DK0752008T3 - DNA-mutagenese ved hjælp af tilfældig fragmentering og resamling - Google Patents

DNA-mutagenese ved hjælp af tilfældig fragmentering og resamling

Info

Publication number
DK0752008T3
DK0752008T3 DK95911826T DK95911826T DK0752008T3 DK 0752008 T3 DK0752008 T3 DK 0752008T3 DK 95911826 T DK95911826 T DK 95911826T DK 95911826 T DK95911826 T DK 95911826T DK 0752008 T3 DK0752008 T3 DK 0752008T3
Authority
DK
Denmark
Prior art keywords
polynucleotides
assembly
population
random fragmentation
dna mutagenesis
Prior art date
Application number
DK95911826T
Other languages
Danish (da)
English (en)
Inventor
Willem P C Stemmer
Andreas Crameri
Original Assignee
Maxygen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22733354&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0752008(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Maxygen Inc filed Critical Maxygen Inc
Application granted granted Critical
Publication of DK0752008T3 publication Critical patent/DK0752008T3/da

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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2468—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on beta-galactose-glycoside bonds, e.g. carrageenases (3.2.1.83; 3.2.1.157); beta-agarase (3.2.1.81)
    • C12N9/2471—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02006—Beta-lactamase (3.5.2.6)
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK95911826T 1994-02-17 1995-02-17 DNA-mutagenese ved hjælp af tilfældig fragmentering og resamling DK0752008T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/198,431 US5605793A (en) 1994-02-17 1994-02-17 Methods for in vitro recombination
PCT/US1995/002126 WO1995022625A1 (en) 1994-02-17 1995-02-17 Dna mutagenesis by random fragmentation and reassembly

Publications (1)

Publication Number Publication Date
DK0752008T3 true DK0752008T3 (da) 2002-06-17

Family

ID=22733354

Family Applications (2)

Application Number Title Priority Date Filing Date
DK95911826T DK0752008T3 (da) 1994-02-17 1995-02-17 DNA-mutagenese ved hjælp af tilfældig fragmentering og resamling
DK98122040T DK0934999T3 (da) 1994-02-17 1995-02-17 DNA-mutagenese ved hjælp af tilfældig fragmentering og resamling

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98122040T DK0934999T3 (da) 1994-02-17 1995-02-17 DNA-mutagenese ved hjælp af tilfældig fragmentering og resamling

Country Status (12)

Country Link
US (14) US5605793A (enExample)
EP (4) EP0752008B2 (enExample)
JP (6) JPH10500561A (enExample)
CN (1) CN1145641A (enExample)
AT (2) ATE211761T1 (enExample)
AU (3) AU703264C (enExample)
CA (1) CA2182393C (enExample)
DE (5) DE934999T1 (enExample)
DK (2) DK0752008T3 (enExample)
ES (2) ES2176324T3 (enExample)
RU (1) RU2157851C2 (enExample)
WO (1) WO1995022625A1 (enExample)

