DE69637481T2 - Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8 - Google Patents
Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8 Download PDFInfo
- Publication number
- DE69637481T2 DE69637481T2 DE69637481T DE69637481T DE69637481T2 DE 69637481 T2 DE69637481 T2 DE 69637481T2 DE 69637481 T DE69637481 T DE 69637481T DE 69637481 T DE69637481 T DE 69637481T DE 69637481 T2 DE69637481 T2 DE 69637481T2
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- Germany
- Prior art keywords
- human
- antibody
- antigen
- acid sequence
- binding
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
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- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
- C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A—HUMAN NECESSITIES
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- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43093895A | 1995-04-27 | 1995-04-27 | |
| US430938 | 1995-04-27 | ||
| PCT/US1996/005928 WO1996033735A1 (en) | 1995-04-27 | 1996-04-29 | Human antibodies derived from immunized xenomice |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69637481D1 DE69637481D1 (de) | 2008-05-15 |
| DE69637481T2 true DE69637481T2 (de) | 2009-04-09 |
Family
ID=23709725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69637481T Expired - Lifetime DE69637481T2 (de) | 1995-04-27 | 1996-04-29 | Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20090149637A1 (enExample) |
| EP (3) | EP0822830B1 (enExample) |
| JP (10) | JP4312259B2 (enExample) |
| KR (2) | KR20050085971A (enExample) |
| AT (1) | ATE390933T1 (enExample) |
| AU (1) | AU5632296A (enExample) |
| CA (2) | CA2219361C (enExample) |
| DE (1) | DE69637481T2 (enExample) |
| ES (1) | ES2304786T3 (enExample) |
| WO (1) | WO1996033735A1 (enExample) |
Families Citing this family (1590)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6657103B1 (en) | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6300129B1 (en) * | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US7084260B1 (en) | 1996-10-10 | 2006-08-01 | Genpharm International, Inc. | High affinity human antibodies and human antibodies against human antigens |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US7597886B2 (en) | 1994-11-07 | 2009-10-06 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
| US5795966A (en) † | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| JP4312259B2 (ja) * | 1995-04-27 | 2009-08-12 | アムジェン フレモント インク. | 免疫したゼノマウス(XenoMouse)に由来するヒト抗体 |
| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| EP0823941A4 (en) * | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
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2005
- 2005-07-04 JP JP2005195484A patent/JP2005336200A/ja active Pending
- 2005-10-07 JP JP2005294297A patent/JP2006115839A/ja not_active Withdrawn
-
2007
- 2007-01-05 JP JP2007000544A patent/JP2007167070A/ja not_active Withdrawn
- 2007-08-08 US US11/891,292 patent/US20090149637A1/en not_active Abandoned
-
2008
- 2008-04-25 JP JP2008114842A patent/JP2008253268A/ja not_active Withdrawn
- 2008-09-09 JP JP2008231138A patent/JP4772092B2/ja not_active Expired - Fee Related
- 2008-12-24 JP JP2008326847A patent/JP2009136290A/ja not_active Withdrawn
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2009
- 2009-12-14 JP JP2009282350A patent/JP2010057507A/ja not_active Withdrawn
-
2010
- 2010-07-15 US US12/837,454 patent/US20120117669A1/en not_active Abandoned
- 2010-07-30 JP JP2010171583A patent/JP2011004751A/ja active Pending
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2012
- 2012-07-30 US US13/561,449 patent/US20130117871A1/en not_active Abandoned
- 2012-11-08 JP JP2012246268A patent/JP2013074891A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE69637481D1 (de) | 2008-05-15 |
| EP1978033A2 (en) | 2008-10-08 |
| JP2011004751A (ja) | 2011-01-13 |
| EP1709970A1 (en) | 2006-10-11 |
| JP2005336200A (ja) | 2005-12-08 |
| CA2219361A1 (en) | 1996-10-31 |
| JPH11505523A (ja) | 1999-05-21 |
| JP2008253268A (ja) | 2008-10-23 |
| US20130117871A1 (en) | 2013-05-09 |
| EP1978033A3 (en) | 2008-12-24 |
| KR20050085971A (ko) | 2005-08-29 |
| EP0822830A1 (en) | 1998-02-11 |
| AU5632296A (en) | 1996-11-18 |
| ES2304786T3 (es) | 2008-10-16 |
| JP2009136290A (ja) | 2009-06-25 |
| JP2010057507A (ja) | 2010-03-18 |
| JP4312259B2 (ja) | 2009-08-12 |
| JP2007167070A (ja) | 2007-07-05 |
| CA2761116A1 (en) | 1996-10-31 |
| EP0822830A4 (en) | 2003-03-19 |
| ATE390933T1 (de) | 2008-04-15 |
| US20120117669A1 (en) | 2012-05-10 |
| JP2013074891A (ja) | 2013-04-25 |
| US20090149637A1 (en) | 2009-06-11 |
| KR19990008096A (ko) | 1999-01-25 |
| WO1996033735A1 (en) | 1996-10-31 |
| CA2219361C (en) | 2012-02-28 |
| JP4772092B2 (ja) | 2011-09-14 |
| JP2006115839A (ja) | 2006-05-11 |
| JP2009039127A (ja) | 2009-02-26 |
| KR100654645B1 (ko) | 2007-04-04 |
| EP0822830B1 (en) | 2008-04-02 |
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