ES2304786T3 - Anticuerpos anti-il-8 humanos, derivados a partir de xenoratones inmunizados. - Google Patents

Anticuerpos anti-il-8 humanos, derivados a partir de xenoratones inmunizados. Download PDF

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Publication number
ES2304786T3
ES2304786T3 ES96913247T ES96913247T ES2304786T3 ES 2304786 T3 ES2304786 T3 ES 2304786T3 ES 96913247 T ES96913247 T ES 96913247T ES 96913247 T ES96913247 T ES 96913247T ES 2304786 T3 ES2304786 T3 ES 2304786T3
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Prior art keywords
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human
antigen
antibody
binds
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Expired - Lifetime
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ES96913247T
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English (en)
Spanish (es)
Inventor
Raju Kucherlapati
Aya Jakobovits
Sue Klapholz
Daniel G. Brenner
Daniel J. Capon
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Amgen Fremont Inc
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Amgen Fremont Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/244—Interleukins [IL]
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
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    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
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ES96913247T 1995-04-27 1996-04-29 Anticuerpos anti-il-8 humanos, derivados a partir de xenoratones inmunizados. Expired - Lifetime ES2304786T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43093895A 1995-04-27 1995-04-27
US430938 1995-04-27
PCT/US1996/005928 WO1996033735A1 (en) 1995-04-27 1996-04-29 Human antibodies derived from immunized xenomice

Publications (1)

Publication Number Publication Date
ES2304786T3 true ES2304786T3 (es) 2008-10-16

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ES96913247T Expired - Lifetime ES2304786T3 (es) 1995-04-27 1996-04-29 Anticuerpos anti-il-8 humanos, derivados a partir de xenoratones inmunizados.

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Country Link
US (3) US20090149637A1 (enExample)
EP (3) EP0822830B1 (enExample)
JP (10) JP4312259B2 (enExample)
KR (2) KR20050085971A (enExample)
AT (1) ATE390933T1 (enExample)
AU (1) AU5632296A (enExample)
CA (2) CA2219361C (enExample)
DE (1) DE69637481T2 (enExample)
ES (1) ES2304786T3 (enExample)
WO (1) WO1996033735A1 (enExample)

Families Citing this family (1590)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6657103B1 (en) 1990-01-12 2003-12-02 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6300129B1 (en) * 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US7084260B1 (en) 1996-10-10 2006-08-01 Genpharm International, Inc. High affinity human antibodies and human antibodies against human antigens
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