Families Citing this family (2442)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
DE69132905T2 (de) * 1990-12-06 2002-08-01 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Detektion von Nukleinsäuresequenzen
US6150141A (en) * 1993-09-10 2000-11-21 Trustees Of Boston University Intron-mediated recombinant techniques and reagents
US6309883B1 (en) * 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6335160B1 (en) * 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5837458A (en) * 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6165793A (en) * 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US20060257890A1 (en) * 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6117679A (en) * 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6406855B1 (en) * 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6808904B2 (en) * 1994-06-16 2004-10-26 Syngenta Participations Ag Herbicide-tolerant protox genes produced by DNA shuffling
GB9824544D0 (en) 1998-11-09 1999-01-06 Medical Res Council Screening system
US7285416B2 (en) * 2000-01-24 2007-10-23 Gendaq Limited Regulated gene expression in plants
US7262055B2 (en) 1998-08-25 2007-08-28 Gendaq Limited Regulated gene expression in plants
CA2196419C (en) 1994-08-20 2007-08-21 Yen Choo Improvements in or relating to binding proteins for recognition of dna
US6063562A (en) * 1994-09-16 2000-05-16 Sepracor, Inc. In vitro method for predicting the evolutionary response of HIV protease to a drug targeted thereagainst
US7597886B2 (en) * 1994-11-07 2009-10-06 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US7820798B2 (en) * 1994-11-07 2010-10-26 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
WO1996017932A1 (en) * 1994-12-09 1996-06-13 Wakunaga Seiyaku Kabushiki Kaisha Method of inhibiting non specific hybridization in primer extension
US20010053523A1 (en) * 1995-06-02 2001-12-20 M&E Biotech A/S. Method for identification of biologically active peptides and nucleic acids
US6936289B2 (en) 1995-06-07 2005-08-30 Danisco A/S Method of improving the properties of a flour dough, a flour dough improving composition and improved food products
US6406723B1 (en) 1997-04-09 2002-06-18 Danisco A/S Method for preparing flour doughs and products made from such doughs using glycerol oxidase and lipase
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
US6720140B1 (en) 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US6964861B1 (en) * 1998-11-13 2005-11-15 Invitrogen Corporation Enhanced in vitro recombinational cloning of using ribosomal proteins
US6495357B1 (en) * 1995-07-14 2002-12-17 Novozyme A/S Lipolytic enzymes
US6057103A (en) * 1995-07-18 2000-05-02 Diversa Corporation Screening for novel bioactivities
US6004788A (en) 1995-07-18 1999-12-21 Diversa Corporation Enzyme kits and libraries
US5958672A (en) 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US6455254B1 (en) 1995-07-18 2002-09-24 Diversa Corporation Sequence based screening
WO1997007205A1 (en) * 1995-08-11 1997-02-27 Novo Nordisk A/S Method for preparing polypeptide variants
EP0859841B1 (en) * 1995-08-18 2002-06-19 MorphoSys AG Protein/(poly)peptide libraries
US5965408A (en) * 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
GB9621295D0 (en) * 1995-12-07 1996-11-27 Cambridge Antibody Tech Specific binding members,materials and methods
US6358709B1 (en) 1995-12-07 2002-03-19 Diversa Corporation End selection in directed evolution
US6238884B1 (en) 1995-12-07 2001-05-29 Diversa Corporation End selection in directed evolution
US6764835B2 (en) 1995-12-07 2004-07-20 Diversa Corporation Saturation mutageneis in directed evolution
US20020028443A1 (en) * 1999-09-27 2002-03-07 Jay M. Short Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process
US6713279B1 (en) 1995-12-07 2004-03-30 Diversa Corporation Non-stochastic generation of genetic vaccines and enzymes
US7018793B1 (en) * 1995-12-07 2006-03-28 Diversa Corporation Combinatorial screening of mixed populations of organisms
US6361974B1 (en) * 1995-12-07 2002-03-26 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6489145B1 (en) 1996-07-09 2002-12-03 Diversa Corporation Method of DNA shuffling
US20030219752A1 (en) * 1995-12-07 2003-11-27 Diversa Corporation Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof
US6352842B1 (en) 1995-12-07 2002-03-05 Diversa Corporation Exonucease-mediated gene assembly in directed evolution
WO2000053744A2 (en) * 1999-03-09 2000-09-14 Diversa Corporation End selection in directed evolution
US6790605B1 (en) * 1995-12-07 2004-09-14 Diversa Corporation Methods for obtaining a desired bioactivity or biomolecule using DNA libraries from an environmental source
US6939689B2 (en) 1995-12-07 2005-09-06 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US6344328B1 (en) 1995-12-07 2002-02-05 Diversa Corporation Method for screening for enzyme activity
US20020031771A1 (en) * 1995-12-07 2002-03-14 Short Jay M. Sequence based screening
US6537776B1 (en) * 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US5939250A (en) * 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
US6740506B2 (en) 1995-12-07 2004-05-25 Diversa Corporation End selection in directed evolution
US20020164580A1 (en) * 1995-12-07 2002-11-07 Diversa Corporation Combinatorial screening of mixed populations of organisms
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US5976846A (en) * 1996-01-13 1999-11-02 Passmore; Steven E. Method for multifragment in vivo cloning and mutation mapping
AU1874997A (en) * 1996-02-15 1997-09-02 Pangenetics B.V. Molecules for the induction of immunological tolerance
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6096548A (en) * 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
US6372480B1 (en) 1996-04-19 2002-04-16 Mycogen Corporation Pesticidal proteins
US6242211B1 (en) 1996-04-24 2001-06-05 Terragen Discovery, Inc. Methods for generating and screening novel metabolic pathways
US20020120118A1 (en) * 1996-05-22 2002-08-29 Short Jay M. Enzymes having endoglucanase activity and methods of use thereof
US7465571B1 (en) 1996-05-22 2008-12-16 Verenium Corporation Endoglucanases
US6617434B1 (en) 1996-05-31 2003-09-09 North Shore Long Island Jewish Research Institute Identificiaton of differentially methylated and mutated nucleic acids
US5871917A (en) 1996-05-31 1999-02-16 North Shore University Hospital Research Corp. Identification of differentially methylated and mutated nucleic acids
ATE397088T1 (de) 1996-07-10 2008-06-15 Lonza Ag Verfahren zur herstellung von (s)- oder (r)-3,3,3-trifluor-2-hydroxy-2-methylpropionsaü e
JPH1066577A (ja) * 1996-08-07 1998-03-10 Novo Nordisk As 核酸プールおよびその製造方法
JPH1066576A (ja) * 1996-08-07 1998-03-10 Novo Nordisk As 突出末端を有する２本鎖ｄｎａ及びこれを用いたｄｎａのシャフリング方法
GB9618960D0 (en) 1996-09-11 1996-10-23 Medical Science Sys Inc Proteases
WO1998013485A1 (en) * 1996-09-27 1998-04-02 Maxygen, Inc. Methods for optimization of gene therapy by recursive sequence shuffling and selection
US7883872B2 (en) * 1996-10-10 2011-02-08 Dyadic International (Usa), Inc. Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose
US5811381A (en) * 1996-10-10 1998-09-22 Mark A. Emalfarb Cellulase compositions and methods of use
US6838238B1 (en) 1996-10-17 2005-01-04 Invitrogen Corporation Morphatides: novel shape and structure libraries
US6242669B1 (en) 1996-10-30 2001-06-05 Mycogen Corporation Pesticidal toxins and nucleotide sequences which encode these toxins
IL119586A (en) * 1996-11-07 2001-09-13 Univ Ramot Discontinuous library of a single biological unit and a method for its preparation
US20070009930A1 (en) * 1996-12-18 2007-01-11 Maxygen, Inc. Methods and compositions for polypeptide engineering
AU1022402A (en) * 1997-01-17 2002-03-14 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
EP1717322B1 (en) 1997-01-17 2012-07-18 Codexis Mayflower Holdings, LLC Evolution of whole cells and organisms by recursive sequence recombination
WO1998031816A1 (en) 1997-01-17 1998-07-23 Regents Of The University Of Minnesota Dna molecules and protein displaying improved triazine compound degrading ability
US7148054B2 (en) * 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6261804B1 (en) * 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
IL131016A (en) 1997-01-21 2004-12-15 Gen Hospital Corp Selection of proteins using RNA-protein blends
US8207093B2 (en) * 1997-01-21 2012-06-26 The General Hospital Corporation Selection of proteins using RNA-protein fusions
GB9701425D0 (en) * 1997-01-24 1997-03-12 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
CN1246150A (zh) * 1997-01-31 2000-03-01 科斯米克斯分子生物有限公司 组合文库的多样性的产生
IL156002A0 (en) 1997-02-12 2003-12-23 Eugene Y Chan Methods and products for analyzing polymers
US5851808A (en) 1997-02-28 1998-12-22 Baylor College Of Medicine Rapid subcloning using site-specific recombination
US6410220B1 (en) 1997-02-28 2002-06-25 Nature Technology Corp Self-assembling genes, vectors and uses thereof
DE69840382D1 (de) * 1997-03-18 2009-02-05 Novozymes As Methode zur herstellung einer bibliothek mittels dna-shuffling
US6291165B1 (en) * 1997-03-18 2001-09-18 Novo Nordisk A/S Shuffling of heterologous DNA sequences
US6159688A (en) 1997-03-18 2000-12-12 Novo Nordisk A/S Methods of producing polynucleotide variants
US6159687A (en) 1997-03-18 2000-12-12 Novo Nordisk A/S Methods for generating recombined polynucleotides
DK1015575T3 (da) * 1997-03-18 2010-08-23 Novozymes As Shuffling af heterologe DNA-sekvenser
US5948653A (en) * 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
EP0985033A4 (en) * 1997-04-04 2005-07-13 Biosite Inc POLYVALENT AND POLYCLONAL LIBRARIES
DK0974111T3 (da) 1997-04-11 2003-04-22 California Inst Of Techn Apparat og metode til automatiseret design af proteiner
US6558901B1 (en) * 1997-05-02 2003-05-06 Biomerieux Vitek Nucleic acid assays
IL124275A (en) * 1997-05-02 2002-03-10 Bio Merieux Vitek Inc A method to produce sequences of nucleic acids
GB9712512D0 (en) 1997-06-16 1997-08-20 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
US7087420B1 (en) 1997-07-17 2006-08-08 Cambia Microbial β-glucuronidase genes, gene products and uses thereof
US6391547B1 (en) * 1997-09-09 2002-05-21 Center For The Application Of Molecular Biology To International Agriculture Microbial β-glucuronidase genes, gene products and uses thereof
DE19731990A1 (de) * 1997-07-25 1999-01-28 Studiengesellschaft Kohle Mbh Verfahren zur Herstellung und Identifizierung von neuen Hydrolasen mit verbesserten Eigenschaften
WO1999011818A1 (fr) * 1997-08-28 1999-03-11 Isao Karube Procede de detection d'acides nucleiques ou de polypeptides hautement fonctionnels
US6602677B1 (en) 1997-09-19 2003-08-05 Promega Corporation Thermostable luciferases and methods of production
EP2860252A1 (en) 1997-09-19 2015-04-15 Promega Corporation Thermostable luciferases and methods of production
WO1999019467A1 (en) 1997-10-13 1999-04-22 Novo Nordisk A/S α-AMYLASE MUTANTS
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
CN101125873A (zh) * 1997-10-24 2008-02-20 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
DE69836092T2 (de) 1997-10-24 2007-05-10 Invitrogen Corp., Carlsbad Rekombinatorisches klonieren unter verwendung von nukleinsaüren mit rekombinationsstellen
US7351578B2 (en) * 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
AU1124499A (en) 1997-10-28 1999-05-17 Maxygen, Inc. Human papillomavirus vectors
US7232576B2 (en) 1997-10-31 2007-06-19 New Horizons Diagnostics Corp Throat lozenge for the treatment of Streptococcus Group A
US6423299B1 (en) 1997-10-31 2002-07-23 Vincent Fischetti Composition for treatment of a bacterial infection of an upper respiratory tract
US6399098B1 (en) 1997-10-31 2002-06-04 New Horizons Diagnostics Corp Composition for treating dental caries caused by streptococcus mutans
US6752988B1 (en) * 2000-04-28 2004-06-22 New Horizons Diagnostic Corp Method of treating upper resiratory illnesses
US20030129147A1 (en) * 1997-10-31 2003-07-10 Vincent Fischetti Use of bacterial phage associated lysing proteins for treating bacterial dental caries
US20030129146A1 (en) * 1997-10-31 2003-07-10 Vincent Fischetti The use of bacterial phage associated lysing proteins for treating bacterial dental caries
US20030082110A1 (en) * 1997-10-31 2003-05-01 Vincent Fischetti Use of bacterial phage associated lysing proteins for treating bacterial dental caries
US6277399B1 (en) 1997-10-31 2001-08-21 New Horizon Diagnostics Corporation Composition incorporating bacterial phage associated lysing enzymes for treating dermatological infections
US6406692B1 (en) 1997-10-31 2002-06-18 New Horizons Diagnostics Corp Composition for treatment of an ocular bacterial infection
US6428784B1 (en) * 1997-10-31 2002-08-06 New Horizons Diagnostics Corp Vaginal suppository for treating group B Streptococcus infection
US20020136712A1 (en) * 1997-10-31 2002-09-26 Fischetti Vincent Bacterial phage associated lysing enzymes for the prophylactic and therapeutic treatment of colonization and infections caused by streptococcus pneumoniae
US6056954A (en) 1997-10-31 2000-05-02 New Horizons Diagnostics Corp Use of bacterial phage associated lysing enzymers for the prophylactic and therapeutic treatment of various illnesses
US6399097B1 (en) 1997-10-31 2002-06-04 New Horizons Diagnostics Corporation Composition for treatment of a bacterial infection of the digestive tract
US6432444B1 (en) 1997-10-31 2002-08-13 New Horizons Diagnostics Corp Use of bacterial phage associated lysing enzymes for treating dermatological infections
AU1449499A (en) 1997-10-31 1999-05-24 Maxygen, Incorporated Modification of virus tropism and host range by viral genome shuffling
US7321023B2 (en) * 1997-11-07 2008-01-22 Incyte Corporation SP16 protein
ES2337027T3 (es) * 1997-12-05 2010-04-20 Europaisches Laboratorium Fur Molekularbiologie (Embl) Nuevo metodo de clonacion de dna basado en el sistema de recombinacion rece-rect de e. coli.
IL136574A0 (en) 1997-12-08 2001-06-14 California Inst Of Techn A method for forming a polynucleotide of desired properties
AR017831A1 (es) 1997-12-10 2001-10-24 Pioneer Hi Bred Int Metodo para alterar la composicion de aminoacidos de una proteina nativa de interes, proteina elaborada, y polinucleotido
US6303848B1 (en) 1998-01-16 2001-10-16 Large Scale Biology Corporation Method for conferring herbicide, pest, or disease resistance in plant hosts
US20030027173A1 (en) * 1998-01-16 2003-02-06 Della-Cioppa Guy Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
US20030166169A1 (en) * 1998-01-16 2003-09-04 Padgett Hal S. Method for constructing viral nucleic acids in a cell-free manner
US20020164585A1 (en) * 1998-01-16 2002-11-07 Sean Chapman Method for enhancing RNA or protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids
US6468745B1 (en) 1998-01-16 2002-10-22 Large Scale Biology Corporation Method for expressing a library of nucleic acid sequence variants and selecting desired traits
US6426185B1 (en) 1998-01-16 2002-07-30 Large Scale Biology Corporation Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
US6541011B2 (en) 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
US7390619B1 (en) * 1998-02-11 2008-06-24 Maxygen, Inc. Optimization of immunomodulatory properties of genetic vaccines
TR200002537T2 (tr) * 1998-03-17 2000-11-21 Novartis Ag. Mlo proteinlerini kodlayan ve bitki üzerinde mantar direnci veren genler
WO2003066847A2 (en) 2002-02-08 2003-08-14 Novozymes A/S Phytase variants
CN1314911A (zh) 1998-05-01 2001-09-26 麦克西根股份有限公司 用dna改组优化害虫抗性基因
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6902918B1 (en) 1998-05-21 2005-06-07 California Institute Of Technology Oxygenase enzymes and screening method
US20030207345A1 (en) * 1998-05-21 2003-11-06 California Institute Of Technology Oxygenase enzymes and screening method
EP2284272B1 (en) 1998-06-10 2014-08-13 Novozymes A/S Mannanases
US7153655B2 (en) * 1998-06-16 2006-12-26 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence
JP2002517995A (ja) 1998-06-17 2002-06-25 マキシジェン， インコーポレイテッド 所望の特性を有するポリヌクレオチドを生成するための方法
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
US6846655B1 (en) 1998-06-29 2005-01-25 Phylos, Inc. Methods for generating highly diverse libraries
ATE231186T1 (de) 1998-07-21 2003-02-15 Danisco Lebensmittel
US20030153042A1 (en) * 1998-07-28 2003-08-14 California Institute Of Technology Expression of functional eukaryotic proteins
US20040191772A1 (en) * 1998-08-12 2004-09-30 Dupret Daniel Marc Method of shuffling polynucleotides using templates
US6951719B1 (en) * 1999-08-11 2005-10-04 Proteus S.A. Process for obtaining recombined nucleotide sequences in vitro, libraries of sequences and sequences thus obtained
US6991922B2 (en) * 1998-08-12 2006-01-31 Proteus S.A. Process for in vitro creation of recombinant polynucleotide sequences by oriented ligation
US20030104417A1 (en) * 1998-08-12 2003-06-05 Proteus S.A. Template-mediated, ligation-oriented method of nonrandomly shuffling polynucleotides
US20060242731A1 (en) * 1998-08-12 2006-10-26 Venkiteswaran Subramanian DNA shuffling to produce herbicide selective crops
JP2002522089A (ja) * 1998-08-12 2002-07-23 マキシジェン， インコーポレイテッド 除草剤選択性作物を生成するためのｄｎａシャッフリング
EP1104459A1 (en) 1998-08-12 2001-06-06 Maxygen, Inc. Dna shuffling of monooxygenase genes for production of industrial chemicals
US20030092023A1 (en) * 1998-08-12 2003-05-15 Daniel Dupret Method of shuffling polynucleotides using templates
DK1105360T3 (da) 1998-08-17 2009-11-02 Bristol Myers Squibb Co Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler
WO2000014271A1 (en) * 1998-09-03 2000-03-16 Loma Linda University METHOD FOR STUDYING PROTEIN INTERACTIONS $i(IN VIVO)
US20070178475A1 (en) * 1998-09-17 2007-08-02 Nehls Michael C Novel human polynucleotides and polypeptides encoded thereby
US7897843B2 (en) 1999-03-23 2011-03-01 Mendel Biotechnology, Inc. Transcriptional regulation of plant biomass and abiotic stress tolerance
US20050086718A1 (en) 1999-03-23 2005-04-21 Mendel Biotechnology, Inc. Plant transcriptional regulators of abiotic stress
ATE286136T1 (de) * 1998-10-06 2005-01-15 Mark Aaron Emalfarb Transformationsystem in filamentösen fungiziden chrysosporium-wirtszellen
AU6510799A (en) 1998-10-07 2000-04-26 Maxygen, Inc. Dna shuffling to produce nucleic acids for mycotoxin detoxification
EP1157093A1 (en) * 1998-10-16 2001-11-28 Xencor, Inc. Protein design automation for protein libraries
US7315786B2 (en) 1998-10-16 2008-01-01 Xencor Protein design automation for protein libraries
US20020048772A1 (en) 2000-02-10 2002-04-25 Dahiyat Bassil I. Protein design automation for protein libraries
US6403312B1 (en) 1998-10-16 2002-06-11 Xencor Protein design automatic for protein libraries
US7479472B1 (en) 1998-10-19 2009-01-20 The Board Of Trustees Of The Leland Stanford Junior University DNA-templated combinatorial library chemistry
JP5043254B2 (ja) 1998-10-26 2012-10-10 ノボザイムス アクティーゼルスカブ 糸状面細胞内の問題のｄｎａライブラリーの作製及びスクリーニング
GB9823468D0 (en) 1998-10-28 1998-12-23 Secr Defence Novel enzyme
JP3267576B2 (ja) * 1998-11-09 2002-03-18 三光純薬株式会社 プローブ高分子の形成方法
EP1129184A1 (en) 1998-11-10 2001-09-05 Maxygen, Inc. Modified adp-glucose pyrophosphorylase for improvement and optimation of plant phenotypes
US6438561B1 (en) * 1998-11-19 2002-08-20 Navigation Technologies Corp. Method and system for using real-time traffic broadcasts with navigation systems
CN100381566C (zh) 1998-11-20 2008-04-16 科森生物科学公司 产生环氧噻酮及其衍生物的重组方法和材料
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
ES2639020T3 (es) 1998-11-27 2017-10-25 Ucb Pharma S.A. Composiciones y métodos para incrementar la mineralización de la substancia ósea
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
DE69943346D1 (de) 1998-12-18 2011-05-19 Novozymes As Subtilase Enzyme der I-S1- und I-S2-Untergruppen mit einem zusätzlichen Aminosäurerest in einer aktiven Schleifenregion
US6570003B1 (en) * 2001-01-09 2003-05-27 Lexion Genetics Incorporated Human 7TM proteins and polynucleotides encoding the same
US20020103359A1 (en) * 1999-12-07 2002-08-01 Gregory Donoho Novel human membrane proteins and polynucleotides encoding the same
US20020055626A1 (en) * 2000-06-09 2002-05-09 Turner C. Alexander Novel human seven transmembrane proteins and polynucleotides encoding the same
US20020031802A1 (en) * 2000-05-12 2002-03-14 Yi Hu Novel seven transmembrane proteins and polynucleotides encoding the same
US20040005673A1 (en) * 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
JP2002537762A (ja) * 1999-01-05 2002-11-12 トラスティーズ オブ ボストン ユニバーシティ 改良型核酸クローニング
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
US7070934B2 (en) 1999-01-12 2006-07-04 Sangamo Biosciences, Inc. Ligand-controlled regulation of endogenous gene expression
US7013219B2 (en) * 1999-01-12 2006-03-14 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6368861B1 (en) * 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US20030054390A1 (en) * 1999-01-19 2003-03-20 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6917882B2 (en) * 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6436675B1 (en) 1999-09-28 2002-08-20 Maxygen, Inc. Use of codon-varied oligonucleotide synthesis for synthetic shuffling
AU2415200A (en) * 1999-01-18 2000-08-01 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
JP2002534965A (ja) 1999-01-19 2002-10-22 マキシジェン， インコーポレイテッド 所望の特徴を有する文字ストリング、ポリヌクレオチドおよびポリペプチドを作製するための方法
US7873477B1 (en) * 2001-08-21 2011-01-18 Codexis Mayflower Holdings, Llc Method and system using systematically varied data libraries
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
US8457903B1 (en) 1999-01-19 2013-06-04 Codexis Mayflower Holdings, Llc Method and/or apparatus for determining codons
US20070065838A1 (en) * 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7702464B1 (en) 2001-08-21 2010-04-20 Maxygen, Inc. Method and apparatus for codon determining
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US20090130718A1 (en) * 1999-02-04 2009-05-21 Diversa Corporation Gene site saturation mutagenesis
IL144657A0 (en) 1999-02-11 2002-06-30 Maxygen Inc High throughput mass spectrometry
WO2000050620A2 (en) 1999-02-26 2000-08-31 Human Genome Sciences, Inc. Human endokine alpha and methods of use
DE60042969D1 (de) * 1999-03-02 2009-10-29 Life Technologies Corp Zubereitungen und methoden zur verwendung in rekombinatorischem klonen von nukleinsäuren
JP3399518B2 (ja) * 1999-03-03 2003-04-21 インターナショナル・ビジネス・マシーンズ・コーポレーション 半導体構造およびその製造方法
AU3391900A (en) 1999-03-05 2000-09-21 Maxygen, Inc. Encryption of traits using split gene sequences
US6531316B1 (en) 1999-03-05 2003-03-11 Maxyag, Inc. Encryption of traits using split gene sequences and engineered genetic elements
WO2000053617A1 (en) * 1999-03-08 2000-09-14 Protogene Laboratories, Inc. Methods and compositions for economically synthesizing and assembling long dna sequences
US8148110B2 (en) * 1999-03-15 2012-04-03 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by β-lactamase reporter fragment complementation
KR100312070B1 (ko) * 1999-03-15 2001-11-03 박호군 고속 선별법을 포함하는 개선된 형질을 갖는 효소 변이체의 제조방법
US7105315B2 (en) * 1999-06-16 2006-09-12 Incyte Genomics, Inc. Transmembrane protein differentially expressed in cancer
US20030104526A1 (en) 1999-03-24 2003-06-05 Qiang Liu Position dependent recognition of GNN nucleotide triplets by zinc fingers
US7030215B2 (en) * 1999-03-24 2006-04-18 Sangamo Biosciences, Inc. Position dependent recognition of GNN nucleotide triplets by zinc fingers
AU3419300A (en) 1999-03-30 2000-10-23 Novozymes A/S Alpha-amylase variants
DE60041536D1 (de) 1999-03-31 2009-03-26 Novozymes As Polypeptide mit alkaliner alpha-amylase-aktivität und für diese kodierende nukleinsäuren
EP2011864B1 (en) 1999-03-31 2014-12-31 Novozymes A/S Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same
US6703240B1 (en) 1999-04-13 2004-03-09 Maxygar, Inc. Modified starch metabolism enzymes and encoding genes for improvement and optimization of plant phenotypes
US20020110809A1 (en) * 1999-04-30 2002-08-15 Nehls Michael C. Novel human polynucleotides and polypeptides encoded thereby
US20020095031A1 (en) * 1999-05-04 2002-07-18 Nehls Michael C. Novel human polynucleotides and polypeptides encoded thereby
AU4393100A (en) 1999-05-20 2000-12-12 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 125 and 126
ATE408678T1 (de) 1999-05-20 2008-10-15 Novozymes As Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 129 und 130
AU4392900A (en) 1999-05-20 2000-12-12 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 127 and 128
EP1183342B2 (en) 1999-05-20 2012-06-13 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 128 and 129
DE60040149D1 (de) 1999-05-20 2008-10-16 Novozymes As Subtilase-enzyme der i-s1 und i-s2 untergruppen mit wenigstens einem zusätzlichen aminosäurerest zwischen positionen 126 und 127
DE60040282D1 (de) 1999-05-20 2008-10-30 Novozymes As SUBTILASE ENZYME DER I-S1 UND I-S2 UNTERGRUPPEN MIT MINDESTENS EINER ZUSäTZLICHEN AMINOSäURE ZWISCHEN POSITION 132 UND 133
US7332308B1 (en) 1999-05-21 2008-02-19 The Penn State Research Foundation Incrementally truncated nucleic acids and methods of making same
JP2003509010A (ja) * 1999-05-31 2003-03-11 ノボザイムス アクティーゼルスカブ ペプチドのスクリーニング方法
EP1067181A1 (en) * 1999-06-10 2001-01-10 Rijksuniversiteit te Groningen Enzyme selection
CA2378687A1 (en) * 1999-06-18 2000-12-28 Elitra Pharmaceuticals, Inc. Nucleotide sequences of moraxella catarrhalis genome
AU5805500A (en) * 1999-07-07 2001-01-30 Maxygen Aps A method for preparing modified polypeptides
US6421613B1 (en) * 1999-07-09 2002-07-16 Pioneer Hi-Bred International, Inc. Data processing of the maize prolifera genetic sequence
AR029759A1 (es) 1999-07-09 2003-07-16 Novozymes As Variante de glucoamilasa original, una construccion de adn, un vector de expresion recombinante, una celula, un proceso para convertir almidon, uso de una variante de glucoamilasa para un proceso de fermentacion y metodo para mejorar la estabilidad termica.
US6387620B1 (en) * 1999-07-28 2002-05-14 Gilead Sciences, Inc. Transcription-free selex
US7179638B2 (en) 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
US6653151B2 (en) 1999-07-30 2003-11-25 Large Scale Proteomics Corporation Dry deposition of materials for microarrays using matrix displacement
GB9918154D0 (en) * 1999-08-02 1999-10-06 Zeneca Ltd Expression system
WO2001012821A1 (en) 1999-08-12 2001-02-22 Pfizer Products Inc. Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
US6251604B1 (en) * 1999-08-13 2001-06-26 Genopsys, Inc. Random mutagenesis and amplification of nucleic acid
US6720142B1 (en) * 1999-08-19 2004-04-13 University Of Rochester Method of determining evolutionary potential of mutant resistance genes and use thereof to screen for drug efficacy
US20080003673A1 (en) * 1999-09-02 2008-01-03 Alejandro Abuin Novel human proteases and polynucleotides encoding the same
US6448388B1 (en) 2000-08-16 2002-09-10 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
US20030166902A1 (en) * 2001-02-20 2003-09-04 Yi Hu Novel human protease and polynucleotides encoding the same
US6716614B1 (en) * 1999-09-02 2004-04-06 Lexicon Genetics Incorporated Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
US20050153323A1 (en) * 2000-07-28 2005-07-14 Yi Hu Novel human proteases and polynucleotides encoding the same
US20030050464A1 (en) * 2000-07-28 2003-03-13 Yi Hu Novel human proteases and polynucleotides encoding the same
US6472588B1 (en) * 1999-09-10 2002-10-29 Texas Tech University Transgenic cotton plants with altered fiber characteristics transformed with a sucrose phosphate synthase nucleic acid
US20020127215A1 (en) * 1999-09-14 2002-09-12 Lawrence Loomis Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections
US7063837B2 (en) * 1999-09-14 2006-06-20 New Horizons Diagnostics Corp Syrup composition containing phage associated lytic enzymes
US6867291B1 (en) * 2000-09-15 2005-03-15 Lexicon Genetics Incorporated Human hemicentin proteins and polynucleotides encoding the same
US20020107382A1 (en) * 2000-09-27 2002-08-08 Friddle Carl Johan Novel human protease inhibitor proteins and polynucleotides encoding the same
US6790660B1 (en) 2001-09-18 2004-09-14 Lexicon Genetics Incorporated Human kielin-like proteins and polynucleotides encoding the same
US6841377B1 (en) 2001-06-13 2005-01-11 Lexicon Genetics Incorporated Human kinase and polynucleotides encoding the same
US6716616B1 (en) * 1999-09-28 2004-04-06 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
US6900045B2 (en) * 2000-08-31 2005-05-31 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
US6541252B1 (en) 2000-05-19 2003-04-01 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US20080050809A1 (en) * 1999-09-28 2008-02-28 Alejandro Abuin Novel human kinases and polynucleotides encoding the same
US6511840B1 (en) 2000-06-15 2003-01-28 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
US6759527B2 (en) 2001-03-20 2004-07-06 Lexicon Genetics Incorporated Human kinase and polynucleotides encoding the same
US6586230B1 (en) 2000-10-27 2003-07-01 Lexicon Genetics Incorporated Human kinase and polynucleotides encoding the same
US6797510B1 (en) * 2001-05-24 2004-09-28 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US20040002474A1 (en) * 1999-10-07 2004-01-01 Maxygen Inc. IFN-alpha homologues
CA2387479A1 (en) 1999-10-11 2001-04-19 Lexicon Genetics Incorporated Human ldl receptor family proteins and polynucleotides encoding the same
US7430477B2 (en) 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
MXPA02003754A (es) 1999-10-13 2003-10-14 Univ Leland Stanford Junior Biosintesis de sustratos de policetido sintasa.
AU1198701A (en) * 1999-10-13 2001-04-23 Lexicon Genetics Incorporated Novel human membrane proteins
US20080213878A1 (en) * 1999-10-19 2008-09-04 Gregory Donoho Novel human membrane proteins and polynucleotides encoding the same
US20030013865A1 (en) * 2001-03-12 2003-01-16 Yu Xuanchuan (Sean) Novel human EGF-family proteins and polynucleotides encoding the same
US6346249B1 (en) * 1999-10-22 2002-02-12 Ludwig Institute For Cancer Research Methods for reducing the effects of cancers that express A33 antigen using A33 antigen specific immunoglobulin products
GB9925161D0 (en) 1999-10-26 1999-12-22 Secr Defence Novel enzyme
US6635438B2 (en) * 1999-11-02 2003-10-21 Catch, Inc. Enzymatic cycling assays for homocysteine and cystathionine
AU1456101A (en) 1999-11-03 2001-05-14 Maxygen, Inc. Antibody diversity generation
DE19953854C2 (de) 1999-11-09 2002-01-17 Max Planck Gesellschaft Verfahren zur Herstellung von Biopolymeren mit veränderten Eigenschaften
WO2001034784A1 (en) 1999-11-10 2001-05-17 Novozymes A/S Fungamyl-like alpha-amylase variants
US6686515B1 (en) 1999-11-23 2004-02-03 Maxygen, Inc. Homologous recombination in plants
CA2392470A1 (en) * 1999-11-26 2001-05-31 Basf Plant Science Gmbh Method for the mutagenesis of nucleotide sequences from plants algae or fungi
US7115712B1 (en) * 1999-12-02 2006-10-03 Maxygen, Inc. Cytokine polypeptides
JP2004504005A (ja) * 1999-12-07 2004-02-12 レキシコン・ジェネティクス・インコーポレーテッド ヒト新規キナーゼタンパクおよびそれをコードするポリヌクレオチド
EP1235909A1 (en) 1999-12-09 2002-09-04 Lexicon Genetics Incorporated Human adam-ts proteases and polynucleotides encoding the same
ATE391789T1 (de) 1999-12-10 2008-04-15 Invitrogen Corp Verwendung einer vielzahl von rekombinationsstellen mit einzigartiger spezifität beim rekombinatorischen klonen
US20020042055A1 (en) * 1999-12-23 2002-04-11 Affholter Joseph A. Alteration of hydrolase genes and screening of the resulting libraries for the ability to catalyze specific reactions
DE60035434T2 (de) * 1999-12-27 2008-05-15 Crucell Holland B.V. Auswahl von epitop-bindungsfähigen verbindungen aus bibliotheken
US6927046B1 (en) * 1999-12-30 2005-08-09 Archer-Daniels-Midland Company Increased lysine production by gene amplification using coryneform bacteria
SG121902A1 (en) * 2000-01-11 2006-05-26 Maxygen Inc Integrated systems for diversity generation and screening
US6395485B1 (en) * 2000-01-11 2002-05-28 Aventis Cropscience N.V. Methods and kits for identifying elite event GAT-ZM1 in biological samples
WO2001053493A2 (en) * 2000-01-18 2001-07-26 Lexicon Genetics Incorporated Human kinase protein and polynucleotides encoding the same
EP1250463B1 (en) 2000-01-24 2006-04-05 Compound Therapeutics, Inc. Sensitive, multiplexed diagnostic assays for protein analysis
US7022479B2 (en) * 2000-01-24 2006-04-04 Compound Therapeutics, Inc. Sensitive, multiplexed diagnostic assays for protein analysis
AU2002219944B2 (en) 2000-11-28 2008-02-21 Medimmune, Llc Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
EP1257579B1 (en) * 2000-02-04 2009-08-05 Lexicon Pharmaceuticals, Inc. Novel human g protein coupled receptor proteins and polynucleotides encoding the same
EP1621617A1 (en) * 2000-02-10 2006-02-01 Xencor, Inc. Protein design automation for protein libraries
WO2001059066A2 (en) * 2000-02-10 2001-08-16 Xencor, Inc. Protein design automation for protein libraries
AU2001241939A1 (en) * 2000-02-28 2001-09-12 Maxygen, Inc. Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation
EP1268815A2 (en) * 2000-02-29 2003-01-02 Maxygen, Inc. Triazine degrading enzymes
US6436677B1 (en) * 2000-03-02 2002-08-20 Promega Corporation Method of reverse transcription
JP2004500106A (ja) * 2000-03-10 2004-01-08 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトｇ共役タンパク質受容体キナーゼおよびそれをコードするポリヌクレオチド
EP1276861A2 (en) * 2000-03-24 2003-01-22 Maxygen, Inc. Methods for modulating cellular and organismal phenotypes
US6767736B2 (en) * 2000-04-03 2004-07-27 Lexicon Genetics Incorporated Human ion channel protein and polynucleotides encoding the same
WO2001079509A1 (en) * 2000-04-12 2001-10-25 Lexicon Genetics Incorporated Human metalloprotease and polynucleotides encoding the same
US6926898B2 (en) 2000-04-12 2005-08-09 Human Genome Sciences, Inc. Albumin fusion proteins
US7129326B2 (en) * 2000-04-14 2006-10-31 Genencor International, Inc. Methods for selective targeting
EP1360500B1 (en) * 2000-04-14 2010-01-13 Genencor International, Inc. Methods for selective targeting
AU2001259156A1 (en) * 2000-04-27 2001-11-07 Lexicon Genetics Incorporated Novel membrane proteins and polynucleotides encoding the same
AU2001259205A1 (en) * 2000-04-28 2001-11-12 New Horizons Diagnostic Corporation The use of bacterial phage associated lysing enzymes for treating various illnesses
US6534292B1 (en) * 2000-05-08 2003-03-18 Genencor International, Inc. Methods for forming recombined nucleic acids
JP2003533205A (ja) * 2000-05-12 2003-11-11 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトリポカリン相同体およびそれをコードするポリヌクレオチド
US7115403B1 (en) 2000-05-16 2006-10-03 The California Institute Of Technology Directed evolution of galactose oxidase enzymes
WO2001088133A2 (en) 2000-05-18 2001-11-22 Lexicon Genetics Incorporated Human semaphorin homologs and polynucleotides encoding the same
US7244560B2 (en) * 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US20030032059A1 (en) * 2000-05-23 2003-02-13 Zhen-Gang Wang Gene recombination and hybrid protein development
AU2001274923A1 (en) * 2000-05-23 2001-12-03 Lexicon Genetics Incorporated Novel human thrombospondin-like proteins and polynucleotides encoding the same
US6790667B1 (en) * 2000-05-30 2004-09-14 Lexicon Genetics Incorporated Human mitochondrial proteins and polynucleotides encoding the same
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
AU2001275337A1 (en) * 2000-06-07 2001-12-17 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
US6465632B1 (en) * 2000-06-09 2002-10-15 Lexicon Genetics Incorporated Human phosphatases and polynucleotides encoding the same
FR2810339B1 (fr) * 2000-06-14 2004-12-10 Hoechst Marion Roussel Inc Banques combinatoires ameliorees par recombinaison dans la levure et procede d'analyse
EP1294949A4 (en) 2000-06-15 2004-08-25 Human Genome Sciences Inc HUMAN TUMORNESCROSE FACTOR DELTA AND EPSILON
AU2001268427B2 (en) 2000-06-16 2007-03-29 Glaxosmithkline Intellectual Property Limited Antibodies that immunospecifically bind to blys
US7468475B2 (en) 2000-06-16 2008-12-23 Schmuelling Thomas Method for modifying plant morphology, biochemistry and physiology
EP1297146A2 (en) * 2000-06-23 2003-04-02 Maxygen, Inc. Novel chimeric promoters
US6406863B1 (en) * 2000-06-23 2002-06-18 Genetastix Corporation High throughput generation and screening of fully human antibody repertoire in yeast
US6410271B1 (en) 2000-06-23 2002-06-25 Genetastix Corporation Generation of highly diverse library of expression vectors via homologous recombination in yeast
AU2001272978A1 (en) 2000-06-23 2002-01-08 Maxygen, Inc. Novel co-stimulatory molecules
US6410246B1 (en) 2000-06-23 2002-06-25 Genetastix Corporation Highly diverse library of yeast expression vectors
AU2001267333A1 (en) 2000-06-26 2002-01-08 Novozymes A/S Lipolytic enzyme
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
AU7151601A (en) * 2000-06-27 2002-01-08 Lexicon Genetics Inc Novel human gaba receptors and polynucleotides encoding the same
AU2001271912A1 (en) * 2000-07-07 2002-01-21 Maxygen, Inc. Molecular breeding of transposable elements
US6994963B1 (en) 2000-07-10 2006-02-07 Ambion, Inc. Methods for recombinatorial nucleic acid synthesis
US6858422B2 (en) * 2000-07-13 2005-02-22 Codexis, Inc. Lipase genes
AU2001273559A1 (en) * 2000-07-18 2002-01-30 Enchira Biotechnology Corporation Methods of ligation mediated chimeragenesis utilizing populations of scaffold and donor nucleic acids
CA2416691A1 (en) * 2000-07-21 2002-01-31 Incyte Genomics, Inc. Proteases
US7435562B2 (en) 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
US6878861B2 (en) * 2000-07-21 2005-04-12 Washington State University Research Foundation Acyl coenzyme A thioesterases
US6887685B1 (en) 2000-07-25 2005-05-03 Lexicon Genetics Incorporated Human thymosin protein and polynucleotides encoding the same
EP1354031A2 (en) * 2000-07-31 2003-10-22 Maxygen, Inc. Nucleotide incorporating enzymes
AU2001280968A1 (en) * 2000-07-31 2002-02-13 Menzel, Rolf Compositions and methods for directed gene assembly
CA2702204C (en) 2000-08-01 2011-09-06 Novozymes A/S Alpha-amylase mutants with altered properties
JP3859947B2 (ja) * 2000-08-04 2006-12-20 独立行政法人理化学研究所 突然変異導入方法
ES2394877T3 (es) 2000-08-14 2013-02-06 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Recombinación homóloga mejorada mediada por proteínas de recombinación de lambda
WO2002016547A2 (en) 2000-08-21 2002-02-28 Novozymes A/S Subtilase enzymes
US7198924B2 (en) * 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
WO2002015675A1 (en) 2000-08-22 2002-02-28 Mendel Biotechnology, Inc. Genes for modifying plant traits iv
AU8833901A (en) * 2000-08-22 2002-03-04 Lexicon Genetics Inc Novel human proteases and polynucleotides encoding the same
WO2002016435A2 (en) * 2000-08-22 2002-02-28 Lexicon Genetics Incorporated Human 7tm proteins and polynucleotides encoding the same
US7879540B1 (en) 2000-08-24 2011-02-01 Promega Corporation Synthetic nucleic acid molecule compositions and methods of preparation
JP2004527215A (ja) * 2000-08-24 2004-09-09 マキシジェン， インコーポレイテッド 構築物、および代謝経路操作におけるそれらの使用
US20030157643A1 (en) * 2000-08-24 2003-08-21 Almond Brian D Synthetic nucleic acids from aquatic species
FR2813314B1 (fr) * 2000-08-25 2004-05-07 Biomethodes Procede de mutagenese dirigee massive
DE60143959D1 (de) 2000-08-25 2011-03-10 Basf Plant Science Gmbh En kodieren
US6395504B1 (en) 2000-09-01 2002-05-28 New Horizons Diagnostics Corp. Use of phage associated lytic enzymes for the rapid detection of bacterial contaminants
US7229790B2 (en) * 2000-09-01 2007-06-12 Lexicon Pharmaceuticals, Inc. Human GABA transporter protein and polynucleotides encoding the same
EP1322786A4 (en) * 2000-09-11 2005-11-16 Univ Rochester METHOD FOR IDENTIFYING PUTATIVE ANTIBIOTIC RESISTANCE GENES
CA2422749A1 (en) * 2000-09-21 2002-03-28 Merck & Co., Inc. Method for generating recombinant polynucleotides
US20020142324A1 (en) * 2000-09-22 2002-10-03 Xun Wang Fungal target genes and methods to identify those genes
WO2002027007A2 (en) 2000-09-25 2002-04-04 Regents Of The University Of Michigan Production of viral vectors
ATE326533T1 (de) 2000-09-27 2006-06-15 Lexicon Genetics Inc Menschliche ionenaustauschproteine und dafür kodierende polynukleotiden
US20040091920A1 (en) * 2000-09-27 2004-05-13 Mitsubishi Chemical Corporation Method of constructing a mutant DNA library and use thereof
AU2001292254A1 (en) * 2000-09-27 2002-04-08 Mitsubishi Chemical Corporation Method of constructing mutant dna library and utilization thereof
US6777232B1 (en) 2000-10-02 2004-08-17 Lexicon Genetics Incorporated Human membrane proteins and polynucleotides encoding the same
AU2002230390A1 (en) * 2000-10-05 2002-04-29 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Ixodes scapularis tissue factor pathway inhibitor
WO2002031745A1 (en) * 2000-10-10 2002-04-18 Genencor International, Inc. Information rich libraries
EP1304386B1 (en) * 2000-10-11 2006-10-04 Sanko Junyaku Co., Ltd. Method of constructing self-assembly probes and method of detecting the same
AU2002213183A1 (en) 2000-10-12 2002-04-22 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
EP2333055A1 (en) 2000-10-13 2011-06-15 Novozymes A/S Subtilase variants
US20040091994A1 (en) 2000-10-13 2004-05-13 Carsten Andersen Alpha-amylase variant with altered properties
US7001763B1 (en) 2000-10-17 2006-02-21 Lexicon Genetics Incorporated Human semaphorin proteins and polynucleotides encoding the same
US7045283B2 (en) 2000-10-18 2006-05-16 The Regents Of The University Of California Methods of high-throughput screening for internalizing antibodies
EP1624062A3 (en) * 2000-10-27 2006-02-22 Lexicon Genetics Incorporated Human 7tm proteins and polynucleotides encoding them
US7060442B2 (en) * 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
WO2005012515A2 (en) 2003-04-29 2005-02-10 Pioneer Hi-Bred International, Inc. Novel glyphosate-n-acetyltransferase (gat) genes
EP1330524A2 (en) * 2000-10-30 2003-07-30 Lexicon Genetics Incorporated Novel human 7tm proteins and polynucleotides encoding the same
AU2002239410B2 (en) 2000-10-31 2008-05-01 Eisai Inc. CYP1B1 nucleic acids and methods of use
US7202070B2 (en) * 2000-10-31 2007-04-10 Biocatalytics, Inc. Method for reductive amination of a ketone using a mutated enzyme
WO2002036759A2 (en) * 2000-11-01 2002-05-10 Lexicon Genetics Incorporated Polynucleotides encoding human meltrin beta (adam19) metalloendopeptidases
CA2427928A1 (en) * 2000-11-02 2002-12-27 New Horizons Diagnostics Corporation The use of bacterial phage associated lytic enzymes to prevent food poisoning
JP3777158B2 (ja) * 2000-11-10 2006-05-24 アミコージェン・インコーポレイテッド 一方向性の一本鎖ｄｎａ切片を用いた組換えｄｎａライブラリーの製造方法
WO2002050278A2 (en) * 2000-11-15 2002-06-27 Lexicon Genetics Incorporated Novel human secreted proteins and polynucleotides encoding the same
EP1830190A3 (en) * 2000-11-17 2008-07-09 University Of Rochester In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
CN1306272C (zh) * 2000-11-17 2007-03-21 罗切斯特大学 筛选编码抗原特异性免疫球蛋白分子或其抗原特异性片段的方法
WO2002042438A2 (en) * 2000-11-20 2002-05-30 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
CA2431007A1 (en) 2000-12-11 2002-07-18 Lexicon Genetics Incorporated Novel human kinase and polynucleotides encoding the same
US6958213B2 (en) * 2000-12-12 2005-10-25 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function
AU3264202A (en) * 2000-12-12 2002-06-24 Lexicon Genetics Inc Novel human kinases and polynucleotides encoding the same
DE10062086A1 (de) * 2000-12-13 2002-07-04 Wella Ag Mittel und Verfahren zum Färben von Keratinfasern
EP1427847B1 (en) 2000-12-13 2010-07-28 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
US6583269B1 (en) * 2000-12-18 2003-06-24 Lexicon Genetics Incorporated Human protease inhibitor and polynucleotides encoding the same
WO2002050271A2 (en) * 2000-12-20 2002-06-27 Lexicon Genetics Incorporated Human ion channel protein and polynucleotides encoding the same
US6852844B1 (en) 2000-12-20 2005-02-08 Lexicon Genetics Incorporated Human protocadherin proteins and polynucleotides encoding the same
US20020150895A1 (en) * 2000-12-22 2002-10-17 Raymond Wheeler Method and apparatus for filtering and extending RNA alignment coverage
US20020086292A1 (en) 2000-12-22 2002-07-04 Shigeaki Harayama Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules
US7070973B2 (en) * 2000-12-26 2006-07-04 Board Of Regents Of The University Of Nebraska Butyrylcholinesterase variants and methods of use
WO2002059325A2 (en) * 2000-12-27 2002-08-01 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US20020119522A1 (en) * 2000-12-28 2002-08-29 Friddle Carl Johan Novel human ion channel-related proteins and polynucleotides encoding the same
US20020115844A1 (en) * 2001-01-05 2002-08-22 Yu Xuanchuan Sean Novel human lipase and polynucleotides encoding the same
US7273923B2 (en) 2001-01-22 2007-09-25 Sangamo Biosciences, Inc. Zinc finger proteins for DNA binding and gene regulation in plants
WO2002059287A2 (en) * 2001-01-23 2002-08-01 Lexicon Genetics Incorporated Novel human kinases and polynucleotides encoding the same
US20030104402A1 (en) * 2001-01-23 2003-06-05 University Of Rochester Methods of producing or identifying intrabodies in eukaryotic cells
US20020115846A1 (en) * 2001-01-24 2002-08-22 Xuanchuan (Sean) Yu Novel human lipase and polynucleotides encoding the same
EP1683865A3 (en) 2001-02-02 2006-10-25 Eli Lilly & Company Mammalian proteins and in particular CD200
US20020127674A1 (en) * 2001-02-02 2002-09-12 Xuanchuan Yu Novel human transporter protein and polynucleotides encoding the same
AU2002255495A1 (en) * 2001-02-02 2002-08-19 University Of Rochester Methods of identifying regulator molecules
WO2002064612A2 (en) 2001-02-09 2002-08-22 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
US6849449B2 (en) * 2001-03-01 2005-02-01 Regents Of The University Of Michigan Orphanin FQ receptor nucleic acids
MXPA02012739A (es) 2001-03-09 2004-04-20 Nugen Technologies Inc Metodos y composiciones para amplificacion de secuencias de arn.
AU2002252296A1 (en) * 2001-03-12 2002-09-24 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
WO2002072603A2 (en) * 2001-03-12 2002-09-19 Lexicon Genetics Incorporated Novel human dectin proteins and polynucleotides encoding the same
US6994995B1 (en) 2001-03-16 2006-02-07 Lexicon Genetics Incorporated Human synaptotagmin and polynucleotides encoding the same
US7807408B2 (en) * 2001-03-19 2010-10-05 President & Fellows Of Harvard College Directed evolution of proteins
PT1423400E (pt) * 2001-03-19 2006-12-29 Harvard College Evolução de nova função molecular
US7678554B2 (en) 2001-03-19 2010-03-16 President And Fellows Of Harvard College Nucleic acid shuffling
US20030049619A1 (en) * 2001-03-21 2003-03-13 Simon Delagrave Methods for the synthesis of polynucleotides and combinatorial libraries of polynucleotides
AR035799A1 (es) 2001-03-30 2004-07-14 Syngenta Participations Ag Toxinas insecticidas aisladas de bacillus thuringiensis y sus usos.
CA2443319A1 (en) * 2001-04-06 2002-10-17 Lexicon Genetics Incorporated Novel human kinase and polynucleotides encoding the same
CA2443516A1 (en) * 2001-04-06 2002-10-17 Lexicon Genetics Incorporated Novel human kinases and polynucleotides encoding the same
FR2823219B1 (fr) * 2001-04-10 2003-07-04 Pasteur Institut Mutants de la desoxycytidine kinase possedant une activite enzymatique elargie
US6644173B2 (en) * 2001-04-11 2003-11-11 Keuring, Incorporated Beverage filter cartridge holder
JP2004536579A (ja) 2001-04-13 2004-12-09 ヒューマン　ジノーム　サイエンシーズ，　インコーポレイテッド 血管内皮増殖因子２
AU2002307340A1 (en) * 2001-04-16 2002-10-28 California Institute Of Technology Peroxide-driven cytochrome p450 oxygenase variants
US6607895B2 (en) 2001-04-16 2003-08-19 Lexicon Genetics Incorporated Human adenylsuccinate synthetase and polynucleotides encoding the same
US20030077804A1 (en) * 2001-04-19 2003-04-24 Invitrogen Corporation Compositions and methods for recombinational cloning of nucleic acid molecules
EP1381680A1 (en) * 2001-04-25 2004-01-21 Proteus Template-mediated, ligation-oriented method of nonrandomly shuffling polynucleotides
FR2824073B1 (fr) * 2001-04-25 2003-12-19 Proteus Procede de creation in vitro de sequences polynucleotidiques recombinees par ligation orientee
WO2002088313A2 (en) * 2001-04-30 2002-11-07 Lexicon Genetics Incorporated Novel human nuclear transporters and polynucleotides encoding the same
AU2002254773B2 (en) * 2001-05-03 2005-12-08 Rensselaer Polytechnic Institute Novel methods of directed evolution
EP1950305A1 (en) 2001-05-09 2008-07-30 Monsanto Technology, LLC Tyr a genes and uses thereof
EP1463749A4 (en) * 2001-05-09 2005-04-13 Lexicon Genetics Inc NEW HUMAN KINASES AND THESE CODING POLYNUCLEOTIDES
EP3000881A3 (en) 2001-05-15 2016-07-20 Novozymes A/S Alpha-amylase variant with altered properties
ATE401398T1 (de) * 2001-05-17 2008-08-15 Proteus Verfahren zur herstellung von polynukleotidfragmenten zur verwendung im shuffling
WO2002094123A2 (en) 2001-05-18 2002-11-28 Danisco A/S Method of preparing a dought with an enzime
WO2002094992A2 (en) * 2001-05-18 2002-11-28 Rigel Pharmaceuticals, Incorporated Directed evolution of protein in mammalian cells
CA2448505A1 (en) * 2001-05-21 2002-11-28 Invitrogen Corporation Compositions and methods for use in isolation of nucleic acid molecules
MXPA03010747A (es) 2001-05-25 2004-03-02 Human Genome Sciences Inc Anticuerpos que se unen inmunoespecificamente a receptores de ligando inductor de apoptosis relacionado con factor de necrosis tumoral.
US20020193585A1 (en) * 2001-05-25 2002-12-19 Walke D. Wade Novel human transporter proteins and polynucleotides encoding the same
AU2002303879B2 (en) 2001-05-29 2007-08-09 Lexicon Pharmaceuticals, Inc. Novel human hydroxylases and polynucleotides encoding the same
WO2002099080A2 (en) * 2001-06-05 2002-12-12 Gorilla Genomics, Inc. Methods for low background cloning of dna using long oligonucleotides
AU2002311012A1 (en) 2001-06-06 2002-12-16 Novozymes A/S Endo-beta-1,4-glucanase from bacillus
US20030027301A1 (en) * 2001-06-14 2003-02-06 Yi Hu Novel human transporter proteins and polynucleotides encoding the same
US7727713B2 (en) * 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
AU2002322388A1 (en) 2001-06-22 2003-01-08 E.I. Du Pont De Nemours And Company Defensin polynucleotides and methods of use
EP1925672A1 (en) 2001-06-22 2008-05-28 Syngeta Participations AG Abiotic stress responsive polynucleotides and polypeptides
DK2295544T3 (en) 2001-06-26 2016-09-26 Novozymes As Polypeptides with cellobiohydrolase I activity and the same coding polynucleotides
EP1404825A2 (en) * 2001-06-27 2004-04-07 Roche Diagnostics GmbH A WALK-THROUGH TECHNIQUE FOR i IN VITRO /i RECOMBINATION OF POLYNUCLEOTIDE SEQUENCES
GB0115841D0 (en) 2001-06-28 2001-08-22 Medical Res Council Ligand
AU2002318186A1 (en) * 2001-07-03 2003-01-21 Lexicon Genetics Incorporated Novel human kielin-like proteins and polynucleotides encoding the same
DK200101090A (da) 2001-07-12 2001-08-16 Novozymes As Subtilase variants
US20040213765A1 (en) * 2001-07-13 2004-10-28 Vincent Fischetti Use of bacterial phage associated lytic enzymes to prevent food poisoning
WO2003008624A2 (en) * 2001-07-15 2003-01-30 Keck Graduate Institute Nucleic acid amplification using nicking agents
EP1277835A1 (en) * 2001-07-19 2003-01-22 Libragen Methods of creating genetic diversity
US7226768B2 (en) 2001-07-20 2007-06-05 The California Institute Of Technology Cytochrome P450 oxygenases
ATE286124T1 (de) 2001-07-23 2005-01-15 Dsm Ip Assets Bv Verfahren zur herstellung von polynukleotidvarianten
DE60232523D1 (de) 2001-07-26 2009-07-16 Stratagene California Multi-stellen-mutagenese
US6867189B2 (en) * 2001-07-26 2005-03-15 Genset S.A. Use of adipsin/complement factor D in the treatment of metabolic related disorders
US6833441B2 (en) 2001-08-01 2004-12-21 Abmaxis, Inc. Compositions and methods for generating chimeric heteromultimers
CA2456229A1 (en) * 2001-08-03 2003-02-13 Diversa Corporation Epoxide hydrolases, nucleic acids encoding them and methods for making and using them
US6943001B2 (en) * 2001-08-03 2005-09-13 Diversa Corporation Epoxide hydrolases, nucleic acids encoding them and methods for making and using them
US6987079B2 (en) * 2001-08-14 2006-01-17 W.R. Grace & Co.-Conn. Supported catalyst systems
EP1425382A4 (en) * 2001-08-14 2004-10-06 Lexicon Genetics Inc NEW HUMAN COLLAGEN PROTEINS AND THESE CODING POLYNUCLEOTIDS
ATE365211T1 (de) * 2001-08-20 2007-07-15 Regenesis Bioremediation Produ Biosensor für kleinmolekulare analyten
US7647184B2 (en) * 2001-08-27 2010-01-12 Hanall Pharmaceuticals, Co. Ltd High throughput directed evolution by rational mutagenesis
KR100942880B1 (ko) 2001-08-29 2010-02-17 제넨테크, 인크. 유사분열촉진 활성을 가진 Ｂｖ８ 핵산 및 폴리펩티드
US7635798B2 (en) * 2001-08-31 2009-12-22 Dow Agrosciences, Llc Nucleic acid compositions conferring altered metabolic characteristics
KR100428998B1 (ko) * 2001-09-10 2004-04-28 한국과학기술원 모체 단백질과는 크기와 서열이 다른 단백질의 변이집단을생산하는 방법
WO2003025215A1 (en) * 2001-09-14 2003-03-27 The University Of Queensland Detection of dna methylation
WO2003025132A2 (en) * 2001-09-14 2003-03-27 Invitrogen Corporation Dna polymerases and mutants thereof
US7582425B2 (en) * 2001-09-21 2009-09-01 The Regents Of The University Of Michigan Atlastin
US7108975B2 (en) * 2001-09-21 2006-09-19 Regents Of The University Of Michigan Atlastin
US20030104445A1 (en) * 2001-09-25 2003-06-05 Hayes Robert J. RNA dependent RNA polymerase mediated protein evolution
DE10147074A1 (de) * 2001-09-25 2003-05-08 Beru Ag Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung
US20030186374A1 (en) 2001-10-01 2003-10-02 Hufton Simon E. Multi-chain eukaryotic display vectors and uses thereof
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7173003B2 (en) * 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
EP2292273A3 (en) 2001-10-10 2011-11-23 BioGeneriX AG Remodeling and glycoconjugation of peptides
US20040005709A1 (en) * 2001-10-24 2004-01-08 Hoogenboom Henricus Renerus Jacobus Mattheus Hybridization control of sequence variation
WO2003035679A2 (en) 2001-10-25 2003-05-01 Medical Research Council Molecules
EP1840211A1 (en) 2001-10-31 2007-10-03 Danisco A/S Pyranosone dehydratase from phanerochaete chrysosporium
US7175983B2 (en) * 2001-11-02 2007-02-13 Abmaxis, Inc. Adapter-directed display systems
WO2003050914A1 (en) * 2001-12-05 2003-06-19 E-Tenna Corporation Capacitively-loaded bent-wire monopole on an artificial magnetic conductor
US6989261B2 (en) * 2001-12-20 2006-01-24 Eli Lilly And Company Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
DE10162727A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14391) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
US7049121B2 (en) * 2001-12-20 2006-05-23 Applied Molecular Evolution Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
DE10162728A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10163884A1 (de) 2001-12-22 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus sp. (DSM 14392) und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease
MY139056A (en) * 2001-12-28 2009-08-28 Ab Enzymes Gmbh Microbially-expressed thermotolerant phytase for animal feed
