10-02 2022-12-28 Symphogen As Anti-pd-1 antibodies and compositions
TW201722985A (en) 2015-11-02 2017-07-01 戊瑞治療有限公司 CD80 extracellular domain polypeptides and their use in cancer treatment
CA3005804C (en) 2015-11-22 2022-03-29 Ventana Medical Systems, Inc. Methods of identifying immune cells in pd-l1 positive tumor tissue
WO2017151818A2 (en) 2016-03-02 2017-09-08 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
US10613092B2 (en) 2016-04-01 2020-04-07 Agilent Technologies, Inc. Scoring methods for anti-PD therapy eligibility and compositions for performing same
SG11201808783XA (en) 2016-04-15 2018-11-29 Alpine Immune Sciences Inc Cd80 variant immunomodulatory proteins and uses thereof
WO2017181148A2 (en) 2016-04-15 2017-10-19 Alpine Immune Sciences, Inc. Icos ligand variant immunomodulatory proteins and uses thereof
CN109475628A (en) 2016-05-18 2019-03-15 库尔生物制药有限公司 T cell modulability multimeric polypeptide and its application method
CA3022331A1 (en) 2016-05-18 2017-11-23 Albert Einstein College Of Medicine, Inc. Variant pd-l1 polypeptides, t-cell modulatory multimeric polypeptides, and methods of use thereof
CA3032120A1 (en) 2016-07-28 2018-02-01 Alpine Immune Sciences, Inc. Cd155 variant immunomodulatory proteins and uses thereof
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
JP7142630B2 (en) 2016-10-14 2022-09-27 ゼンコア インコーポレイテッド IL15/IL15Rα heterodimeric FC-fusion protein
US20200040059A1 (en) 2016-10-20 2020-02-06 Alpine Immune Sciences, Inc. Secretable variant immunomodulatory proteins and engineered cell therapy
CN110809581A (en) 2017-03-16 2020-02-18 高山免疫科学股份有限公司 PD-L2 variant immunomodulatory proteins and uses thereof
HRP20231382T1 (en) 2017-03-16 2024-02-16 Alpine Immune Sciences, Inc. Pd-l1 variant immunomodulatory proteins and uses thereof
SG11201907769XA (en) 2017-03-16 2019-09-27 Alpine Immune Sciences Inc Cd80 variant immunomodulatory proteins and uses thereof
SG11202006148UA (en) 2018-01-03 2020-07-29 Alpine Immune Sciences Inc Multi-domain immunomodulatory proteins and methods of use thereof
US12065476B2 (en) 2018-06-15 2024-08-20 Alpine Immune Sciences, Inc. PD-1 variant immunomodulatory proteins and uses thereof
KR20210089146A (en) 2018-09-19 2021-07-15 알파인 이뮨 사이언시즈, 인코포레이티드 Methods and uses of variant CD80 proteins and related constructs

Also Published As

Publication number Publication date
AU2018235838B2 (en) 2023-12-14
KR20190140924A (en) 2019-12-20
AU2024201667A1 (en) 2024-04-04
US11117950B2 (en) 2021-09-14
EP3596114A2 (en) 2020-01-22
AU2018235838A1 (en) 2019-09-05
US11230588B2 (en) 2022-01-25
JP2020511143A (en) 2020-04-16
BR112019018747A2 (en) 2020-05-05
US20210163571A1 (en) 2021-06-03
US11639375B2 (en) 2023-05-02
NZ756395A (en) 2024-01-26
US20210130436A1 (en) 2021-05-06
US20210155669A1 (en) 2021-05-27
US11117949B2 (en) 2021-09-14
MX2019010887A (en) 2019-10-15
IL268781A (en) 2019-10-31
US20210171603A1 (en) 2021-06-10
CN110662758A (en) 2020-01-07
WO2018170026A3 (en) 2018-10-18
US11096988B2 (en) 2021-08-24
JP2023058027A (en) 2023-04-24
US20240002466A1 (en) 2024-01-04
CA3054068A1 (en) 2018-09-20
JP7386083B2 (en) 2023-11-24
US20210188942A1 (en) 2021-06-24
US20210155668A1 (en) 2021-05-27
WO2018170026A2 (en) 2018-09-20
US11117948B2 (en) 2021-09-14

Similar Documents

Publication Publication Date Title
SG11201907769XA (en) Cd80 variant immunomodulatory proteins and uses thereof
SG11201808783XA (en) Cd80 variant immunomodulatory proteins and uses thereof
SG11201908280SA (en) "chimeric molecules and uses thereof"
SG11201808457PA (en) Icos ligand variant immunomodulatory proteins and uses thereof
SG11201810179RA (en) Novel crispr enzymes and systems
SG11201807252QA (en) Anti-lag-3 antibodies
SG11201808622SA (en) Chimeric receptors to flt3 and methods of use thereof
SG11201803593QA (en) Engineered nucleic-acid targeting nucleic acids
SG11201807912SA (en) Vaccine against rsv
SG11201807401RA (en) Therapeutic membrane vesicles
SG11201901528RA (en) Proteolytically cleavable chimeric polypeptides and methods of use thereof
SG11201907754RA (en) Anti-phf-tau antibodies and uses thereof
SG11201810003UA (en) Using programmable dna binding proteins to enhance targeted genome modification
SG11201803169WA (en) Cellulase variants and polynucleotides encoding same
SG11201908367TA (en) Flavor modifiers for meat analog products
SG11201900746RA (en) Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions
SG11201906341XA (en) Improved serum albumin binders
SG11201900201YA (en) Methods for quantitating individual antibodies from a mixture
SG11201809374VA (en) Cd40l-fc fusion polypeptides and methods of use thereof
SG11201908325PA (en) Process for the preparation of glucuronide drug-linkers and intermediates thereof
SG11201803703UA (en) Anti-complement factor c1q fab fragments and uses thereof
SG11201807636XA (en) Process for producing a polyacrylamide solution with increased viscosity
SG11201900845YA (en) Uses of il-13 antagonists for treating atopic dermatitis
SG11201903012RA (en) Anti-c1s antibodies and methods of use thereof
SG11201909419XA (en) Hydrogel for cell culture and biomedical applications