KR100475305B1 (ko) * 2002-01-08 2005-03-10 주식회사 마이크로아이디 단일가닥 특이적인 ｄｎａ 절단효소 엑소뉴클리아제ⅶ을 이용하여 키메라 ｄｎａ 라이브러리를 만드는 방법
US20040009498A1 (en) * 2002-01-14 2004-01-15 Diversa Corporation Chimeric antigen binding molecules and methods for making and using them
AU2003209340A1 (en) * 2002-01-18 2003-09-02 Bristol-Myers Squibb Company Predictor sets for tyrosine kinase pathways
US7262054B2 (en) * 2002-01-22 2007-08-28 Sangamo Biosciences, Inc. Zinc finger proteins for DNA binding and gene regulation in plants
DE20200926U1 (de) * 2002-01-23 2002-04-18 Hegenscheidt-MFD GmbH & Co. KG, 41812 Erkelenz Festwalzgerät einer Festwalzmaschine für Kurbelwellen
US20040096826A1 (en) * 2002-01-30 2004-05-20 Evans Glen A. Methods for creating recombination products between nucleotide sequences
US7255986B2 (en) * 2002-01-31 2007-08-14 The Board Of Trustees Operating Michigan State University Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
RS50813B (sr) * 2002-02-12 2010-08-31 Pfizer Products Inc. Streptomyces avermitilis gen koji određuje odnos b2:b1 avermektina
AU2002306484A1 (en) 2002-02-13 2003-09-04 Dow Global Technologies Inc. Over-expression of extremozyme genes in pseudomonads and closely related bacteria
US20030224404A1 (en) * 2002-02-25 2003-12-04 Manuel Vega High throughput directed evolution of nucleic acids by rational mutagenesis
US20030166010A1 (en) * 2002-02-25 2003-09-04 Affholter Joseph A. Custom ligand design for biomolecular filtration and purification for bioseperation
JP4722396B2 (ja) * 2002-02-26 2011-07-13 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 遺伝要素の組換え方法
EP1485404A4 (en) * 2002-02-27 2005-03-30 California Inst Of Techn NEW GLUCOSE 6-OXIDASES
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
BR0308161A (pt) * 2002-03-01 2006-06-06 Ravgen Inc métodos para a detecção de distúrbios genéticos
EP2315145B1 (en) 2002-03-01 2015-11-25 Codexis Mayflower Holdings, LLC Methods, systems, and software for identifying functional biomolecules
US7244592B2 (en) 2002-03-07 2007-07-17 Dyax Corp. Ligand screening and discovery
WO2003078583A2 (en) 2002-03-09 2003-09-25 Maxygen, Inc. Optimization of crossover points for directed evolution
WO2003078645A2 (en) * 2002-03-11 2003-09-25 Nugen Technologies, Inc. Methods for generating double stranded dna comprising a 3’ single stranded portion and uses of these complexes for recombination
AU2003218630A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
EP1487850A2 (en) * 2002-03-15 2004-12-22 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
DE60324778D1 (de) 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
US20050221318A1 (en) * 2002-03-15 2005-10-06 Gouliaev Alex H Building block forming a c-c bond upon reaction
AU2003230693B2 (en) * 2002-03-20 2010-09-30 J.R. Simplot Company Refined plant transformation
US20050034188A1 (en) * 2002-03-20 2005-02-10 J. R. Simplot Company Refined plant transformation
CN100497378C (zh) 2002-03-22 2009-06-10 拜尔生物科学公司 新的苏云金芽孢杆菌杀昆虫蛋白质
US20030228598A1 (en) * 2002-03-25 2003-12-11 The Regents Of The University Of California DNA/RNA as a write/read medium
US20030180781A1 (en) * 2002-03-25 2003-09-25 The Regents Of The University Of California Constructing very long DNA sequences from synthetic DNA molecules
US7452666B2 (en) * 2002-03-25 2008-11-18 Lawrence Livermore National Security, Llc Synthesis of DNA
US20030186301A1 (en) * 2002-03-25 2003-10-02 The Regents Of The University Of California Constructing user-defined, long DNA sequences
AU2003218456A1 (en) * 2002-04-01 2003-10-20 Human Genome Sciences, Inc. Antibodies that specifically bind to gmad
WO2003087763A2 (en) 2002-04-03 2003-10-23 Celltech R & D, Inc. Association of polymorphisms in the sost gene region with bone mineral density
EP2270049A3 (en) 2002-04-12 2011-03-09 Medimmune, Inc. Recombinant anti-interleukin-9-antibody
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
EP1497418B1 (en) 2002-04-19 2012-10-17 Verenium Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
US6776751B2 (en) * 2002-04-22 2004-08-17 Kendor Laboratory Products, Lp Rotor cover attachment apparatus
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
DE60333285D1 (de) 2002-05-14 2010-08-19 Martek Biosciences Corp Carotinsynthase-gen und dessen verwendung
ATE356871T1 (de) * 2002-05-17 2007-04-15 Alligator Bioscience Ab Eine methode zur in vitro molekularen evolution der proteinfunktion
DE10222858A1 (de) 2002-05-23 2003-12-04 Basf Ag Verfahren zur fermentativen Herstellung schwefelhaltiger Feinchemikalien
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
WO2003106639A2 (en) * 2002-06-14 2003-12-24 Dyax Corporation Recombination of nucleic acid library members
US7425618B2 (en) 2002-06-14 2008-09-16 Medimmune, Inc. Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
AU2003247582A1 (en) * 2002-06-20 2004-01-06 Board Of Trustees Operating Michigan State University Plastid division and related genes and proteins, and methods of use
DE60336555D1 (de) * 2002-06-21 2011-05-12 Novo Nordisk Healthcare Ag Pegylierte glykoformen von faktor vii
US20060002935A1 (en) 2002-06-28 2006-01-05 Domantis Limited Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
CN1678634A (zh) * 2002-06-28 2005-10-05 多曼蒂斯有限公司 免疫球蛋白单个变体抗原结合区及其特异性构建体
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
AU2003247650A1 (en) 2002-06-28 2004-01-19 Dow Agrosciences Llc Pesticidally active proteins and polynucleotides obtainable from paenibacillus species
US20040219516A1 (en) * 2002-07-18 2004-11-04 Invitrogen Corporation Viral vectors containing recombination sites
ES2420929T3 (es) 2002-07-18 2013-08-27 Monsanto Technology Llc Procedimientos de utilización de polinucleótidos artificiales y sus composiciones para reducir el silenciamiento de transgenes
US7560260B2 (en) 2002-07-25 2009-07-14 Bio-Rad Laboratories, Inc. Compositions with polymerase activity
EP2264155A1 (en) 2002-07-25 2010-12-22 Bio-Rad Laboratories, Inc. Hybrid polymerase methods and compositions
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
AU2003304275A1 (en) 2002-08-06 2005-01-21 Pioneer Hi-Bred International, Inc. Ap1 amine oxidase variants
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
PT1534335E (pt) 2002-08-14 2012-02-28 Macrogenics Inc Anticorpos específicos de fcγriib e processos para a sua utilização
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
US7361635B2 (en) 2002-08-29 2008-04-22 Sangamo Biosciences, Inc. Simultaneous modulation of multiple genes
US20060020396A1 (en) * 2002-09-09 2006-01-26 Rene Gantier Rational directed protein evolution using two-dimensional rational mutagenesis scanning
WO2004022593A2 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US20050202438A1 (en) * 2002-09-09 2005-09-15 Rene Gantier Rational directed protein evolution using two-dimensional rational mutagenesis scanning
US7563600B2 (en) 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
AU2003285856A1 (en) 2002-09-18 2004-04-23 Mendel Biotechnology, Inc. Polynucleotides and polypeptides in plants
CA2832136C (en) 2002-09-27 2015-11-17 Xencor Optimized fc variants and methods for their generation
GB0222846D0 (en) 2002-10-03 2002-11-06 Choo Yen Cell culture
AU2002951899A0 (en) * 2002-10-04 2002-10-24 Macquarie University Random drift mutagenesis
US6863731B2 (en) * 2002-10-18 2005-03-08 Controls Corporation Of America System for deposition of inert barrier coating to increase corrosion resistance
JP3447009B1 (ja) * 2002-10-29 2003-09-16 實 平垣 構築物用構成体およびその製造方法
CN102838654B (zh) 2002-10-30 2016-05-18 纽韦卢森公司 合成双功能复合物的方法
JP2006504438A (ja) * 2002-11-01 2006-02-09 エヴォジェニクス・ピーティーワイ・リミテッド リバビリンおよび／またはｒｎａレプリカーゼを使用した変異誘発方法
TWI319007B (en) 2002-11-06 2010-01-01 Novozymes As Subtilase variants
US7365186B2 (en) * 2002-11-22 2008-04-29 Arborgen, Llc Vascular-preferred promoter sequences and uses thereof
CN102584951A (zh) * 2002-11-25 2012-07-18 金克克国际有限公司 皮肤或毛发结合肽
AU2003298920A1 (en) * 2002-12-04 2004-06-23 Applied Molecular Evolution, Inc. Butyrylcholinesterase variants that alter the activity of chemotherapeutic agents
DE60330406D1 (de) 2002-12-19 2010-01-14 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
WO2004056988A2 (en) 2002-12-20 2004-07-08 Novozymes A/S Galactanase variants
WO2004056981A2 (en) 2002-12-20 2004-07-08 Novozymes A/S Polypeptides having cellobiohydrolase ii activity and polynucleotides encoding same
US7553930B2 (en) * 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
US20050221443A1 (en) * 2003-01-06 2005-10-06 Xencor, Inc. Tumor necrosis factor super family agonists
US20050130892A1 (en) * 2003-03-07 2005-06-16 Xencor, Inc. BAFF variants and methods thereof
US20060014248A1 (en) * 2003-01-06 2006-01-19 Xencor, Inc. TNF super family members with altered immunogenicity
US7355008B2 (en) 2003-01-09 2008-04-08 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
EP2290085B1 (en) 2003-01-17 2017-12-13 DuPont Nutrition Biosciences ApS Method for the in situ production of an emulsifier in a foodstuff
MXPA05007654A (es) 2003-01-17 2005-09-30 Danisco Metodo.
US7955814B2 (en) 2003-01-17 2011-06-07 Danisco A/S Method
US20050196766A1 (en) 2003-12-24 2005-09-08 Soe Jorn B. Proteins
US8709435B2 (en) 2003-01-21 2014-04-29 Biomay Ag Hypallergenic mosaic antigens and methods of making same
AU2004206250B8 (en) * 2003-01-21 2009-09-17 Bristol-Myers Squibb Company Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof
ES2316963T3 (es) 2003-02-20 2009-04-16 Athenix Corporation Genes delta-entotoxino y los metodos para su uso.
US20060269920A1 (en) * 2003-02-21 2006-11-30 Nuevolution A/S Method for obtaining structural information about an encoded molecule
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
EP2194133B1 (en) 2003-03-06 2015-12-02 BASF Enzymes LLC Amylases, nucleic acids encoding them and methods for making and using them
CA2515583C (en) 2003-03-07 2015-07-14 Diversa Corporation Hydrolases, nucleic acids encoding them and methods for making and using them
CN102225194B (zh) 2003-03-12 2014-07-16 健泰科生物技术公司 Bv8和/或EG-VEGF促进造血的用途
AU2004221824B2 (en) * 2003-03-14 2009-08-27 Ratiopharm Gmbh Branched water-soluble polymers and their conjugates
DK1608748T3 (da) * 2003-03-20 2009-06-29 Nuevolution As Ligeringskodning af små molekyler
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
EP1615946B1 (en) * 2003-03-26 2020-05-06 Sudhir Paul Proteolytic and covalent antibodies
US20070042433A1 (en) * 2003-03-26 2007-02-22 Jianxin Bao Neuregulin protein regulation of synaptic proteins
WO2004087059A2 (en) 2003-03-26 2004-10-14 The University Of Texas Covalent attachment of ligands to nucleophilic proteins guided by non-covalent binding
CA2520382C (en) * 2003-03-27 2014-01-28 Sudhir Paul Lupus antibodies for passive immunotherapy of hiv/aids
EP1613733B1 (en) 2003-04-04 2015-06-03 BASF Enzymes LLC Pectate lyases, nucleic acids encoding them and methods for making and using them
CA2522345A1 (en) 2003-04-09 2004-11-18 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
KR101224235B1 (ko) 2003-04-11 2013-01-25 메디뮨 엘엘씨 재조합 ｉｌ­９ 항체 및 그의 용도
JP2006523465A (ja) 2003-04-14 2006-10-19 ニューゲン テクノロジーズ， インコーポレイテッド ランダムにプライミングされる複合プライマーを用いる大規模増幅
US20040214194A1 (en) * 2003-04-17 2004-10-28 Mj Bioworks, Inc. Methods of making hybrid proteins
EP2228379A1 (en) 2003-04-25 2010-09-15 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore
US7834147B2 (en) * 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
ATE471370T1 (de) 2003-05-02 2010-07-15 Novozymes Inc Varianten von beta-glukosidasen
US20050009772A1 (en) * 2003-05-06 2005-01-13 The Regents Of The University Of California Methods and compositions for the treatment of glaucoma and other retinal diseases
JP4819670B2 (ja) 2003-05-07 2011-11-24 ノボザイムス アクティーゼルスカブ 変異体スブチリシン酵素（サブチラーゼ）
US7521242B2 (en) 2003-05-09 2009-04-21 The United States Of America As Represented By The Department Of Health And Human Services Host cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acids
US7932364B2 (en) * 2003-05-09 2011-04-26 Novo Nordisk A/S Compositions and methods for the preparation of human growth hormone glycosylation mutants
EP1628680B1 (en) 2003-05-15 2012-10-24 Novartis Vaccines and Diagnostics, Inc. Hiv polynucleotides and polypeptides derived from botswana mj4
US7173010B2 (en) * 2003-05-19 2007-02-06 Regents Of The University Of Michigan Orphanin FQ receptor
US7655833B2 (en) * 2003-05-29 2010-02-02 Brookhaven Science Associates, Llc ADS genes for reducing saturated fatty acid levels in seed oils
CN1860231A (zh) * 2003-06-06 2006-11-08 阿博根有限公司 转录因子
NZ544386A (en) * 2003-06-06 2010-07-30 Arborgen Llc Polypeptides with cellulose synthase GDP forming activity
CN1835974A (zh) 2003-06-16 2006-09-20 细胞技术研究与发展公司 对硬化素特异的抗体和用于增加骨矿化的方法
WO2005017105A2 (en) 2003-06-17 2005-02-24 California University Of Technology Regio- and enantioselective alkane hydroxylation with modified cytochrome p450
WO2005017106A2 (en) * 2003-06-17 2005-02-24 California Institute Of Technology Libraries of optimized cytochrome p450 enzymes and the optimized p450 enzymes
EP1633865B1 (en) 2003-06-18 2011-09-28 Bayer Pharma Aktiengesellschaft New biological entities and the use thereof
EP1639106B1 (en) 2003-06-19 2010-05-26 Novozymes A/S Proteases
WO2005001057A2 (en) 2003-06-23 2005-01-06 North Carolina State University Lactobacillus acidophilus nucleic acids encoding fructo-oligosaccharide utilization compounds and uses thereof
WO2005028615A2 (en) * 2003-06-26 2005-03-31 Invitrogen Corporation Methods and compositions for detecting promoter activity and expressing fusion proteins
CN103484486B (zh) 2003-07-02 2018-04-24 维莱尼姆公司 葡聚糖酶，编码它们的核酸以及制备和使用它们的方法
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
WO2005017116A2 (en) * 2003-08-11 2005-02-24 California Institute Of Technology Thermostable peroxide-driven cytochrome p450 oxygenase variants and methods of use
US7741089B2 (en) 2003-08-11 2010-06-22 Verenium Corporation Laccases, nucleic acids encoding them and methods for making and using them
EP1660186B1 (en) 2003-08-18 2013-12-25 MedImmune, LLC Humanization of antibodies
US20060228350A1 (en) * 2003-08-18 2006-10-12 Medimmune, Inc. Framework-shuffling of antibodies
WO2005021586A2 (en) * 2003-08-21 2005-03-10 Wisconsin Alumni Research Foundation Metabolic engineering of viomycin biosynthesis
ES2538824T3 (es) 2003-08-25 2015-06-24 Novozymes, Inc. Variantes de glucósido hidrolasas
DK1673457T3 (da) 2003-08-25 2011-09-05 Funzyme Biotechnologies Sa Nye svampeproteiner og nukleinsyrer, der koder for disse
WO2005023993A2 (en) 2003-09-09 2005-03-17 Integrigen, Inc. Methods and compositions for generation of germline human antibody genes
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
ATE437650T1 (de) * 2003-10-07 2009-08-15 United Therapeutics Corp Tyrosinasemutante und verfahren zur verwendung davon
BRPI0414959A (pt) 2003-10-10 2006-11-07 Novozymes As variante de uma protease precursora, sequência de ácido nucleico isolado, construção de ácido nucleico, vetor de expressão e célula hospedeira recombinantes, métodos para produzir a variante de protease, para melhorar o valor nutricional de uma ração animal, e para tratar proteìnas, planta transgênica, ou parte da planta, animal transgênico, não humano, ou produtos, ou elementos deste, aditivo e composição de ração animal, uso da variante de protease e/ou da composição, protease, e, estrutura 3d
EP1675871A2 (en) 2003-10-10 2006-07-05 Xencor Inc. Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders
US20050084868A1 (en) * 2003-10-16 2005-04-21 Wolfgang Aehle Generation of stabilized proteins by combinatorial consensus mutagenesis
WO2005040372A1 (en) 2003-10-23 2005-05-06 Novozymes A/S Protease with improved stability in detergents
DK1682656T3 (da) 2003-10-28 2013-11-18 Novozymes Inc Polypeptider med beta-glucosidaseaktivitet og polynukleotider, der koder for dem
CA2542574C (en) 2003-11-12 2014-03-18 E. I. Du Pont De Nemours And Company Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast
WO2005052161A2 (en) 2003-11-19 2005-06-09 Genencor International, Inc. Serine proteases, nucleic acids encoding serine enzymes and vectors and host cells incorporating same
US7985569B2 (en) 2003-11-19 2011-07-26 Danisco Us Inc. Cellulomonas 69B4 serine protease variants
CA2546698A1 (en) * 2003-11-20 2005-06-02 Agency For Science, Technology And Research Method
US20080305992A1 (en) * 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8633157B2 (en) * 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
NZ547168A (en) * 2003-11-24 2010-05-28 Biogenerix Ag Glycopegylated erythropoietin
DE602004027538D1 (de) * 2003-12-01 2010-07-15 Life Technologies Corp Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
US20060040856A1 (en) * 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
ES2422187T3 (es) * 2003-12-03 2013-09-09 Biogenerix Ag Factor estimulante de colonias de granulocitos glicopegilados
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
CA2486900A1 (en) * 2003-12-04 2005-06-04 F. Hoffmann-La Roche Ag A method for obtaining circular mutated and/or chimaeric polynucleotides
US20070169227A1 (en) 2003-12-16 2007-07-19 Pioneer Hi-Bred International Inc. Dominant Gene Suppression Transgenes and Methods of Using Same
US7718408B2 (en) 2003-12-24 2010-05-18 Danisco A/S Method
GB0716126D0 (en) 2007-08-17 2007-09-26 Danisco Process
CA2550800A1 (en) 2003-12-24 2005-07-21 Danisco A/S Methods to produce variant glycolipid acyltransferases and variant glycolipid acyltransferases with enhanced activity towards glycolipids.
NZ548123A (en) * 2004-01-08 2010-05-28 Novo Nordisk As O-linked glycosylation of peptides
DK1713825T3 (da) 2004-01-30 2012-11-05 Novozymes Inc Polypeptider med cellulolytisk forøgende aktivitet og polynukleotider der koder for samme
US7432057B2 (en) * 2004-01-30 2008-10-07 Michigan State University Genetic test for PSE-susceptible turkeys
WO2006078256A2 (en) 2004-02-12 2006-07-27 Novozymes, Inc. Polypeptides having xylanase activity and polynucleotides encoding same
JP4891220B2 (ja) 2004-02-25 2012-03-07 ノボザイムス アクティーゼルスカブ 菌類細胞壁分解酵素
KR20120035233A (ko) 2004-02-25 2012-04-13 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 신규한 바실루스 투링기엔시스 결정 폴리펩티드, 폴리뉴클레오티드, 및 이의 조성물
EP1733055A4 (en) * 2004-02-27 2009-03-11 Harvard College polynucleotide
US7459289B2 (en) 2004-03-08 2008-12-02 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
GB0405637D0 (en) 2004-03-12 2004-04-21 Danisco Protein
US7569223B2 (en) * 2004-03-22 2009-08-04 The Rockefeller University Phage-associated lytic enzymes for treatment of Streptococcus pneumoniae and related conditions
CA2560613C (en) 2004-03-22 2015-11-24 Solvay Pharmaceuticals Gmbh Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants
WO2005090566A2 (en) * 2004-03-22 2005-09-29 Nuevolution A/S Ligational encoding using building block oligonucleotides
EP1786463A4 (en) * 2004-03-26 2009-05-20 Human Genome Sciences Inc ANTIBODY AGAINST NOGO RECEPTOR
CA2561073C (en) * 2004-03-27 2014-01-14 The Arizona Board Of Regents On Behalf Of The University Of Arizona Composition and method for cancer treatment
RU2409938C2 (ru) 2004-04-02 2011-01-27 КРОПДИЗАЙН Н.Фи. Способ повышения выхода семян растения, способ производства трансгенного растения, имеющего повышенную урожайность семян, генная конструкция для экспрессии в растении и трансгенное растение
JP2008505853A (ja) 2004-04-13 2008-02-28 クインテセンス バイオサイエンシーズ インコーポレーティッド 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体
PL2308976T5 (pl) 2004-04-30 2017-10-31 Dow Agrosciences Llc Nowe geny odporności na herbicydy
US7622125B2 (en) * 2004-05-05 2009-11-24 Novartis Vaccines And Diagnostics, Inc. Polycistronic HIV vector constructs
KR101083595B1 (ko) * 2004-05-14 2011-11-16 가톨릭대학교 산학협력단 단백질 형질도입 도메인 유전자를 함유하는 재조합베큘로바이러스 발현벡터
US7674621B2 (en) 2004-05-21 2010-03-09 The United States Of America As Represented By The Department Of Health And Human Services Plasmids and phages for homologous recombination and methods of use
WO2005121351A2 (en) 2004-05-27 2005-12-22 Novozymes, Inc. Methods for transforming and expression screening of filamentous fungal cells with a dna library
US7825293B2 (en) 2004-05-28 2010-11-02 Cropdesign N.V. Plants having improved growth characteristics and a method for making the same
ES2352172T3 (es) 2004-06-09 2011-02-16 Pioneer-Hi-Bred International, Inc. Péptidos de transito de plastidio.
AU2005264938B2 (en) 2004-06-16 2011-11-24 Verenium Corporation Compositions and methods for enzymatic decolorization of chlorophyll
US20060008844A1 (en) 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins
CN101014704A (zh) 2004-06-21 2007-08-08 诺维信公司 蛋白酶
US7985892B1 (en) 2004-06-29 2011-07-26 Dow Agrosciences Llc Truncated Cry35 proteins
WO2006005032A2 (en) 2004-06-29 2006-01-12 Novozymes, Inc. Polypeptides having alpha-glucosidase activity and polynucleotides encoding same
CN101124323A (zh) 2004-06-30 2008-02-13 先锋高级育种国际公司 保护植物免受致病真菌侵害的方法
BR122015026849C8 (pt) 2004-07-02 2017-06-20 Du Pont cassete de expressão, microorganismo transformado, método para indução de resistência a patógeno de planta em uma planta, composição anti-patogênica e método para proteção de uma planta contra um patógeno de planta
CA2571864C (en) 2004-07-05 2014-09-23 Novozymes A/S Alpha-amylase variants with altered properties
CA2573443A1 (en) 2004-07-12 2006-01-19 Cropdesign N.V. Plants having improved growth characteristics and method for making the same
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
CN102533440B (zh) 2004-07-16 2017-09-19 杜邦营养生物科学有限公司 用酶使油脱胶的方法
CA2574802A1 (en) 2004-07-20 2006-02-02 Isogenis, Inc. Specific inhibition of autoimmunity and diseases associated with autoantigens
WO2006020372A2 (en) * 2004-07-23 2006-02-23 Neose Technologies, Inc. Enzymatic modification of glycopeptides
WO2006012902A2 (en) 2004-08-02 2006-02-09 Novozymes A/S Creation of diversity in polypeptides
WO2006017694A1 (en) * 2004-08-05 2006-02-16 Biosite Incorporated Compositions and methods for phage display of polypeptides
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
US7148051B2 (en) * 2004-08-16 2006-12-12 E. I. Du Pont De Nemours And Company Production of 3-hydroxycarboxylic acid using nitrilase
FI20050753A7 (fi) 2004-09-03 2006-03-04 Licentia Oy Uudet peptidit
WO2006031811A2 (en) * 2004-09-10 2006-03-23 Neose Technologies, Inc. Glycopegylated interferon alpha
US7563443B2 (en) * 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
US7728118B2 (en) 2004-09-17 2010-06-01 Promega Corporation Synthetic nucleic acid molecule compositions and methods of preparation
JP2008513540A (ja) 2004-09-21 2008-05-01 メディミューン，インコーポレーテッド 呼吸器合胞体ウイルスに対する抗体及び該ウイルス用のワクチンを製造する方法
US7453025B2 (en) * 2004-09-22 2008-11-18 Arborgen, Llc Reproductive ablation constructs
US7799906B1 (en) 2004-09-22 2010-09-21 Arborgen, Llc Compositions and methods for modulating lignin of a plant
GB0421598D0 (en) 2004-09-29 2004-10-27 Cambridge Advanced Tech Modification of plant development and morphology
WO2006049777A2 (en) * 2004-09-30 2006-05-11 Trustees Of Dartmouth College Nucleic acid sequences encoding luciferase for expression in filamentous fungi
US7666630B2 (en) 2004-09-30 2010-02-23 Novozymes, Inc. Polypeptides having lipase activity and polynucleotides encoding same
EP1809747B1 (en) 2004-10-04 2016-12-14 Novozymes A/S Polypeptides having phytase activity and polynucleotides encoding same
AR050895A1 (es) 2004-10-04 2006-11-29 Novozymes As Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican
GB0422052D0 (en) 2004-10-04 2004-11-03 Dansico As Enzymes
EP2163632A1 (en) 2004-10-05 2010-03-17 SunGene GmbH Constitutive expression cassettes for regulation of plant expression
AU2005294298C1 (en) 2004-10-08 2017-03-09 Corteva Agriscience Llc Oil and seeds with reduced saturate levels of fatty acids
KR20070084069A (ko) 2004-10-08 2007-08-24 도만티스 리미티드 Ｔｎｆｒ1에 대한 단일 도메인 항체 및 이의 사용 방법
GB0423139D0 (en) * 2004-10-18 2004-11-17 Danisco Enzymes
WO2006047791A2 (en) * 2004-10-27 2006-05-04 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library device and method for use
WO2006047639A2 (en) 2004-10-27 2006-05-04 Medimmune, Inc. Modulation of antibody specificity by tailoring the affinity to cognate antigens
US20060141626A1 (en) * 2004-10-27 2006-06-29 Monsanto Technology Llc Non-random method of gene shuffling
EP1814573B1 (en) 2004-10-29 2016-03-09 ratiopharm GmbH Remodeling and glycopegylation of fibroblast growth factor (fgf)
ATE493500T1 (de) 2004-10-29 2011-01-15 Cropdesign Nv Pflanzen mit veränderten wachstumseigenschaften und verfahren zu deren herstellung
EP1655364A3 (en) 2004-11-05 2006-08-02 BASF Plant Science GmbH Expression cassettes for seed-preferential expression in plants
ATE540110T1 (de) 2004-11-11 2012-01-15 Modular Genetics Inc Oligonukleotid-leiterkonstruktion und system zur erzeugung von molekularer vielfalt
EP1814996A2 (en) 2004-11-19 2007-08-08 Novozymes A/S Polypeptides having antimicrobial activity and polynucleotides encoding same
EP1662000B1 (en) 2004-11-25 2011-03-30 SunGene GmbH Expression cassettes for guard cell-preferential expression in plants
EP1666599A3 (en) 2004-12-04 2006-07-12 SunGene GmbH Expression cassettes for mesophyll- and/or epidermis-preferential expression in plants
EP1669455B1 (en) 2004-12-08 2009-10-28 SunGene GmbH Expression cassettes for vascular tissue-preferential expression in plants
EP1669456A3 (en) 2004-12-11 2006-07-12 SunGene GmbH Expression cassettes for meristem-preferential expression in plants
MX2007007107A (es) 2004-12-22 2007-08-08 Novozymes North America Inc Polipeptidos que tienen actividad de glucoamilasa y polinucleotidos que los codifican.
US7198927B2 (en) * 2004-12-22 2007-04-03 E. I. Du Pont De Nemours And Company Enzymatic production of glycolic acid
EP2003205B1 (en) 2004-12-28 2013-05-01 Pioneer Hi-Bred International, Inc. Improved grain quality through altered expression of seed proteins
EP1838332A1 (en) * 2005-01-06 2007-10-03 Neose Technologies, Inc. Glycoconjugation using saccharyl fragments
CA2593682C (en) * 2005-01-10 2016-03-22 Neose Technologies, Inc. Glycopegylated granulocyte colony stimulating factor
EP1846442B1 (en) 2005-01-13 2010-04-21 Pioneer Hi-Bred International, Inc. Maize cyclo1 gene and promoter
JP2008526259A (ja) * 2005-01-13 2008-07-24 コドン デバイシズ インコーポレイテッド 蛋白質デザインのための組成物及び方法
US8426683B2 (en) 2005-01-27 2013-04-23 Cropdesign N.V. Plants having increased yield and a method for making the same
US20060263357A1 (en) 2005-05-05 2006-11-23 Tedder Thomas F Anti-CD19 antibody therapy for autoimmune disease
PT1853718E (pt) 2005-02-15 2015-11-12 Univ Duke Anticorpos anti-cd19 e usos em oncologia
US12570965B2 (en) 2005-03-02 2026-03-10 Instituto Nacional De Technologia Agropecuaria Herbicide-resistant rice plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use
EP1869174B1 (en) 2005-03-10 2015-02-18 BASF Enzymes LLC Lyase enzymes, nucleic acids encoding them and methods for making and using them
EA018577B1 (ru) 2005-03-15 2013-09-30 Верениум Корпорейшн Целлюлазы, нуклеиновые кислоты, кодирующие их, и способы их получения и применения
CN100577805C (zh) * 2005-03-16 2010-01-06 中国科学院沈阳应用生态研究所 一种基因改组的方法及所获得的重组基因和编码蛋白
AR052947A1 (es) 2005-03-18 2007-04-11 Novozymes As Polipeptidos que tienen actividad antimicrobiana y polinucleotidos que codifican para los mismos
EP1869192B1 (en) 2005-03-18 2016-01-20 MedImmune, LLC Framework-shuffling of antibodies
AU2006226192A1 (en) 2005-03-19 2006-09-28 Medical Research Council Improvements in or relating to treatment and prevention of viral infections
US11214817B2 (en) 2005-03-28 2022-01-04 California Institute Of Technology Alkane oxidation by modified hydroxylases
US8715988B2 (en) 2005-03-28 2014-05-06 California Institute Of Technology Alkane oxidation by modified hydroxylases
EP1871788B1 (en) 2005-04-01 2009-09-16 Athenix Corporation Axmi-027 a family of delta-endotoxin genes and methods for their use
US9187546B2 (en) * 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
JP2008537885A (ja) 2005-04-15 2008-10-02 ノース・キャロライナ・ステイト・ユニヴァーシティ 細菌の付着およびストレス耐性を修飾する方法および組成物
JP5838021B2 (ja) 2005-04-15 2015-12-24 マクロジェニクス，インコーポレーテッド 共有結合型ダイアボディとその使用
ATE552343T1 (de) 2005-04-19 2012-04-15 Basf Plant Science Gmbh Endosperm-spezifische expression und/oder expression in keimenden embryos monokotyledoner pflanzen
CA2606475C (en) 2005-04-27 2015-06-16 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
US7592429B2 (en) * 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
CN1861789B (zh) * 2005-05-13 2010-04-28 中国科学院沈阳应用生态研究所 一种综合的基因改组方法及所获得的重组基因和编码蛋白
AR053269A1 (es) 2005-05-16 2007-04-25 Monsanto Technology Llc Plantas y semillas de maiz con mejoramiento de asparagina y proteina
US20060281113A1 (en) * 2005-05-18 2006-12-14 George Church Accessible polynucleotide libraries and methods of use thereof
US20060263974A1 (en) * 2005-05-18 2006-11-23 Micron Technology, Inc. Methods of electrically interconnecting different elevation conductive structures, methods of forming capacitors, methods of forming an interconnect between a substrate bit line contact and a bit line in DRAM, and methods of forming DRAM memory cell
US20060271262A1 (en) * 2005-05-24 2006-11-30 Mclain Harry P Iii Wireless agricultural network
WO2006127910A2 (en) * 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated erythropoietin formulations
US20080255026A1 (en) * 2005-05-25 2008-10-16 Glycopegylated Factor 1X Glycopegylated Factor Ix
US20110003744A1 (en) * 2005-05-25 2011-01-06 Novo Nordisk A/S Glycopegylated Erythropoietin Formulations
WO2006133013A2 (en) * 2005-06-03 2006-12-14 The Regents Of The University Of California Methods of generating protein variants with altered function
ES2335232T3 (es) 2005-06-21 2010-03-23 Xoma Technology Ltd. Anticuerpos y fragmentos de los mismos que se unen a la il-1 beta.
KR20080025174A (ko) 2005-06-23 2008-03-19 메디뮨 인코포레이티드 응집 및 단편화 프로파일이 최적화된 항체 제제
US7582291B2 (en) * 2005-06-30 2009-09-01 The Rockefeller University Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
EP2532750B1 (en) 2005-07-01 2016-04-27 Basf Se Herbicide-resistant sunflower plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use
US8119858B2 (en) 2005-07-06 2012-02-21 Cropdesign N.V. Plant yield improvement by Ste20-like gene expression
EP2385111B1 (en) 2005-07-08 2016-09-07 Novozymes A/S Subtilase variants
US20070184487A1 (en) * 2005-07-12 2007-08-09 Baynes Brian M Compositions and methods for design of non-immunogenic proteins
WO2007009082A1 (en) * 2005-07-12 2007-01-18 Codon Devices, Inc. Compositions and methods for biocatalytic engineering
WO2007011722A2 (en) 2005-07-15 2007-01-25 President And Fellows Of Harvard College Reaction discovery system
CA2615797C (en) 2005-07-18 2014-04-29 Pioneer Hi-Bred International, Inc. Modified frt recombination sites and methods of use
PL2278002T3 (pl) 2005-07-29 2017-12-29 Abbott Laboratories Gmbh Pankreatyna o zmniejszonej zawartości wirusowej
RU2421462C2 (ru) 2005-07-29 2011-06-20 Таргитид Гроус, Инк. Защитное действие доминантно-негативного мутантного белка krp от ингибирования активного комплекса циклин-cdk krp дикого типа
DE102005037351B3 (de) * 2005-08-08 2007-01-11 Geneart Ag Verfahren für die kontinuierliche zielgerichtete Evolution von Proteinen in vitro
WO2007021672A2 (en) * 2005-08-10 2007-02-22 Acambis Inc. Vaccination against dengue virus infection
DK2573114T3 (en) 2005-08-10 2016-07-04 Macrogenics Inc The identification and production of antibodies with variant Fc regions, and methods of using same
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
CN101297034A (zh) 2005-08-24 2008-10-29 洛克菲勒大学 Ply-gbs突变溶素
AU2006283904B2 (en) 2005-08-26 2012-07-12 Novozymes Adenium Biotech A/S Polypeptides having antimicrobial activity and polynucleotides encoding same
US7541431B2 (en) * 2005-09-07 2009-06-02 Maine Medical Center Cristin/R-spondin ligands active in the Wnt signaling pathway and methods, compositions and kits relating thereto
EP1929046B1 (en) 2005-09-07 2012-07-11 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
AR055439A1 (es) 2005-09-15 2007-08-22 Cropdesign Nv Plantas con rendimiento aumentado y metodo para elaborarlas
US8173613B2 (en) * 2005-09-22 2012-05-08 Maine Medical Center Modulation of mesenchymal and metastatic cell growth
EP1941023B1 (en) 2005-09-30 2017-04-05 Novozymes Inc. Methods for enhancing the degradation or conversion of cellulosic material
US7312079B1 (en) 2005-10-06 2007-12-25 Lexicon Pharmaceuticals, Inc. Variants of FAM3C
US7470532B2 (en) 2005-10-19 2008-12-30 E.I. Du Pont De Nemours And Company Mortierella alpina C16/18 fatty acid elongase
PL1947926T3 (pl) 2005-10-28 2015-08-31 Dow Agrosciences Llc Nowe geny odporności na herbicydy
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
EP1948807B1 (en) 2005-11-07 2015-09-30 CropDesign N.V. Plants having improved growth characteristics and a method for making the same
US8853492B2 (en) 2005-11-07 2014-10-07 Cropdesign N.V. Plants having improved growth characteristics and a method for making the same
AR056790A1 (es) 2005-11-08 2007-10-24 Cropdesign Nv Plantas con caracteristicas de crecimiento aumentado y un metodo para obtenerlas
US20070118920A1 (en) 2005-11-09 2007-05-24 Basf Agrochemical Products B.V. Herbicide-resistant sunflower plants, polynucleotides encoding herbicide-resistant acetohydroxyacid synthase large subunit proteins, and methods of use
AR056778A1 (es) 2005-11-10 2007-10-24 Pioneer Hi Bred Int Secuencias dof ( que se unen a adn con un dedo ) y metodos para usarlas
US20070199096A1 (en) 2005-11-14 2007-08-23 E.I. Du Pont De Nemours And Company Compositions and Methods for Altering Alpha- and Beta-Tocotrienol Content
CA2630216A1 (en) * 2005-11-18 2007-05-31 Gloucester Pharmaceuticals, Inc. Metabolite derivatives of the hdac inhibitor fk228
GB2432366B (en) * 2005-11-19 2007-11-21 Alligator Bioscience Ab A method for in vitro molecular evolution of protein function
GB0526664D0 (en) * 2005-11-30 2006-02-08 Plasticell Ltd Method
LT3018206T (lt) * 2005-12-01 2021-12-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
EP1954805B1 (en) 2005-12-01 2015-07-22 CropDesign N.V. Plants having improved growth characteristics and methods for making the same
US7674958B2 (en) 2005-12-01 2010-03-09 Athenix Corporation GRG23 and GRG51 genes conferring herbicide resistance
JP4789271B2 (ja) * 2005-12-02 2011-10-12 シンセティック ゲノミクス、インク． エラーが最小化された核酸分子の合成
KR100784478B1 (ko) * 2005-12-05 2007-12-11 한국과학기술원 기능요소의 동시 삽입에 의한 신기능을 갖는 단백질을제조하는 방법
US20080313769A9 (en) 2006-01-12 2008-12-18 Athenix Corporation EPSP synthase domains conferring glyphosate resistance
EP1987142A4 (en) 2006-02-02 2009-07-15 Verenium Corp ESTERASES AND ASSOCIATED NUCLEIC ACIDS AND METHODS
NZ595502A (en) 2006-02-10 2013-11-29 Verenium Corp Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
ES2682284T3 (es) 2006-02-14 2018-09-19 Bp Corporation North America Inc. Xilanasas, ácidos nucleicos que las codifican y métodos para elaborarlas y usarlas
AU2007223364B2 (en) 2006-03-02 2014-02-13 Athenix Corporation Methods and compositions for improved enzyme activity in transgenic plant
EP2650306A1 (en) 2006-03-06 2013-10-16 Aeres Biomedical Limited Humanized Anti-CD22 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
KR101622894B1 (ko) 2006-03-07 2016-05-19 바스프 엔자임스 엘엘씨 알돌라제, 이것을 코딩하는 핵산과 그 제조 방법 및 사용 방법
ES2416104T3 (es) 2006-03-07 2013-07-30 Cargill, Incorporated Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas
US20070214515A1 (en) 2006-03-09 2007-09-13 E.I.Du Pont De Nemours And Company Polynucleotide encoding a maize herbicide resistance gene and methods for use
EP1999257B1 (en) 2006-03-20 2011-06-22 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
US8703278B2 (en) * 2006-03-28 2014-04-22 Honeywell International Inc. Light weight printed wiring board
EP2004817A2 (en) 2006-03-30 2008-12-24 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
CA2638978A1 (en) 2006-03-31 2007-10-11 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
DK2365064T3 (en) 2006-04-04 2015-03-30 Novozymes As Phytasevarianter
EP1842915A1 (en) 2006-04-04 2007-10-10 Libragen Method of in vitro polynucleotide sequences shuffling by recursive circular DNA molecules fragmentation and ligation
EP2251349A1 (en) 2006-04-19 2010-11-17 Pioneer Hi-Bred International, Inc. Isolated polynucleotide molecules corresponding to mutant and wild-type alleles of the maize D9 gene and methods of use
US9539303B2 (en) * 2006-04-24 2017-01-10 Celgene Corporation Treatment of Ras-expressing tumors
DE602007012343D1 (de) 2006-05-16 2011-03-17 Du Pont Antimykotische polypeptide
PL2018435T3 (pl) 2006-05-17 2012-11-30 Pioneer Hi Bred Int Sztuczne minichromosomy roślinne
US20090087840A1 (en) * 2006-05-19 2009-04-02 Codon Devices, Inc. Combined extension and ligation for nucleic acid assembly
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
EP2035562A2 (en) 2006-05-30 2009-03-18 CropDesign N.V. Plants with modulated expression of extensin receptor-like kinase having enhanced yield-related traits and a method for making the same
US8957027B2 (en) * 2006-06-08 2015-02-17 Celgene Corporation Deacetylase inhibitor therapy
EP2035555A2 (en) 2006-06-08 2009-03-18 BASF Plant Science GmbH Plants having improved growth characteristics and method for making the same
EP2599870A3 (en) 2006-06-15 2013-09-11 CropDesign N.V. Plants having enhanced yield-related traits and a method for making the same
EP2032704A2 (en) 2006-06-15 2009-03-11 CropDesign N.V. Plants with modulated expression of nac transcription factors having enhanced yield-related traits and a method for making the same
EP2041163A2 (en) 2006-06-15 2009-04-01 Athenix Corporation A family of pesticidal proteins and methods for their use
CA2853387C (en) 2006-06-19 2018-04-17 National Research Council Of Canada Nucleic acid encoding n-methylputrescine oxidase and uses thereof
US8840882B2 (en) * 2006-06-23 2014-09-23 Quintessence Biosciences, Inc. Modified ribonucleases
EP2029173B1 (en) 2006-06-26 2016-07-20 MacroGenics, Inc. Fc riib-specific antibodies and methods of use thereof
US20080004410A1 (en) * 2006-06-30 2008-01-03 Yu-Chin Lai Hydrophilic macromonomers having alpha,beta-conjugated carboxylic terminal group and medical devices incorporating same
US7572618B2 (en) 2006-06-30 2009-08-11 Bristol-Myers Squibb Company Polynucleotides encoding novel PCSK9 variants
US7977535B2 (en) 2006-07-12 2011-07-12 Board Of Trustees Of Michigan State University DNA encoding ring zinc-finger protein and the use of the DNA in vectors and bacteria and in plants
CN101489412B (zh) 2006-07-13 2013-03-27 诺维信公司 细菌淀粉酶在牛类动物的饲料中的用途
WO2008010991A2 (en) 2006-07-17 2008-01-24 Quintessence Biosciences, Inc. Methods and compositions for the treatment of cancer
CN101516388B (zh) * 2006-07-21 2012-10-31 诺和诺德公司 通过o-联糖基化序列的肽的糖基化
WO2008012058A1 (en) * 2006-07-25 2008-01-31 Commonwealth Scientific And Industrial Research Organisation Identification of a novel type of sucrose synthase and use thereof in fiber modification
EP2543733A1 (en) 2006-08-02 2013-01-09 CropDesign N.V. Plants having improved characteristics and a method for making the same
CA2659414A1 (en) 2006-08-02 2008-02-07 Cropdesign N.V. Use of synovial sarcoma translocation (syt) polypeptide for increasing plant yield under abiotic stress
CN106222185B (zh) 2006-08-04 2021-12-03 维莱尼姆公司 葡聚糖酶、编码它们的核酸及制备和使用它们的方法
US8252559B2 (en) * 2006-08-04 2012-08-28 The California Institute Of Technology Methods and systems for selective fluorination of organic molecules
EP2069513A4 (en) * 2006-08-04 2012-03-21 California Inst Of Techn METHOD AND SYSTEMS FOR THE SELECTIVE FLUORINATION OF ORGANIC MOLECULES
US7968691B2 (en) 2006-08-23 2011-06-28 Danisco Us Inc. Pullulanase variants with increased productivity
EP2484696B1 (en) 2006-08-28 2017-08-16 Kyowa Hakko Kirin Co., Ltd. Antagonistic hLIGHT-specific human monoclonal antibodies
US8053191B2 (en) 2006-08-31 2011-11-08 Westend Asset Clearinghouse Company, Llc Iterative nucleic acid assembly using activation of vector-encoded traits
EP2064325B1 (en) 2006-09-01 2011-12-07 Therapeutic Human Polyclonals, Inc. Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
EP2061904A2 (en) 2006-09-06 2009-05-27 Ortho-McNeil Pharmaceutical, Inc. Biomarkers for assessing response to c-met treatment
US8323653B2 (en) 2006-09-08 2012-12-04 Medimmune, Llc Humanized anti-CD19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
EP2057274B1 (en) 2006-09-21 2013-12-11 DSM IP Assets B.V. Phospholipases, nucleic acids encoding them and methods for making and using them
US8877478B2 (en) 2006-09-21 2014-11-04 Verenium Corporation Phytases, nucleic acids encoding them and methods for making and using them
CN101522045A (zh) 2006-09-29 2009-09-02 诺维信公司 用于动物饲料的木聚糖酶
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
WO2008060780A2 (en) * 2006-10-04 2008-05-22 Novo Nordisk A/S Glycerol linked pegylated sugars and glycopeptides
GB0620715D0 (en) 2006-10-18 2006-11-29 Univ Durham Ethanol production
US20100162433A1 (en) 2006-10-27 2010-06-24 Mclaren James Plants with improved nitrogen utilization and stress tolerance
US20100036091A1 (en) * 2006-11-10 2010-02-11 Amgen Inc. Antibody-based diagnostics and therapeutics
WO2008133722A2 (en) * 2006-11-10 2008-11-06 Ucb Pharma S.A. Anti human sclerostin antibodies
US20100247552A1 (en) 2006-11-10 2010-09-30 Massachusetts Institute Of Technology Pak modulators
AR064252A1 (es) 2006-11-16 2009-03-25 Cropdesign Nv Plantas que presentan caracteristicas acrecentadas relacionadas con el rendimiento y un metodo para producir las mismas
EP2084284A1 (en) 2006-11-24 2009-08-05 Cropdesign N.V. Transgenic plants comprising as transgene a class i tcp or clavata 1 (clv1) or cah3 polypeptide having increased seed yield and a method for making the same
EP2099818A2 (en) 2006-11-29 2009-09-16 Novozymes Inc. Bacillus licheniformis chromosome
CN101595214B (zh) 2006-11-29 2013-06-12 诺维信股份有限公司 改进向细菌细胞中导入dna的方法
EP2094831B1 (en) * 2006-12-07 2015-09-16 Dow AgroSciences LLC Novel selectable marker genes
US9862956B2 (en) 2006-12-10 2018-01-09 Danisco Us Inc. Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi
EP2505651A3 (en) 2006-12-10 2013-01-09 Dyadic International, Inc. Isolated fungus with reduced protease activity
WO2008071767A1 (en) 2006-12-15 2008-06-19 Cropdesign N.V. Plants having enhanced seed yield-related traits and a method for making the same
CN101578370B (zh) 2006-12-20 2015-11-25 孟山都巴西有限公司 编码c3hc4家族植物蛋白质的核酸分子和改变植物纤维素和木素含量的方法
EP2094852B1 (en) 2006-12-20 2014-01-22 Monsanto do Brasil LTDA Nucleic acid constructs and methods for altering plant fiber length and/or plant height
PL3101128T3 (pl) 2006-12-21 2019-09-30 Basf Enzymes Llc Amylazy i glukoamylazy, kwasy nukleinowe kodujące te związki oraz sposoby wytwarzania tych związków oraz stosowania ich
EP2405011A3 (en) 2006-12-21 2012-07-25 BASF Plant Science GmbH Plants having enhanced yield-related traits and a method for making the same
CN103497238A (zh) * 2006-12-29 2014-01-08 细胞基因公司 制备Romidepsin
EP2102230A2 (en) * 2006-12-29 2009-09-23 Gloucester Pharmaceuticals, Inc. Purifiction of romidepsin
DE102007003143A1 (de) 2007-01-16 2008-07-17 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease
CA2673954C (en) 2007-01-25 2015-09-15 Danisco A/S Production of a lipid acyltransferase from transformed bacillus licheniformis cells
WO2008092910A1 (en) 2007-01-30 2008-08-07 Cropdesign N.V. Plants having enhanced yield-related traits and a method for making the same
CN104212822A (zh) 2007-01-30 2014-12-17 Bp法人北美有限公司 用于处理木质纤维素的酶、编码它们的核酸及其制备和应用方法
WO2008092935A2 (en) 2007-01-31 2008-08-07 Basf Plant Science Gmbh Plants having enhanced yield-related traits and/or increased abiotic stress resistance, and a method for making the same
WO2008121435A2 (en) * 2007-02-02 2008-10-09 The California Institute Of Technology Methods for generating novel stabilized proteins
US8143046B2 (en) 2007-02-07 2012-03-27 Danisco Us Inc., Genencor Division Variant Buttiauxella sp. phytases having altered properties
US20080268517A1 (en) * 2007-02-08 2008-10-30 The California Institute Of Technology Stable, functional chimeric cytochrome p450 holoenzymes
CN101627116B (zh) 2007-02-08 2013-07-10 科德克希思公司 酮还原酶及其用途
EP2118281A2 (en) 2007-02-12 2009-11-18 Codexis, Inc. Structure-activity relationships
KR20090119910A (ko) 2007-02-16 2009-11-20 바스프 플랜트 사이언스 게엠베하 외떡잎 식물에서 배-특이적 발현의 조절을 위한 핵산 서열
AR065552A1 (es) 2007-02-28 2009-06-17 Crop Functional Genomics Ct Plantas con rasgos aumentados relacionados con el rendimiento y un metodo para producirlas
DK2129781T3 (da) 2007-03-26 2014-03-31 Novozymes As Hafnia-phytase
US20080248511A1 (en) * 2007-03-26 2008-10-09 Promega Corporation Methods to quench light from optical reactions
DE102007016139A1 (de) 2007-03-30 2008-10-02 Jenabios Gmbh Verfahren zur regioselektiven Oxygenierung von N-Heterozyklen
KR101540823B1 (ko) 2007-03-30 2015-07-30 메디뮨 엘엘씨 항체 제제
EP2144923B1 (en) * 2007-04-03 2013-02-13 BioGeneriX AG Methods of treatment using glycopegylated g-csf
WO2009031031A2 (en) 2007-04-04 2009-03-12 Basf Se Herbicide-resistant brassica plants and methods of use
US20100112663A1 (en) 2007-04-09 2010-05-06 Novozymes A/S Enzymatic Treatment of Skin and Hide Degreasing
EP2228386B1 (en) 2007-05-03 2015-03-18 BASF Plant Science GmbH Plants having enhanced yield-related traits and a method for making the same
PT2164868E (pt) 2007-05-04 2015-08-04 Technophage Investigaçao E Desenvolvimento Em Biotecnologia Sa Domínios variáveis de anticorpos de coelho manipulados e suas utilizações
BRPI0811466A2 (pt) 2007-05-07 2014-10-14 Medimmune Llc Anticorpo anti-icos isolado, ácido nucleico, vetor, célula isolada, métodos para produzir um anticorpo, para tratar uma doença ou distúrbio, para tratar ou prevenir a rejeição em um paciente de transplante humano, para tratar uma malignidade de célula t em um ser humano, para esgotar células t que expressam icos em um paciente humano, para romper a arquitetura do centro germinal em um órgão linfóide secundário de um primata, para esgotar células b centrais germinais de órgão linfóide secundário de um primata, e para esgotar células b comutadas em classes circulantes em um primata, e, composição farmacêutica.
WO2008137993A1 (en) * 2007-05-08 2008-11-13 Duke University Compositions and methods for characterizing and regulating olfactory sensation
AR066520A1 (es) 2007-05-09 2009-08-26 Dow Agrosciences Llc Nuevos genes de resistencia a herbicidas
US8044186B2 (en) * 2007-05-11 2011-10-25 Wisconsin Alumni Research Foundation Heterologous production of capreomycin and generation of new capreomycin derivatives through metabolic engineering
PT3072525T (pt) 2007-05-14 2018-04-20 Astrazeneca Ab Métodos para reduzir os níveis de basófilos
KR101255413B1 (ko) 2007-05-23 2013-04-17 재단법인 작물유전체기능연구사업단 향상된 수확량 관련 형질을 갖는 식물 및 이의 제조 방법
CA2688306C (en) 2007-05-25 2021-07-06 Jonathan Page Nucleic acid sequences encoding transcription factors regulating alkaloid biosynthesis and their use in modifying plant metabolism
WO2008145629A2 (en) 2007-05-25 2008-12-04 Cropdesign N.V. Yield enhancement in plants by modulation of maize alfins
EP2162535A4 (en) * 2007-06-04 2011-02-23 Novo Nordisk As O-linked glycosylation using N-acetylglucosamine transferases
WO2008154639A2 (en) 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
EP2158221B1 (en) 2007-06-21 2018-08-29 MacroGenics, Inc. Covalent diabodies and uses thereof
US7968811B2 (en) * 2007-06-29 2011-06-28 Harley-Davidson Motor Company Group, Inc. Integrated ignition and key switch
EP2078090A2 (en) 2007-06-29 2009-07-15 BASF Plant Science GmbH Plants having enhanced yield-related traits and a method for making the same
CA2693144A1 (en) 2007-07-17 2009-01-22 The General Hospital Corporation Methods to identify and enrich for populations of ovarian cancer stem cells and somatic ovarian stem cells and uses thereof
EP2173884B1 (en) 2007-07-20 2013-09-18 BASF Plant Science GmbH Plants having increased yield-related traits and a method for making the same
CA2697186A1 (en) 2007-07-31 2009-02-05 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
AR067748A1 (es) 2007-07-31 2009-10-21 Basf Plant Science Gmbh Plantas que tienen rasgos mejorados relacionados con el rendimiento y un metodo para obtenerlas
US7923236B2 (en) 2007-08-02 2011-04-12 Dyadic International (Usa), Inc. Fungal enzymes
CN104307581B (zh) * 2007-08-09 2017-04-12 诺思可有限公司 关联的多参数单细胞测定及残余生物材料回收的方法和装置
JP2010536385A (ja) 2007-08-24 2010-12-02 コデクシス， インコーポレイテッド （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド
US8207112B2 (en) * 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
WO2009033071A2 (en) 2007-09-07 2009-03-12 Dyadic International, Inc. Novel fungal enzymes
US7749708B2 (en) * 2007-09-12 2010-07-06 Transgenomic, Inc. Method for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule
US7579155B2 (en) * 2007-09-12 2009-08-25 Transgenomic, Inc. Method for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US12529164B2 (en) 2007-09-14 2026-01-20 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
CA2699066A1 (en) 2007-09-14 2009-03-19 Basf Plant Science Gmbh Plants having increased yield-related traits and a method for making the same comprising expression of a growth-regulating factor (grf) polypeptide
WO2009036379A2 (en) 2007-09-14 2009-03-19 Adimab, Inc. Rationally designed, synthetic antibody libraries and uses therefor
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
EP2193195B1 (en) 2007-09-18 2014-12-17 Novozymes A/S Polypeptides having tyrosinase activity and polynucleotides encoding same
WO2009037338A1 (en) 2007-09-21 2009-03-26 Basf Plant Science Gmbh Plants having increased yield-related traits and a method for making the same
NZ601191A (en) 2007-10-03 2014-01-31 Verenium Corp Xylanases, nucleic acids encoding them and methods for making and using them
CA2702043A1 (en) * 2007-10-08 2009-04-16 Quintessence Biosciences, Inc. Compositions and methods for ribonuclease-based therapies
WO2009049126A2 (en) 2007-10-10 2009-04-16 Athenix Corporation Synthetic genes encoding cry1ac
US20090144852A1 (en) 2007-10-16 2009-06-04 Athenix Corporation Axmi-066 and axmi-076: delta-endotoxin proteins and methods for their use
DE102007051092A1 (de) 2007-10-24 2009-04-30 Henkel Ag & Co. Kgaa Subtilisin aus Becillus pumilus und Wasch- und Reinigungsmittel enthaltend dieses neue Subtilisin
AU2008320931B2 (en) 2007-10-29 2014-09-25 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
US7618801B2 (en) * 2007-10-30 2009-11-17 Danison US Inc. Streptomyces protease
US7741088B2 (en) * 2007-10-31 2010-06-22 E.I. Dupont De Nemours And Company Immobilized microbial nitrilase for production of glycolic acid
US7871802B2 (en) * 2007-10-31 2011-01-18 E.I. Du Pont De Nemours And Company Process for enzymatically converting glycolonitrile to glycolic acid
AU2008325249B2 (en) 2007-11-05 2013-10-10 Danisco Us Inc. Alpha-amylase variants with altered properties
WO2009061380A2 (en) 2007-11-05 2009-05-14 Danisco Us Inc., Genencor Division VARIANTS OF BACILLUS sp. TS-23 ALPHA-AMYLASE WITH ALTERED PROPERTIES
CN103773795A (zh) 2007-11-22 2014-05-07 克罗普迪塞恩股份有限公司 具有增强的产量相关性状的植物及其生产方法
CN101883783A (zh) 2007-11-26 2010-11-10 巴斯夫植物科学有限公司 具有增强的产量相关性状的植物及其制备方法
US7867745B2 (en) 2007-11-27 2011-01-11 Novozymes A/S Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same
CA2706639A1 (en) 2007-11-29 2009-06-04 Novozymes A/S Synthase inhibitor screening method
TW200944231A (en) 2007-11-30 2009-11-01 Glaxo Group Ltd Antigen-binding constructs
ES2490608T3 (es) 2007-12-06 2014-09-04 Novozymes A/S Polipéptidos con actividad de esterasa de acetilxilano y polinucleótidos que codifican los mismos
US8318481B2 (en) * 2007-12-07 2012-11-27 Pfenex Inc. High copy number self-replicating plasmids in pseudomonas
AU2008338464A1 (en) * 2007-12-14 2009-06-25 Amgen Inc. Method for treating bone fracture with anti-sclerostin antibodies
EP2235173A2 (en) 2007-12-19 2010-10-06 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
EP2240009A2 (en) 2007-12-20 2010-10-20 BASF Plant Science GmbH Plants having enhanced yield-related traits and a method for making the same
EP2235151B1 (en) 2007-12-21 2012-09-12 DuPont Nutrition Biosciences ApS Process for edible oil refining using a lipid acyltransferase
CA2710922A1 (en) 2008-01-03 2009-07-16 Verenium Corporation Isomerases, nucleic acids encoding them and methods for making and using them
AU2008347234B2 (en) 2008-01-03 2015-05-28 Basf Enzymes Llc Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
CN102037004A (zh) * 2008-01-08 2011-04-27 生物种属学股份公司 使用寡糖基转移酶的多肽的糖缀合
KR20100107501A (ko) 2008-01-18 2010-10-05 메디뮨 엘엘씨 부위 특이적 접합을 위한 시스테인 조작 항체
WO2009092772A2 (en) 2008-01-25 2009-07-30 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
BRPI0906719A2 (pt) 2008-01-31 2015-08-04 Nat Inst For Biolog Sciences Método para alterar o crescimento e/ou desenvolvimento de planta, construção, uso de uma construção, planta, parte de planta ou célula de planta, método para a produção de uma planta transgênica, partes colhíveis de uma planta, produtos derivados de uma planta, e, uso de um ácido nucleico.
MX2010008359A (es) 2008-02-04 2010-08-30 Danisco Us Inc Variantes de alfa-amilasa ts23 con propiedades alteradas.
US20100049602A1 (en) * 2008-02-07 2010-02-25 Softky William R Systems and Methods for Measuring the Effectiveness of Advertising
MX2010008578A (es) 2008-02-08 2010-11-10 Medimmune Llc Anticuerpos anti-receptor 1 de interferon alfa con afinidad reducida al ligando fc.
EP2088432A1 (en) * 2008-02-11 2009-08-12 MorphoSys AG Methods for identification of an antibody or a target
US8034568B2 (en) 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
US8504498B2 (en) 2008-02-12 2013-08-06 Codexis, Inc. Method of generating an optimized, diverse population of variants
WO2009102901A1 (en) 2008-02-12 2009-08-20 Codexis, Inc. Method of generating an optimized, diverse population of variants
US20130189239A1 (en) 2008-02-27 2013-07-25 Novo Nordisk A/S Conjugated Factor VIII Molecules
US7846666B2 (en) 2008-03-21 2010-12-07 Nugen Technologies, Inc. Methods of RNA amplification in the presence of DNA
US20110020368A1 (en) 2008-03-25 2011-01-27 Nancy Hynes Treating cancer by down-regulating frizzled-4 and/or frizzled-1
US20110020830A1 (en) * 2008-03-31 2011-01-27 Schneider Jane C Design for rapidly cloning one or more polypeptide chains into an expression system
CA2721332A1 (en) 2008-04-16 2009-10-22 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
WO2009133464A2 (en) 2008-04-30 2009-11-05 Danisco A/S Oxidation process
CN102076713B (zh) 2008-05-02 2015-03-25 诺华股份有限公司 改进的基于纤连蛋白的结合分子及其用途
AU2009242486B2 (en) 2008-05-02 2013-10-10 Cellscript, Inc. RNA polyphosphatase compositions, kits, and uses thereof
BRPI0912244A2 (pt) 2008-05-05 2016-10-11 Basf Plant Science Gmbh método para intensificar as características relacionadas com o rendimento em plantas em relação às plantas de controle, constructo, uso do mesmo, planta, parte de planta ou célula de planta, método para a produção de uma planta transgênica, planta transgênica, partes colhíveis de uma planta, produtos, e, uso de um ácido nucleico.
EP2283034B1 (en) 2008-05-08 2013-08-07 Alellyx Applied Genomics Genes and methods for increasing disease resistance in plants
SG157299A1 (en) 2008-05-09 2009-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
EP2297310A2 (en) 2008-05-23 2011-03-23 E. I. du Pont de Nemours and Company Novel dgat genes for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
EP2294086B1 (en) 2008-06-04 2017-09-13 ModiQuest B.V. Anti-inflammatory agents
AU2009254546B2 (en) 2008-06-06 2014-09-25 Novozymes A/S Variants of a family 44 xyloglucanase
EP4545638A3 (en) 2008-06-06 2025-07-16 The Procter & Gamble Company Detergent composition comprising a variant of a family 44 xyloglucanase
MX2010013113A (es) 2008-06-06 2010-12-21 Danisco Inc Variantes de alfa-amilasa geobacillus stearothermophilus con propiedades mejoradas.
US8383346B2 (en) 2008-06-13 2013-02-26 Codexis, Inc. Combined automated parallel synthesis of polynucleotide variants
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
ES2705694T3 (es) 2008-06-13 2019-03-26 Codexis Inc Método de síntesis de variantes de polinucleótidos
CA2724993A1 (en) 2008-06-20 2009-12-23 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
EP2481737A1 (en) 2008-06-24 2012-08-01 Merck Sharp & Dohme Corp. Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
EP2297189A2 (en) 2008-06-25 2011-03-23 Athenix Corporation Toxin genes and methods for their use
EP2304037A1 (en) 2008-06-26 2011-04-06 BASF Plant Science GmbH Plants having enhanced yield-related traits and a method for making the same
MX2010014379A (es) 2008-07-02 2011-05-19 Athenix Corp Axmi-115, axmi-113, axmi-005, axmi-163 y axmi-184: proteinas insecticidas vip3a de bacillus thuringiensis y metodos para su uso.
DE112009001560T5 (de) 2008-07-04 2012-01-26 Basf Plant Science Gmbh Planzen mit gesteigerten ertragsbezogenen Eigenschaften und Verfahren zur Herstellung derselben
CN102099480A (zh) 2008-07-17 2011-06-15 巴斯夫植物科学有限公司 具有增强的产量相关性状的植物和用于产生该植物的方法
CN102159233A (zh) 2008-07-18 2011-08-17 诺维信阿德宁生物技术公司 使用哺乳动物β防御素的炎性肠病的治疗
MX2011000501A (es) 2008-07-18 2011-05-23 Squibb Bristol Myers Co Composiciones monovalentes para union a cd28 y metodos de uso.
WO2010011600A2 (en) * 2008-07-22 2010-01-28 Northwestern University Method for removal or inactivation of heparin
EP2318535A2 (en) 2008-07-31 2011-05-11 BASF Plant Science GmbH Plants having modified growth characteristics and a method for making the same
PY09026846A (es) 2008-08-05 2015-09-01 Novartis Ag Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5
CA2733505A1 (en) 2008-08-20 2010-02-25 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
WO2010027710A2 (en) 2008-08-27 2010-03-11 Codexis, Inc. Ketoreductase polypeptides and uses thereof
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010025238A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
SI2329014T1 (sl) 2008-08-29 2015-01-30 Codexis, Inc. Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
WO2010033237A2 (en) * 2008-09-22 2010-03-25 Calmune Corporation Methods for creating diversity in libraries and libraries, display vectors and methods, and displayed molecules
AU2009293640A1 (en) * 2008-09-22 2010-03-25 Calmune Corporation Methods and vectors for display of 2G12 -derived domain exchanged antibodies
BRPI0918991A2 (pt) 2008-09-24 2017-09-19 Basf Plant Science Gmbh Métodos para intensificar traços relacionados com o rendimento em plantas em relação ás plantas de controle, e para produzir uma planta transgênica, planta, parte de planta ou célula de planta, construção, uso de uma construção, partes colhíveis de uma planta, produtos, uso em um ácido nucleico, molécula de ácido nucleico isolada, e, polipeptídeo isolado
CA2738447C (en) 2008-09-25 2019-01-08 Danisco Us Inc. Alpha-amylase blends and methods for using said blends
MX2011003132A (es) 2008-09-26 2011-04-21 Novozymes As Variantes de fitasa de hafnia.
DK2346995T3 (en) 2008-09-26 2019-02-11 Tocagen Inc GENETERIVE VECTORS AND CYTOSINDEAMINASES
NZ592464A (en) 2008-09-26 2013-05-31 Basf Agrochemical Products Bv Herbicide resistant acetohydroxyacid synthase large subunit (AHAS) mutants and methods of use thereof
BRPI0920743A2 (pt) 2008-10-01 2016-09-20 Quintessence Biosciences Inc ribonucleases terapeuticas
US8252562B2 (en) * 2008-10-03 2012-08-28 E. I. Du Pont De Nemours And Company Enzyme powder comprising spray-dried formulation comprising a CE-7 enzyme
EP2364366B1 (en) * 2008-11-05 2014-01-08 MorphoSys AG Deconvolution method
US9221902B2 (en) 2008-11-07 2015-12-29 Fabrus, Inc. Combinatorial antibody libraries and uses thereof
WO2010056804A1 (en) 2008-11-12 2010-05-20 Medimmune, Llc Antibody formulation
CN102272309A (zh) 2008-11-12 2011-12-07 巴斯夫植物科学有限公司 具有增强的非生物胁迫耐受性和/或增强的产量相关性状的植物及其制备方法
WO2010059413A2 (en) 2008-11-20 2010-05-27 Novozymes, Inc. Polypeptides having amylolytic enhancing activity and polynucleotides encoding same
AU2009324213A1 (en) 2008-12-03 2011-07-07 Basf Plant Science Gmbh Plants having enhanced abiotic stress tolerance and/or enhanced yield-related traits and a method for making the same
US7771983B2 (en) 2008-12-04 2010-08-10 Novozymos, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
CA2743707A1 (en) 2008-12-04 2010-06-10 Pioneer Hi-Bred International, Inc. Methods and compositions for enhanced yield by targeted expression of knotted1
US20110296557A1 (en) 2008-12-12 2011-12-01 Novozymes, Inc. Polypeptides Having Lipase Activity And Polynucleotides Encoding Same
WO2010068800A1 (en) 2008-12-12 2010-06-17 Novozymes, Inc. Polypeptides having aspartic endopeptidase activity and polynucleotides encoding same
WO2010074972A1 (en) 2008-12-15 2010-07-01 Novozymes, Inc. Polypeptides having catalase activity and polynucleotides encoding same
EP2366025A1 (en) 2008-12-15 2011-09-21 Athenix Corporation Genes encoding nematode toxins
WO2010074955A1 (en) 2008-12-16 2010-07-01 Novozymes, Inc. Polypeptides having carboxypeptidase activity and polynucleotides encoding same
US20110271407A1 (en) 2008-12-16 2011-11-03 Novozymes, Inc. Polypeptides Having Alpha-Mannosidase Activity And Polynucleotides Encoding Same
US20110252508A1 (en) 2008-12-17 2011-10-13 Basf Plant Science Gmbh Plants Having Enhanced Yield-Related Traits and/or Abiotic Stress Tolerance and a Method for Making the Same
JP5734201B2 (ja) 2008-12-19 2015-06-17 マクロジェニクス，インコーポレーテッド 共有結合型ダイアボディ及びその使用
EP2379729A2 (en) 2008-12-19 2011-10-26 Novozymes A/S Use of enzymes having silicase activity
CA2747812A1 (en) 2008-12-22 2010-07-01 Athenix Corporation Pesticidal genes from brevibacillus and methods for their use
EP2379724B1 (en) 2008-12-23 2015-01-21 Athenix Corporation Axmi-150 delta-endotoxin gene and methods for its use
EP2382308B1 (en) 2008-12-25 2015-03-04 Codexis, Inc. Enone reductases
HUE036104T2 (hu) 2009-01-08 2018-06-28 Codexis Inc Transzamináz polipeptidek
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
EP2206723A1 (en) 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
EP2379720B1 (en) 2009-01-20 2016-08-17 Alona Zilberberg Mir-21 promoter driven targeted cancer therapy
CN102361973B (zh) 2009-01-21 2015-09-02 诺维信公司 具有酯酶活性的多肽和编码该多肽的核酸
WO2010088387A1 (en) 2009-01-28 2010-08-05 Novozymes, Inc. Polypeptides having beta-glucosidase activity and polynucleotides encoding same
CN104232679A (zh) 2009-01-28 2014-12-24 巴斯夫植物科学有限公司 具有增强的产量相关性状的植物及其制备方法
WO2010088463A2 (en) 2009-01-30 2010-08-05 Novozymes, Inc. Polypeptides having expansin activity and polynucleotides encoding same
WO2010088447A1 (en) 2009-01-30 2010-08-05 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
WO2010087927A2 (en) 2009-02-02 2010-08-05 Medimmune, Llc Antibodies against and methods for producing vaccines for respiratory syncytial virus
EP2393929A1 (en) 2009-02-05 2011-12-14 Athenix Corporation Variant axmi-r1 delta-endotoxin genes and methods for their use
WO2010091221A1 (en) 2009-02-06 2010-08-12 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
US8679814B2 (en) 2009-02-06 2014-03-25 University Of Chile Protein and DNA sequence encoding a cold adapted xylanase
SG172789A1 (en) 2009-02-11 2011-08-29 Novozymes Biopharma Dk As Albumin variants and conjugates
CN102325876A (zh) 2009-02-19 2012-01-18 诺维信公司 酿造方法
MY189620A (en) * 2009-02-20 2022-02-21 Malaysian Palm Oil Board A constitutive promoter from oil palm
CA2753287A1 (en) 2009-02-24 2010-09-02 Glaxo Group Limited Antigen-binding constructs
EP2401296A1 (en) 2009-02-24 2012-01-04 Glaxo Group Limited Multivalent and/or multispecific rankl-binding constructs
US20110305693A1 (en) 2009-02-24 2011-12-15 Glaxo Group Limited Anitigen-binding constructs
CN102482333A (zh) 2009-02-25 2012-05-30 巴斯夫植物科学有限公司 具有增强的产量相关性状的植物及其制备方法
EP2401369B1 (en) 2009-02-26 2014-12-24 Codexis, Inc. Beta-glucosidase variant enzymes and related polynucleotides
JP5746055B2 (ja) 2009-02-27 2015-07-08 アテニックス・コーポレーションＡｔｈｅｎｉｘ Ｃｏｒｐｏｒａｔｏｎ 殺虫性タンパク質及びその使用方法
WO2010097436A1 (en) 2009-02-27 2010-09-02 Novozymes A/S Mutant cells having reduced expression of metallopeptidase, suitable for recombinant polypeptide production
CA2753918A1 (en) 2009-03-06 2010-09-10 Athenix Corporation Methods and compositions for controlling plant pests
EP2405920A1 (en) 2009-03-06 2012-01-18 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Novel therapy for anxiety
CN102421792B (zh) 2009-03-11 2015-11-25 阿森尼克斯公司 Axmi-001、axmi-002、axmi-030、axmi-035和axmi-045: 来自苏云金芽孢杆菌的杀虫蛋白及其用法
EP2408314A1 (en) 2009-03-17 2012-01-25 Novozymes A/S Polypeptides having tyrosinase activity and polynucleotides encoding same
BRPI1013886A2 (pt) 2009-03-17 2016-10-11 Codexis Inc variantes de endoglucanases, polinucleotídeos e usos a elas relacionados
CN102365360A (zh) 2009-03-24 2012-02-29 诺维信公司 具有乙酰木聚糖酯酶活性的多肽和编码该多肽的多核苷酸
AU2010227419A1 (en) 2009-03-27 2011-10-20 Proyecto De Biomedicina Cima, S.L. Methods and compositions for the treatment of cirrhosis and liver fibrosis
WO2010111674A2 (en) 2009-03-27 2010-09-30 Life Technologies Corporation Methods and apparatus for single molecule sequencing using energy transfer detection
CN102428170B (zh) 2009-03-31 2015-03-18 科德克希思公司 改良的内切葡聚糖酶
RU2011144134A (ru) 2009-04-01 2013-05-10 ДАНИСКО ЮЭс ИНК. Композиции и способы, включающие варианты альфа-амилазы с измененными свойствами
EP2241323A1 (en) 2009-04-14 2010-10-20 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Tenascin-W and brain cancers
GB0908770D0 (en) 2009-04-24 2009-07-01 Danisco Method
US20120102599A1 (en) 2009-04-29 2012-04-26 Crop Functional Genomics Center Plants Having Enhanced Yield-Related Traits and a Method for Making the Same
WO2010125036A2 (en) 2009-04-29 2010-11-04 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and a method for making the same
CA2760700A1 (en) 2009-05-04 2010-11-11 Pioneer Hi-Bred International, Inc. Yield enhancement in plants by modulation of ap2 transcription factor
EP2427480A1 (en) 2009-05-06 2012-03-14 BASF Plant Science Company GmbH Plants having enhanced yield-related traits and/or enhanced abiotic stress tolerance and a method for making the same
EP2248893A1 (en) 2009-05-06 2010-11-10 Novozymes A/S DFPase Enzymes from Octopus Vulgaris
MY186558A (en) * 2009-05-13 2021-07-27 Malaysian Palm Oil Board A constitutive promoter from oil palm type 2
EP2432876A1 (en) 2009-05-19 2012-03-28 Danisco A/S Use
HUE030948T2 (en) 2009-05-21 2017-06-28 Basf Enzymes Llc Phytases, nucleic acids and processes encoding them for their production and use
KR101703695B1 (ko) 2009-05-22 2017-02-08 큐알엔에이, 인크. 전사 인자 ｅ3(ｔｆｅ3)에 대한 천연 안티센스 전사체의 억제에 의해 ｔｆｅ3 및 인슐린 수용체 기질 2(ｉｒｓ2)의 치료
US9989533B2 (en) 2009-05-28 2018-06-05 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Anti-TNF induced apoptosis (ATIA) diagnostic markers and therapies
NZ596603A (en) 2009-05-29 2013-07-26 Morphosys Ag A collection of antibodies or fragments having properties relevant to developability
EP2435561B1 (en) 2009-05-29 2018-08-08 Novozymes Inc. Methods for enhancing the degradation or conversion of cellulosic material
ES2534078T3 (es) 2009-06-02 2015-04-17 Novozymes Inc. Polipéptidos con actividad de celobiohidrolasa y polinucleótidos que codifican los mismos
MX2011013224A (es) 2009-06-09 2012-06-01 Pioneer Hi Bred Int Promotor de endospermo temprano y metodos de uso.
AR077042A1 (es) 2009-06-12 2011-07-27 Danisco Metodo para tratar una composicion que contiene pirofiofitina
US20100317539A1 (en) * 2009-06-12 2010-12-16 Guo-Liang Yu Library of Engineered-Antibody Producing Cells
CA2762616C (en) 2009-06-16 2015-08-18 Codexis, Inc. Beta-glucosidase variant enzymes and related polynucleotides
US9683023B2 (en) 2009-06-19 2017-06-20 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and a method for making the same
HUE055413T2 (hu) 2009-06-22 2021-11-29 Codexis Inc Ketoreduktáz-közvetített sztereoszelektív útvonal alfa-klóralkoholokhoz
BRPI1015234A2 (en) 2009-06-22 2018-02-20 Medimmune Llc fc regions designed for site specific conjugation.
WO2010151787A1 (en) 2009-06-26 2010-12-29 Novozymes North America, Inc. Heat-stable carbonic anhydrases and their use
CN102648281B (zh) 2009-07-02 2017-04-05 阿森尼克斯公司 Axmi‑205杀虫基因和它的使用方法
WO2011000924A1 (en) 2009-07-03 2011-01-06 Abbott Products Gmbh Spray-dried amylase, pharmaceutical preparations comprising the same and use
CA2767169A1 (en) 2009-07-07 2011-01-13 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
US20120288914A1 (en) 2009-07-07 2012-11-15 Pioneer Hi Bred International Inc. Crystal structure of glyphosate acetyltransferase (glyat) and methods of use
US8614081B2 (en) 2009-07-23 2013-12-24 Codexis, Inc. Nitrilase biocatalysts
MX2012001060A (es) 2009-07-24 2012-03-14 Novozymes As Carbohidrato-oxidasas.
WO2011009182A2 (pt) 2009-07-24 2011-01-27 Embrapa - Empresa Brasileira De Pesquisa Agropecuária Molécula de ácido nucléico isolada, construção gênica, vetor, célula transgênica, método para obtenção de uma célula e de uma planta transgênica, polipeptídeo isolado e purificado, composição pesticida biodegradável, método para o controle de uma praga, método de obtenção de linhagens transgênicas resistentes a um inseto praga
WO2011014458A1 (en) 2009-07-28 2011-02-03 Novozymes, Inc. Polypeptides having phytase activity and polynucleotides encoding same
US8461415B2 (en) 2009-07-31 2013-06-11 Athenix Corp. AXMI-192 family of pesticidal genes and methods for their use
DK2464657T3 (en) 2009-08-10 2015-06-29 Morphosys Ag New screening strategies for the identification of antibodies or fragments thereof which bind an antigen with enzymatic activity
MX2012001882A (es) 2009-08-13 2012-04-11 Crucell Holland Bv Anticuerpos contra el virus sincitial respiratorio (rsv) humano y metodos de uso.
EP2464661B1 (en) 2009-08-13 2018-01-17 The Johns Hopkins University Methods of modulating immune function with anti-b7-h7cr antibodies
CN104530202A (zh) 2009-08-19 2015-04-22 巴斯夫植物科学有限公司 具有增强的产量相关性状的植物和用于产生该植物的方法
WO2011022548A2 (en) 2009-08-19 2011-02-24 Codexis, Inc. Ketoreductase polypeptides for the preparation of phenylephrine
US8592649B2 (en) 2009-08-20 2013-11-26 Pioneer Hi Bred International Inc Functional expression of shuffled yeast nitrate transporter (YNT1) in maize to improve nitrate uptake under low nitrate environment
US8409830B2 (en) 2009-08-21 2013-04-02 Novozymes A/S Polypeptides having isoamylase activity and methods of use
EP2292266A1 (en) 2009-08-27 2011-03-09 Novartis Forschungsstiftung, Zweigniederlassung Treating cancer by modulating copine III
US8741611B2 (en) 2009-09-01 2014-06-03 Novozymes, Inc. Methods for improving malic acid production in filamentous fungi
WO2011028708A1 (en) 2009-09-04 2011-03-10 Codexis, Inc. Variant cbh2 cellulases and related polynucleotides
WO2011029166A1 (en) 2009-09-09 2011-03-17 Braskem S.A. Microorganisms and process for producing n-propanol
US8293483B2 (en) 2009-09-11 2012-10-23 Epitomics, Inc. Method for identifying lineage-related antibodies
DK3269804T3 (da) 2009-09-17 2020-11-23 Novozymes Inc Polypeptider med cellulolyseforbedrende aktivitet og polynukleotider, som koder for dem
WO2011035205A2 (en) 2009-09-18 2011-03-24 Calmune Corporation Antibodies against candida, collections thereof and methods of use
DK3301208T3 (da) 2009-09-18 2020-12-14 Codexis Inc Reduceret codon-mutagenese
EP2478095A1 (en) 2009-09-18 2012-07-25 Novozymes Inc. Polypeptides having beta-glucosidase activity and polynucleotides encoding same
EP2480573A1 (en) 2009-09-22 2012-08-01 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Treating cancer by modulating mex-3
EP2480650B1 (en) 2009-09-25 2017-03-22 Novozymes A/S Subtilase variants
PH12012500517A1 (en) 2009-09-25 2012-11-12 Basf Plant Science Co Gmbh Plants having enhanced yield-related traits and a method for making the same
CN102648277B (zh) 2009-09-25 2015-05-20 诺维信公司 蛋白酶变体的用途
EA201270440A1 (ru) 2009-09-25 2012-10-30 Басф Плант Сайенс Компани Гмбх Растения с улучшенными характеристиками урожайности и способ их получения
CA2775347A1 (en) 2009-09-29 2011-04-07 Novozymes A/S Polypeptides having xylanase activity and polynucleotides encoding same
WO2011041397A1 (en) 2009-09-29 2011-04-07 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
WO2011039319A1 (en) 2009-09-30 2011-04-07 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
BR112012007375A2 (pt) 2009-09-30 2016-11-22 Novozymes As polipeptídeo isolado, polinucleotídeo isolado, métodos para produzir um polipeptídeo, para produzir um mutante de uma célula precursora, para inibir a expressão de um polipeptídeo, para produzir uma proteína, para degradar ou converter um material celulósico, para produzir um produto de fermentação e para fermentar um material celulósico, planta transgênica, parte de planta ou célula de planta transformada, molécula de rna inibitória de filamento duplo, e, composição detergente
US8222012B2 (en) * 2009-10-01 2012-07-17 E. I. Du Pont De Nemours And Company Perhydrolase for enzymatic peracid production
BR112012009381A2 (pt) 2009-10-02 2017-03-01 Syngenta Participations Ag "proteínas inseticidas"
MX2012004029A (es) 2009-10-07 2012-05-08 Macrogenics Inc Polipeptidos que contienen la region fc que exhiben funcion efectora mejorada debido a alteraciones del grado de fucosilacion, y metodos para su uso.
WO2011045352A2 (en) 2009-10-15 2011-04-21 Novartis Forschungsstiftung Spleen tyrosine kinase and brain cancers
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
KR20120126061A (ko) 2009-10-22 2012-11-20 재단법인 작물유전체기능연구사업단 향상된 수확량 관련 형질을 갖는 식물 및 이의 제조 방법
WO2011050037A1 (en) 2009-10-23 2011-04-28 Novozymes, Inc. Cellobiohydrolase variants and polynucleotides encoding same
BR112012009044A2 (pt) 2009-10-26 2015-09-01 Pioneer Hi Bred Int Molécula de ácido nucléico isolada, cassete de expressão, vetor, célula vegetal, planta, semente transgênica, método para expressão de um polinucleotídeo em uma planta ou célula vegetal e método para expressão de um polinucleotídeo, preferencialmente em tecidos somáticos de óvulo de uma planta
WO2011059740A1 (en) 2009-10-29 2011-05-19 Novozymes, Inc. Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
AU2010311332B2 (en) 2009-10-30 2015-04-23 Albumedix Ltd. Albumin variants
US20120213801A1 (en) 2009-10-30 2012-08-23 Ekaterina Gresko Phosphorylated Twist1 and cancer
WO2011051327A2 (en) 2009-10-30 2011-05-05 Novartis Ag Small antibody-like single chain proteins
BR112012010394A2 (pt) 2009-11-02 2017-06-27 Plant Sensory Systems Llc método para a biossíntese de taurina ou hipotaurina em células
WO2011051466A1 (en) 2009-11-02 2011-05-05 Novartis Ag Anti-idiotypic fibronectin-based binding molecules and uses thereof
WO2011056872A2 (en) 2009-11-03 2011-05-12 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
CN103068976A (zh) 2009-11-06 2013-04-24 诺维信股份有限公司 具有纤维二糖水解酶活性的多肽和编码该多肽的多核苷酸
DK2496692T3 (en) 2009-11-06 2016-06-27 Novozymes Inc POLYPEPTIDES WITH xylanase AND POLYNUCLEOTIDES ENCODING THEM
DE112010004383T5 (de) 2009-11-13 2012-08-23 Basf Plant Science Company Gmbh Pflanzen mit gesteigerten Ertragsmerkmalen und Verfahren zu deren Herstellung
GB0920089D0 (en) 2009-11-17 2009-12-30 Danisco Method
WO2011063198A2 (en) 2009-11-20 2011-05-26 St. Jude Children's Research Hospital Methods and compositions for modulating the activity of the interleukin-35 receptor complex
RU2413226C1 (ru) * 2009-11-20 2011-02-27 Дина Дамировна Гайнетдинова Способ определения нестабильности генома у детей, больных детским церебральным параличом с перивентрикулярной лейкомаляцией
US8993840B2 (en) 2009-11-23 2015-03-31 E I du Pont de Nemours and Compay Sucrose transporter genes for increasing plant seed lipids
US8652813B2 (en) 2009-11-25 2014-02-18 Codexis, Inc. Recombinant Thermoascus aurantiacus β-glucosidase variants
WO2011066185A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Microfluidic devices and methods for gene synthesis
ES2455269T3 (es) 2009-11-25 2014-04-15 Codexis, Inc. Variantes de beta-glucosidasa recombinante para la producción de azúcares solubles de biomasa celulósica
EP2504449B1 (en) 2009-11-25 2016-03-23 Gen9, Inc. Methods and apparatuses for chip-based dna error reduction
CN102725412B (zh) 2009-11-27 2017-09-22 巴斯夫植物科学有限公司 优化的内切核酸酶及其用途
AU2010325563B2 (en) 2009-11-27 2017-02-02 Basf Plant Science Company Gmbh Chimeric endonucleases and uses thereof
WO2011064751A1 (en) 2009-11-27 2011-06-03 Basf Plant Science Company Gmbh Chimeric endonucleases and uses thereof
CA2782154C (en) 2009-11-30 2018-10-16 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
CN102869770B (zh) 2009-11-30 2015-12-16 诺维信公司 具有葡糖淀粉酶活性的多肽和编码该多肽的多核苷酸
CA2782036C (en) 2009-12-01 2019-01-15 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
MX2012006397A (es) 2009-12-02 2012-11-30 Amgen Inc PROTEINAS DE ENLACE QUE ENLAZAN A FGFR1C HUMANO, ß-KLOTHO HUMANA Y TANTO FGFR1C HUMANO COMO ß-KLOTHO HUMANA.
TW201125577A (en) 2009-12-02 2011-08-01 Novozymes As Use of defensins for treatment of infective endocarditis
WO2011067349A1 (en) 2009-12-03 2011-06-09 Novozymes A/S Variants of a polypeptide with lipolytic activity and improved stability
WO2011071982A2 (en) 2009-12-08 2011-06-16 Codexis, Inc. Synthesis of prazole compounds
US8951770B2 (en) 2009-12-09 2015-02-10 Novozymes A/S GH8 xylanase variants
WO2013003290A1 (en) 2011-06-28 2013-01-03 Codexis, Inc. Protein variant generation by region shuffling
US8653024B2 (en) 2009-12-11 2014-02-18 Adenium Biotech Aps Use of AMPs for treatment of UTI/cystitis
ES2668202T3 (es) 2009-12-11 2018-05-17 Novozymes A/S Variantes de proteasa
US20120220513A1 (en) 2009-12-29 2012-08-30 Novozymes A/S Polypeptides Having Detergency Enhancing Effect
WO2011082304A1 (en) 2009-12-31 2011-07-07 Pioneer Hi-Bred International, Inc. Engineering plant resistance to diseases caused by pathogens
CN102884183B (zh) 2010-01-04 2015-09-16 诺维信公司 趋于钙耗竭和酸性pH的α-淀粉酶的稳定化
WO2011085075A2 (en) 2010-01-07 2011-07-14 Gen9, Inc. Assembly of high fidelity polynucleotides
US20120295793A1 (en) 2010-01-22 2012-11-22 Proteus Methods of generating modified polynucleotide libraries and methods of using the same for directed protein evolution
AU2011208891B2 (en) 2010-01-25 2015-01-15 Bayer Cropscience Nv Methods for manufacturing plant cell walls comprising chitin
WO2011092233A1 (en) 2010-01-29 2011-08-04 Novartis Ag Yeast mating to produce high-affinity combinations of fibronectin-based binders
EP3892709A3 (en) 2010-02-10 2022-01-19 Novozymes A/S Variants and compositions comprising variants with high stability in presence of a chelating agent
AR080154A1 (es) 2010-02-10 2012-03-14 Immunogen Inc Anticuerpos cd20 y su utilizacion
US9080192B2 (en) 2010-02-10 2015-07-14 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
EP2357220A1 (en) 2010-02-10 2011-08-17 The Procter & Gamble Company Cleaning composition comprising amylase variants with high stability in the presence of a chelating agent
AR080201A1 (es) 2010-02-18 2012-03-21 Athenix Corp Genes delta-endotoxinicos de bacillus thuringiensis (axmi218, axmi219, axmi220, axmi226, axmi227, axmi228, axmi229, axmi230, y axmi231), y metodos para su uso
MX2012009632A (es) 2010-02-18 2012-09-28 Athenix Corp Genes delta-endotoxinicos axmi221z, axmi222z, axmi223z, axmi224z, axmi225z y metodos para su uso.
CN102939385A (zh) 2010-02-24 2013-02-20 巴斯夫植物科学有限公司 具有增强的产量相关性状的植物和用于产生该植物的方法
US9388423B2 (en) 2010-02-24 2016-07-12 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and a method for making the same
JP5833576B2 (ja) 2010-02-25 2015-12-16 ノボザイムス アクティーゼルスカブ リゾチームの変異体及びそれをコードするポリヌクレオチド
WO2011104284A1 (en) 2010-02-25 2011-09-01 Novozymes A/S Polypeptides having antimicrobial activity
EP2361927A1 (en) 2010-02-26 2011-08-31 BASF Plant Science Company GmbH Plants having enhanced yield-related traits and a method for making the same
EP2361985A1 (en) 2010-02-26 2011-08-31 BASF Plant Science Company GmbH Plants having enhanced yield-related traits and a method for making the same
WO2011109524A2 (en) 2010-03-03 2011-09-09 Novozymes, Inc. Xylanase variants and polynucleotides encoding same
US20130004519A1 (en) 2010-03-05 2013-01-03 Ruth Chiquet-Ehrismann Smoci, tenascin-c and brain cancers
CN102844418B (zh) 2010-03-12 2015-11-25 杜邦营养生物科学有限公司 方法
DE112011100940T5 (de) 2010-03-18 2013-01-24 Basf Plant Science Company Gmbh Pflanzen mit gesteigerten Ertragsmerkmalen und Verfahren zu deren Herstellung
BR112012022880A2 (pt) 2010-03-18 2015-09-15 Basf Plant Science Co Gmbh métodos para aumentar o rendimento e/ou traços relacionados ao rendimento em plantas em relação a plantas de controle, para a produção de uma planta transgênica e para a produção de um produto, planta, construção, uso de uma construção, planta transgênica, partes colhíveis de uma planta, produtos derivados de uma planta e uso de um ácido nucleíco
WO2011114251A1 (en) 2010-03-18 2011-09-22 Danisco A/S Foodstuff
EA201290937A1 (ru) 2010-03-19 2013-06-28 Басф Плант Сайенс Компани Гмбх Растения с улучшенными характеристиками урожайности и способ их получения
CN102892891A (zh) 2010-03-19 2013-01-23 巴斯夫植物科学有限公司 具有增强的产量相关性状的植物和用于产生该植物的方法
US9556248B2 (en) 2010-03-19 2017-01-31 The Board Of Trustees Of The Leland Stanford Junior University Hepatocyte growth factor fragments that function as potent met receptor agonists and antagonists
EP2371845A1 (en) 2010-03-22 2011-10-05 BASF Plant Science Company GmbH Plants having enhanced yield-related traits and a method for making the same
CN102917600B (zh) 2010-03-26 2015-07-08 诺维信公司 热稳定性肌醇六磷酸酶变体
US9222109B2 (en) 2010-03-28 2015-12-29 Novozymes A/S Enzymatic hydroxylation of aliphatic hydrocarbon
CN102834521B (zh) 2010-03-30 2018-02-27 诺维信公司 用于增强来自发酵工艺副产物的方法
WO2011123576A2 (en) 2010-03-31 2011-10-06 Codexis, Inc. Production of monoterpenes
WO2011123450A1 (en) 2010-03-31 2011-10-06 Novozymes, Inc. Cellobiohydrolase variants and polynucleotides encoding same
KR20130070576A (ko) 2010-04-09 2013-06-27 노보자임스 바이오파마 디케이 에이/에스 알부민 유도체 및 변이체
CA2795806C (en) 2010-04-14 2019-01-08 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
US8383793B2 (en) 2010-04-15 2013-02-26 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
EP2561076A1 (en) 2010-04-19 2013-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Modulating xrn1
HUE026367T2 (en) 2010-05-04 2016-06-28 Codexis Inc Biocatalysts for ezetimibe synthesis
MX2012012927A (es) 2010-05-06 2013-05-01 Novartis Ag Composiciones y metodos de uso para anticuerpos multivalentes terapeuticos de proteina relacionada con lipoproteina de baja densidad 6 (lrp6).
SG185416A1 (en) 2010-05-06 2012-12-28 Novartis Ag Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies
AR080745A1 (es) 2010-05-06 2012-05-02 Du Pont Gen y proteina acc (acido 1-aminociclopropano-1-carboxilico) sintasa 3 de maiz y sus usos
EP2569331A1 (en) 2010-05-10 2013-03-20 Perseid Therapeutics LLC Polypeptide inhibitors of vla4
SMT202000095T1 (it) 2010-05-14 2020-03-13 Amgen Inc Formulazioni di anticorpi anti-sclerostina ad alta concentrazione
CA2800734A1 (en) 2010-05-25 2011-12-01 Universite De Strasbourg Combination of anti-envelope antibodies and anti-receptor antibodies for the treatment and prevention of hcv infection
EP2576804B1 (en) 2010-05-28 2016-12-14 Codexis, Inc. Pentose fermentation by a recombinant microorganism
WO2011153317A1 (en) 2010-06-04 2011-12-08 Novozymes, Inc. C4 dicarboxylic acid production in filamentous fungi
US20130089538A1 (en) 2010-06-10 2013-04-11 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute forBiomedical Researh Treating cancer by modulating mammalian sterile 20-like kinase 3
EP2579734A1 (en) 2010-06-11 2013-04-17 Novozymes A/S A method to reduce biogenic amine content in food
US8835604B2 (en) 2010-06-12 2014-09-16 Adenium Biotech Aos Antimicrobial peptide variants and polynucleotides encoding same
DK2582799T3 (en) 2010-06-17 2018-02-12 Codexis Inc BIOCATALATORS AND PROCEDURES FOR THE SYNTHESIS OF (S) -3- (1-AMINOETHYL) -PHENOL
EP2582809A1 (en) 2010-06-17 2013-04-24 DuPont Nutrition Biosciences ApS Process
IN2013CN00459A (enExample) 2010-06-21 2015-07-03 Novozymes Inc
AU2011271094B2 (en) 2010-06-21 2015-01-22 Novozymes, Inc. Aspergillus aculeatus derived polypeptides having C4-dicarboxylic acid transporter activity and polynucleotides encoding same
EP2998401A3 (en) 2010-06-24 2016-07-06 BASF Plant Science Company GmbH Plants having enhanced yield-related traits and a method for making the same
EP4449858A3 (en) 2010-06-25 2025-04-16 Corteva Agriscience LLC Compositions and methods for enhancing resistance to northern leaf blight in maize
AU2011268562A1 (en) 2010-06-25 2013-01-10 Basf Plant Science Company Gmbh Plants with enhanced yield-related traits and producing method thereof
US8574878B2 (en) 2010-06-28 2013-11-05 Behnaz Behrouzian Fatty alcohol forming acyl reductases (FARs) and methods of use thereof
US8420364B2 (en) 2010-06-30 2013-04-16 Codexis, Inc. Highly stable beta-class carbonic anhydrases useful in carbon capture systems
EP2588604B1 (en) 2010-06-30 2016-06-29 Novozymes, Inc. Polypeptides having beta-glucosidase activity and polynucleotides encoding same
GB201011513D0 (en) 2010-07-08 2010-08-25 Danisco Method
EP2591000B1 (en) 2010-07-09 2017-05-17 Janssen Vaccines & Prevention B.V. Anti-human respiratory syncytial virus (rsv) antibodies and methods of use
CN103108648A (zh) 2010-07-12 2013-05-15 细胞基因公司 罗米地辛固体形式及其用途
MX381912B (es) 2010-07-16 2025-03-13 Adimab Llc Colecciones de anticuerpos.
EP2593555A4 (en) 2010-07-16 2014-02-26 Basf Plant Science Co Gmbh PLANTS HAVING ENHANCED YIELD LINKS AND METHOD FOR OBTAINING SAME
WO2012013197A2 (en) 2010-07-30 2012-02-02 Aalborg Universitet Aspergillus encoding beta-glucosidases and nucleic acids encoding same
AU2011283646B2 (en) 2010-07-30 2015-07-09 Novartis Ag Fibronectin cradle molecules and libraries thereof
ES2667100T3 (es) 2010-08-02 2018-05-09 Macrogenics, Inc. Diacuerpos covalentes y sus usos
WO2012021401A1 (en) 2010-08-12 2012-02-16 Novozymes, Inc. Compositions comprising a polypeptide having cellulolytic enhancing activity and a bicyclic compound and uses thereof
CA2805941A1 (en) 2010-08-13 2012-02-16 Pioneer Hi-Bred International, Inc. Methods and compositions for targeting sequences of interest to the chloroplast
WO2012024100A2 (en) 2010-08-16 2012-02-23 Merck Sharp & Dohme Corp. Process for preparing aminocyclohexyl ether compounds
WO2012022734A2 (en) 2010-08-16 2012-02-23 Medimmune Limited Anti-icam-1 antibodies and methods of use
US9322027B2 (en) 2010-08-20 2016-04-26 Shell Oil Company Expression constructs comprising fungal promoters
ME02637B (me) 2010-08-20 2017-06-20 Novartis Ag Antitela za receptor 3 faktora rasta epiderma (her3)
ES2623288T3 (es) 2010-08-20 2017-07-10 Codexis, Inc. Uso de proteínas de la familia de glicólido hidrolasa 61 en el procesamiento de celulosa
CA2807785A1 (en) 2010-08-23 2012-03-01 Pioneer Hi-Bred International, Inc. Novel defensin variants and methods of use
MX2013002137A (es) 2010-08-24 2013-05-17 Basf Plant Science Co Gmbh Plantas que tienen mejores rasgos relacionados con el rendimiento y un metodo para prepararlas.
CN107299095B (zh) 2010-08-24 2021-05-11 诺维信公司 热稳定性Persephonella碳酸酐酶及其用途
JP2013535988A (ja) 2010-08-26 2013-09-19 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 変異ｈｐｇｇモチーフおよびｈｄａｓｈモチーフδ５デサチュラーゼおよび多価不飽和脂肪酸の製造におけるそれらの使用
JP5963749B2 (ja) 2010-08-26 2016-08-03 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ 変異δ９エロンガーゼおよび多価不飽和脂肪酸の製造におけるそれらの使用
WO2012030811A1 (en) 2010-08-30 2012-03-08 Novozymes A/S Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
WO2012030858A2 (en) 2010-08-30 2012-03-08 Novozymes A/S Polypeptides having hemicellulolytic activity and polynucleotides encoding same
US8629325B2 (en) 2010-08-30 2014-01-14 Novozymes A/S Polypeptides having beta-glucosidase activity and polynucleotides encoding same
US9303074B2 (en) 2010-08-30 2016-04-05 Novoyzmes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
US9267126B2 (en) 2010-08-30 2016-02-23 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
WO2012030849A1 (en) 2010-08-30 2012-03-08 Novozymes A/S Polypeptides having xylanase activity and polynucleotides encoding same
US20130171159A1 (en) 2010-09-10 2013-07-04 Brian Arthur Hemmings Phosphorylated twist1 and metastasis
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
EP2616483A1 (en) 2010-09-16 2013-07-24 Novozymes A/S Lysozymes
BR112013006612A2 (pt) 2010-09-22 2017-10-24 Bayer Ip Gmbh uso de agentes de controle biológico ou químico para controle de insetos e nematódeos em culturas resistentes
EP2622070B1 (en) 2010-09-30 2016-08-03 Novozymes, Inc. Variants of polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
EP2622068B1 (en) 2010-09-30 2016-07-20 Novozymes, Inc. Variants of polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
MX2013002586A (es) 2010-10-01 2013-03-21 Novozymes Inc Variantes de beta-glucosidasa y polinucleotidos que codifican las mismas.
RU2583293C2 (ru) 2010-10-01 2016-05-10 Новозимс А/С Полипептиды, обладающие эндопептидазной активностью, и кодирующие их полинуклеотиды
CA2811787A1 (en) 2010-10-06 2012-04-19 Bp Corporation North America Inc. Variant cbh i polypeptides
WO2012058293A1 (en) 2010-10-26 2012-05-03 Novozymes North America, Inc. Methods of saccharifying sugarcane trash
EP2632943A1 (en) 2010-10-29 2013-09-04 Novozymes A/S Polypeptides having succinyl-coa:aceto acetate transferase activity and polynucleotides encoding same
MX2013004353A (es) 2010-10-29 2013-06-28 Novozymes Inc Produccion recombinante de n-propanol e isopropanol.
DK2635689T3 (en) 2010-11-02 2015-07-06 Novozymes Inc METHODS OF PREPARATION OF cellulosic material WITH A GH61-POLYPEPTIDE
EP2635594B1 (en) 2010-11-04 2017-01-11 Novozymes Inc. Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
CN103429620B (zh) 2010-11-05 2018-03-06 酵活有限公司 在Fc结构域中具有突变的稳定异源二聚的抗体设计
EP2637515B1 (en) 2010-11-08 2017-09-06 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
DK2638154T3 (da) 2010-11-08 2017-01-02 Novozymes As Polypeptider med glucoamylaseaktivitet og polynukleotider, der koder for dem
CA2815969A1 (en) 2010-11-10 2012-05-18 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and method for making the same
WO2012064975A1 (en) 2010-11-12 2012-05-18 Gen9, Inc. Protein arrays and methods of using and making the same
BR112013009026A2 (pt) 2010-11-12 2016-07-12 Novozymes Inc polipeptídeo isolado, célula hospedeira recombinante, métodos para produzir um polipeptídeo, um mutante de uma célula precursora, uma proteína, e um produto de fermentação, para inibir a expressão de um polipeptídeo, para degradar ou converter um material celulósico, e método para fermentar um material celulósico, planta transgênica, parte de planta ou célula de planta, molécula de rna inibidora de filamento duplo, polinucleotídeo isolado, e, formulação de caldo integral ou composição de cultura de célula
CA2817697C (en) 2010-11-12 2021-11-16 Gen9, Inc. Methods and devices for nucleic acids synthesis
BR112013011442A2 (pt) 2010-11-12 2020-08-11 Novozymes A/S polipeptídeo isolado, polinucleotídeo isolado, construto de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, método de produção do polipeptídeo, composição, uso do polipeptídeo ou da composição, métodos de redução do teor de componentes contendo fósforo em um óleo comestível, e para desengomagem de uma composição de óleo
EP2640738A1 (en) 2010-11-15 2013-09-25 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Anti-fungal agents
WO2012068509A1 (en) 2010-11-18 2012-05-24 Novozymes, Inc. Chimeric polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
EP2640742B1 (en) 2010-11-19 2018-08-15 MorphoSys AG A collection of antibody sequences its use
WO2012069466A1 (en) 2010-11-24 2012-05-31 Novartis Ag Multispecific molecules
MX2013005847A (es) 2010-11-24 2013-12-12 Glaxo Group Ltd Proteinas de union a antigeno multiespecificas que eligen como blanco a hgf.
US8927235B2 (en) 2010-12-06 2015-01-06 Novozymes A/S Methods of hydrolyzing oligomers in hemicellulosic liquor
DK2649187T3 (da) 2010-12-08 2018-01-29 Codexis Inc Biokatalysatorer og fremgangsmåder til syntesen af armodafinil
EP2655632A1 (en) 2010-12-22 2013-10-30 Pioneer Hi-Bred International Inc. Viral promoter, truncations thereof, and methods of use
BR112013014988A2 (pt) 2010-12-22 2017-06-27 Du Pont molécula de ácido nucléico isolada, constructo de dna, vetor, célula vegetal, planta, semente transgênica proveniente da planta, método para expressão de uma sequência de nucleotídeos em uma planta, método para expressão de uma sequência de nucleotídeos em uma célula vegetal, método para expressar seletivamente uma sequência de nucleotídeos em tecidos vegetais verdes de milho
MX2013007532A (es) 2010-12-28 2013-09-16 Pioneer Hi Bred Int Nuevo gen de bacillus thuringiensis con actividad contra el orden lepidoptera.
WO2012097128A1 (en) 2011-01-14 2012-07-19 Two Blades Foundation Citrus trees with resistance to citrus canker
EP2665819A4 (en) 2011-01-20 2014-09-10 Basf Plant Science Co Gmbh PLANTS WITH IMPROVED PERFORMANCE CHARACTERISTICS AND METHOD FOR THE PRODUCTION THEREOF
MX2013007720A (es) 2011-01-26 2013-08-09 Novozymes As Polipeptidos que tienen actividad celobiohidrolasa y polinucleotidos que codifican para los mismos.
WO2012103322A1 (en) 2011-01-26 2012-08-02 Novozymes A/S Polypeptides having endoglucanase activity and polynucleotides encoding same
US9157075B2 (en) 2011-01-26 2015-10-13 Novozymes, Inc. Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
EP2668266B1 (en) 2011-01-26 2018-01-03 Novozymes A/S Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
DK2668270T3 (en) 2011-01-26 2019-01-07 Novozymes Inc Polypeptides with cellobiohydrolase activity and polynucleotides encoding them
US20120189633A1 (en) 2011-01-26 2012-07-26 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies and uses thereof
DK2670853T3 (en) 2011-01-31 2017-08-28 Novozymes North America Inc Process for enzymatic refining of pretreated cellulosic material for sugars
WO2012106579A1 (en) 2011-02-03 2012-08-09 Bristol-Myers Squibb Company Amino acid dehydrogenase and its use in preparing amino acids from keto acids
WO2012112411A1 (en) 2011-02-15 2012-08-23 Pioneer Hi-Bred International, Inc. Root-preferred promoter and methods of use
JP2014511409A (ja) 2011-02-16 2014-05-15 ノボザイムス アクティーゼルスカブ 金属プロテアーゼを含む洗剤組成物
JP2014506945A (ja) 2011-02-16 2014-03-20 ノボザイムス アクティーゼルスカブ 金属プロテアーゼを含む洗剤組成物
US20140024103A1 (en) 2011-02-16 2014-01-23 Astrid Benie Detergent Compositions Comprising Metalloproteases
EP2678352B1 (en) 2011-02-23 2017-12-06 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
CA2825632C (en) 2011-02-23 2020-07-07 Dupont Nutrition Biosciences Aps Process for treating plant oil
AR085251A1 (es) 2011-02-23 2013-09-18 Danisco Proceso para tratar aceite vegetal
CN103797114A (zh) 2011-02-23 2014-05-14 杜邦营养生物科学有限公司 生产能够水解叶绿素或叶绿素衍生物的重组酶的方法
CN103492573A (zh) 2011-02-28 2014-01-01 巴斯夫植物科学有限公司 具有增强的产量相关性状的植物和其生产方法
US20140033368A1 (en) 2011-02-28 2014-01-30 Valerie Frankard Plants Having Enhanced Yield-Related Traits and Producing Methods Thereof
WO2012118848A1 (en) 2011-02-28 2012-09-07 Novozymes, Inc. Microorganism for c4-dicarboxylic acid production
JP2014509588A (ja) 2011-03-01 2014-04-21 アムジエン・インコーポレーテツド 二特異性結合剤
US20140068816A1 (en) 2011-03-01 2014-03-06 Christophe Reuzeau Plants Having Enhanced Yield-Related Traits and Producing Methods Thereof
CN103608461B (zh) 2011-03-09 2016-08-03 诺维信公司 增加多肽的纤维素分解增强活性的方法
US8878007B2 (en) 2011-03-10 2014-11-04 Pioneer Hi Bred International Inc Bacillus thuringiensis gene with lepidopteran activity
WO2012122477A1 (en) 2011-03-10 2012-09-13 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
WO2012127001A1 (en) 2011-03-23 2012-09-27 Novozymes A/S Methods for producing secreted polypeptides
WO2012127002A1 (en) 2011-03-23 2012-09-27 Novozymes A/S Sweet-tasting polypeptide from gram-positive bacteria
US9145457B2 (en) 2011-03-25 2015-09-29 Amgen Inc. Sclerostin antibody crystals and formulations thereof
US9879294B2 (en) 2011-03-25 2018-01-30 Novozymes A/S Methods for degrading or converting cellulosic material
US8663962B2 (en) 2011-03-30 2014-03-04 Codexis, Inc. Pentose fermentation by a recombinant microorganism
WO2012135436A1 (en) 2011-03-30 2012-10-04 Athenix Corp. Axmi238 toxin gene and methods for its use
WO2012135501A2 (en) 2011-03-30 2012-10-04 Athenix Corp. Axmi232, axmi233, and axmi249 toxin genes and methods for their use
WO2012135659A2 (en) 2011-03-31 2012-10-04 Novozymes A/S Methods for enhancing the degradation or conversion of cellulosic material
WO2012135719A1 (en) 2011-03-31 2012-10-04 Novozymes, Inc. Cellulose binding domain variants and polynucleotides encoding same
EP3971297A1 (en) 2011-04-05 2022-03-23 BASF Agricultural Solutions Seed US LLC Axmi115 variant insecticidal gene and methods for its use
EP2694537A1 (en) 2011-04-08 2014-02-12 Danisco US Inc. Compositions
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
US20140157443A1 (en) 2011-04-14 2014-06-05 St. Jude Children's Research Hospital Methods and compositions for detecting and modulating a novel mtor complex
MX383544B (es) 2011-04-21 2025-03-14 Univ Rockefeller Lisinas de bacteriofago de streptococcus para la deteccion y tratamiento de bacterias gram positivas
DK2702153T3 (en) 2011-04-28 2019-03-18 Novozymes Inc Polypeptides with endoglucanase activity and polynucleotides encoding them
DK2702162T3 (da) 2011-04-29 2020-05-18 Novozymes Inc Fremgangsmåder til forbedring af nedbrydningen eller omdannelsen af celluloseholdigt materiale
WO2012150319A1 (en) 2011-05-05 2012-11-08 Novozymes Biopharma Dk A/S Albumin variants
EP2710132A1 (en) 2011-05-19 2014-03-26 Novozymes, Inc. Methods for enhancing the degradation of cellulosic material with chitin binding proteins
EP2710133A1 (en) 2011-05-19 2014-03-26 Novozymes, Inc. Methods for enhancing the degradation of cellulosic material with chitin binding proteins
US9376495B2 (en) 2011-05-21 2016-06-28 Macrogenics, Inc. Deimmunized serum-binding domains and their use in extending serum half-life
EP2527448A1 (en) 2011-05-23 2012-11-28 Novozymes A/S Simultaneous site-specific integrations of multiple gene-copies in filamentous fungi
US9150625B2 (en) 2011-05-23 2015-10-06 E I Du Pont De Nemours And Company Chloroplast transit peptides and methods of their use
EP2527432A1 (en) 2011-05-23 2012-11-28 Novozymes A/S Bi-directional cytosine deaminase-encoding selection marker
DK2714738T3 (en) 2011-05-24 2019-01-28 Zyngenia Inc MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS
EP2717911A1 (en) 2011-06-06 2014-04-16 Novartis Forschungsstiftung, Zweigniederlassung Protein tyrosine phosphatase, non-receptor type 11 (ptpn11) and triple-negative breast cancer
US9244074B2 (en) 2011-06-07 2016-01-26 University Of Hawaii Biomarker of asbestos exposure and mesothelioma
US9561274B2 (en) 2011-06-07 2017-02-07 University Of Hawaii Treatment and prevention of cancer with HMGB1 antagonists
WO2012172495A1 (en) 2011-06-14 2012-12-20 Novartis Ag Compositions and methods for antibodies targeting tem8
EP2721160A2 (en) 2011-06-14 2014-04-23 Synthon Biopharmaceuticals B.V. Compositions and methods for making and biocontaining auxotrophic transgenic plants
CA2844470A1 (en) 2011-06-21 2013-05-10 Pioneer Hi-Bred International, Inc. Methods and compositions for producing male sterile plants
CN103620029B (zh) 2011-06-24 2017-06-09 诺维信公司 具有蛋白酶活性的多肽和编码它们的多核苷酸
US8778652B2 (en) 2011-06-30 2014-07-15 Codexis, Inc. Pentose fermentation by a recombinant microorganism
EP3421595B1 (en) 2011-06-30 2020-10-07 Novozymes A/S Alpha-amylase-variants
EP2726500B1 (en) 2011-06-30 2019-03-20 Novozymes A/S Method for screening alpha-amylases
WO2014003769A1 (en) 2012-06-29 2014-01-03 Athenix Corp. Axmi277 nematode toxin and methods for its use
EP2540824A1 (en) 2011-06-30 2013-01-02 The Procter & Gamble Company Cleaning compositions comprising amylase variants reference to a sequence listing
MX337984B (es) 2011-07-06 2016-03-30 Novozymes As Variantes de alfa amilasa y polinucleotidos que codifican la misma.
WO2013004639A2 (en) 2011-07-07 2013-01-10 Novozymes A/S Enzymatic preparation of diols
JP6219277B2 (ja) 2011-07-08 2017-10-25 ディフェンシン セラピューティクス アンパルトセルスカブＤｅｆｅｎｓｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ａｐｓ 炎症性腸疾患の経口治療
AR087167A1 (es) 2011-07-12 2014-02-26 Two Blades Foundation Genes de resistencia al tizon tardio
WO2013012643A1 (en) 2011-07-15 2013-01-24 Syngenta Participations Ag Polynucleotides encoding trehalose-6-phosphate phosphatase and methods of use thereof
CN103827298A (zh) 2011-07-15 2014-05-28 诺维信公司 脂肪酶变体及其编码多核苷酸
WO2013012788A2 (en) 2011-07-15 2013-01-24 Syngenta Participations Ag Methods of increasing yield and stress tolerance in a plant
WO2013016207A2 (en) 2011-07-22 2013-01-31 California Institute Of Technology Stable fungal cel6 enzyme variants
CN109022518A (zh) 2011-07-22 2018-12-18 诺维信北美公司 用于预处理纤维素材料和改进其水解的方法
BR122020017359B1 (pt) 2011-07-28 2021-10-13 Syngenta Participations Ag Método para controle de uma praga de nemátodos
MX351526B (es) 2011-07-28 2017-10-18 Athenix Corp Proteinas variantes axmi205 y sus metodos de uso.
MX363910B (es) 2011-07-28 2019-04-08 Athenix Corp Gen de la toxina axmi270 y sus metodos de uso.
US20140223599A1 (en) 2011-07-29 2014-08-07 Athenix Corp. Axmi279 pesticidal gene and methods for its use
BR112014002622A2 (pt) 2011-08-03 2019-09-24 Du Pont método para introduzir no genoma de uma célula vegetal um sítio alvo para a integração específica de sítio, célula vegetal, parte de planta, planta ou semente, método para integrar um polinucleotídeo de interesse em um sítio alvo no genoma de uma célula vegetal
ES2667554T3 (es) 2011-08-04 2018-05-11 Amgen Inc. Método para el tratamiento de los defectos de espacio óseo
EP2739728B1 (en) 2011-08-04 2017-07-12 Novozymes A/S Polypeptides having endoglucanase activity and polynucleotides encoding same
BR112014002401B1 (pt) 2011-08-04 2021-08-03 Novozymes A/S Célula hospedeira transgênica de fungo filamentoso, métodos para produzir um polipeptídeo e uma proteína, e, construto de ácido nucleico ou um vetor de expressão
US9506044B2 (en) 2011-08-10 2016-11-29 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
WO2013021064A1 (en) 2011-08-10 2013-02-14 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
WO2013021062A1 (en) 2011-08-10 2013-02-14 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
EP2742129B1 (en) 2011-08-10 2017-08-02 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
WO2013021059A1 (en) 2011-08-10 2013-02-14 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
WO2013021065A1 (en) 2011-08-10 2013-02-14 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
US9487761B2 (en) 2011-08-10 2016-11-08 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
EP2744898A1 (en) 2011-08-15 2014-06-25 Novozymes A/S Polypeptides having cellulase activity and polynucleotides encoding same
WO2013024156A2 (en) 2011-08-17 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Combinations of anti-hcv-entry factor antibodies and interferons for the treatment and the prevention of hcv infection
WO2013024157A2 (en) 2011-08-17 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Combinations of host targeting agents for the treatment and the prevention of hcv infection
WO2013024155A1 (en) 2011-08-17 2013-02-21 Inserm (Institut National De La Sante Et De La Recherche Medicale) Combinations of anti-hcv-entry factor antibodies and direct acting antivirals for the treatment and the prevention of hcv infection
US20140295027A1 (en) 2011-08-19 2014-10-02 Novozymes A/S Polypeptides Having Protease Activity
WO2013026794A1 (en) 2011-08-19 2013-02-28 Novozymes Novel immunomodulatory peptide
BR112014003444A2 (pt) 2011-08-19 2017-03-14 Novozymes Inc célula hospedeira recombinante, e, método para produzir um ácido c4-dicarboxílico
WO2013028701A1 (en) 2011-08-22 2013-02-28 Codexis, Inc. Gh61 glycoside hydrolase protein variants and cofactors that enhance gh61 activity
CA2846690A1 (en) 2011-08-26 2013-03-07 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
JP2014526899A (ja) 2011-08-26 2014-10-09 ジェン９・インコーポレイテッド 核酸の高忠実度アセンブリのための組成物および方法
US12188028B1 (en) 2011-08-30 2025-01-07 Monsanto Technology, Llc Methods for making genetic regulatory elements
US11377663B1 (en) 2011-08-30 2022-07-05 Monsanto Technology Llc Genetic regulatory elements
DK2751279T3 (da) 2011-08-31 2017-11-20 St Jude Children's Res Hospital Fremgangsmåder og sammensætninger til påvisning af niveauet af lysosomal exocytose-aktivitet og fremgangsmåder til anvendelse
CN103930543B (zh) 2011-09-06 2020-11-27 诺维信公司 葡糖淀粉酶变体和编码它们的多核苷酸
EP2753640B1 (en) 2011-09-08 2016-03-09 Codexis, Inc. Biocatalysts and methods for the synthesis of substituted lactams
CN103764905A (zh) 2011-09-09 2014-04-30 诺维信公司 改进纸张材料的特性
CA2847236A1 (en) 2011-09-09 2013-03-14 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
EP2756091A1 (en) 2011-09-13 2014-07-23 Novozymes North America, Inc. Methods of hydrolyzing and fermenting cellulosic material
US20140308705A1 (en) 2011-09-20 2014-10-16 Novozymes A/S Polypeptides Having Cellulolytic Enhancing Activity And Polynucleotides Encoding Same
ES2628190T3 (es) 2011-09-22 2017-08-02 Novozymes A/S Polipéptidos con actividad de proteasa y polinucleótidos que codifican los mismos
IN2014CN02910A (enExample) 2011-09-23 2015-07-03 Novozymes As
EP2751261B1 (en) 2011-09-30 2018-08-29 Novozymes, Inc. Dehydrogenase variants and polynucleotides encoding same
WO2013044867A1 (en) 2011-09-30 2013-04-04 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
EP2760997A4 (en) 2011-09-30 2015-02-11 Codexis Inc MUSHROOM PROTEASE
CA2851270C (en) 2011-10-05 2023-03-14 The Rockefeller University Dimeric bacteriophage lysins
KR102434073B1 (ko) 2011-10-11 2022-08-18 비엘라 바이오, 인크. Cd40l 특이적 tn3 유래 스카폴드 및 이의 사용 방법
US9353362B2 (en) 2011-10-11 2016-05-31 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
CA3253390A1 (en) 2011-10-17 2025-06-17 Novozymes A/S Variants of alpha-amylase and the polynucleotides encoding them
HUE039835T2 (hu) 2011-10-17 2019-02-28 Novozymes As Alfa-amiláz variánsok és az azokat kódoló polinukleotidok
EP2771467A1 (en) 2011-10-28 2014-09-03 E. I. Du Pont de Nemours and Company Methods and compositions for silencing genes using artificial micrornas
US10308921B2 (en) 2011-10-31 2019-06-04 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
ES2697674T3 (es) 2011-11-01 2019-01-25 Bionomics Inc Procedimientos para bloquear el crecimiento de células madre cancerosas
HK1201855A1 (en) 2011-11-01 2015-09-11 Bionomics, Inc. Antibodies and methods of treating cancer
WO2013067060A1 (en) 2011-11-01 2013-05-10 Bionomics, Inc. Anti-gpr49 antibodies
EP2773664A1 (en) 2011-11-01 2014-09-10 Bionomics, Inc. Anti-gpr49 antibodies
WO2013064195A1 (en) 2011-11-04 2013-05-10 Enel Ingegneria E Ricerca S.P.A. A new heat-stable carbonic anhydrase and uses thereof
US9574010B2 (en) 2011-11-04 2017-02-21 Zymeworks Inc. Stable heterodimeric antibody design with mutations in the Fc domain
WO2013068431A1 (en) 2011-11-08 2013-05-16 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute For Biomedical Research New treatment for neurodegenerative diseases
US20140294732A1 (en) 2011-11-08 2014-10-02 Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute Early diagnostic of neurodegenerative diseases
EP2794873A1 (en) 2011-11-08 2014-10-29 Novozymes A/S Methods for production of archeae protease in yeast
HK1200842A1 (en) 2011-11-18 2015-08-14 Albumedix Ltd Proteins with improved half-life and other properties
CN106479990B (zh) 2011-11-18 2020-09-18 科德克希思公司 用于制备羟基取代的氨基甲酸酯的生物催化剂
EP2780449B1 (en) 2011-11-18 2018-04-11 Novozymes, Inc. Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same
CN103958672A (zh) 2011-11-21 2014-07-30 诺维信股份有限公司 Gh61多肽变体以及编码所述变体的多核苷酸
DK2782998T3 (en) 2011-11-22 2018-04-16 Novozymes Inc POLYPEPTIDES WITH BETA-XYLOSIDASE ACTIVITY AND POLYNUCLEOTIDES CODING THEM
JP6105615B2 (ja) 2011-11-25 2017-03-29 ノボザイムス アクティーゼルスカブ リゾチーム活性を有するポリペプチドおよびそれをコードするポリヌクレオチド
US20140342433A1 (en) 2011-11-25 2014-11-20 Novozymes A/S Subtilase Variants and Polynucleotides Encoding Same
US9624481B2 (en) 2011-12-01 2017-04-18 Novozymes, Inc. Polypeptides having beta-xylosidase activity and polynucleotides encoding same
US9404093B2 (en) 2011-12-02 2016-08-02 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
US9169469B2 (en) 2011-12-02 2015-10-27 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
CN108341873B (zh) 2011-12-05 2022-03-25 诺华股份有限公司 表皮生长因子受体3(her3)的抗体
EP2788382A2 (en) 2011-12-05 2014-10-15 Novartis AG Antibodies for epidermal growth factor receptor 3 (her3) directed to domain ii of her3
WO2013087027A1 (en) 2011-12-16 2013-06-20 Novozymes, Inc. Polypeptides having laccase activity and polynucleotides encoding same
WO2013091547A1 (en) 2011-12-19 2013-06-27 Novozymes, Inc. Polypeptides having catalase activity and polynucleotides encoding same
MX2014007446A (es) 2011-12-20 2014-08-01 Novozymes As Variantes de subtilasa y polinucleotidos que las codifican.
DK2794869T3 (en) 2011-12-20 2018-01-02 Novozymes Inc CELLOBIO HYDROLASE VARIABLES AND POLYNUCLEOTIDES CODING THEM
US9611462B2 (en) 2011-12-20 2017-04-04 Codexis, Inc. Endoglucanase 1B (EG1B) variants
EP2607468A1 (en) 2011-12-20 2013-06-26 Henkel AG & Co. KGaA Detergent compositions comprising subtilase variants
SG10201703249PA (en) 2011-12-21 2017-05-30 Novartis Ag Compositions and methods for antibodies targeting factor p
CA2860220C (en) 2011-12-22 2021-07-13 E. I. Du Pont De Nemours And Company Use of the soybean or medicago truncatula sucrose synthase promoter to increase plant seed oil content
EP3539982B1 (en) 2011-12-23 2025-02-19 Pfizer Inc. Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
KR20190120401A (ko) 2011-12-28 2019-10-23 암젠 인크 항스클레로스틴 항체의 이용을 통한 치조골 소실의 치료 방법
ES2667318T3 (es) 2011-12-28 2018-05-10 Novozymes A/S Polipéptidos con actividad de proteasa
WO2013102825A1 (en) 2012-01-02 2013-07-11 Novartis Ag Cdcp1 and breast cancer
WO2013103371A1 (en) 2012-01-06 2013-07-11 Pioneer Hi-Bred International, Inc. Ovule specific promoter and methods of use
US9006515B2 (en) 2012-01-06 2015-04-14 Pioneer Hi Bred International Inc Pollen preferred promoters and methods of use
WO2013103366A1 (en) 2012-01-06 2013-07-11 Pioneer Hi-Bred International, Inc. A method to screen plants for genetic elements inducing parthenogenesis in plants
EP2800760A1 (en) 2012-01-06 2014-11-12 Pioneer Hi-Bred International Inc. Compositions and methods for the expression of a sequence in a reproductive tissue of a plant
WO2013104659A2 (en) 2012-01-13 2013-07-18 Dupont Nutrition Biosciences Aps Process
WO2013104660A1 (en) 2012-01-13 2013-07-18 Dupont Nutrition Biosciences Aps Process for treating a plant oil comprising hydrolysing chlorophyll or a chlorophyll derivative and involving partial caustic neutralisation
BR112014018294B1 (pt) 2012-01-26 2022-01-11 Norfolk Plant Sciences, Ltd Método para produzir uma planta, cassete de expressão, e, célula bacteriana
US9801398B2 (en) 2012-01-26 2017-10-31 Novozymes A/S Use of polypeptides having protease activity in animal feed and detergents
AR089793A1 (es) 2012-01-27 2014-09-17 Du Pont Metodos y composiciones para generar locus de rasgos transgenicos complejos
US9506077B2 (en) 2012-02-01 2016-11-29 Dow Agrosciences Llc Synthetic chloroplast transit peptides
EP4570895A3 (en) 2012-02-03 2026-01-14 Novozymes A/S Lipase variants and polynucleotides encoding same
DK2623586T3 (da) 2012-02-03 2017-11-13 Procter & Gamble Sammensætninger og fremgangsmåder til overfladebehandling med lipaser
EP2628785B1 (en) 2012-02-17 2016-05-18 Henkel AG & Co. KGaA Detergent compositions comprising subtilase variants
MX350713B (es) 2012-02-17 2017-09-14 Novozymes As Variantes de subtilisina y polinucleotidos que las codifican.
PT2817325T (pt) 2012-02-20 2019-10-01 Novozymes As Polipéptidos que têm atividade da endoglucanase e polinucleotídeos codificando mesmos
GB201203374D0 (en) 2012-02-28 2012-04-11 Univ Sheffield Alkane production
CN104302662B (zh) 2012-03-08 2018-03-13 阿森尼克斯公司 苏云金芽孢杆菌毒素基因axmi335及其使用方法
BR112014022166B1 (pt) 2012-03-08 2022-08-30 Basf Se Molécula de ácido nucleico codificando um polipeptídeo recombinante delta-endotoxina axmi345, vetor, célula hospedeira, composição, e métodos para matar uma praga, produzir um polipeptídeo e proteger uma planta de uma praga
BR112014022649B1 (pt) 2012-03-14 2023-03-28 E.I. Du Pont De Nemours And Company Métodos de produção de uma planta transgênica, métodos de identificação de um alelo fraco de fea3, métodos de produção de uma planta e método de identificação de uma primeira planta de milho
EP2825025A1 (en) 2012-03-14 2015-01-21 E. I. Du Pont de Nemours and Company Nucleotide sequences encoding fasciated ear4 (fea4) and methods of use thereof
EP2825657A1 (en) 2012-03-14 2015-01-21 E. I. Du Pont de Nemours and Company Improving agronomic characteristics of plants through abph2
EP3330283A3 (en) 2012-03-16 2018-07-11 Albumedix A/S Albumin variants
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
WO2013142770A1 (en) 2012-03-23 2013-09-26 Codexis, Inc. Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
US20150266961A1 (en) 2012-03-29 2015-09-24 Novartis Forschungsstiftung, Zweigniederlassung, Fridrich Miescher Institute Inhibition of interleukin-8 and/or its receptor cxcr1 in the treatment of her2/her3-overexpressing breast cancer
US9458478B2 (en) 2012-03-31 2016-10-04 Novozymes A/S Epoxidation using peroxygenase
EP2834353B1 (en) 2012-04-02 2017-07-19 Novozymes A/S Lipase variants and polynucleotides encoding same
US9446102B2 (en) 2012-04-23 2016-09-20 Novozymes A/S Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same
EP2841570B1 (en) 2012-04-23 2017-12-20 Novozymes A/S Polypeptides having glucuronyl esterase activity and polynucleotides encoding same
CA2871505C (en) 2012-04-24 2021-10-12 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
CA2870773A1 (en) 2012-04-25 2013-10-31 Novozymes A/S Method of baking
WO2013160372A1 (en) 2012-04-27 2013-10-31 Dupont Nutrition Biosciences Aps Process for treating plant oil involving addition of serial doses of chlorophyll or chlorophyll derivative degrading enzyme
WO2013160374A1 (en) 2012-04-27 2013-10-31 Dupont Nutrition Biosciences Aps Process for refining crude plant oil involving enzymatic hydrolysis and gum recycling
CN104245926B (zh) 2012-04-27 2021-05-07 诺维信股份有限公司 Gh61多肽变体以及编码其的多核苷酸
US20150184173A1 (en) 2012-05-04 2015-07-02 E I Du Pont De Nemours And Company Compositions and methods comprising sequences having meganuclease activity
CN113201519A (zh) 2012-05-07 2021-08-03 诺维信公司 具有黄原胶降解活性的多肽以及编码其的核苷酸
WO2013169725A2 (en) 2012-05-08 2013-11-14 Codexis, Inc. Biocatalysts and methods for hydroxylation of chemical compounds
JP6351572B2 (ja) 2012-05-10 2018-07-04 ザイムワークス，インコーポレイテッド Ｆｃドメインに突然変異を有する免疫グロブリン重鎖のヘテロ多量体構築物
WO2013170050A1 (en) 2012-05-11 2013-11-14 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
EP2850180A1 (en) 2012-05-18 2015-03-25 Novozymes A/S Bacterial mutants with improved transformation efficiency
WO2013178699A1 (en) 2012-05-31 2013-12-05 Novozymes A/S Isopropanol production by bacterial hosts
EP2855670A2 (en) 2012-05-31 2015-04-08 Novozymes A/S Polypeptides having organophosphorous hydrolase activity
SG11201407017WA (en) 2012-06-04 2014-12-30 Irm Llc Site-specific labeling methods and molecules produced thereby
US8980578B2 (en) 2012-06-11 2015-03-17 Codexis, Inc. Fungal beta-xylosidase variants
WO2013188291A2 (en) 2012-06-15 2013-12-19 E. I. Du Pont De Nemours And Company Methods and compositions involving als variants with native substrate preference
US20130337442A1 (en) 2012-06-15 2013-12-19 Pioneer Hi-Bred International, Inc. Genetic loci associated with soybean cyst nematode resistance and methods of use
EP2861749A1 (en) 2012-06-19 2015-04-22 Novozymes Bioag A/S Enzymatic reduction of hydroperoxides
MX364390B (es) 2012-06-20 2019-04-25 Novozymes As Uso de polipeptidos que tienen actividad proteasa en alimentos para animales y detergentes.
US20150337336A1 (en) 2012-06-22 2015-11-26 Phytogene, Inc. Enzymes and methods for styrene synthesis
EP2677035A1 (en) 2012-06-22 2013-12-25 BASF Plant Science Company GmbH Plants having enhanced yield-related traits and a method for making the same
WO2014004393A1 (en) 2012-06-25 2014-01-03 Gen9, Inc. Methods for nucleic acid assembly and high throughput sequencing
WO2014001482A1 (en) 2012-06-29 2014-01-03 Novartis Forschungsstiftung, Zweigniererlassung, Friedrich Miescher Institute For Biomedical Research Treating diseases by modulating a specific isoform of mkl1
US20150184154A1 (en) 2012-07-05 2015-07-02 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Resear New treatment for neurodegenerative diseases
JP6770312B2 (ja) 2012-07-05 2020-10-14 ユセベ ファルマ ソシエテ アノニム 骨疾患の治療
CN104471048B (zh) 2012-07-12 2018-11-16 诺维信公司 具有脂肪酶活性的多肽及编码它的多核苷酸
EP2875179B1 (en) 2012-07-18 2018-02-21 Novozymes A/S Method of treating polyester textile
US20150152452A1 (en) 2012-07-20 2015-06-04 Novozymes A/S Enzymatic Oxidation of 5-Hydroxymethylfurfural and Derivatives Thereof
EP4063391A1 (en) 2012-07-25 2022-09-28 Celldex Therapeutics, Inc. Anti-kit antibodies and uses thereof
US9353385B2 (en) 2012-07-30 2016-05-31 Evolva, Inc. Sclareol and labdenediol diphosphate synthase polypeptides, encoding nucleic acid molecules and uses thereof
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN114891871A (zh) 2012-08-14 2022-08-12 10X基因组学有限公司 微胶囊组合物及方法
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
CN104583394B (zh) 2012-08-16 2019-06-07 诺维信公司 用内切葡聚糖酶处理纺织品的方法
TR201815368T4 (tr) 2012-08-16 2018-11-21 Bangladesh Jute Res Institute Macrophomina Phaseolina'dan elde edilen selüloz ve hemiselüloz parçalama enzimleri ve bunların kullanımları.
TR201809053T4 (tr) 2012-08-16 2018-07-23 Bangladesh Jute Res Institute Macrophomina phaseolina'dan elde edilen pektin parçalama enzimleri ve bunların kullanımları.
US9828595B2 (en) 2012-08-17 2017-11-28 Novozymes A/S Thermostable asparaginase variants and polynucleotides encoding same
WO2014029820A1 (en) 2012-08-22 2014-02-27 Novozymes A/S Detergent compositions comprising metalloproteases
MX2015002211A (es) 2012-08-22 2015-05-08 Novozymes As Metaloproteasa de exiguobacterium.
US9315791B2 (en) 2012-08-22 2016-04-19 Novozymes A/S Metalloproteases from alicyclobacillus
US9758793B2 (en) 2012-08-30 2017-09-12 Athenix Corp. AXMI-234 and AXMI-235 delta-endotoxin genes and methods for their use
WO2014033266A1 (en) 2012-08-31 2014-03-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-sr-bi antibodies for the inhibition of hepatitis c virus infection
AU2013311668B2 (en) 2012-09-05 2019-02-28 Novozymes A/S Polypeptides having protease activity
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
US9816102B2 (en) 2012-09-13 2017-11-14 Indiana University Research And Technology Corporation Compositions and systems for conferring disease resistance in plants and methods of use thereof
BR112015005884A2 (pt) 2012-09-19 2017-08-08 Novozymes Inc E Novozymes As processos para degradação de um material celulósico, para produção de um produto da fermentação, e de fermentação de um material celulósico, composição, e, formulação de caldo inteiro ou composição de cultura de células
WO2014047453A2 (en) 2012-09-20 2014-03-27 Novozymes A/S Screening polynucleotide libraries for variants that encode functional proteins
WO2014052630A1 (en) 2012-09-27 2014-04-03 Novozymes, Inc. Bacterial mutants with improved transformation efficiency
EP2904099B1 (en) 2012-10-05 2018-12-19 Novozymes A/S Preventing adhesion of bacteria
EP3586610B1 (en) 2012-10-08 2024-09-25 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
SG11201502757QA (en) 2012-10-09 2015-05-28 Igenica Biotherapeutics Inc Anti-c16orf54 antibodies and methods of use thereof
CA2887571A1 (en) 2012-10-11 2014-04-17 Pioneer Hi-Bred International, Inc. Guard cell promoters and uses thereof
US9404094B2 (en) 2012-10-12 2016-08-02 Novozymes A/S Polypeptides having peroxygenase activity
US9453207B2 (en) 2012-10-12 2016-09-27 Novozymes A/S Polypeptides having peroxygenase activity
EP2906685B1 (en) 2012-10-12 2018-08-15 Novozymes A/S Polypeptides having peroxygenase activity
WO2014056916A2 (en) 2012-10-12 2014-04-17 Novozymes A/S Polypeptides having peroxygenase activity
CN104718287B (zh) 2012-10-12 2018-02-06 诺维信公司 具有过氧合酶活性的多肽
EP2906689B1 (en) 2012-10-12 2018-12-12 Novozymes A/S Polypeptides having peroxygenase activity
EP2906686B1 (en) 2012-10-12 2018-08-29 Novozymes A/S Polypeptides having peroxygenase activity
WO2014062544A2 (en) 2012-10-15 2014-04-24 Pioneer Hi-Bred International, Inc. Methods and compositions to enhance activity of cry endotoxins
WO2014063097A1 (en) 2012-10-19 2014-04-24 Danisco Us Inc. Stabilization of biomimetic membranes
JP2015532124A (ja) 2012-10-23 2015-11-09 モンタナ ステート ユニバーシティ アミロース含量が増加した高品質デュラムコムギの生成
WO2014066141A2 (en) 2012-10-24 2014-05-01 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
US9663532B2 (en) 2012-10-29 2017-05-30 University Of Rochester Artemisinin derivatives, methods for their preparation and their use as antimalarial agents
WO2014068010A1 (en) 2012-10-31 2014-05-08 Novozymes A/S Isopropanol production by bacterial hosts
CN105121647A (zh) 2012-11-01 2015-12-02 不列颠哥伦比亚大学 细胞色素p450和细胞色素p450还原酶多肽、编码核酸分子及其用途
CA2890766A1 (en) 2012-11-08 2014-05-15 Novozymes Biopharma Dk A/S Albumin variants
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
WO2014076232A2 (en) 2012-11-19 2014-05-22 Novozymes A/S Isopropanol production by recombinant hosts using an hmg-coa intermediate
US9611515B2 (en) 2012-11-20 2017-04-04 Codexis, Inc. Pentose fermentation by a recombinant microorganism
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
EP2925873B1 (en) 2012-11-30 2017-07-12 Novozymes, Inc. 3-hydroxypropionic acid production by recombinant yeasts
WO2014084859A1 (en) 2012-11-30 2014-06-05 Novartis Ag Molecules and methods for modulating tmem16a activities
DK2928921T3 (da) 2012-12-05 2021-04-19 Novartis Ag Sammensætninger og fremgangsmåder til antistoffer målrettet epo
EP2929027B1 (en) 2012-12-06 2018-02-21 Agilent Technologies, Inc. Molecular fabrication
US20150307871A1 (en) 2012-12-07 2015-10-29 Novozymes A/S Method for generating site-specific mutations in filamentous fungi
TR201910918T4 (tr) 2012-12-07 2019-08-21 Novozymes As Bakterilerin yapışmasının önlenmesi.
DK2928865T3 (en) 2012-12-07 2018-06-18 Merck Sharp & Dohme BIOCATALYTIC TRANSAMINATION PROCEDURE
EP2740840A1 (en) 2012-12-07 2014-06-11 Novozymes A/S Improving drainage of paper pulp
US20150368627A1 (en) 2012-12-11 2015-12-24 Novozymes A/S Polypeptides Having Phospholipase C Activity and Polynucleotides Encoding Same
WO2014090765A1 (en) 2012-12-12 2014-06-19 Bayer Cropscience Ag Use of 1-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl]-5-amino-3-trifluoromethyl)-1 h-1,2,4 tfia zole for controlling nematodes in nematode-resistant crops
EP3567116A1 (en) 2012-12-14 2019-11-13 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2014090940A1 (en) 2012-12-14 2014-06-19 Novozymes A/S Removal of skin-derived body soils
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9765373B2 (en) 2012-12-14 2017-09-19 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
ES2772032T3 (es) 2012-12-17 2020-07-07 Novozymes As Alfa-amilasas y polinucleótidos que las codifican
KR20150095684A (ko) 2012-12-18 2015-08-21 노파르티스 아게 히알루로난에 결합하는 펩티드 태그를 이용하는 조성물 및 방법
WO2014099798A1 (en) 2012-12-19 2014-06-26 Novozymes A/S Polypeptides having cellulolytic enhancinc activity and polynucleotides encoding same
US9551042B2 (en) 2012-12-21 2017-01-24 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
SG11201504752YA (en) 2012-12-21 2015-07-30 Codexis Inc Engineered biocatalysts and methods for synthesizing chiral amines
EP2938628A4 (en) 2012-12-24 2016-10-19 Novozymes As POLYPEPTIDES WITH ENDOGLUCANASE ACTIVITY AND POLYNUCLEOTIDES FOR CODING THEREOF
CN103060279B (zh) 2012-12-25 2014-08-13 北京大北农科技集团股份有限公司 除草剂抗性蛋白质、其编码基因及用途
CN103013938B (zh) 2012-12-25 2014-12-17 北京大北农科技集团股份有限公司 除草剂抗性蛋白质、其编码基因及用途
EP3321360A3 (en) 2013-01-03 2018-06-06 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
CN105051180B (zh) 2013-01-18 2020-06-12 科德克希思公司 用于碳青霉烯类合成的工程化的生物催化剂
RU2695146C2 (ru) 2013-01-31 2019-07-22 Кодексис, Инк. Способы, системы и программное обеспечение для идентификации биомолекул со взаимодействующими компонентами
WO2014120916A1 (en) 2013-02-01 2014-08-07 Bristol-Myers Squibb Company Pegylated domain antibodies monovalent for cd28 binding and methods of use
WO2014122109A1 (en) 2013-02-05 2014-08-14 Novozymes A/S Enzymatic preparation of indigo dyes and intermediates
MX2015010078A (es) 2013-02-06 2016-01-25 Novozymes As Uso de polipeptidos con actividad proteasa en alimentos para animales.
EA201591465A1 (ru) 2013-02-08 2015-12-30 АйАрЭм ЭлЭлСи Специфичные участки для модификации антител для получения иммуноконъюгатов
WO2014124258A2 (en) 2013-02-08 2014-08-14 Irm Llc Specific sites for modifying antibodies to make immunoconjugates
KR20230003659A (ko) 2013-02-08 2023-01-06 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
MX2015010527A (es) 2013-02-13 2016-03-04 Athenix Corp Uso de axmi184 para el control de los insectos del gusano de raiz.
ES2900102T3 (es) * 2013-02-20 2022-03-15 Univ Emory Composiciones para la secuenciación de ácidos nucleicos en mezclas
US9617573B2 (en) 2013-02-28 2017-04-11 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
US9487773B2 (en) * 2013-03-01 2016-11-08 Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa Cell-based methods for coupling protein interactions and binding molecule selection
CN105247054B (zh) 2013-03-07 2019-06-18 阿则耐克斯公司 毒素基因及其使用方法
CN105164254B (zh) 2013-03-08 2019-06-28 诺维信公司 纤维二糖水解酶变体和编码它们的多核苷酸
WO2014164775A1 (en) 2013-03-11 2014-10-09 Pioneer Hi-Bred International, Inc. Methods and compositions to improve the spread of chemical signals in plants
BR112015022742A2 (pt) 2013-03-11 2018-11-27 Pionner Hi Bred Int Inc métodos e composições que empregam um domínio de estabilização dependente de sulfonilureia
GB201308828D0 (en) 2013-03-12 2013-07-03 Verenium Corp Phytase
US9803214B2 (en) 2013-03-12 2017-10-31 Pioneer Hi-Bred International, Inc. Breeding pair of wheat plants comprising an MS45 promoter inverted repeat that confers male sterility and a construct that restores fertility
US9243258B2 (en) 2013-03-12 2016-01-26 Pioneer Hi Bred International Inc Root-preferred promoter and methods of use
US9273322B2 (en) 2013-03-12 2016-03-01 Pioneer Hi Bred International Inc Root-preferred promoter and methods of use
US9498532B2 (en) 2013-03-13 2016-11-22 Novartis Ag Antibody drug conjugates
WO2014150599A1 (en) 2013-03-14 2014-09-25 Allylix, Inc. Valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof
GB201308843D0 (en) 2013-03-14 2013-07-03 Verenium Corp Phytase formulation
CA2904537A1 (en) 2013-03-14 2014-09-25 Pioneer Hi-Bred International, Inc. Compositions having dicamba decarboxylase activity and methods of use
WO2014159239A2 (en) 2013-03-14 2014-10-02 Novartis Ag Antibodies against notch 3
EP2970995A1 (en) 2013-03-14 2016-01-20 Pioneer Hi-Bred International, Inc. Compositions having dicamba decarboxylase activity and methods of use
MX2015013163A (es) 2013-03-15 2016-04-04 Zyngenia Inc Complejos multiespecificos multivalente y monovalentes y sus usos.
MX366978B (es) 2013-03-15 2019-08-01 Novartis Ag Conjugados de anticuerpo - farmaco.
MX377653B (es) 2013-03-15 2025-03-11 Orpro Therapeutics Inc Producto y uso para normalización de la viscoelasticidad del moco.
CN105209475B (zh) * 2013-03-15 2018-06-12 Gen9股份有限公司 多重核酸合成的组合物和方法
EP3533866A1 (en) 2013-03-21 2019-09-04 Novozymes A/S Polypeptides having phospholipase a activity and polynucleotides encoding same
US9631164B2 (en) 2013-03-21 2017-04-25 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
PL2986722T3 (pl) 2013-04-18 2019-10-31 Codexis Inc Skonstruowane polipeptydy amoniakoliazy fenyloalaniny
WO2014170218A1 (en) 2013-04-18 2014-10-23 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
WO2014173980A2 (en) 2013-04-23 2014-10-30 Novozymes A/S Liquid automatic dish washing detergent compositions
WO2014177541A2 (en) 2013-04-30 2014-11-06 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
EP3372680B1 (en) 2013-04-30 2020-11-11 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
CN105164244B (zh) 2013-05-03 2019-08-20 诺维信公司 洗涤剂酶的微囊化
US9556465B2 (en) 2013-05-10 2017-01-31 Novozymes A/S Polypeptides having xylanase activity and polynucleotides encoding same
MX392247B (es) 2013-05-14 2025-03-24 Novozymes As Composiciones detergentes.
US20160083703A1 (en) 2013-05-17 2016-03-24 Novozymes A/S Polypeptides having alpha amylase activity
CN114634921B (zh) 2013-06-06 2024-09-10 诺维信公司 α-淀粉酶变体以及对其进行编码的多核苷酸
EP3003390B1 (en) 2013-06-06 2021-07-07 Pierre Fabre Médicament Anti-c10orf54 antibodies and uses thereof
EP2816115A1 (en) 2013-06-17 2014-12-24 BASF Plant Science Company GmbH Plants having one or more enhanced yield-related traits and a method for making the same
US20160122772A1 (en) 2013-06-21 2016-05-05 Novozymes A/S Production of Polypeptides Without Secretion Signal in Bacillus
AR096601A1 (es) 2013-06-21 2016-01-20 Novartis Ag Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso
UY35620A (es) 2013-06-21 2015-01-30 Novartis Ag Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso
WO2014207224A1 (en) 2013-06-27 2014-12-31 Novozymes A/S Subtilase variants and polynucleotides encoding same
WO2014207227A1 (en) 2013-06-27 2014-12-31 Novozymes A/S Subtilase variants and polynucleotides encoding same
JP2016523098A (ja) 2013-07-04 2016-08-08 ノボザイムス アクティーゼルスカブ 再付着防止効果を有するポリペプチドおよびそれをコードするポリヌクレオチド
CA2917103C (en) 2013-07-09 2021-01-12 Board Of Trustees Of Michigan State University Transgenic plants produced with a k-domain, and methods and expression cassettes related thereto
US11459579B2 (en) 2013-07-09 2022-10-04 Board Of Trustees Of Michigan State University Transgenic plants produced with a K-domain, and methods and expression cassettes related thereto
WO2015004102A1 (en) 2013-07-09 2015-01-15 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
DK3022300T3 (en) 2013-07-17 2018-10-22 Novozymes As : Pullulan chimeras and polynucleotides encoding them
CN105408492A (zh) 2013-07-25 2016-03-16 巴斯夫酶有限责任公司 肌醇六磷酸酶
EP2832853A1 (en) 2013-07-29 2015-02-04 Henkel AG&Co. KGAA Detergent composition comprising protease variants
CN105358686A (zh) 2013-07-29 2016-02-24 诺维信公司 蛋白酶变体以及对其进行编码的多核苷酸
EP3027747B1 (en) 2013-07-29 2018-02-07 Novozymes A/S Protease variants and polynucleotides encoding same
US9845484B2 (en) 2013-07-31 2017-12-19 Novozymes A/S 3-hydroxypropionic acid production by recombinant yeasts expressing an insect aspartate 1-decarboxylase
US20160178610A1 (en) 2013-08-07 2016-06-23 Friedrich Miescher Institute For Biomedical Research New screening method for the treatment Friedreich's ataxia
US10287329B2 (en) 2013-08-08 2019-05-14 Pioneer Hi-Bred International, Inc. Insecticidal polypeptides having broad spectrum activity and uses thereof
UY35696A (es) 2013-08-09 2015-03-27 Athenix Corp ?molécula de adn recombinante que comprende al gen de toxina axmi440, vector, célula huésped, plantas, composiciones y métodos relacionados?.
US9862967B2 (en) 2013-08-09 2018-01-09 Athenix Corp. AXMI281 toxin gene and methods for its use
US10010094B2 (en) 2013-08-15 2018-07-03 Novozymes A/S Polypeptides having beta-1,3-galactanase activity and polynucleotides encoding same
US10006045B2 (en) 2013-08-16 2018-06-26 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
EA201690560A1 (ru) 2013-09-11 2016-10-31 Пайонир Хай-Бред Интернэшнл, Инк. Регуляторные элементы растений и способы их применения
BR122020001770B1 (pt) 2013-09-13 2022-11-29 Pioneer Hi-Bred International, Inc Construto de dna, método de obtenção de planta transgênica, proteína de fusão, método para controlar uma população de praga de inseto, método para inibir o crescimento ou matar uma praga de inseto
SG10201914005TA (en) 2013-09-19 2020-03-30 Univ Leland Stanford Junior Methods and compositions for producing hepatocyte-like cells
WO2015048016A2 (en) 2013-09-24 2015-04-02 E. I. Du Pont De Nemours And Company Fasciated inflorescence (fin) sequences and methods of use
DK3049973T3 (en) 2013-09-27 2018-10-22 Codexis Inc AUTOMATED SCREENING OF ENZYM VARIENTS
WO2015050959A1 (en) 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
WO2015049370A1 (en) 2013-10-03 2015-04-09 Novozymes A/S Detergent composition and use of detergent composition
WO2015059133A1 (en) 2013-10-22 2015-04-30 Novozymes A/S Cellobiose dehydrogenase variants and polynucleotides encoding same
CN106232619B (zh) 2013-11-13 2022-09-09 科德克希思公司 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法
WO2015077525A1 (en) 2013-11-25 2015-05-28 Bayer Cropscience Lp Use of axmi-011 for the control of hemipteran insects
EP2876156A1 (en) 2013-11-26 2015-05-27 Commissariat A L'energie Atomique Et Aux Energies Alternatives New enzymes and method for preparing hydroxylated L-lysine or L-ornithine and analogs thereof
CN105764330B (zh) 2013-11-27 2019-04-30 纳幕尔杜邦公司 与对非生物胁迫的响应相关联的基因座
CN110219055A (zh) * 2013-11-27 2019-09-10 Gen9股份有限公司 核酸文库及其制造方法
WO2015079064A2 (en) 2013-11-29 2015-06-04 Novozymes A/S Peroxygenase variants
US9309314B2 (en) 2013-12-03 2016-04-12 Agency For Science, Technology And Research (A*Star) Polypeptides, nucleic acids and uses thereof
CA3236911A1 (en) 2013-12-09 2015-06-18 BASF Agricultural Solutions Seed US LLC Axmi477, axmi482, axmi486 and axmi525 toxin genes and methods for their use
CN122012456A (zh) 2013-12-11 2026-05-12 诺维信公司 角质酶变体以及对其进行编码的多核苷酸
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
EP2886656A1 (en) 2013-12-18 2015-06-24 Commissariat A L'energie Atomique Et Aux Energies Alternatives New enzyme and method for preparing 4-hydroxyl benzyl alcohol and derivatives thereof
DK3083936T3 (en) 2013-12-19 2018-10-22 Danisco Us Inc USE OF HYDROPHOBINES TO INCREASE GAS TRANSFER IN AEROBE FERMENTATION PROCESSES
EP3453757B1 (en) 2013-12-20 2020-06-17 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
WO2015100277A2 (en) 2013-12-23 2015-07-02 University Of Rochester Methods and compositions for ribosomal synthesis of macrocyclic peptides
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
EP2896698A1 (en) 2014-01-17 2015-07-22 BASF Plant Science Company GmbH Plants having one or more enhanced yield-related traits and a method for making the same
EP3097192B1 (en) 2014-01-22 2018-07-25 Novozymes A/S Pullulanase variants and polynucleotides encoding same
EP3097112B1 (en) 2014-01-22 2020-05-13 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
RS60593B1 (sr) 2014-01-24 2020-08-31 Ngm Biopharmaceuticals Inc Antitela koja vezuju domen 2 beta-kloto i postupci za njihovu upotrebu
JP6602772B2 (ja) 2014-01-28 2019-11-06 ダイス モレキュルズ エスヴィー， エルエルシー 認識化合物付着モノリス、そのアレイ、およびその使用
US20170166920A1 (en) 2014-01-30 2017-06-15 Two Blades Foundation Plants with enhanced resistance to phytophthora
CN114763376A (zh) 2014-02-07 2022-07-19 先锋国际良种公司 杀昆虫蛋白及其使用方法
RU2747978C2 (ru) 2014-02-07 2021-05-18 Пайонир Хай-Бред Интернэшнл, Инк. Инсектицидные белки и способы их применения
EP2910640B1 (en) 2014-02-25 2018-12-05 Biopract GmbH A method for improving substrate degradation in agricultural biogas plants
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US10155935B2 (en) 2014-03-12 2018-12-18 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
BR112016020065A2 (pt) 2014-03-12 2018-02-20 Novartis Ag sítios específicos para modificar anticorpos para fazer imunoconjugados
EP3119862B1 (en) 2014-03-19 2022-09-07 Novozymes A/S Polypeptides having phospholipase c activity and polynucleotides encoding same
WO2015143144A1 (en) 2014-03-19 2015-09-24 Novozymes A/S Method for enhancing activity of an x143 polypeptide
US20170121741A1 (en) 2014-04-01 2017-05-04 Dupont Nutrition Biosciences Aps Method for increasing crude palm oil yields
WO2015150457A1 (en) 2014-04-01 2015-10-08 Novozymes A/S Polypeptides having alpha amylase activity
CA2944649C (en) 2014-04-04 2022-06-21 Bionomics, Inc. Humanized antibodies that bind lgr5
WO2015157656A1 (en) 2014-04-10 2015-10-15 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
US9694361B2 (en) 2014-04-10 2017-07-04 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
CN106164236B (zh) 2014-04-11 2021-02-02 诺维信公司 洗涤剂组合物
US10030215B2 (en) 2014-04-15 2018-07-24 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
EP3145536B1 (en) 2014-04-16 2021-10-27 Codexis, Inc. Engineered tyrosine ammonia lyase
US10865416B2 (en) 2014-04-17 2020-12-15 Boehringer Ingelheim Rcv Gmbh & Co Kg Recombinant host cell engineered to overexpress helper proteins
BR112016023769A2 (pt) 2014-04-17 2017-10-17 Boehringer Ingelheim Rcv Gmbh célula hospedeira recombinante para a expressão de proteínas de interesse
AR100159A1 (es) 2014-04-22 2016-09-14 Du Pont Genes de anhidrasa carbónica plastídica para el incremento de aceite en semillas con expresión incrementada de dgat
WO2015171603A1 (en) 2014-05-06 2015-11-12 Two Blades Foundation Methods for producing plants with enhanced resistance to oomycete pathogens
CA2948491C (en) 2014-05-09 2024-01-16 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Vaccines against genital herpes simplex infections
CN106459934A (zh) 2014-05-15 2017-02-22 诺维信公司 包括具有磷脂酶c活性的多肽的组合物及其应用
EP3149178B1 (en) 2014-05-27 2020-07-15 Novozymes A/S Lipase variants and polynucleotides encoding same
CA2950273C (en) 2014-05-30 2022-06-21 Novozymes A/S Variants of gh family 11 xylanase and polynucleotides encoding same
EP2952584A1 (en) 2014-06-04 2015-12-09 Boehringer Ingelheim RCV GmbH & Co KG Improved protein production
US20170121695A1 (en) 2014-06-12 2017-05-04 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
EP3154579A1 (en) 2014-06-13 2017-04-19 Friedrich Miescher Institute for Biomedical Research New treatment against influenza virus
ES2694296T3 (es) 2014-06-17 2018-12-19 Centre National De La Recherche Scientifique (Cnrs) Anticuerpos monoclonales anti-pVHL y usos de los mismos
CN106573961B (zh) 2014-06-20 2022-01-04 豪夫迈·罗氏有限公司 基于chagasin的支架组合物、方法和应用
ES2712402T3 (es) 2014-06-25 2019-05-13 Novozymes As Variantes de xilanasa y polinucleótidos que las codifican
US20170290876A1 (en) 2014-06-25 2017-10-12 Novartis Ag Compositions and methods for long acting proteins
US20170327553A1 (en) 2014-06-25 2017-11-16 Novartis Ag Compositions and methods for long acting proteins
KR20170026383A (ko) 2014-06-26 2017-03-08 10엑스 제노믹스, 인크. 핵산 서열의 분석
EP4574974A3 (en) 2014-06-26 2025-10-08 10x Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
EP4235677A3 (en) 2014-06-26 2023-11-22 10X Genomics, Inc. Processes and systems for nucleic acid sequence assembly
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
WO2016001319A1 (en) 2014-07-03 2016-01-07 Novozymes A/S Improved stabilization of non-protease enzyme
EP3739029A1 (en) 2014-07-04 2020-11-18 Novozymes A/S Subtilase variants and polynucleotides encoding same
EP3327122B1 (en) 2014-07-04 2021-02-17 Novozymes A/S Subtilase variants and polynucleotides encoding same
US9708587B2 (en) 2014-07-09 2017-07-18 Codexis, Inc. P450-BM3 variants with improved activity
WO2016020791A1 (en) 2014-08-05 2016-02-11 Novartis Ag Ckit antibody drug conjugates
MA40094B1 (fr) 2014-08-06 2022-05-31 Univ Miami Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation
TW201613977A (en) 2014-08-07 2016-04-16 Novartis Ag Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use
EA201790336A1 (ru) 2014-08-07 2017-06-30 Новартис Аг Антитела к ангиопоэтинподобному белку 4 и способы применения
CA2955828A1 (en) 2014-08-08 2016-02-11 Pioneer Hi-Bred International, Inc. Ubiquitin promoters and introns and methods of use
MX2017001946A (es) 2014-08-12 2017-06-19 Novartis Ag Conjugados de farmacos con anticuerpos anti-cdh6.
US20170267980A1 (en) 2014-08-20 2017-09-21 Novozymes A/S Xyloglucan Endotransglycosylase variants and Polynucleotides Encoding Same
US9963687B2 (en) 2014-08-27 2018-05-08 New England Biolabs, Inc. Fusion polymerase and method for using the same
JP6594955B2 (ja) 2014-08-27 2019-10-23 ニユー・イングランド・バイオレイブス・インコーポレイテツド シントン形成
EP3189137A1 (en) 2014-09-05 2017-07-12 Novozymes A/S Carbohydrate binding module variants and polynucleotides encoding same
US9732373B2 (en) 2014-09-11 2017-08-15 Promega Corporation Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
BR112017003757A2 (pt) 2014-09-12 2017-12-26 Du Pont ?plantas de milho, partes de planta de milho ou sementes de milho?
WO2016046768A1 (en) 2014-09-24 2016-03-31 Friedrich Miescher Institute For Biomedical Research Lats and breast cancer
EP3197270B1 (en) 2014-09-26 2025-12-03 Pioneer Hi-Bred International, Inc. Wheat ms1 polynucleotides, polypeptides, and methods of use
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
DK3208335T3 (da) * 2014-10-14 2020-08-31 Mgi Tech Co Ltd Fremgangsmåde til brydning af nukleinsyre og tilføjelse af adapter ved hjælp af transposase og reagens
WO2016061206A1 (en) 2014-10-16 2016-04-21 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
WO2016061197A1 (en) 2014-10-16 2016-04-21 Pioneer Hi-Bred International, Inc. Insecticidal polypeptides having improved activity spectrum and uses thereof
UA124757C2 (uk) 2014-10-16 2021-11-17 Піонір Хай-Бред Інтернешнл, Інк. Інсектицидний поліпептид проти лускокрилого або твердокрилого шкідника та його застосування
GB201418713D0 (en) 2014-10-21 2014-12-03 Kymab Ltd Bindings Proteins
WO2016062875A2 (en) 2014-10-23 2016-04-28 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
EP3172329A1 (en) 2014-10-24 2017-05-31 Danisco US Inc. Method for producing alcohol by use of a tripeptidyl peptidase
CN107105707B (zh) 2014-10-24 2022-07-22 杜邦营养生物科学有限公司 脯氨酸耐受性三肽基肽酶及其用途
JP2017532042A (ja) 2014-10-29 2017-11-02 １０エックス ゲノミクス，インコーポレイテッド 標的化核酸配列決定のための方法及び組成物
US10619145B2 (en) 2014-11-04 2020-04-14 Novozymes A/S Polypeptides having serine protease activity and polynucleotides encoding same and their application in animal feed
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
WO2016073610A1 (en) 2014-11-07 2016-05-12 Novozymes A/S Xylanase based bleach boosting
UY36401A (es) 2014-11-14 2016-06-30 Novartis Ag Conjugados anticuerpos-fármacos
WO2016079305A1 (en) 2014-11-20 2016-05-26 Novozymes A/S Alicyclobacillus variants and polynucleotides encoding same
CN107002050A (zh) 2014-11-25 2017-08-01 科德克希思公司 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法
EP4421812A3 (en) * 2014-11-26 2024-12-04 Biolojic Design Ltd. Computer assisted antibody re-epitoping
WO2016087327A1 (en) 2014-12-01 2016-06-09 Novozymes A/S Polypeptides having pullulanase activity comprising the x25, x45 and cbm41 domains
WO2016090059A1 (en) 2014-12-02 2016-06-09 Novozymes A/S Laccase variants and polynucleotides encoding same
MX2017006695A (es) 2014-12-04 2017-08-21 Novozymes As Variantes de subtilasa y polinucleotidos que las codifican.
EP3227425B1 (en) 2014-12-04 2025-02-12 Novozymes A/S Liquid cleaning compositions comprising protease variants
EP3227442B1 (en) 2014-12-05 2022-02-16 Novozymes A/S Lipase variants and polynucleotides encoding same
KR102693806B1 (ko) 2014-12-11 2024-08-09 피에르 파브르 메디카먼트 항-c10orf54 항체들 및 그들의 용도들
EP3795582B1 (en) 2014-12-12 2023-09-13 Syngenta Participations Ag Compositions and methods for controlling plant pests
MA41142A (fr) 2014-12-12 2017-10-17 Amgen Inc Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
US20180000076A1 (en) 2014-12-16 2018-01-04 Novozymes A/S Polypeptides Having N-Acetyl Glucosamine Oxidase Activity
US20170369902A1 (en) 2014-12-16 2017-12-28 Pioneer Hi-Bred International, Inc. Restoration of male fertility in wheat
UY36449A (es) 2014-12-19 2016-07-29 Novartis Ag Composiciones y métodos para anticuerpos dirigidos a bmp6
WO2016100910A1 (en) 2014-12-19 2016-06-23 Novozymes A/S Recombinant host cells for the production of 3-hydroxypropionic acid
WO2016097352A1 (en) 2014-12-19 2016-06-23 Novozymes A/S Protease variants and polynucleotides encoding same
MX383142B (es) 2014-12-19 2025-03-13 Novozymes As Composiciones que comprenden polipéptidos que tienen actividad xilanasa y polipéptidos que tienen actividad arabinofuranosidasa.
EP3741849A3 (en) 2014-12-19 2021-03-17 Novozymes A/S Protease variants and polynucleotides encoding same
CA2970638A1 (en) 2014-12-22 2016-06-30 Codexis, Inc. Human alpha-galactosidase variants
AU2016207023B2 (en) 2015-01-12 2019-12-05 10X Genomics, Inc. Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
CA2968417A1 (en) 2015-01-13 2016-07-21 10X Genomics, Inc. Systems and methods for visualizing structural variation and phasing information
EP4663761A3 (en) 2015-01-15 2026-03-04 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
CN107406853A (zh) 2015-02-04 2017-11-28 先锋国际良种公司 新颖的Bt毒素受体和使用方法
SG11201705996PA (en) 2015-02-09 2017-09-28 10X Genomics Inc Systems and methods for determining structural variation and phasing using variant call data
EP4147575A1 (en) 2015-02-09 2023-03-15 BioConsortia, Inc. Agriculturally beneficial microbes, microbial compositions, and consortia
DK3256577T3 (da) 2015-02-10 2020-09-14 Codexis Inc Ketoreduktase polypeptider til syntesen af chirale forbindelser
US10610575B2 (en) 2015-02-12 2020-04-07 Dsm Ip Assets B.V. Method for improving feed digestibility in bovine animals
FI3739045T3 (fi) 2015-02-24 2024-11-13 Novozymes As Sellobiohydrolaasivariantteja ja niitä koodittavia polynukleotideja
AU2016222719B2 (en) 2015-02-24 2022-03-31 10X Genomics, Inc. Methods for targeted nucleic acid sequence coverage
EP4286516A3 (en) 2015-02-24 2024-03-06 10X Genomics, Inc. Partition processing methods and systems
EP3262180A1 (en) 2015-02-25 2018-01-03 Danisco US Inc. Alpha-glucosidase, compositions & methods
EP3262161B1 (en) 2015-02-27 2021-06-30 Novozymes A/S Mutant host cells for the production of 3-hydroxypropionic acid
PL3265123T3 (pl) 2015-03-03 2023-03-13 Kymab Limited Przeciwciała, zastosowania i sposoby
MX376048B (es) 2015-03-11 2025-03-07 Corteva Agriscience Llc Combinaciones insecticidas de pip-72 y métodos de uso.
WO2016142536A1 (en) 2015-03-11 2016-09-15 Genencor International B.V. Enzymatic activity of lytic polysaccharide monooxygenase
JP6862348B2 (ja) 2015-03-12 2021-04-21 メディミューン，エルエルシー アルブミン融合タンパク質を精製する方法
US11492632B2 (en) 2015-03-19 2022-11-08 Pioneer Hi-Bred International, Inc. Methods and compositions for accelerated trait introgression
EP3070103A1 (en) 2015-03-19 2016-09-21 Institut Hospitalier Universitaire De Strasbourg Anti-Claudin 1 monoclonal antibodies for the prevention and treatment of hepatocellular carcinoma
BR112017020007B1 (pt) 2015-03-19 2022-09-20 Novozymes A/S Método para preparar um mosto com um nível aumentado de nitrogênio livre aminado (fan) e uso de uma protease
US20180073017A1 (en) 2015-04-07 2018-03-15 Novozymes A/S Methods for selecting enzymes having enhanced activity
US20180355404A1 (en) 2015-04-07 2018-12-13 Novozymes A/S Methods for selecting enzymes having lipase activity
CN107636134A (zh) 2015-04-10 2018-01-26 诺维信公司 洗涤剂组合物
WO2016162556A1 (en) 2015-04-10 2016-10-13 Novozymes A/S Laundry method, use of dnase and detergent composition
MA44954A (fr) 2015-04-17 2019-03-20 Agbiome Inc Gènes pesticides et leurs procédés d'utilisation
CA2981088A1 (en) 2015-04-22 2016-10-27 AgBiome, Inc. Pesticidal genes and methods of use
CN104805508B (zh) * 2015-04-29 2017-07-14 江南大学 一种基于合成单链dna文库进化代谢途径的方法
CA2984901A1 (en) 2015-05-06 2016-11-10 Pioneer Hi-Bred International, Inc. Methods and compositions for the production of unreduced, non-recombined gametes and clonal offspring
CN107531762A (zh) 2015-05-07 2018-01-02 科德克希思公司 青霉素g酰化酶
US20180142224A1 (en) 2015-05-08 2018-05-24 Novozymes A/S Alpha-amylase variants having improved performance and stability
JP7175612B2 (ja) 2015-05-08 2022-11-21 ノボザイムス アクティーゼルスカブ アルファ－アミラーゼ多様体およびこの多様体をコードするポリヌクレオチド
AR105416A1 (es) 2015-05-08 2017-10-04 Novozymes As VARIANTES DE a-AMILASA Y POLINUCLEÓTIDOS QUE LAS CODIFICAN
CA2985458A1 (en) 2015-05-09 2016-11-17 Two Blades Foundation Late blight resistance gene from solanum americanum and methods of use
CA2985198A1 (en) 2015-05-19 2016-11-24 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
EP3297661B1 (en) 2015-05-21 2021-06-30 Full Spectrum Genetics, Inc. Method of improving characteristics of proteins
CN107532154B (zh) 2015-05-27 2022-09-27 国投生物科技投资有限公司 具有纤维二糖水解酶活性的多肽以及对其进行编码的多核苷酸
WO2016196202A1 (en) 2015-05-29 2016-12-08 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
CA2987598A1 (en) 2015-06-03 2016-12-08 AgBiome, Inc. Pesticidal genes and methods of use
WO2016193420A1 (en) 2015-06-04 2016-12-08 Novozymes A/S Use of m4 metalloprotease in wort production
SG11201707815RA (en) 2015-06-05 2017-12-28 Novartis Ag Antibodies targeting bone morphogenetic protein 9 (bmp9) and methods therefor
EP3310908B1 (en) 2015-06-16 2020-08-05 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
US20190194315A1 (en) 2015-06-17 2019-06-27 Novartis Ag Antibody drug conjugates
CN107771218B (zh) 2015-06-17 2021-12-31 先锋国际良种公司 植物调节元件及其使用方法
US10676727B2 (en) 2015-06-18 2020-06-09 Novozymes A/S Polypeptides having trehalase activity and the use thereof in process of producing fermentation products
EP3106508B1 (en) 2015-06-18 2019-11-20 Henkel AG & Co. KGaA Detergent composition comprising subtilase variants
CN121406620A (zh) 2015-06-18 2026-01-27 诺维信公司 枯草杆菌酶变体以及编码它们的多核苷酸
BR112017027821A2 (pt) 2015-06-22 2019-05-14 AgBiome, Inc. genes pesticidas e métodos de uso
ES2879249T3 (es) 2015-06-24 2021-11-22 Genencor Int Bv Polipéptidos que tienen actividad de desmetilación
US9938558B2 (en) 2015-06-25 2018-04-10 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
US10632157B2 (en) 2016-04-15 2020-04-28 Ascus Biosciences, Inc. Microbial compositions and methods of use for improving fowl production
ES2978111T3 (es) 2015-06-25 2024-09-05 Native Microbials Inc Métodos, aparatos y sistemas para analizar cepas de microorganismos de comunidades heterogéneas complejas, predecir e identificar relaciones funcionales e interacciones de las mismas, y seleccionar y sintetizar conjuntos microbianos basados en las mismas
US10851399B2 (en) 2015-06-25 2020-12-01 Native Microbials, Inc. Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
WO2018126026A1 (en) 2016-12-28 2018-07-05 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing complete microorganism strains in complex heterogeneous communities, determining functional relationships and interactions thereof, and identifying and synthesizing bioreactive modificators based thereon
AU2016282355B2 (en) 2015-06-26 2020-04-09 Novozymes A/S Method for producing a coffee extract
WO2016207373A1 (en) 2015-06-26 2016-12-29 Novozymes A/S Polypeptides having peroxygenase activity
JOP20160131B1 (ar) 2015-06-26 2022-03-14 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
CA2990822A1 (en) 2015-06-26 2016-12-29 Dupont Nutrition Biosciences Aps Aminopeptidases for protein hydrlyzates
EP3313990A4 (en) 2015-06-26 2019-01-23 Novozymes A/S BIO-finishing system
CA2987160C (en) 2015-07-01 2022-12-13 Novozymes A/S Methods of reducing odor
AU2016286612B2 (en) 2015-07-02 2021-01-28 Novozymes A/S Animal feed compositions and uses thereof
CN114292829A (zh) 2015-07-06 2022-04-08 诺维信公司 脂肪酶变体以及编码它们的多核苷酸
JP6691558B2 (ja) 2015-07-07 2020-04-28 コデクシス， インコーポレイテッド 改善された活性を持つ新規のｐ４５０−ｂｍ３バリアント
CN108138153A (zh) 2015-07-24 2018-06-08 诺维信股份有限公司 具有阿拉伯呋喃糖苷酶活性的多肽以及编码它们的多核苷酸
WO2017019491A1 (en) 2015-07-24 2017-02-02 Novozymes Inc. Polypeptides having beta-xylosidase activity and polynucleotides encoding same
US11102981B2 (en) 2015-07-25 2021-08-31 Bioconsortia, Inc. Agriculturally beneficial microbes, microbial compositions, and consortia
EP3331914A1 (en) 2015-08-03 2018-06-13 Novartis AG Methods of treating fgf21-associated disorders
CN116003550A (zh) 2015-08-06 2023-04-25 先锋国际良种公司 植物来源的杀昆虫蛋白及其使用方法
BR112018003179A2 (pt) 2015-08-20 2018-09-25 Albumedix As conjugados e variantes de albumina
WO2017035270A1 (en) 2015-08-24 2017-03-02 Novozymes A/S Beta-alanine aminotransferases for the production of 3-hydroxypropionic acid
AU2016321204B2 (en) 2015-09-08 2022-12-01 Cold Spring Harbor Laboratory Genetic copy number determination using high throughput multiplex sequencing of smashed nucleotides
EP3842457A1 (en) 2015-09-09 2021-06-30 Novartis AG Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules
TWI799366B (zh) 2015-09-15 2023-04-21 美商建南德克公司 胱胺酸結骨架平臺
CA2998970C (en) 2015-09-22 2021-07-13 F. Hoffmann-La Roche Ag Ompg variants
US10479984B2 (en) 2015-09-22 2019-11-19 Novozymes A/S Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
BR112018006237A2 (pt) 2015-09-29 2018-10-09 Celgene Corp proteínas de ligação a pd-1 e métodos de uso das mesmas
EP3763818A1 (en) 2015-10-06 2021-01-13 Pierce Biotechnology, Inc. Devices and methods for producing proteins
WO2017060475A2 (en) 2015-10-07 2017-04-13 Novozymes A/S Polypeptides
WO2017062790A1 (en) 2015-10-09 2017-04-13 Two Blades Foundation Cold shock protein receptors and methods of use
US10675589B2 (en) 2015-10-14 2020-06-09 Novozymes A/S Cleaning of water filtration membranes
EP3362574B1 (en) 2015-10-14 2021-07-07 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
CN108291212A (zh) 2015-10-14 2018-07-17 诺维信公司 多肽变体
US20180171318A1 (en) 2015-10-14 2018-06-21 Novozymes A/S Polypeptides Having Protease Activity and Polynucleotides Encoding Same
WO2017070219A1 (en) 2015-10-20 2017-04-27 Novozymes A/S Lytic polysaccharide monooxygenase (lpmo) variants and polynucleotides encoding same
ES3069936T3 (en) 2015-10-28 2026-06-11 Novozymes As Detergent composition comprising amylase and protease variants
US20180348224A1 (en) 2015-10-28 2018-12-06 Friedrich Miescher Institute For Biomedical Resear Ch Tenascin-w and biliary tract cancers
ITUB20155272A1 (it) 2015-11-02 2017-05-02 Scuola Normale Superiore Intracellular antibody
WO2017079286A1 (en) 2015-11-03 2017-05-11 Two Blades Foundation Wheat stripe rust resistance genes and methods of use
US20180258438A1 (en) 2015-11-06 2018-09-13 Pioneer Hi-Bred International, Inc. Generation of complex trait loci in soybean and methods of use
US11001821B2 (en) 2015-11-24 2021-05-11 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
EP3384031A1 (en) 2015-11-30 2018-10-10 Pioneer Hi-Bred International, Inc. Plant regulatory elements and methods of use thereof
EP3384019B1 (en) 2015-12-01 2020-06-24 Novozymes A/S Methods for producing lipases
KR102723865B1 (ko) 2015-12-04 2024-10-29 10엑스 제노믹스, 인크. 핵산 분석을 위한 방법 및 조성물
JP6821598B2 (ja) 2015-12-07 2021-01-27 ザイマージェン インコーポレイテッド Ｃｏｒｙｎｅｂａｃｔｅｒｉｕｍ ｇｌｕｔａｍｉｃｕｍ由来のプロモーター
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
US10035995B2 (en) 2015-12-07 2018-07-31 Eastman Chemical Company CALB variants
ES2932192T3 (es) 2015-12-07 2023-01-16 Henkel Ag & Co Kgaa Composiciones para el lavado de vajilla que comprenden polipéptidos que tienen actividad beta-glucanasa y sus usos
CA3007840C (en) 2015-12-07 2020-09-15 Zymergen Inc. Microbial strain improvement by a htp genomic engineering platform
EP3390431A1 (en) 2015-12-18 2018-10-24 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
TW201731872A (zh) 2015-12-18 2017-09-16 諾華公司 標靶CD32b之抗體及其使用方法
JP7146637B2 (ja) 2015-12-22 2022-10-04 アルブミディクス リミティド 改善されたタンパク質発現株
BR112018012887B1 (pt) 2015-12-22 2024-02-06 Pioneer Hi-Bred International, Inc Cassete de expressão, vetor, métodos de obtenção de célula vegetal e planta transgênica, métodos para expressar um polinucleotídeo
WO2017112847A1 (en) 2015-12-22 2017-06-29 Albumedix A/S Improved protein expression strains
WO2017112538A2 (en) 2015-12-22 2017-06-29 AgBiome, Inc. Pesticidal genes and methods of use
CN108603185B (zh) 2015-12-30 2022-05-17 诺维信公司 酶变体以及编码它们的多核苷酸
PL3400285T3 (pl) 2016-01-07 2026-05-25 Native Microbials, Inc. Sposoby poprawy wytwarzania mleka poprzez podawanie konsorcjów mikrobiologicznych
EP3851457A1 (en) 2016-01-21 2021-07-21 Novartis AG Multispecific molecules targeting cll-1
US20210171927A1 (en) 2016-01-29 2021-06-10 Novozymes A/S Beta-glucanase variants and polynucleotides encoding same
JP6735348B2 (ja) 2016-02-11 2020-08-05 １０エックス ジェノミクス， インコーポレイテッド 全ゲノム配列データのデノボアセンブリのためのシステム、方法及び媒体
GB201602535D0 (en) 2016-02-12 2016-03-30 Univ Edinburgh Improved flu vaccine yield
US11685911B2 (en) 2016-02-16 2023-06-27 Monaghan Mushroom S Group Fungal polypeptides having lysozyme activity
WO2017147163A1 (en) 2016-02-22 2017-08-31 Danisco Us Inc. Fungal high-level protein production system
CA3013166A1 (en) 2016-02-23 2017-08-31 Da Volterra Beta-lactamase variants
US10988749B2 (en) 2016-02-23 2021-04-27 Da Volterra Beta-lactamase variants
MX2018009216A (es) 2016-02-25 2018-11-09 Dupont Nutrition Biosci Aps Metodo para producir un hidrolizado de proteina empleando una tripeptidil peptidasa de aspergillus fumigatus.
EP3423576B1 (en) 2016-02-29 2021-05-12 Genia Technologies, Inc. Polymerase variants
BR112018067371A2 (pt) 2016-03-02 2019-01-15 Novozymes As variante de celobio-hidrolase, composição de enzimas, formulação de caldo inteiro ou composição de cultura de células, polinucleotídeo, célula hospedeira recombinante, planta, parte de planta ou célula de planta transgênica, métodos para produção e para obtenção de uma variante de celobio-hidrolase, planta trangênica, e, processos para degradação de um material celulósico, para produção de um produto de fermentação e para fermentação de um material celulósico
GB201604124D0 (en) 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
US10745487B2 (en) 2016-03-22 2020-08-18 Bionomics Limited Method of treating cancer by administering an anti-LGR5 monoclonal antibody
CN109072209A (zh) 2016-03-24 2018-12-21 诺维信公司 纤维二糖水解酶变体和编码其的多核苷酸
CN117986363A (zh) 2016-03-31 2024-05-07 恩格姆生物制药公司 结合蛋白及其使用方法
US9988641B2 (en) 2016-04-05 2018-06-05 Corn Products Development, Inc. Compositions and methods for producing starch with novel functionality
WO2017177153A1 (en) 2016-04-07 2017-10-12 Novozymes A/S Methods for selecting enzymes having protease activity
WO2017180715A2 (en) 2016-04-14 2017-10-19 Pioneer Hi-Bred International, Inc. Insecticidal polypeptides having improved activity spectrum and uses thereof
BR112018071198A2 (pt) 2016-04-15 2019-04-24 Ascus Biosciences, Inc. métodos para melhorar a produção agrícola de aves pela administração de consórcios microbianos ou de cepas purificadas dos mesmos
CA3021391A1 (en) 2016-04-19 2017-10-26 Pioneer Hi-Bred International, Inc. Insecticidal combinations of polypeptides having improved activity spectrum and uses thereof
JP7138567B2 (ja) 2016-04-27 2022-09-16 ノバルティス アーゲー 成長分化因子１５に対する抗体およびそれらの使用
US10626354B2 (en) 2016-04-29 2020-04-21 Novozymes A/S Detergent compositions and uses thereof
PL3448409T3 (pl) 2016-04-29 2026-02-23 Defensin Therapeutics Aps Leczenie chorób wątroby, dróg żółciowych i trzustki defensynami
US20240218340A1 (en) 2016-05-03 2024-07-04 Novozymes A/S Enzyme Variants and Polynucleotides Encoding Same
CN109068660B (zh) 2016-05-04 2023-05-02 先锋国际良种公司 杀昆虫蛋白及其使用方法
KR102382489B1 (ko) 2016-05-05 2022-04-01 코덱시스, 인코포레이티드 페니실린 ｇ 아실라제
JP6985295B2 (ja) 2016-05-09 2021-12-22 ノボザイムス アクティーゼルスカブ 向上した性能を有する変異体ポリペプチドおよびその使用
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
EP3246401A1 (en) 2016-05-20 2017-11-22 Commissariat À L'Énergie Atomique Et Aux Énergies Alternatives New fatty acid decarboxylase and its uses
AU2017269498A1 (en) 2016-05-24 2018-11-08 Novozymes A/S Polypeptides having alpha-galactosidase activity and polynucleotides encoding same
ES3014057T3 (en) 2016-05-24 2025-04-16 Novozymes As Gastric stable polypeptides having alpha-galactosidase activity and polynucleotides encoding same
AU2017270269A1 (en) 2016-05-24 2018-11-15 Novozymes A/S Compositions comprising polypeptides having galactanase activity and polypeptides having beta-galactosidase activity
CN109312321A (zh) 2016-05-24 2019-02-05 诺维信公司 包含具有半乳聚糖酶活性的多肽和具有β-半乳糖苷酶活性的多肽的组合物
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
WO2017205535A1 (en) 2016-05-27 2017-11-30 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
WO2017210188A1 (en) 2016-05-31 2017-12-07 Novozymes A/S Stabilized liquid peroxide compositions
WO2017207762A1 (en) 2016-06-03 2017-12-07 Novozymes A/S Subtilase variants and polynucleotides encoding same
WO2017211803A1 (en) 2016-06-07 2017-12-14 Novozymes A/S Co-expression of heterologous polypeptides to increase yield
IL263448B2 (en) 2016-06-09 2023-10-01 Codexis Inc Biological catalysts and methods for hydroxylation of chemical compounds
WO2017216724A1 (en) 2016-06-15 2017-12-21 Novartis Ag Methods for treating disease using inhibitors of bone morphogenetic protein 6 (bmp6)
EP3471744A4 (en) 2016-06-15 2020-07-29 Codexis, Inc. REVISED BETA-GLUCOSIDASES AND GLUCOSYLATION PROCESSES
WO2017215790A1 (en) 2016-06-17 2017-12-21 National Hellenic Research Foundation Systems for recombinant protein production
CN109642237B (zh) 2016-06-24 2022-09-30 先锋国际良种公司 植物调节元件及其使用方法
US10544411B2 (en) 2016-06-30 2020-01-28 Zymergen Inc. Methods for generating a glucose permease library and uses thereof
CN117721095A (zh) 2016-06-30 2024-03-19 诺维信公司 脂肪酶变体及包含表面活性剂和脂肪酶变体的组合物
EP3478833A4 (en) 2016-06-30 2019-10-02 Zymergen, Inc. METHOD FOR PRODUCING A BACTERIAL HEMOGLOBIN LIBRARY AND ITS USE
WO2018002379A2 (en) 2016-07-01 2018-01-04 Novozymes A/S Enzymatic preparation of indigo dyes and in situ dyeing process
CN109788735A (zh) 2016-07-01 2019-05-21 先锋国际良种公司 来自植物的杀昆虫蛋白及其使用方法
WO2018002261A1 (en) 2016-07-01 2018-01-04 Novozymes A/S Detergent compositions
CN109715794A (zh) 2016-07-05 2019-05-03 诺维信公司 果胶裂解酶变体以及编码它们的多核苷酸
RU2752204C2 (ru) 2016-07-08 2021-07-23 Новозимс А/С Варианты ксиланазы и кодирующие их полинуклеотиды
MX2019000139A (es) 2016-07-08 2019-06-10 Novozymes As Polipeptidos que tienen actividad xilanasa y polinucleotidos que los codifican.
WO2018007573A1 (en) 2016-07-08 2018-01-11 Novozymes A/S Detergent compositions with galactanase
CN109415708A (zh) 2016-07-13 2019-03-01 宝洁公司 食物芽孢杆菌脱氧核糖核酸酶变体及其用途
CN109790525A (zh) 2016-07-18 2019-05-21 诺维信公司 脂肪酶变体、编码其的多核苷酸及其用途
WO2018017792A1 (en) 2016-07-20 2018-01-25 Novozymes A/S Heat-stable metagenomic carbonic anhydrases and their use
FI3487996T3 (fi) 2016-07-21 2024-07-10 Novozymes As Seriiniproteaasivariantteja ja niitä koodittavia polynukleotideja
CN109661465A (zh) 2016-07-21 2019-04-19 诺维信公司 丝氨酸蛋白酶变体以及对其进行编码的多核苷酸
WO2018015444A1 (en) 2016-07-22 2018-01-25 Novozymes A/S Crispr-cas9 genome editing with multiple guide rnas in filamentous fungi
WO2018026868A1 (en) 2016-08-01 2018-02-08 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
US11512300B2 (en) 2016-08-24 2022-11-29 Novozymes A/S Xanthan lyase variants and polynucleotides encoding same
WO2018037064A1 (en) 2016-08-24 2018-03-01 Henkel Ag & Co. Kgaa Detergent compositions comprising xanthan lyase variants i
EP3504330A1 (en) 2016-08-24 2019-07-03 Novozymes A/S Gh9 endoglucanase variants and polynucleotides encoding same
AU2017317564B2 (en) 2016-08-24 2021-09-30 Henkel Ag & Co. Kgaa Detergent composition comprising GH9 endoglucanase variants I
WO2018038906A1 (en) 2016-08-26 2018-03-01 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
US10787679B2 (en) 2016-09-06 2020-09-29 AgBiome, Inc. Pesticidal genes and methods of use
JP2019534858A (ja) 2016-09-09 2019-12-05 ジェネンテック， インコーポレイテッド Ｆｒｉｚｚｌｅｄの選択的ペプチド阻害剤
US11578316B2 (en) 2016-09-16 2023-02-14 Dupont Nutrition Biosciences Aps Acetolactate decarboxylase variants having improved specific activity
EP3515943A4 (en) 2016-09-19 2020-05-06 Celgene Corporation METHODS OF TREATING VITILIGO WITH PD-1 BINDING PROTEINS
EP3515944A4 (en) 2016-09-19 2020-05-06 Celgene Corporation METHOD FOR TREATING IMMUNE DISEASES USING PD-1 BINDING PROTEINS
ES2940673T3 (es) 2016-09-20 2023-05-10 22Nd Century Ltd Llc Promotores específicos de tricomas para la manipulación de cannabinoides y otros compuestos en tricomas glandulares
US20190284647A1 (en) 2016-09-29 2019-09-19 Novozymes A/S Spore Containing Granule
CA3038972A1 (en) 2016-09-30 2018-04-05 Dow Agrosciences Llc Binary insecticidal cry toxins
US20210284933A1 (en) 2016-10-25 2021-09-16 Novozymes A/S Detergent compositions
CN109863167B (zh) 2016-11-01 2022-12-23 先锋国际良种公司 杀昆虫蛋白及其使用方法
WO2018085370A1 (en) 2016-11-02 2018-05-11 Novozymes A/S Processes for reducing production of primeverose during enzymatic saccharification of lignocellulosic material
WO2018083248A1 (en) 2016-11-03 2018-05-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
WO2018089860A1 (en) 2016-11-11 2018-05-17 2D Genomics Inc. Methods for processing nucleic acid samples
US20180135080A1 (en) * 2016-11-15 2018-05-17 Genomic Vision Sa Method for the monitoring of modified nucleases induced-gene editing events by molecular combing
EP3541954A1 (en) 2016-11-21 2019-09-25 Novozymes A/S Yeast cell extract assisted construction of dna molecules
CN110072997A (zh) 2016-11-23 2019-07-30 诺维信公司 具有蛋白酶活性的多肽和编码其的多核苷酸
BR112019010476A2 (pt) 2016-11-23 2019-09-10 BASF Agricultural Solutions Seed US LLC molécula de ácido nucleico recombinante, vetor, célula hospedeira, planta transgênica, semente transgênica, polipeptídeo recombinante, composição, método para controlar uma população de pragas, para matar pragas, para produzir um polipeptídeo, planta ou célula vegetal, método para proteger uma planta contra uma praga, para aumentar o rendimento em uma planta, uso e produto primário
US20210292723A1 (en) 2016-11-29 2021-09-23 Novozymes A/S Alpha-Amylase Variants and Polynucleotides Encoding Same
MX2019006122A (es) 2016-11-30 2019-08-14 Novozymes As Metodo de hornear.
WO2018106792A1 (en) 2016-12-06 2018-06-14 Novozymes A/S Improved processes for production of ethanol from xylose-containing cellulosic substrates using engineered yeast strains
CA3045079A1 (en) 2016-12-13 2018-06-21 Defensin Therapeutics Aps Methods for treating inflammatory conditions of the lungs
CA3044404A1 (en) 2016-12-14 2018-06-21 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
CA3047121A1 (en) 2016-12-16 2018-06-21 Two Blades Foundation Late blight resistance genes and methods of use
MX383442B (es) 2016-12-20 2025-03-14 Colgate Palmolive Co Composiciones para el cuidado bucal y métodos para blanquear los dientes.
CN110114465A (zh) 2016-12-20 2019-08-09 诺维信公司 用于戊糖发酵的重组酵母菌株
US10413500B2 (en) 2016-12-20 2019-09-17 Colgate-Palmolive Company Oral care compositions and methods for whitening teeth
WO2018118553A1 (en) 2016-12-20 2018-06-28 Colgate-Palmolive Company Oral care compositions and methods for increasing the stability of the same
AU2017380488B2 (en) 2016-12-21 2023-09-14 Novozymes A/S Polypeptides having lysozyme activity, polynucleotides encoding same and uses and compositions thereof
US20190364908A1 (en) 2016-12-22 2019-12-05 BASF Agricultural Solutions Seed US LLC Use of cry14 for the control of nematode pests
MX2019007491A (es) 2016-12-22 2019-09-06 Pioneer Hi Bred Int Proteinas insecticidas y metodos para su uso.
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN118320078A (zh) 2016-12-23 2024-07-12 诺华股份有限公司 采用抗因子XI/XIa抗体治疗的方法
KR102616666B1 (ko) 2016-12-23 2023-12-27 노파르티스 아게 인자 xi 항체 및 사용 방법
MX2019007760A (es) 2016-12-28 2020-02-10 Ascus Biosciences Inc Metodos, aparatos y sistemas para analisis de cepa de microorganismo de comunidades heterogeneas complejas con analisis rastreador, determinacion de relaciones funcionales e interacciones de estas, y sintesis de agrupaciones microbianas que incluyen agrupaciones microbianas dosificadas y agrupaciones microbianas inoculativas.
TW201825515A (zh) 2017-01-04 2018-07-16 美商伊繆諾金公司 Ｍｅｔ抗體以及其免疫結合物及用途
KR102696584B1 (ko) 2017-01-05 2024-08-19 코덱시스, 인코포레이티드 페니실린 ｇ 아실라아제
CN110431234B (zh) 2017-01-18 2024-04-16 巴斯夫农业种子解决方案美国有限责任公司 Bp005毒素基因及其使用方法
AR110756A1 (es) 2017-01-18 2019-05-02 Bayer Cropscience Lp Uso de bp005 para el control de patógenos de planta
WO2018140214A1 (en) 2017-01-24 2018-08-02 Pioneer Hi-Bred International, Inc. Nematicidal protein from pseudomonas
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
EP4310183B1 (en) 2017-01-30 2025-07-09 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
WO2018140859A2 (en) 2017-01-30 2018-08-02 AgBiome, Inc. Pesticidal genes and methods of use
RU2019123965A (ru) 2017-02-01 2021-02-01 Дзе Проктер Энд Гэмбл Компани Очищающие композиции, содержащие варианты амилазы
EP3577219B1 (en) 2017-02-01 2023-08-23 Novozymes A/S Alpha-amylase variants
KR20260006703A (ko) 2017-02-03 2026-01-13 테이트 앤드 라일 솔루션스 유에스에이 엘엘씨 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법
JOP20190187A1 (ar) 2017-02-03 2019-08-01 Novartis Ag مترافقات عقار جسم مضاد لـ ccr7
CA3052911A1 (en) 2017-02-08 2018-08-16 Novartis Ag Fgf21 mimetic antibodies and uses thereof
MX2019009371A (es) 2017-02-08 2019-09-23 Pionner Hi Bred Int Inc Combinaciones insecticidas de proteinas insecticidas derivadas de plantas y metodos para su uso.
AU2018217495B2 (en) 2017-02-13 2021-03-04 Codexis, Inc. Engineered phenylalanine ammonia lyase polypeptides
MX2019009551A (es) 2017-02-20 2020-01-30 Novozymes As Enzima lipolitica para usarse en horneado.
EP3363900A1 (en) * 2017-02-21 2018-08-22 ETH Zurich Evolution-guided multiplexed dna assembly of dna parts, pathways and genomes
CA3055530A1 (en) 2017-03-07 2018-09-13 Danisco Us Inc. Thermostable glucoamylase and methods of use, thereof
US11479798B2 (en) 2017-03-29 2022-10-25 Boehringer Ingelheim Rcv Gmbh & Co Kg Recombinant host cell with altered membrane lipid composition
US11149233B2 (en) 2017-03-31 2021-10-19 Novozymes A/S Polypeptides having RNase activity
CN110651040A (zh) 2017-03-31 2020-01-03 诺维信公司 具有dna酶活性的多肽
CN110651041A (zh) 2017-03-31 2020-01-03 诺维信公司 具有dna酶活性的多肽
EP3601549B1 (en) 2017-03-31 2026-07-01 Novozymes A/S POLYPEPTIDES WITH DNASE ACTIVITY
WO2018185618A1 (en) 2017-04-03 2018-10-11 Novartis Ag Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment
CN110651029B (zh) 2017-04-04 2022-02-15 诺维信公司 糖基水解酶
WO2018185152A1 (en) 2017-04-04 2018-10-11 Novozymes A/S Polypeptide compositions and uses thereof
EP3607039A1 (en) 2017-04-04 2020-02-12 Novozymes A/S Polypeptides
BR112019021223A2 (pt) 2017-04-11 2020-04-28 Novozymes A/S variante de glucoamilase, métodos para aumentar a atividade de hidrólise de amido em bruto de uma glucoamilase e para produzir uma variante de glucoamilase, composição, uso de uma variante de glucoamilase, processos para produzir um produto de fermentação e para produzir um produto de xarope, polinucleotídeo codificando a variante de glucoamilase, construto de ácido nucleico, vetor de expressão, e, célula hospedeira.
US11046973B2 (en) 2017-04-11 2021-06-29 AgBiome, Inc. Pesticidal genes and methods of use
WO2018200517A1 (en) 2017-04-24 2018-11-01 Tesaro, Inc. Methods of manufacturing of niraparib
WO2018197520A1 (en) 2017-04-24 2018-11-01 Dupont Nutrition Biosciences Aps Methods and compositions of anti-crispr proteins for use in plants
JP7045725B2 (ja) 2017-04-27 2022-04-01 コデクシス， インコーポレイテッド ケトレダクターゼポリペプチドおよびポリヌクレオチド
MX389322B (es) 2017-04-28 2025-03-20 Native Microbials Inc Metodos para complementar dietas con alto consumo de granos y/o alto valor energetico en rumiantes, mediante la administracion de un bioensamble sintetico de microbios, o cepas purificadas de los mismos
WO2018202846A1 (en) 2017-05-05 2018-11-08 Novozymes A/S Compositions comprising lipase and sulfite
EP3622064B1 (en) 2017-05-08 2025-05-14 Novozymes A/S Mannanase variants and polynucleotides encoding same
CA3058095A1 (en) 2017-05-08 2018-11-15 Novozymes A/S Mannanase variants and polynucleotides encoding same
CA3062550A1 (en) 2017-05-08 2018-11-15 Codexis, Inc. Engineered ligase variants
WO2018206535A1 (en) 2017-05-08 2018-11-15 Novozymes A/S Carbohydrate-binding domain and polynucleotides encoding the same
RU2019140646A (ru) 2017-05-11 2021-06-11 Пайонир Хай-Бред Интернэшнл, Инк. Инсектицидные белки и способы их применения
KR20200010285A (ko) 2017-05-19 2020-01-30 지머젠 인코포레이티드 증가된 nadph를 유도하는 생합성 경로의 게놈 공학
WO2018213774A1 (en) 2017-05-19 2018-11-22 10X Genomics, Inc. Systems and methods for analyzing datasets
WO2018215937A1 (en) 2017-05-24 2018-11-29 Novartis Ag Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer
KR102920712B1 (ko) 2017-05-24 2026-01-30 노파르티스 아게 항체-사이토카인 생착된 단백질 및 암 치료에 있어서의 사용 방법
JOP20190271A1 (ar) 2017-05-24 2019-11-21 Novartis Ag بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة
US20200362058A1 (en) 2017-05-24 2020-11-19 Novartis Ag Antibody-cytokine engrafted proteins and methods of use
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN116064732A (zh) 2017-05-26 2023-05-05 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
BR112019024827A2 (pt) 2017-05-26 2020-06-16 Pioneer Hi-Bred International, Inc. Construto de dna, planta transgênica ou progênie da mesma, composição e método para controlar uma população de pragas de insetos
WO2018220116A1 (en) 2017-05-31 2018-12-06 Novozymes A/S Xylose fermenting yeast strains and processes thereof for ethanol production
AU2018275794A1 (en) 2017-06-02 2019-12-05 Novozymes A/S Improved yeast for ethanol production
KR20200014836A (ko) 2017-06-06 2020-02-11 지머젠 인코포레이티드 고 처리량 트랜스포존 돌연변이유발
JP7227162B2 (ja) 2017-06-06 2023-02-21 ザイマージェン インコーポレイテッド 真菌株を改良するためのｈｔｐゲノム操作プラットフォーム
KR102741381B1 (ko) 2017-06-06 2024-12-11 지머젠 인코포레이티드 사카로폴리스포라 스피노사를 개량하기 위한 고 처리량(htp) 게놈 공학 플랫폼
ES2875579T3 (es) 2017-06-06 2021-11-10 Zymergen Inc Plataforma de ingeniería genómica de HTP para mejorar Escherichia coli
WO2018224544A1 (en) 2017-06-08 2018-12-13 Novozymes A/S Compositions comprising polypeptides having cellulase activity and amylase activity, and uses thereof in cleaning and detergent compositions
WO2018224035A1 (en) 2017-06-09 2018-12-13 Novozymes A/S Polypeptide, use and method for hydrolysing protein
WO2018231462A1 (en) 2017-06-14 2018-12-20 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
EP4026908A1 (en) 2017-06-20 2022-07-13 Albumedix Ltd Improved protein expression strains
EP3642339B1 (en) 2017-06-22 2025-09-10 Novozymes A/S Xylanase variants and polynucleotides encoding same
EP3645713A4 (en) 2017-06-27 2021-06-30 Codexis, Inc. PENICILLIN-G ACYLASES
DK3645555T3 (da) 2017-06-28 2022-03-07 Novozymes As Polypeptider med trehalaseaktivitet og polynukleotider, der koder for disse
JP2020530267A (ja) 2017-06-30 2020-10-22 コデクシス， インコーポレイテッド Ｔ７ ｒｎａポリメラーゼバリアント
US20200181542A1 (en) 2017-06-30 2020-06-11 Novozymes A/S Enzyme Slurry Composition
KR102773542B1 (ko) 2017-06-30 2025-02-25 코덱시스, 인코포레이티드 T7 rna 폴리머라제 변이체
EP4085919A3 (en) 2017-07-21 2023-02-08 Novartis AG Compositions and methods to treat cancer
KR102683528B1 (ko) 2017-07-24 2024-07-10 노보자임스 에이/에스 습식 제분에서의 gh5 및 gh30
US11261458B2 (en) 2017-07-28 2022-03-01 Two Blades Foundation Potyvirus resistance genes and methods of use
EP4230642A2 (en) 2017-08-03 2023-08-23 Agbiome, Inc. Pesticidal genes and methods of use
CA3070281A1 (en) 2017-08-08 2019-02-14 Novozymes A/S Polypeptides having trehalase activity and the use thereof in process of producing fermentation products
US11634400B2 (en) 2017-08-19 2023-04-25 University Of Rochester Micheliolide derivatives, methods for their preparation and their use as anticancer and antiinflammatory agents
EP3673056A1 (en) 2017-08-24 2020-07-01 Henkel AG & Co. KGaA Detergent compositions comprising gh9 endoglucanase variants ii
CN111344404A (zh) 2017-08-24 2020-06-26 诺维信公司 黄原胶裂解酶变体以及编码其的多核苷酸
WO2019038058A1 (en) 2017-08-24 2019-02-28 Novozymes A/S GH9 ENDOGLUCANASE VARIANTS AND POLYNUCLEOTIDES ENCODING SUCH VARIANTS
US20210130744A1 (en) 2017-08-24 2021-05-06 Henkel Ag & Co. Kgaa Detergent composition comprising xanthan lyase variants ii
AU2018322748B2 (en) 2017-08-29 2024-05-02 Novozymes A/S Baker's yeast expressing anti-staling/freshness amylases
HUE072278T2 (hu) 2017-08-31 2025-11-28 Novozymes As D-pszikóz-3-epimeráz aktivitású polipeptidek és ezeket kódoló polinukleotidok
US20200196633A1 (en) 2017-09-01 2020-06-25 Novozymes A/S Animal Feed Additives Comprising Polypeptide Having Protease Activity and Uses Thereof
WO2019046703A1 (en) 2017-09-01 2019-03-07 Novozymes A/S METHODS OF ENHANCING GENOME EDITION IN FUNGI
CN111050566A (zh) 2017-09-01 2020-04-21 诺维信公司 包含具有蛋白酶活性的多肽的动物饲料添加剂及其用途
WO2019052907A2 (en) 2017-09-07 2019-03-21 Total Raffinage Chimie METHOD FOR DETECTING THE HYDROGEN PEROXIDE CONVERSION ACTIVITY OF AN ENZYME
WO2019047199A1 (en) 2017-09-11 2019-03-14 Danisco Us Inc. GLUCOAMYLASE AND METHODS OF USE THEREOF
BR112020006045A2 (pt) 2017-09-25 2020-10-06 Pioneer Hi-Bred International, Inc. molécula de ácido nucleico, cassete de expressão, vetor, célula vegetal, planta, semente da planta, método para produzir uma planta transgênica, planta transgênica, semente da planta transgênica, método para aprimorar a eficiência de maturação de embrião somático e método para produzir uma planta dicotiledônea transgênica ou uma planta gimnosperma transgênica
BR112020005803A2 (pt) 2017-09-25 2020-12-01 Agrospheres, Inc. composições e métodos para produção e administração moduláveis de produtos biológicos
MX2020003779A (es) 2017-09-27 2020-08-03 Procter & Gamble Composiciones detergentes que comprenden lipasas.
CN118910005A (zh) 2017-09-27 2024-11-08 诺维信公司 脂肪酶变体和包含此类脂肪酶变体的微囊组合物
US11746310B2 (en) 2017-10-02 2023-09-05 Novozymes A/S Polypeptides having mannanase activity and polynucleotides encoding same
CN111373036A (zh) 2017-10-02 2020-07-03 诺维信公司 具有甘露聚糖酶活性的多肽和编码它们的多核苷酸
WO2019070883A1 (en) 2017-10-04 2019-04-11 Novozymes A/S POLYPEPTIDES WITH PROTEASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME
US20200165626A1 (en) 2017-10-13 2020-05-28 Pioneer Hi-Bred International, Inc. Virus-induced gene silencing technology for insect control in maize
WO2019079629A1 (en) 2017-10-18 2019-04-25 Ascus Biosciences, Inc. IMPROVING POULTRY PRODUCTION BY ADMINISTERING A SYNTHETIC BIO-ASSEMBLY OF MICROBES OR PURIFIED STEM THEREFOR
WO2019083818A1 (en) 2017-10-23 2019-05-02 Novozymes A/S IMPROVING EXPRESSION OF PROTEASE BY CO-EXPRESSION WITH PROPEPTIDE
KR20200074982A (ko) 2017-10-25 2020-06-25 다 볼떼라 베타-락타마아제 변이체
WO2019081983A1 (en) 2017-10-25 2019-05-02 Novartis Ag CD32B TARGETING ANTIBODIES AND METHODS OF USE
WO2019081724A1 (en) 2017-10-27 2019-05-02 Novozymes A/S VARIANTS OF DNASE
PL3476936T3 (pl) 2017-10-27 2022-04-11 The Procter & Gamble Company Kompozycje detergentu zawierające odmiany polipeptydowe
WO2019089402A1 (en) 2017-10-30 2019-05-09 Dow Agrosciences Llc Plant promoter for transgene expression
DE102017125558A1 (de) 2017-11-01 2019-05-02 Henkel Ag & Co. Kgaa Reinigungszusammensetzungen, die dispersine i enthalten
DE102017125559A1 (de) 2017-11-01 2019-05-02 Henkel Ag & Co. Kgaa Reinigungszusammensetzungen, die dispersine ii enthalten
DE102017125560A1 (de) 2017-11-01 2019-05-02 Henkel Ag & Co. Kgaa Reinigungszusammensetzungen, die dispersine iii enthalten
SG11202003094PA (en) 2017-11-07 2020-05-28 Codexis Inc Transglutaminase variants
KR20200095472A (ko) 2017-11-10 2020-08-10 디펜신 테라퓨틱스 에이피에스 조산아에서의 점막 방어 및 장/폐 기능의 성숙화
EP3707252A1 (en) 2017-11-10 2020-09-16 Novozymes A/S Temperature-sensitive cas9 protein
CN111989400B (zh) 2017-11-14 2024-05-24 丹尼斯科美国公司 α-淀粉酶、组合物和方法
EP3625361A1 (en) 2017-11-15 2020-03-25 10X Genomics, Inc. Functionalized gel beads
WO2019099908A1 (en) 2017-11-17 2019-05-23 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019096903A1 (en) 2017-11-20 2019-05-23 Novozymes A/S New galactanases (ec 3.2.1.89) for use in soy processing
KR20200097251A (ko) 2017-11-24 2020-08-18 디펜신 테라퓨틱스 에이피에스 디펜신에 의한 이식편 대 숙주 질환의 예방 및 치료
WO2019108619A1 (en) 2017-11-28 2019-06-06 Two Blades Foundation Methods and compositions for enhancing the disease resistance of plants
US11725197B2 (en) 2017-12-04 2023-08-15 Novozymes A/S Lipase variants and polynucleotides encoding same
ES2954431T3 (es) 2017-12-08 2023-11-22 Novozymes As Variantes de alfa-amilasa y polinucleótidos que codifican las mismas
FI3720955T3 (fi) 2017-12-08 2023-09-05 Novozymes As Alfa-amylaasivariantteja ja niitä koodaavia polynukleotideja
AU2018383752B2 (en) 2017-12-13 2025-01-30 Codexis, Inc. Carboxyesterase polypeptides for amide coupling
CN111465688A (zh) 2017-12-13 2020-07-28 葛兰素史密斯克莱知识产权发展有限公司 羧酸酯酶催化剂
CN111630061B (zh) 2017-12-19 2025-02-18 先锋国际良种公司 杀昆虫多肽及其用途
WO2019125804A1 (en) 2017-12-20 2019-06-27 Basf Se Nucleases and methods for making and using them
WO2019122083A1 (en) 2017-12-22 2019-06-27 Novozymes A/S Wheat milling process and gh8 xylanases
US10907173B2 (en) 2017-12-22 2021-02-02 AgBiome, Inc. Pesticidal genes and methods of use
MX2020007394A (es) 2018-01-10 2020-09-03 Brightseed Inc Metodo para modular el metabolismo.
EP3737226A1 (en) 2018-01-12 2020-11-18 Two Blades Foundation Stem rust resistance genes and methods of use
MX2020007914A (es) 2018-01-29 2020-10-28 Novozymes As Microorganismos con uso de nitrogeno mejorado para produccion de etanol.
US20210071155A1 (en) 2018-02-08 2021-03-11 Novozymes A/S Lipase Variants and Compositions Thereof
US20210123033A1 (en) 2018-02-08 2021-04-29 Novozymes A/S Lipases, Lipase Variants and Compositions Thereof
BR112020016306A2 (pt) 2018-02-12 2020-12-15 Curators Of The University Of Missouri Gene (saur) suprarregulado pequeno de auxina para o melhoramento da arquitetura do sistema radicular da planta, tolerância ao encharcamento, resistência à seca, e rendimento
US20190264140A1 (en) 2018-02-28 2019-08-29 The Procter & Gamble Company Methods of cleaning
US11525151B2 (en) 2018-03-09 2022-12-13 Danisco Us Inc. Glucoamylases and methods of use, thereof
WO2019177976A1 (en) 2018-03-12 2019-09-19 Pioneer Hi-Bred International, Inc. Methods for plant transformation
EP3765185B1 (en) 2018-03-13 2023-07-19 Novozymes A/S Microencapsulation using amino sugar oligomers
CN112020302B9 (zh) 2018-03-14 2023-05-09 先锋国际良种公司 来自植物的杀昆虫蛋白及其使用方法
CA3092075A1 (en) 2018-03-14 2019-09-19 Pioneer Hi-Bred International, Inc. Insecticidal proteins from plants and methods for their use
WO2019183183A1 (en) 2018-03-20 2019-09-26 Zymergen Inc. A htp platform for the genetic engineering of chinese hamster ovary cells
PE20210313A1 (es) 2018-03-28 2021-02-12 Bristol Myers Squibb Co Proteinas de fusion interleucina-2/receptor alfa de interleucina-2 y metodos de uso
WO2019185726A1 (en) 2018-03-29 2019-10-03 Novozymes A/S Mannanase variants and polynucleotides encoding same
EP3774879B1 (en) 2018-03-30 2026-01-28 Amgen Inc. C-terminal antibody variants
US11530391B2 (en) 2018-04-06 2022-12-20 Braskem S.A. NADH-dependent enzyme mutants to convert acetone into isopropanol
EP3775271B1 (en) 2018-04-06 2025-03-12 10X Genomics, Inc. Systems and methods for quality control in single cell processing
CN112105729B (zh) 2018-04-09 2024-05-14 诺维信公司 具有α-淀粉酶活性的多肽以及编码它们的多核苷酸
US11566239B2 (en) 2018-04-19 2023-01-31 Novozymes A/S Stabilized cellulase variants
CN112272701B (zh) 2018-04-19 2024-05-14 诺维信公司 稳定化的纤维素酶变体
WO2019204584A1 (en) 2018-04-20 2019-10-24 AgBiome, Inc. Pesticidal proteins and methods of use
US11708571B2 (en) 2018-05-17 2023-07-25 Bp Corporation North America Inc. Production of 2-keto-3-deoxy-d-gluconic acid in filamentous fungi
WO2019226508A1 (en) 2018-05-22 2019-11-28 Pioneer Hi-Bred International, Inc. Plant regulatory elements and methods of use thereof
UY38247A (es) 2018-05-30 2019-12-31 Novartis Ag Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
BR112020022593A2 (pt) 2018-05-31 2021-02-09 Novozymes A/S método para tratar polpa de dissolução, polpa de dissolução, fibra têxtil ou celulose derivatizada, e, uso de uma monoxigenase lítica de polissacarídeo.
PE20210320A1 (es) 2018-06-01 2021-02-16 Novartis Ag Moleculas de union contra bcma y usos de las mismas
AU2019282149B2 (en) 2018-06-05 2025-08-21 Life Edit Therapeutics, Inc. RNA-guided nucleases and active fragments and variants thereof and methods of use
WO2019236848A1 (en) 2018-06-06 2019-12-12 Zymergen Inc. Manipulation of genes involved in signal transduction to control fungal morphology during fermentation and production
EP3807409A4 (en) 2018-06-12 2022-08-03 Codexis, Inc. Engineered tyrosine ammonia lyase
SG11202012529VA (en) 2018-06-27 2021-01-28 Boehringer Ingelheim Rcv Gmbh Means and methods for increased protein expression by use of transcription factors
WO2020002575A1 (en) 2018-06-28 2020-01-02 Novozymes A/S Polypeptides having pectin lyase activity and polynucleotides encoding same
EP3833747A1 (en) 2018-06-28 2021-06-16 Pioneer Hi-Bred International, Inc. Methods for selecting transformed plants
CA3105609A1 (en) 2018-07-04 2020-01-09 Danisco Us Inc Glucoamylases and methods of use, thereof
AU2019302422B2 (en) 2018-07-09 2022-08-04 Codexis, Inc. Engineered phosphopentomutase variant enzymes
JP7461658B2 (ja) 2018-07-09 2024-04-04 コデクシス， インコーポレイテッド 操作されたプリンヌクレオシドホスホリラーゼバリアント酵素
EP3821000A4 (en) 2018-07-09 2022-07-20 Codexis, Inc. MANIPULATED GALACTOSE OXIDASE ENZYME VARIANTS
JP7491588B2 (ja) 2018-07-09 2024-05-28 コデクシス， インコーポレイテッド 操作されたパントテン酸キナーゼ改変体酵素
CN112673105A (zh) 2018-07-09 2021-04-16 科德克希思公司 工程化脱氧核糖磷酸醛缩酶
WO2020014306A1 (en) 2018-07-10 2020-01-16 Immunogen, Inc. Met antibodies and immunoconjugates and uses thereof
EP3820833A4 (en) 2018-07-12 2022-08-03 Codexis, Inc. MODIFIED AMMONIA-LYASE PHENYLALANINE POLYPEPTIDES
KR20250024129A (ko) 2018-07-20 2025-02-18 피에르 파브르 메디카먼트 Vista의 수용체
CN112601818A (zh) 2018-07-25 2021-04-02 诺维信公司 用于生产乙醇的表达酶的酵母
IL319918A (en) 2018-07-30 2025-05-01 Tate & Lyle Solutions Usa Llc Engineered glycosyltransferases and methods for glycosylation of steviol glycoside
EP3829608B1 (en) 2018-08-01 2024-01-10 Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Compositions comprising herpes simplex virus-1 for use in methods of treating and preventing cancer
CN112689677B (zh) 2018-08-29 2024-09-03 先锋国际良种公司 杀昆虫蛋白及其使用方法
US11473076B2 (en) 2018-08-31 2022-10-18 Novozymes A/S Animal feed additives and compositions comprising an S8 serine protease
EP3847263A1 (en) 2018-09-07 2021-07-14 Basf Plant Science Company GmbH Improved method for the production of high levels of pufa in plants
US12460221B2 (en) 2018-09-07 2025-11-04 Basf Plant Science Company Gmbh Method for the production of high levels of PUFA in plants
CA3110664A1 (en) 2018-09-07 2020-03-12 Basf Plant Science Company Gmbh Improved method for the production of high levels of pufa in plants
SG11202102851XA (en) 2018-09-27 2021-04-29 Celgene Corp SIRPa BINDING PROTEINS AND METHODS OF USE THEREOF
CN113056476A (zh) 2018-10-03 2021-06-29 诺维信公司 具有α-甘露聚糖降解活性的多肽以及编码它们的多核苷酸
WO2020076697A1 (en) 2018-10-08 2020-04-16 Novozymes A/S Enzyme-expressing yeast for ethanol production
UY38407A (es) 2018-10-15 2020-05-29 Novartis Ag Anticuerpos estabilizadores de trem2
JP7780186B2 (ja) 2018-10-29 2025-12-04 コデクシス， インコーポレイテッド 操作されたｄｎａポリメラーゼバリアント
EP3874037A4 (en) 2018-10-31 2021-12-15 Zymergen, Inc. DETERMINIST MULTIPLEXED SET OF DNA LIBRARIES
EP3874050A1 (en) 2018-10-31 2021-09-08 Pioneer Hi-Bred International, Inc. Compositions and methods for ochrobactrum-mediated plant transformation
EP3873532A1 (en) 2018-10-31 2021-09-08 Novartis AG Dc-sign antibody drug conjugates
EP3874051A1 (en) 2018-10-31 2021-09-08 Novozymes A/S Genome editing by guided endonuclease and single-stranded oligonucleotide
KR20210099614A (ko) 2018-12-04 2021-08-12 노파르티스 아게 Cd3에 대한 결합 분자 및 이의 용도
WO2020123463A1 (en) 2018-12-12 2020-06-18 Novozymes A/S Polypeptides having xylanase activity and polynucleotides encoding same
AU2019397401A1 (en) 2018-12-14 2021-06-17 Codexis, Inc. Engineered tyrosine ammonia lyase
MY207075A (en) 2018-12-20 2025-01-28 Codexis Inc Human alpha-galactosidase variants
EP3898962A2 (en) 2018-12-21 2021-10-27 Novozymes A/S Polypeptides having peptidoglycan degrading activity and polynucleotides encoding same
AU2019409132B2 (en) 2018-12-21 2026-08-06 Novartis Ag Antibodies to PMEL17 and conjugates thereof
CN113631704A (zh) 2018-12-27 2021-11-09 生命编辑制药股份有限公司 可用于基因编辑的多肽及使用方法
US10973885B2 (en) 2018-12-27 2021-04-13 Colgate-Palmolive Company Oral care compositions
WO2020142236A1 (en) 2019-01-02 2020-07-09 Intima Bioscience, Inc. Modified adeno-associated viral vectors for use in genetic engineering
CN113396218B (zh) 2019-01-15 2025-02-18 科德克希思公司 工程化转氨酶多肽
WO2020159445A1 (en) 2019-01-31 2020-08-06 Agency For Science, Technology And Research Cnx/erp57 inhibitor for use in the treatment or prevention of cancer
WO2020160126A1 (en) 2019-01-31 2020-08-06 Novozymes A/S Polypeptides having xylanase activity and use thereof for improving the nutritional quality of animal feed
WO2020185590A1 (en) 2019-03-08 2020-09-17 Zymergen Inc. Iterative genome editing in microbes
WO2020185584A1 (en) 2019-03-08 2020-09-17 Zymergen Inc. Pooled genome editing in microbes
CN113412333B (zh) 2019-03-11 2025-04-08 先锋国际良种公司 用于克隆植物生产的方法
BR112021018731A2 (pt) 2019-03-21 2021-12-21 Novozymes As Variantes de alfa-amilase e polinucleotídeos codificando as mesmas
JP7743308B2 (ja) 2019-03-27 2025-09-24 パイオニア ハイ－ブレッド インターナショナル， インコーポレイテッド 植物外稙片の形質転換
CA3131705A1 (en) 2019-03-27 2020-10-01 Umc Utrecht Holding B.V. Engineered iga antibodies and methods of use
CA3127173A1 (en) 2019-03-28 2020-10-01 Pioneer Hi-Bred International, Inc. Modified agrobacterium strains and use thereof for plant transformation
WO2020198731A2 (en) 2019-03-28 2020-10-01 Danisco Us Inc Engineered antibodies
CN113785039B (zh) 2019-04-03 2024-06-18 诺维信公司 具有β-葡聚糖酶活性的多肽、编码其的多核苷酸及其在清洁和洗涤剂组合物中的用途
US12247237B2 (en) 2019-04-10 2025-03-11 Novozymes A/S Polypeptide variants
MX2021012289A (es) 2019-04-12 2021-11-12 Novozymes As Variantes de glucosido hidrolasa estabilizadas.
EP3963057A4 (en) 2019-05-01 2023-06-14 Codexis, Inc. MANIPULATED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
US12215359B2 (en) 2019-05-01 2025-02-04 Codexis, Inc. Engineered glucose dehydrogenases and methods for the reductive amination of ketone and amine compounds
WO2020229191A1 (en) 2019-05-15 2020-11-19 Novozymes A/S Temperature-sensitive rna-guided endonuclease
UY38701A (es) 2019-05-21 2020-12-31 Novartis Ag Moléculas de unión a cd19, conjugados, composiciones que las comprenden y usos de las mismas
AU2020279224B2 (en) 2019-05-21 2024-12-05 Novartis Ag Trispecific binding molecules against BCMA and uses thereof
US12037378B2 (en) 2019-05-21 2024-07-16 Novartis Ag Variant CD58 domains and uses thereof
EP3986996A1 (en) 2019-06-24 2022-04-27 The Procter & Gamble Company Cleaning compositions comprising amylase variants
US20220251528A1 (en) 2019-06-24 2022-08-11 Novozymes A/S Alpha-Amylase Variants
US20220251595A1 (en) 2019-06-27 2022-08-11 Two Blades Foundation Engineered atrlp23 pattern recognition receptors and methods of use
EP3994255A1 (en) 2019-07-02 2022-05-11 Novozymes A/S Lipase variants and compositions thereof
KR20220025884A (ko) 2019-07-02 2022-03-03 코덱시스, 인코포레이티드 조작된 아세테이트 키나제 변이체 효소
AU2020300454A1 (en) 2019-07-02 2021-12-23 Codexis, Inc. Engineered sucrose phosphorylase variant enzymes
EP4004211A1 (en) 2019-07-25 2022-06-01 Novozymes A/S Filamentous fungal expression system
WO2021018751A1 (en) 2019-07-26 2021-02-04 Novozymes A/S Enzymatic treatment of paper pulp
MX2021015821A (es) 2019-07-26 2022-02-03 Novozymes As Microorganismos con transporte de nitrogeno mejorado para la produccion de etanol.
MX2022001225A (es) 2019-07-29 2022-03-17 Brightseed Inc Metodo para mejorar la salud digestiva.
MX2021015818A (es) 2019-08-06 2022-02-03 Novozymes As Proteinas de fusion para mejorar la expresion de enzimas.
CN118813654A (zh) 2019-08-12 2024-10-22 生命编辑制药股份有限公司 Rna指导的核酸酶及其活性片段及变体以及使用方法
CN114364795A (zh) 2019-08-22 2022-04-15 巴斯夫欧洲公司 淀粉酶变体
BR112022003705A2 (pt) 2019-08-30 2022-05-24 Codexis Inc Lipase recombinante, composição, sequência de polinucleotídeo recombinante, vetor de expressão, composição farmacêutica para o tratamento de insuficiência pancreática, célula hospedeira, métodos para produzir uma lipase recombinante e para tratar e/ou prevenir os sintomas de insuficiência pancreática, e, uso
CN114760980B (zh) 2019-09-12 2024-10-18 科德克希思公司 针对10-乙酰基-3,7-二羟基吩噁嗪的过氧化物酶活性
EP4031661A1 (en) 2019-09-16 2022-07-27 Novozymes A/S Polypeptides having beta-glucanase activity and polynucleotides encoding same
JP2022548881A (ja) 2019-09-18 2022-11-22 ノバルティス アーゲー Ｅｎｔｐｄ２抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法
TW202124446A (zh) 2019-09-18 2021-07-01 瑞士商諾華公司 與ｅｎｔｐｄ２抗體之組合療法
JP7739271B2 (ja) 2019-10-02 2025-09-16 アボット ダイアベティス ケア インコーポレイテッド タンパク質スイッチによる分析物の検出
EP4038170A1 (en) 2019-10-03 2022-08-10 Novozymes A/S Polypeptides comprising at least two carbohydrate binding domains
BR112022007119A2 (pt) 2019-10-14 2022-07-05 BASF Agricultural Solutions Seed US LLC Molécula de ácido nucleico, ácido nucleico, polipeptídeos, vetor, célula hospedeira, planta transgênica, semente transgênica, composição, métodos para controlar uma população de pragas, para matar uma praga, para produzir um polipeptídeo, para proteger uma planta e para aumentar o rendimento em uma planta, planta, uso do ácido nucleico e produto básico
MX2022004552A (es) 2019-10-14 2022-10-10 BASF Agricultural Solutions Seed US LLC Nuevos genes de resistencia a insectos y métodos de uso.
KR20220100896A (ko) 2019-11-11 2022-07-18 브라이트씨드, 인크. 추출물, 소모가능 생성물 및 추출물에서 생물활성 대사산물을 농후화하는 방법
EP3821946A1 (en) 2019-11-12 2021-05-19 Université de Strasbourg Anti-claudin-1 monoclonal antibodies for the prevention and treatment of fibrotic diseases
IL293038A (en) 2019-11-26 2022-07-01 Codexis Inc Biocatalysts and methods for hydroxylation of chemical compounds
CA3158982A1 (en) 2019-12-10 2021-06-17 Monica TASSONE Microorganism for improved pentose fermentation
EP4077699A1 (en) 2019-12-19 2022-10-26 Basf Se Increasing space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility in the production of fine chemicals
WO2021123184A2 (en) 2019-12-19 2021-06-24 Novozymes A/S Alpha-amylase variants
CN114761551B (zh) 2019-12-19 2025-09-12 诺维信公司 木聚糖酶变体和编码其的多核苷酸
EP4077622A1 (en) 2019-12-19 2022-10-26 The Procter & Gamble Company Cleaning compositions comprising polypeptides having alpha amylase activity
EP4077656A2 (en) 2019-12-20 2022-10-26 Novozymes A/S Polypeptides having proteolytic activity and use thereof
WO2021122528A1 (en) 2019-12-20 2021-06-24 Basf Se Decreasing toxicity of terpenes and increasing the production potential in micro-organisms
MX2022007399A (es) 2019-12-20 2022-09-19 Codexis Inc Variantes de alfa-glucosidasa ácida diseñadas.
EP4085133A1 (en) 2019-12-30 2022-11-09 Lifeedit Therapeutics, Inc. Rna-guided nucleases and active fragments and variants thereof and methods of use
CN115151643A (zh) 2020-01-10 2022-10-04 加利福尼亚大学董事会 用于产生橄榄醇酸和橄榄醇酸类似物的生物合成平台
US12665049B2 (en) * 2020-01-17 2026-06-23 AskBio, Inc. Systems and methods for synthetic regulatory sequence design or production
WO2021148278A1 (en) 2020-01-24 2021-07-29 Novozymes A/S Mutants of a filamentous fungal cell having increased productivity in the production of a polypeptide
EP4097226A1 (en) 2020-01-31 2022-12-07 Novozymes A/S Mannanase variants and polynucleotides encoding same
WO2021152123A1 (en) 2020-01-31 2021-08-05 Novozymes A/S Mannanase variants and polynucleotides encoding same
EP4103711A4 (en) 2020-02-04 2024-02-28 Codexis, Inc. Engineered leucine decarboxylases
WO2021163015A1 (en) 2020-02-10 2021-08-19 Novozymes A/S Process for producing ethanol from raw starch using alpha-amylase variants
MX2022009515A (es) 2020-02-10 2022-09-02 Novozymes As Variantes de alfa-amilasa y polinucleotidos que las codifican.
WO2021163030A2 (en) 2020-02-10 2021-08-19 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
WO2021163212A1 (en) 2020-02-10 2021-08-19 Native Microbials, Inc. Microbial compositions and methods of use for canine enteropathy and dysbiosis
EP4104179B1 (en) 2020-02-13 2026-01-28 10X Genomics, Inc. Systems and methods for joint interactive visualization of gene expression and dna chromatin accessibility
WO2021163637A1 (en) 2020-02-13 2021-08-19 Zymergen Inc. Metagenomic library and natural product discovery platform
US20230090771A1 (en) * 2020-02-21 2023-03-23 Regents Of The University Of Minnesota Novel methods for creating alpha-n-methylated polypeptides
EP4110909A1 (en) 2020-02-26 2023-01-04 Novozymes A/S Polypeptide variants
US20230203191A1 (en) 2020-03-30 2023-06-29 Danisco Us Inc Engineered antibodies
WO2021202463A1 (en) 2020-03-30 2021-10-07 Danisco Us Inc Anti-rsv antibodies
EP4133066A1 (en) 2020-04-08 2023-02-15 Novozymes A/S Carbohydrate binding module variants
CA3179679A1 (en) 2020-04-10 2021-10-14 Codexis, Inc. Carboxyesterase polypeptides for kinetic resolution
US11788071B2 (en) 2020-04-10 2023-10-17 Codexis, Inc. Engineered transaminase polypeptides
US12509670B2 (en) 2020-04-17 2025-12-30 Danisco Us Inc. Glucoamylase and methods of use thereof
CN115516071A (zh) 2020-04-21 2022-12-23 诺维信公司 包含具有果聚糖降解活性的多肽的清洁组合物
JP2023516226A (ja) 2020-04-24 2023-04-18 ライフエディット セラピューティクス，インコーポレイティド Ｒｎａ誘導型ヌクレアーゼとその活性な断片およびバリアント、ならびに利用の方法
US20230181756A1 (en) 2020-04-30 2023-06-15 Novartis Ag Ccr7 antibody drug conjugates for treating cancer
WO2021220218A1 (en) 2020-05-01 2021-11-04 Novartis Ag Immunoglobulin variants
US20230242647A1 (en) 2020-05-01 2023-08-03 Novartis Ag Engineered immunoglobulins
CA3173882A1 (en) 2020-05-11 2021-11-18 Alexandra Briner CRAWLEY Rna-guided nucleic acid binding proteins and active fragments and variants thereof and methods of use
EP4162061A1 (en) 2020-06-04 2023-04-12 Isobionics B.V. Synthetic santalene synthases
CR20220686A (es) 2020-06-17 2023-06-01 Bioconsortia Inc Microbios beneficiosos para la agricultura, composiciones microbianas y consorcios
US20230287383A1 (en) 2020-07-03 2023-09-14 Engenes Biotech Gmbh PYRROLYSYL-tRNA SYNTHETASE VARIANTS AND USES THEREOF
CN115867564A (zh) 2020-07-14 2023-03-28 先锋国际良种公司 杀昆虫蛋白及其使用方法
JP7890972B2 (ja) 2020-07-15 2026-07-15 ライフ エディット セラピューティクス，インコーポレイティド ウラシル安定化タンパク質並びにその活性断片及びバリアント並びに使用方法
JP7846667B2 (ja) 2020-07-16 2026-04-15 レジェンド バイオテック アイルランド リミテッド Ｃｄ２０結合分子及びその使用
CA3186065A1 (en) 2020-07-16 2022-01-20 Xiaohu FAN Cd19 binding molecules and uses thereof
US11479779B2 (en) 2020-07-31 2022-10-25 Zymergen Inc. Systems and methods for high-throughput automated strain generation for non-sporulating fungi
TW202212354A (zh) 2020-08-03 2022-04-01 美商健生生物科技公司 用於病毒治療劑中之多向生物運輸的材料及方法
CN116234816A (zh) 2020-08-10 2023-06-06 纳幕尔杜邦公司 用于在玉蜀黍中增强对北方叶枯病的抗性的组合物和方法
WO2022035649A1 (en) 2020-08-10 2022-02-17 Pioneer Hi-Bred International, Inc. Plant regulatory elements and methods of use thereof
JP2023537982A (ja) 2020-08-13 2023-09-06 ノボザイムス アクティーゼルスカブ フィターゼ変異体及びそれをコードするポリヌクレオチド
EP4200424A1 (en) 2020-08-18 2023-06-28 Novozymes A/S Dispersins expressed with amylase signal peptides
JP7885201B2 (ja) 2020-08-25 2026-07-06 ノボザイムス アクティーゼルスカブ ファミリー４４キシログルカナーゼの変異体
JP2023539634A (ja) 2020-08-28 2023-09-15 コデクシス， インコーポレイテッド 操作されたアミラーゼバリアント
AU2021334371A1 (en) 2020-08-28 2023-03-09 Codexis, Inc. Engineered protease variants
EP4204548A1 (en) 2020-08-28 2023-07-05 Novozymes A/S Polyester degrading protease variants
EP4211235A2 (en) 2020-09-11 2023-07-19 Lifeedit Therapeutics, Inc. Dna modifying enzymes and active fragments and variants thereof and methods of use
US20230365639A1 (en) 2020-09-14 2023-11-16 Aesculus Bio Aps Defensin fragment derived lipopeptides for treatment of drug-resistant microorganisms
CN116209754A (zh) 2020-09-28 2023-06-02 科德克希思公司 用于合成手性胺的工程化生物催化剂及方法
EP4222165A2 (en) 2020-09-30 2023-08-09 Pioneer Hi-Bred International, Inc. Rapid transformation of monocot leaf explants
CN116507725A (zh) 2020-10-07 2023-07-28 诺维信公司 α-淀粉酶变体
CN116710558A (zh) 2020-10-07 2023-09-05 科德克希思公司 工程化磷酸戊糖变位酶变体酶
US20230407273A1 (en) 2020-10-13 2023-12-21 Novozymes A/S Glycosyltransferase variants for improved protein production
EP4237525A1 (en) 2020-10-28 2023-09-06 Novozymes A/S Use of lipoxygenase
WO2022090361A2 (en) 2020-10-29 2022-05-05 Novozymes A/S Lipase variants and compositions comprising such lipase variants
AU2021370998A1 (en) 2020-11-02 2023-05-25 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
US20240271175A1 (en) 2020-11-02 2024-08-15 Novozymes A/S Leader peptides and polynucleotides encoding the same
US20250215081A1 (en) 2020-11-06 2025-07-03 Novartis Ag Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies
AU2021373366A1 (en) 2020-11-06 2023-06-01 Novartis Ag Cd19 binding molecules and uses thereof
WO2022106400A1 (en) 2020-11-18 2022-05-27 Novozymes A/S Combination of immunochemically different proteases
WO2022106404A1 (en) 2020-11-18 2022-05-27 Novozymes A/S Combination of proteases
MX2023006010A (es) 2020-11-24 2023-06-08 Novartis Ag Anticuerpos anti-cd48, conjugados de anticuerpo-farmaco, y usos de los mismos.
US11780890B2 (en) 2020-11-24 2023-10-10 AgBiome, Inc. Pesticidal genes and methods of use
WO2022125960A1 (en) 2020-12-11 2022-06-16 Willow Biosciences, Inc. Recombinant acyl activating enzyme (aae) genes for enhanced biosynthesis of cannabinoids and cannabinoid precursors
US20240052000A1 (en) 2020-12-15 2024-02-15 Novozymes A/S Mutated host cells with reduced cell motility on
WO2022133289A2 (en) 2020-12-18 2022-06-23 Codexis, Inc. Engineered uridine phosphorylase variant enzymes
EP4015626A1 (en) 2020-12-18 2022-06-22 Isobionics B.V. Enzymes and methods for fermentative production of monoterpene esters
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
WO2023288294A1 (en) 2021-07-16 2023-01-19 Novozymes A/S Compositions and methods for improving the rainfastness of proteins on plant surfaces
US20240049721A1 (en) 2020-12-22 2024-02-15 Agrospheres, Inc. Compositions and methods for controlling fungi
US20250199010A1 (en) 2020-12-31 2025-06-19 Alamar Biosciences, Inc. Binder molecules with high affinity and/ or specificity and methods of making and use thereof
CN112725331B (zh) * 2021-01-25 2021-07-20 深圳市狂风生命科技有限公司 一种高通量突变体文库的构建方法
EP4284905A1 (en) 2021-01-28 2023-12-06 Novozymes A/S Lipase with low malodor generation
WO2022171780A2 (en) 2021-02-12 2022-08-18 Novozymes A/S Alpha-amylase variants
WO2022175440A1 (en) 2021-02-18 2022-08-25 Novozymes A/S Inactive heme polypeptides
EP4047088A1 (en) 2021-02-22 2022-08-24 Basf Se Amylase variants
EP4294917A1 (en) 2021-02-22 2023-12-27 Basf Se Amylase variants
EP4305146A1 (en) 2021-03-12 2024-01-17 Novozymes A/S Polypeptide variants
US20240060061A1 (en) 2021-03-15 2024-02-22 Novozymes A/S Dnase variants
EP4060036A1 (en) 2021-03-15 2022-09-21 Novozymes A/S Polypeptide variants
MX2023005793A (es) 2021-03-15 2023-05-29 Procter & Gamble Composiciones de limpieza que contienen variantes de polipeptido.
CA3173950A1 (en) 2021-03-22 2022-09-22 Tyson D. BOWEN Dna modifyng enzymes and active fragments and variants thereof and methods of use
WO2022199418A1 (en) 2021-03-26 2022-09-29 Novozymes A/S Detergent composition with reduced polymer content
EP4314261A1 (en) 2021-04-02 2024-02-07 Codexis, Inc. Engineered acetate kinase variant enzymes
IL305922A (en) 2021-04-02 2023-11-01 Codexis Inc Transgenic enzymes of variant guanylate kinase
US11913037B2 (en) 2021-04-02 2024-02-27 Codexis, Inc. Engineered adenylate kinase variant enzymes
WO2022212832A1 (en) 2021-04-02 2022-10-06 Codexis, Inc. Engineered cyclic gmp-amp synthase (cgas) variant enzymes
US20240180197A1 (en) 2021-04-12 2024-06-06 Novozymes A/S Method for producing a meat analogue product
AU2022258829A1 (en) 2021-04-16 2023-10-26 Novartis Ag Antibody drug conjugates and methods for making thereof
BR112023023044A2 (pt) 2021-05-06 2024-01-23 Agbiome Inc Genes pesticidas e métodos de uso
EP4336997A1 (en) 2021-05-11 2024-03-20 Two Blades Foundation Methods for preparing a library of plant disease resistance genes for functional testing for disease resistance
AU2022279241A1 (en) 2021-05-21 2023-11-30 Syntis Bio, Inc. Engineered methionine gamma lyase variants
CN117355608A (zh) 2021-05-27 2024-01-05 诺维信公司 转录调节物和编码其的多核苷酸
US20240247240A1 (en) 2021-05-28 2024-07-25 Merck Sharp & Dohme Llc Transaminase enzymes for the transamination of (1s,5r)-6,8-dioxabicyclo[3.2.1]octan-4-one
BR112023025624A2 (pt) 2021-06-07 2024-02-27 Novozymes As Célula de levedura recombinante, célula hospedeira recombinante, composição, cocultura, métodos de produção de um derivado de uma célula hospedeira recombinante e de produção de um produto de fermentação, e, uso de uma célula hospedeira recombinante
CA3173953A1 (en) 2021-06-11 2023-12-10 Tyson D. BOWEN Rna polymerase iii promoters and methods of use
CA3220135A1 (en) 2021-06-16 2022-12-22 Novozymes A/S Method for controlling slime in a pulp or paper making process
CN117730090A (zh) 2021-07-13 2024-03-19 诺维信公司 重组角质酶表达
WO2023010083A2 (en) 2021-07-30 2023-02-02 Willow Biosciences, Inc. Recombinant prenyltransferase polypeptides engineered for enhanced biosynthesis of cannabinoids
JP2024528957A (ja) 2021-08-02 2024-08-01 ビーエーエスエフ ソシエタス・ヨーロピア イオニリデンエタンシンターゼによる新規な芳香化合物の生成
WO2023023621A1 (en) 2021-08-19 2023-02-23 Willow Biosciences, Inc. Recombinant olivetolic acid cyclase polypeptides engineered for enhanced biosynthesis of cannabinoids
AU2022356378A1 (en) 2021-09-30 2024-05-02 Two Blades Foundation Plant disease resistance genes against stem rust and methods of use
US20240417709A1 (en) 2021-10-12 2024-12-19 Novozymes A/S Endoglucanase with improved stability
WO2023064938A1 (en) 2021-10-15 2023-04-20 Codexis, Inc. Engineered dna polymerase variants
WO2023069865A1 (en) 2021-10-15 2023-04-27 Codexis, Inc. Engineered terminal deoxynucleotidyl transferase variants
PE20241343A1 (es) 2021-10-15 2024-07-03 Cytomx Therapeutics Inc Complejo polipeptidico activable
US20230174995A1 (en) 2021-10-15 2023-06-08 Cytomx Therapeutics, Inc. Activatable polypeptide complex
CA3234874A1 (en) 2021-10-15 2023-04-20 Martijn Scheffers Glucoamylase variants and methods for use thereof
WO2023064955A1 (en) 2021-10-15 2023-04-20 Cytomx Therapeutics, Inc. Activatable anti-cd3, anti-egfr, heteromultimeric bispecific polypeptide complex
WO2023069921A1 (en) 2021-10-19 2023-04-27 Epimeron Usa, Inc. Recombinant thca synthase polypeptides engineered for enhanced biosynthesis of cannabinoids
JP2024540358A (ja) 2021-11-01 2024-10-31 シンティス バイオ，インコーポレイティド 工学操作ロイシン脱炭酸酵素
EP4444890A1 (en) 2021-12-07 2024-10-16 Agbiome, Inc. Pesticidal genes and methods of use
WO2023104846A1 (en) 2021-12-10 2023-06-15 Novozymes A/S Improved protein production in recombinant bacteria
WO2023118436A1 (en) 2021-12-22 2023-06-29 Novozymes A/S Method of producing a milk-based product
WO2023118565A1 (en) 2021-12-23 2023-06-29 Novozymes A/S Reduction of residual dna in microbial fermentation products
UY40097A (es) 2022-01-07 2023-07-14 Johnson & Johnson Entpr Innovation Inc Materiales y métodos de proteínas de unión a il-1b
JP2025504898A (ja) 2022-01-24 2025-02-19 ライフエディット セラピューティクス，インコーポレイティド Ｒｎａ誘導型ヌクレアーゼ及びその活性断片及びバリアント、並びに使用方法
EP4476240A1 (en) 2022-02-10 2024-12-18 Novozymes A/S Improved expression of recombinant proteins
WO2023161245A1 (en) 2022-02-22 2023-08-31 Novozymes A/S Oral care composition comprising enzymes
CN118660951A (zh) 2022-03-02 2024-09-17 诺维信公司 木葡聚糖酶用于改善洗涤剂的可持续性的用途
EP4242303A1 (en) 2022-03-08 2023-09-13 Novozymes A/S Fusion polypeptides with deamidase inhibitor and deamidase domains
JP2025509233A (ja) 2022-03-08 2025-04-11 ノボザイムス アクティーゼルスカブ デアミダーゼ阻害剤及びデアミダーゼドメインを有する融合ポリペプチド
WO2023173084A1 (en) 2022-03-11 2023-09-14 University Of Rochester Cyclopeptibodies and uses thereof
JP2025510621A (ja) 2022-03-31 2025-04-15 青島清原化合物有限公司 モノアミン酸化酵素及びその応用
IL316174A (en) 2022-04-26 2024-12-01 Novartis Ag Multiple specific antibodies targeting IL-13 and IL-18
CN119053708A (zh) 2022-05-17 2024-11-29 诺维信公司 用于减少游离脂肪酸的方法
EP4544036A1 (en) 2022-06-21 2025-04-30 Novozymes A/S Mannanase variants and polynucleotides encoding same
WO2023247514A1 (en) 2022-06-22 2023-12-28 Novozymes A/S Recombinant mannanase expression
WO2023247664A2 (en) 2022-06-24 2023-12-28 Novozymes A/S Lipase variants and compositions comprising such lipase variants
EP4547210A1 (en) 2022-06-30 2025-05-07 Novozymes A/S Mutanases and oral care compositions comprising same
WO2024013727A1 (en) 2022-07-15 2024-01-18 Janssen Biotech, Inc. Material and methods for improved bioengineered pairing of antigen-binding variable regions
WO2024015953A1 (en) 2022-07-15 2024-01-18 Danisco Us Inc. Methods for producing monoclonal antibodies
JP2025525309A (ja) 2022-07-15 2025-08-05 ノボザイムス アクティーゼルスカブ デアミダーゼ阻害剤活性を有するポリペプチド
EP4311430A1 (en) 2022-07-28 2024-01-31 Limagrain Europe Chlorotoluron tolerance gene and methods of use thereof
WO2024026406A2 (en) 2022-07-29 2024-02-01 Vestaron Corporation Next Generation ACTX Peptides
JP2025526654A (ja) 2022-08-11 2025-08-15 ビーエーエスエフ ソシエタス・ヨーロピア プロテアーゼ、マンナナーゼ及び／又はセルラーゼを含む酵素組成物
WO2024033133A2 (en) 2022-08-11 2024-02-15 Basf Se Enzyme compositions comprising an amylase
AU2023323547A1 (en) 2022-08-12 2025-03-20 Life Edit Therapeutics, Inc. Rna-guided nucleases and active fragments and variants thereof and methods of use
WO2024040020A1 (en) 2022-08-15 2024-02-22 Absci Corporation Quantitative affinity activity specific cell enrichment
WO2024044596A1 (en) 2022-08-23 2024-02-29 AgBiome, Inc. Pesticidal genes and methods of use
WO2024042489A1 (en) 2022-08-25 2024-02-29 LifeEDIT Therapeutics, Inc. Chemical modification of guide rnas with locked nucleic acid for rna guided nuclease-mediated gene editing
CN119948159A (zh) 2022-09-15 2025-05-06 诺维信公司 真菌信号肽
IL320573A (en) 2022-11-04 2025-07-01 Life Edit Therapeutics Inc Developed adenine deaminases and RNA-guided nuclease fusion proteins with internal insertion sites and methods of use
WO2024118901A2 (en) 2022-11-30 2024-06-06 Novozymes A/S Carbonic anhydrase variants and polynucleotides encoding same
CN120989059A (zh) 2022-12-05 2025-11-21 诺维信公司 蛋白酶变体以及编码其的多核苷酸
WO2024120767A1 (en) 2022-12-05 2024-06-13 Novozymes A/S Modified rna polymerase activities
WO2024121191A1 (en) 2022-12-06 2024-06-13 Novozymes A/S Method for producing a meat analogue product involving protein-deamidase
EP4629838A1 (en) 2022-12-08 2025-10-15 Novozymes A/S Polypeptide having lysozyme activity and polynucleotides encoding same
EP4629835A1 (en) 2022-12-08 2025-10-15 Novozymes A/S Fiber-degrading enzymes for animal feed comprising an oil seed material
AR131334A1 (es) 2022-12-13 2025-03-12 Ag Biome Inc Genes plaguicidas y métodos de uso
EP4634355A1 (en) 2022-12-14 2025-10-22 Novozymes A/S Improved lipase (gcl1) variants
CN120322453A (zh) 2022-12-14 2025-07-15 诺维信公司 高强度液体蛋白酶配制品
WO2024127369A1 (en) 2022-12-16 2024-06-20 LifeEDIT Therapeutics, Inc. Guide rnas that target foxp3 gene and methods of use
WO2024127370A1 (en) 2022-12-16 2024-06-20 LifeEDIT Therapeutics, Inc. Guide rnas that target trac gene and methods of use
WO2024126811A1 (en) 2022-12-16 2024-06-20 Boehringer Ingelheim Rcv Gmbh & Co Kg Means and methods for increased protein expression by use of a combination of transport proteins and either chaperones or transcription factors
EP4634395A1 (en) 2022-12-16 2025-10-22 Basf Se New ethylenediamine-n,n'-disuccinic acid (edds) synthases
CN120283060A (zh) 2022-12-19 2025-07-08 诺维信公司 用于使用纤维降解酶和工程化酵母生产发酵产物的工艺
EP4638725A1 (en) 2022-12-19 2025-10-29 Novozymes A/S Carbohydrate esterase family 3 (ce3) polypeptides having acetyl xylan esterase activity and polynucleotides encoding same
CN120380140A (zh) 2022-12-19 2025-07-25 诺维信公司 具有阿魏酸酯酶和/或乙酰木聚糖酯酶活性的碳水化合物酯酶家族1（ce1）多肽和编码其的多核苷酸
AU2023411890A1 (en) 2022-12-19 2025-06-26 Basf Agricultural Solutions Us Llc Single-cell methods for the discovery of disease resistance leads
AU2023408197A1 (en) 2022-12-19 2025-06-26 Basf Agricultural Solutions Us Llc Insect toxin genes and methods for their use
WO2024133344A1 (en) 2022-12-20 2024-06-27 Novozymes A/S A method for providing a candidate biological sequence and related electronic device
EP4389864A1 (en) 2022-12-20 2024-06-26 Basf Se Cutinases
WO2024133497A1 (en) 2022-12-21 2024-06-27 Novozymes A/S Recombinant protease for cell detachment
EP4389865A1 (en) 2022-12-21 2024-06-26 Novozymes A/S Recombinant protease for cell detachment
AU2023410701A1 (en) 2022-12-21 2025-05-22 Novo Nordisk Pharmatech A/S Microbial proteases for cell detachment
EP4389886A1 (en) 2022-12-22 2024-06-26 Novozymes A/S Lactase enzymes and method of producing a milk-based product
IL322082A (en) 2023-01-12 2025-09-01 Novartis Ag Engineered ketoreductase polypeptides
CN120435539A (zh) 2023-01-23 2025-08-05 诺维信公司 清洁组合物及其用途
CN120417880A (zh) 2023-02-22 2025-08-01 诺维信公司 包含转化酶的口腔护理组合物
EP4695394A1 (en) 2023-04-12 2026-02-18 Life Edit Therapeutics, Inc. Compositions and methods for the treatment of huntington's disease by editing the mutant huntingtin gene
AU2024303961A1 (en) 2023-06-13 2025-12-11 Novozymes A/S Processes for producing fermentation products using engineered yeast expressing a beta-xylosidase
EP4735563A1 (en) 2023-06-28 2026-05-06 Novozymes A/S Detergent composition comprising lipases
WO2025008364A1 (en) 2023-07-05 2025-01-09 Novozymes A/S Methods for obtaining plant-based ready-to-drink coffee or tea beverages
AU2024289271A1 (en) 2023-07-05 2025-11-27 Novozymes A/S Foamable dairy products
EP4273249A3 (en) 2023-07-07 2024-05-22 Novozymes A/S Improved expression of recombinant proteins
JP2026522972A (ja) 2023-07-07 2026-07-09 ビーエーエスエフ アグリカルチュラル ソリューションズ ユーエス エルエルシー 線虫有害生物を防除するためのｃｒｙ遺伝子の使用
CN121464215A (zh) 2023-07-10 2026-02-03 诺维信公司 人工信号肽
EP4743480A1 (en) 2023-07-15 2026-05-20 Two Blades Foundation Broad-spectrum polerover gene
EP4750890A2 (en) 2023-07-27 2026-06-03 Life Edit Therapeutics, Inc. Rna-guided nucleases and active fragments and variants thereof and methods of use
WO2025034544A1 (en) 2023-08-04 2025-02-13 Genective Sa Insecticidal proteins compositions and methods of use
WO2025032096A1 (en) 2023-08-09 2025-02-13 Novozymes A/S Methods for obtaining a plant-based food ingredient
AU2024325961A1 (en) 2023-08-15 2026-01-29 Novozymes A/S Polypeptides having alkaline phosphatase activity for animal feed
CN121620590A (zh) 2023-09-01 2026-03-06 诺维信公司 稳定的液体脱酰胺酶组合物
EP4777622A1 (en) 2023-09-13 2026-07-22 Novozymes A/S Stabilized deamidase compositions
EP4780251A1 (en) 2023-09-19 2026-07-29 Novozymes A/S Methods for evaluating protein substrate gelling by microbial transglutaminase
WO2025061911A1 (en) 2023-09-22 2025-03-27 Glaxosmithkline Intellectual Property Development Limited Methods of producing nucleotide triphosphates (ntps)
WO2025068117A1 (en) 2023-09-26 2025-04-03 Novozymes A/S Using protein deamidase in processes for obtaining a seed-based dairy alternative beverage with improved stability
US20250109187A1 (en) 2023-09-28 2025-04-03 Novavax, Inc. ANTI-SARS-CoV-2 SPIKE (S) ANTIBODIES AND THEIR USE IN TREATING COVID-19
WO2024240965A2 (en) 2023-09-29 2024-11-28 Novozymes A/S Droplet-based screening method
CN122422501A (zh) 2023-10-18 2026-07-17 生命编辑治疗股份有限公司 Rna引导的核酸酶及其活性片段和变体以及使用方法
CN122029266A (zh) 2023-10-24 2026-05-12 诺维信公司 木葡聚糖酶用于替代光学增亮剂的用途
KR20260096857A (ko) 2023-10-27 2026-06-24 바스프 아그리컬쳐럴 솔루션즈 유에스 엘엘씨 선충 해충의 방제를 위한 신규 유전자의 사용
WO2025103765A1 (en) 2023-11-17 2025-05-22 Novozymes A/S Lytic polysaccharide monooxygenases and their use in detergent
WO2025111274A2 (en) 2023-11-20 2025-05-30 Novozymes A/S Epimerase variants and polynucleotides encoding same
CN122270290A (zh) 2023-11-30 2026-06-23 诺维信公司 包含肽酶或内酯酶的口腔护理组合物
WO2025133162A1 (en) 2023-12-20 2025-06-26 Novozymes A/S Recombinant protein expression
WO2025132815A1 (en) 2023-12-20 2025-06-26 Novozymes A/S Novel cas nucleases and polynucleotides encoding the same
WO2025132872A1 (en) 2023-12-20 2025-06-26 Novozymes A/S Modified leguminous protein with improved colloidal stability
CN122374461A (zh) 2023-12-22 2026-07-10 诺维信公司 发酵方法
WO2025144700A1 (en) 2023-12-27 2025-07-03 Absci Corporation Nanobody library screening using bacterial surface display
WO2025140303A1 (en) 2023-12-28 2025-07-03 Novozymes A/S Enzymatic treatment of a material comprising corn protein
WO2025155521A1 (en) 2024-01-18 2025-07-24 Pivot Bio, Inc. Host cells for enhanced plant growth
WO2025155518A1 (en) 2024-01-18 2025-07-24 Pivot Bio, Inc. Host cells for enhanced plant growth
WO2025168806A1 (en) 2024-02-08 2025-08-14 Novozymes A/S Polypeptides having carbonic anhydrase activity and polynucleotides encoding same
WO2025174908A1 (en) 2024-02-12 2025-08-21 Life Edit Therapeutics, Inc. Novel rna-guided nucleases and proteins for polymerase editing
WO2025178772A1 (en) 2024-02-23 2025-08-28 Genective Sa Insecticidal proteins compositions and methods of use
WO2025189007A1 (en) 2024-03-07 2025-09-12 The Regents Of The University Of California Defining a caffeine demethylation system for improved decaffeination
WO2025191164A2 (en) 2024-03-12 2025-09-18 Novozymes A/S Use of chymopapain in cell detachment
WO2025193453A1 (en) 2024-03-14 2025-09-18 Genective Sa Insecticidal proteins compositions and methods of use
AU2025239494A1 (en) 2024-03-22 2026-06-25 Novozymes A/S Oral care compositions comprising dnases
WO2025217017A1 (en) 2024-04-08 2025-10-16 Novozymes A/S Compositions and methods for increasing phosphorous availability
WO2025226596A1 (en) 2024-04-24 2025-10-30 Novozymes A/S Methods for producing secreted polypeptides
WO2025229230A1 (en) 2024-05-03 2025-11-06 Novozymes A/S Combined carbon capture and soda ash process
WO2025235515A1 (en) 2024-05-07 2025-11-13 Cytomx Therapeutics, Inc. Activatable polypeptide complex formulations
WO2025235220A1 (en) 2024-05-08 2025-11-13 Genective Sa Insecticidal proteins compositions and methods of use
WO2025235589A1 (en) 2024-05-08 2025-11-13 Codexis, Inc. Dna polymerase variants
WO2025233391A1 (en) 2024-05-09 2025-11-13 Novozymes A/S Stabilized liquid deamidase compositions
WO2025233389A1 (en) 2024-05-09 2025-11-13 Novozymes A/S Stabilized liquid deamidase compositions
EP4650443A1 (en) 2024-05-13 2025-11-19 Novozymes A/S Stabilized liquid deamidase compositions
WO2025242320A1 (en) 2024-05-21 2025-11-27 Novozymes A/S Stabilized ready-to-drink coffee beverages
WO2025242702A1 (en) 2024-05-23 2025-11-27 Glaxosmithkline Intellectual Property Development Limited Enzymatic process for producing n-acetyl galactosamine clusters
WO2025247765A1 (en) 2024-05-30 2025-12-04 Chr. Hansen A/S Non-heated fermented meat analogue product prepared with vegetable protein transglutaminase and pediococcus strains
WO2025257254A1 (en) 2024-06-12 2025-12-18 Novozymes A/S Lipases and lipase variants and the use thereof
WO2025264584A1 (en) 2024-06-20 2025-12-26 Genective Sa Insecticidal proteins, compositions and methods of use
WO2025264577A1 (en) 2024-06-20 2025-12-26 Genective Sa Insecticidal proteins, compositions and methods of use
WO2026006045A1 (en) 2024-06-25 2026-01-02 Genective Sa Insecticidal proteins, compositions and methods of use
TW202617985A (zh) 2024-06-25 2026-05-01 美商生命編輯治療學公司 新穎反轉錄酶及其用途
WO2026010930A1 (en) 2024-07-05 2026-01-08 BASF Agricultural Solutions Seed US LLC Use of axmi277 for the control of rotylenchulus reniformis nematode pests
WO2026017381A1 (en) 2024-07-17 2026-01-22 Novozymes A/S Optimized bacillus host cells
WO2024254620A2 (en) 2024-08-01 2024-12-12 Novozymes A/S Protease for diagnostics
WO2026043743A1 (en) 2024-08-21 2026-02-26 Genective Sa Insecticidal proteins compositions and methods of use
WO2026055006A2 (en) 2024-09-03 2026-03-12 Genective Sa Insecticidal proteins compositions and methods of use
US20260167709A1 (en) 2024-09-11 2026-06-18 Novartis Ag Antibodies targeting il-31
WO2026068782A1 (en) 2024-09-30 2026-04-02 Novozymes A/S Protease variants and polynucleotides encoding same
WO2026076007A1 (en) 2024-10-04 2026-04-09 Genective Sa Insecticidal proteins compositions and methods of use
WO2026076952A1 (en) 2024-10-08 2026-04-16 Novozymes A/S Processes for obtaining dairy protein-based ready-to-drink beverages
WO2026099414A1 (en) 2024-11-08 2026-05-15 Novozymes A/S Method for producing gos syrup
WO2026104217A2 (en) 2024-11-12 2026-05-21 Basf Se Polypeptides having pectinase activity for use in cleaning compositions
WO2026109764A1 (en) 2024-11-22 2026-05-28 Novozymes A/S Stabilized solid formulation of antibodies
WO2026109480A1 (en) 2024-11-25 2026-05-28 Novozymes A/S Gh26 mannanases and their use in detergent
WO2026132184A1 (en) 2024-12-18 2026-06-25 Novozymes A/S Dispersin variants and their use in animal feed
WO2026131655A2 (en) 2024-12-18 2026-06-25 Basf Se Stable mannanase for blends
WO2026132220A1 (en) 2024-12-18 2026-06-25 Novozymes A/S Gastric stable dispersin variants
WO2026132030A1 (en) 2024-12-19 2026-06-25 Novozymes A/S Cas nucleases and polynucleotides encoding the same
WO2026131506A1 (en) 2024-12-20 2026-06-25 Basf Se Apolipoproteins for use in cleaning compositions
WO2026131444A1 (en) 2024-12-20 2026-06-25 Novozymes A/S Alpha-amylases, baking compositions and methods
WO2026131818A1 (en) 2024-12-20 2026-06-25 Basf Agricultural Solutions Us Llc Cell-based assay for determining pesticidal protein toxicity
WO2026139262A1 (en) 2024-12-23 2026-07-02 Basf Se Polypeptides having chitinase activity for use in cleaning compositions
WO2026159189A1 (en) 2025-01-24 2026-07-30 Novozymes A/S Method for producing hybrid meat
WO2026161157A1 (en) 2025-01-24 2026-07-30 Genective Sa Insecticidal proteins compositions and methods of use

Family Cites Families (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994379A (en) * 1983-03-09 1991-02-19 Cetus Corporation Modified signal peptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5422266A (en) 1984-12-31 1995-06-06 University Of Georgia Research Foundation, Inc. Recombinant DNA vectors capable of expressing apoaequorin
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5176995A (en) * 1985-03-28 1993-01-05 Hoffmann-La Roche Inc. Detection of viruses by amplification and hybridization
DE3587814T2 (de) 1985-03-30 1994-11-10 Marc Ballivet Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren.
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
US4959312A (en) 1985-05-31 1990-09-25 The University Of Tennessee Research Corporation Full spectrum mutagenesis
DE3688920D1 (de) * 1985-07-03 1993-09-30 Genencor Int Hybride Polypeptide und Verfahren zu deren Herstellung.
US5866363A (en) 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US4800159A (en) * 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
DK311186D0 (da) * 1986-06-30 1986-06-30 Novo Industri As Enzymer
US5824469A (en) * 1986-07-17 1998-10-20 University Of Washington Method for producing novel DNA sequences with biological activity
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
US4994367A (en) 1988-10-07 1991-02-19 East Carolina University Extended shelf life platelet preparations and process for preparing the same
FR2641793B1 (fr) * 1988-12-26 1993-10-01 Setratech Procede de recombinaison in vivo de sequences d'adn presentant des mesappariements de bases
DD282028A5 (de) 1989-02-16 1990-08-29 Akad Wissenschaften Ddr Verfahren zur herstellung einer thermostabilen, hybriden bacillus-beta-1,3-1,4-glukanase
US5043272A (en) * 1989-04-27 1991-08-27 Life Technologies, Incorporated Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers
US5106727A (en) * 1989-04-27 1992-04-21 Life Technologies, Inc. Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers
US5556750A (en) * 1989-05-12 1996-09-17 Duke University Methods and kits for fractionating a population of DNA molecules based on the presence or absence of a base-pair mismatch utilizing mismatch repair systems
CA2016841C (en) * 1989-05-16 1999-09-21 William D. Huse A method for producing polymers having a preselected activity
CA2016842A1 (en) * 1989-05-16 1990-11-16 Richard A. Lerner Method for tapping the immunological repertoire
IT1231157B (it) * 1989-07-20 1991-11-19 Crc Ricerca Chim Nuovi geni ibridi funzionali di bacillus thuringiensis ottenuti mediante ricombinazione in vivo.
US5574205A (en) 1989-07-25 1996-11-12 Cell Genesys Homologous recombination for universal donor cells and chimeric mammalian hosts
US5023171A (en) * 1989-08-10 1991-06-11 Mayo Foundation For Medical Education And Research Method for gene splicing by overlap extension using the polymerase chain reaction
WO1991006570A1 (en) * 1989-10-25 1991-05-16 The University Of Melbourne HYBRID Fc RECEPTOR MOLECULES
US5071743A (en) 1989-10-27 1991-12-10 Her Majesty The Queen In Right Of Canada, As Represented By The National Research Council Of Canada Process for conducting site-directed mutagenesis
DE3936258C1 (enExample) 1989-10-31 1991-04-25 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften Ev, 3400 Goettingen, De
AU6886991A (en) * 1989-11-08 1991-06-13 United States of America, as represented by the Secretary, U.S. Department of Commerce, The A method of synthesizing double-stranded dna molecules
CA2079802C (en) * 1990-04-05 2001-09-18 Roberto Crea Walk-through mutagenesis
EP0528881A4 (en) 1990-04-24 1993-05-26 Stratagene Methods for phenotype creation from multiple gene populations
US5877402A (en) 1990-05-01 1999-03-02 Rutgers, The State University Of New Jersey DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein
US5851813A (en) * 1990-07-12 1998-12-22 President And Fellows Of Harvard College Primate lentivirus antigenic compositions
US5571208A (en) 1990-07-13 1996-11-05 Caspers; Carl A. Reinforced prosthetic polyurethane hypobaric sleeve
EP0540693B1 (en) 1990-07-24 1999-01-20 F. Hoffmann-La Roche Ag THE REDUCTION OF NON-SPECIFIC AMPLIFICATION DURING $i(IN VITRO) NUCLEIC ACID AMPLIFICATION USING MODIFIED NUCLEIC ACID BASES
US5169764A (en) 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
EP0544809B1 (en) * 1990-08-24 1998-12-16 Ixsys, Inc. Methods of synthesizing oligonucleotides with random codons
US5264563A (en) * 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
IL99553A0 (en) * 1990-09-28 1992-08-18 Ixsys Inc Compositions containing oligonucleotides linked to expression elements,a kit for the preparation of vectors useful for the expression of a diverse population of random peptides and methods utilizing the same
US5871974A (en) * 1990-09-28 1999-02-16 Ixsys Inc. Surface expression libraries of heteromeric receptors
US5698426A (en) * 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
US5770434A (en) * 1990-09-28 1998-06-23 Ixsys Incorporated Soluble peptides having constrained, secondary conformation in solution and method of making same
US5858725A (en) * 1990-10-10 1999-01-12 Glaxo Wellcome Inc. Preparation of chimaeric antibodies using the recombinant PCR strategy
US5187083A (en) * 1990-11-13 1993-02-16 Specialty Laboratories, Inc. Rapid purification of DNA
US5234824A (en) * 1990-11-13 1993-08-10 Specialty Laboratories, Inc. Rapid purification of DNA
US5489523A (en) * 1990-12-03 1996-02-06 Stratagene Exonuclease-deficient thermostable Pyrococcus furiosus DNA polymerase I
IE914504A1 (en) * 1990-12-20 1992-07-01 Ixsys Optimization of binding proteins
DE4112440C1 (enExample) * 1991-04-16 1992-10-22 Diagen Institut Fuer Molekularbiologische Diagnostik Gmbh, 4000 Duesseldorf, De
US5795747A (en) * 1991-04-16 1998-08-18 Evotec Biosystems Gmbh Process for manufacturing new biopolymers
WO1992018846A1 (en) * 1991-04-17 1992-10-29 Bemis Manufacturing Company Method and apparatus for data point analysis
US5512463A (en) * 1991-04-26 1996-04-30 Eli Lilly And Company Enzymatic inverse polymerase chain reaction library mutagenesis
US5514568A (en) * 1991-04-26 1996-05-07 Eli Lilly And Company Enzymatic inverse polymerase chain reaction
EP0519338B1 (en) 1991-06-20 1996-08-28 F. Hoffmann-La Roche Ag Improved methods for nucleic acid amplification
WO1993000103A1 (en) * 1991-06-21 1993-01-07 The Wistar Institute Of Anatomy And Biology Chimeric envelope proteins for viral targeting
US5702931A (en) 1991-07-01 1997-12-30 Berlex Laboratories, Inc. Mutagenesis methods and compositions
US6071889A (en) 1991-07-08 2000-06-06 Neurospheres Holdings Ltd. In vivo genetic modification of growth factor-responsive neural precursor cells
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
GB9115364D0 (en) * 1991-07-16 1991-08-28 Wellcome Found Antibody
US5279952A (en) * 1991-08-09 1994-01-18 Board Of Regents, The University Of Texas System PCR-based strategy of constructing chimeric DNA molecules
JP3540315B2 (ja) * 1991-09-23 2004-07-07 メディカル リサーチ カウンシル キメラ抗体の製造−組合せアプローチ
GB9125979D0 (en) * 1991-12-06 1992-02-05 Wellcome Found Antibody
FR2685004A1 (fr) * 1991-12-11 1993-06-18 Pasteur Institut Procede de generation d'une diversite structurale et fonctionnelle dans une sequence peptidique.
JP3431146B2 (ja) * 1992-01-30 2003-07-28 ジェンザイム・リミテッド 改変した酵素によるキラル合成
US5773267A (en) 1992-02-07 1998-06-30 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University D29 shuttle phasmids and uses thereof
GB9202796D0 (en) * 1992-02-11 1992-03-25 Wellcome Found Antiviral antibody
US5843643A (en) 1992-02-21 1998-12-01 Ratner; Paul L. Site-specific transfection of eukaryotic cells using polypeptide-linked recombinant nucleic acid
CA2131389A1 (en) * 1992-03-02 1993-09-16 John M. Maraganore Thrombin receptor antagonists
EP1477558A1 (en) 1992-03-16 2004-11-17 WOHLSTADTER, Jacob Nathaniel Selection methods
EP0656941B1 (en) 1992-03-24 2005-06-01 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5316935A (en) 1992-04-06 1994-05-31 California Institute Of Technology Subtilisin variants suitable for hydrolysis and synthesis in organic media
JP3559559B2 (ja) 1992-06-03 2004-09-02 ジェネンテク，インコーポレイテッド 向上した治療特性を有する組織プラスミノーゲン活性化因子グリコシル化変異体
CA2115346A1 (en) * 1992-06-15 1993-12-23 John E. Shively Chimeric anti-cea antibody
AU684253B2 (en) * 1992-07-10 1997-12-11 Energy Biosystems Corporation Recombinant dna encoding a desulfurization biocatalyst
US6107062A (en) * 1992-07-30 2000-08-22 Inpax, Inc. Antisense viruses and antisense-ribozyme viruses
FR2694754B1 (fr) 1992-08-12 1994-09-16 Bio Merieux Fragments d'ADN de mycobactéries, amorces d'amplification, sondes d'hybridation, réactifs et procédé de détection de détection de mycobactéries.
CA2126967A1 (en) * 1992-11-04 1994-05-11 Anna M. Wu Novel antibody construct
DE69334261D1 (de) * 1992-11-10 2009-03-19 Applied Molecular Evolution Lösliche peptide, welche eine erzwungene sekundärstruktur in lösung haben und methode zur herstellung derselben
US5360728A (en) * 1992-12-01 1994-11-01 Woods Hole Oceanographic Institution (W.H.O.I.) Modified apoaequorin having increased bioluminescent activity
ATE199392T1 (de) * 1992-12-04 2001-03-15 Medical Res Council Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
US5571708A (en) 1993-04-19 1996-11-05 Bristol-Myers Squibb Company Thrombin-activatable plasminogen activator
IT1264712B1 (it) * 1993-07-13 1996-10-04 Eniricerche Spa Metodo di sintesi biologica di peptidi
US5498531A (en) 1993-09-10 1996-03-12 President And Fellows Of Harvard College Intron-mediated recombinant techniques and reagents
US5474920A (en) 1993-11-23 1995-12-12 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University Modified thermo-resistant DNA polymerases
US5556772A (en) * 1993-12-08 1996-09-17 Stratagene Polymerase compositions and uses thereof
DE4343591A1 (de) * 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5928905A (en) * 1995-04-18 1999-07-27 Glaxo Group Limited End-complementary polymerase reaction
US6165793A (en) 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6395547B1 (en) * 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5521077A (en) * 1994-04-28 1996-05-28 The Leland Stanford Junior University Method of generating multiple protein variants and populations of protein variants prepared thereby
EP0714980A1 (en) 1994-12-02 1996-06-05 Institut Pasteur Hypermutagenesis
WO1996017056A1 (en) 1994-12-02 1996-06-06 Institut Pasteur Hypermutagenesis
US5514588A (en) 1994-12-13 1996-05-07 Exxon Research And Engineering Company Surfactant-nutrients for bioremediation of hydrocarbon contaminated soils and water
US5629179A (en) * 1995-03-17 1997-05-13 Novagen, Inc. Method and kit for making CDNA library
US5824485A (en) * 1995-04-24 1998-10-20 Chromaxome Corporation Methods for generating and screening novel metabolic pathways
US5958672A (en) * 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US6004788A (en) 1995-07-18 1999-12-21 Diversa Corporation Enzyme kits and libraries
US6168919B1 (en) 1996-07-17 2001-01-02 Diversa Corporation Screening methods for enzymes and enzyme kits
US6030779A (en) 1995-07-18 2000-02-29 Diversa Corporation Screening for novel bioactivities
US6057103A (en) 1995-07-18 2000-05-02 Diversa Corporation Screening for novel bioactivities
WO1997007205A1 (en) * 1995-08-11 1997-02-27 Novo Nordisk A/S Method for preparing polypeptide variants
US5962258A (en) 1995-08-23 1999-10-05 Diversa Corporation Carboxymethyl cellulase fromthermotoga maritima
FR2738840B1 (fr) 1995-09-19 1997-10-31 Rhone Poulenc Rorer Sa Souches de levures genetiquement modifiees
US6051409A (en) 1995-09-25 2000-04-18 Novartis Finance Corporation Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells
US5756316A (en) * 1995-11-02 1998-05-26 Genencor International, Inc. Molecular cloning by multimerization of plasmids
US6361974B1 (en) 1995-12-07 2002-03-26 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US5965408A (en) * 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US5962283A (en) 1995-12-07 1999-10-05 Diversa Corporation Transminases and amnotransferases
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
US6238884B1 (en) 1995-12-07 2001-05-29 Diversa Corporation End selection in directed evolution
US20030215798A1 (en) 1997-06-16 2003-11-20 Diversa Corporation High throughput fluorescence-based screening for novel enzymes
US5830696A (en) * 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
US6352842B1 (en) 1995-12-07 2002-03-05 Diversa Corporation Exonucease-mediated gene assembly in directed evolution
US5814473A (en) 1996-02-09 1998-09-29 Diversa Corporation Transaminases and aminotransferases
US6358709B1 (en) 1995-12-07 2002-03-19 Diversa Corporation End selection in directed evolution
DK0873398T3 (da) * 1996-01-10 2005-08-15 Novozymes As Fremgangsmåde til in vivo produktion af et mutantbibliotek i celler
US5942430A (en) 1996-02-16 1999-08-24 Diversa Corporation Esterases
US5958751A (en) 1996-03-08 1999-09-28 Diversa Corporation α-galactosidase
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
US5783431A (en) * 1996-04-24 1998-07-21 Chromaxome Corporation Methods for generating and screening novel metabolic pathways
US5789228A (en) 1996-05-22 1998-08-04 Diversa Corporation Endoglucanases
US5877001A (en) 1996-06-17 1999-03-02 Diverso Corporation Amidase
US5763239A (en) 1996-06-18 1998-06-09 Diversa Corporation Production and use of normalized DNA libraries
US5939300A (en) 1996-07-03 1999-08-17 Diversa Corporation Catalases
US6093873A (en) 1996-08-19 2000-07-25 Institut National De La Sante Et De La Recherche Medicale Genetically engineered mice containing alterations in the gene encoding RXR
US5834458A (en) 1996-10-09 1998-11-10 Eli Lilly And Company Heterocyclic compounds and their use
EP0948615B1 (en) * 1996-12-20 2004-12-15 Novozymes A/S In vivo recombination
US6326204B1 (en) * 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
EP1717322B1 (en) * 1997-01-17 2012-07-18 Codexis Mayflower Holdings, LLC Evolution of whole cells and organisms by recursive sequence recombination
KR20000076363A (ko) * 1997-03-18 2000-12-26 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 Ｄｎａ 라이브러리를 제조하기 위한 시험관내 방법
DK1015575T3 (da) * 1997-03-18 2010-08-23 Novozymes As Shuffling af heterologe DNA-sekvenser
DE69840382D1 (de) * 1997-03-18 2009-02-05 Novozymes As Methode zur herstellung einer bibliothek mittels dna-shuffling
US5948653A (en) 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
US6051049A (en) 1997-05-29 2000-04-18 Exothermic Distribution Corporation Utilization of strontium aluminate in steelmaking
US5948666A (en) 1997-08-06 1999-09-07 Diversa Corporation Isolation and identification of polymerases
US5876997A (en) 1997-08-13 1999-03-02 Diversa Corporation Phytase
IL136574A0 (en) 1997-12-08 2001-06-14 California Inst Of Techn A method for forming a polynucleotide of desired properties
US6087341A (en) 1998-02-12 2000-07-11 The Board Of Trustees Of The Leland Standford Junior University Introduction of nucleic acid into skin cells by topical application
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
AU5134599A (en) 1998-07-28 2000-02-21 California Institute Of Technology Expression of functional eukaryotic proteins
JP2002522089A (ja) 1998-08-12 2002-07-23 マキシジェン， インコーポレイテッド 除草剤選択性作物を生成するためのｄｎａシャッフリング
AU1199000A (en) 1998-09-29 2000-04-17 Maxygen, Inc. Shuffling of codon altered genes
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6397053B1 (en) * 1999-12-30 2002-05-28 Koninklijke Philips Electronics N.V. (Kpenv) Reduction of power consumption with increased standby time in wireless communications device
US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants

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US6420175B1 (en) 2002-07-16
CA2182393C (en) 2005-05-17
EP1205547A3 (en) 2002-07-24
EP1205547A2 (en) 2002-05-15
US5811238A (en) 1998-09-22
EP0752008B2 (en) 2013-04-10
WO1995022625A1 (en) 1995-08-24
RU2157851C2 (ru) 2000-10-20
ATE211761T1 (de) 2002-01-15
AU703264B2 (en) 1999-03-25
US20100222237A1 (en) 2010-09-02
US20040241853A1 (en) 2004-12-02
US6576467B1 (en) 2003-06-10
JP2004254709A (ja) 2004-09-16
CA2182393A1 (en) 1995-08-24
JP3393848B2 (ja) 2003-04-07
US6132970A (en) 2000-10-17
AU2010200270A1 (en) 2010-02-18
JP2003033180A (ja) 2003-02-04
AU2971495A (en) 1995-09-04
US6287861B1 (en) 2001-09-11
US6297053B1 (en) 2001-10-02
JP3485560B2 (ja) 2004-01-13
US6602986B1 (en) 2003-08-05
CN1145641A (zh) 1997-03-19
DE1094108T1 (de) 2002-10-17
EP0752008A1 (en) 1997-01-08
JP2001057893A (ja) 2001-03-06
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US5830721A (en) 1998-11-03
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ATE216722T1 (de) 2002-05-15
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US7288375B2 (en) 2007-10-30
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US6277638B1 (en) 2001-08-21
US20080261833A1 (en) 2008-10-23
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