ATE286136T1 - Transformationsystem in filamentösen fungiziden chrysosporium-wirtszellen - Google Patents
Transformationsystem in filamentösen fungiziden chrysosporium-wirtszellenInfo
- Publication number
- ATE286136T1 ATE286136T1 AT99949459T AT99949459T ATE286136T1 AT E286136 T1 ATE286136 T1 AT E286136T1 AT 99949459 T AT99949459 T AT 99949459T AT 99949459 T AT99949459 T AT 99949459T AT E286136 T1 ATE286136 T1 AT E286136T1
- Authority
- AT
- Austria
- Prior art keywords
- chrysosporium
- filamentous
- transformation system
- sequences
- fungicide
- Prior art date
Links
- 241000123346 Chrysosporium Species 0.000 title abstract 4
- 230000009466 transformation Effects 0.000 title abstract 2
- 230000000855 fungicidal effect Effects 0.000 title 1
- 239000000417 fungicide Substances 0.000 title 1
- 230000002538 fungal effect Effects 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 241001674013 Chrysosporium lucknowense Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/248—Xylanases
- C12N9/2482—Endo-1,4-beta-xylanase (3.2.1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01004—Cellulase (3.2.1.4), i.e. endo-1,4-beta-glucanase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01008—Endo-1,4-beta-xylanase (3.2.1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01091—Cellulose 1,4-beta-cellobiosidase (3.2.1.91)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Radio Relay Systems (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP98/06496 | 1998-10-06 | ||
| PCT/NL1999/000618 WO2000020555A2 (en) | 1998-10-06 | 1999-10-06 | Transformation system in the field of filamentous fungal hosts: in chrysosporium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE286136T1 true ATE286136T1 (de) | 2005-01-15 |
Family
ID=8167095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99949459T ATE286136T1 (de) | 1998-10-06 | 1999-10-06 | Transformationsystem in filamentösen fungiziden chrysosporium-wirtszellen |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6573086B1 (de) |
| EP (1) | EP1117808B1 (de) |
| KR (1) | KR100618495B1 (de) |
| CN (1) | CN1230546C (de) |
| AT (1) | ATE286136T1 (de) |
| AU (1) | AU771539C (de) |
| BR (1) | BRPI9914278B1 (de) |
| CA (1) | CA2345356C (de) |
| DE (1) | DE69922978T2 (de) |
| DK (1) | DK1117808T3 (de) |
| EA (1) | EA005682B1 (de) |
| ES (1) | ES2237159T3 (de) |
| WO (1) | WO2000020555A2 (de) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7883872B2 (en) | 1996-10-10 | 2011-02-08 | Dyadic International (Usa), Inc. | Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose |
| ATE286136T1 (de) | 1998-10-06 | 2005-01-15 | Mark Aaron Emalfarb | Transformationsystem in filamentösen fungiziden chrysosporium-wirtszellen |
| ES2345075T3 (es) * | 1998-10-23 | 2010-09-14 | Meiji Seika Kaisha Ltd. | Endoglucanasas y preparaciones de celulasa que las contienen. |
| KR100312070B1 (ko) * | 1999-03-15 | 2001-11-03 | 박호군 | 고속 선별법을 포함하는 개선된 형질을 갖는 효소 변이체의 제조방법 |
| US7122330B2 (en) | 2000-04-13 | 2006-10-17 | Mark Aaron Emalfarb | High-throughput screening of expressed DNA libraries in filamentous fungi |
| AU782105B2 (en) * | 2000-04-13 | 2005-07-07 | Dyadic International (Usa), Inc. | Novel expression-regulating sequences and expression products in the field of filamentous fungi |
| DE60125534T2 (de) | 2000-05-22 | 2007-04-19 | Meiji Seika Kaisha Ltd. | Endoglukanase nce5 |
| DK2279755T3 (da) | 2001-10-10 | 2014-05-26 | Ratiopharm Gmbh | Remodellering og glycokonjugering af fibroblastvækstfaktor (FGF) |
| WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| FI118339B (fi) * | 2004-09-21 | 2007-10-15 | Ab Enzymes Oy | Uusi lakkaasientsyymi ja sen käyttö |
| EP2292747B1 (de) * | 2004-12-30 | 2017-01-25 | Danisco US Inc. | Cbh2-cellulasevarianten aus hypocrea jecorina |
| MX2008008225A (es) * | 2005-12-22 | 2008-10-01 | Ab Enzymes Oy | Nuevas enzimas. |
| US7256032B2 (en) | 2005-12-22 | 2007-08-14 | Ab Enzymes Oy | Enzymes |
| FI119325B (fi) * | 2005-12-22 | 2008-10-15 | Ab Enzymes Oy | Uusia endoglukanaasi polypeptidejä ja niiden tuotto ja käyttö |
| DK1999257T3 (da) | 2006-03-20 | 2011-10-31 | Novozymes Inc | Polypeptider, der har endo-glucosidaseaktivitet og polynukleotider, der koder for samme |
| DK2004819T3 (en) * | 2006-04-05 | 2015-10-05 | Danisco Us Inc | FILAMENTOUS FUNGI WITH REDUCED CONTENT OF UDP-GALACTOFURANOSE |
| WO2008008793A2 (en) * | 2006-07-10 | 2008-01-17 | Dyadic International Inc. | Methods and compositions for degradation of lignocellulosic material |
| US20080026376A1 (en) | 2006-07-11 | 2008-01-31 | Huaming Wang | KEX2 cleavage regions of recombinant fusion proteins |
| EP2102366A4 (de) | 2006-12-10 | 2010-01-27 | Dyadic International Inc | Expression und hochdurchsatz-screening komplexer exprimierter dna-bibliotheken bei fadenpilzen |
| US9862956B2 (en) | 2006-12-10 | 2018-01-09 | Danisco Us Inc. | Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi |
| DK2069491T3 (en) | 2007-05-10 | 2018-04-09 | Novozymes Inc | COMPOSITIONS AND PROCEDURES FOR IMPROVING THE DECOMPOSITION OR CONVERSION OF CELLULOSE SUBSTANCES |
| US7923236B2 (en) | 2007-08-02 | 2011-04-12 | Dyadic International (Usa), Inc. | Fungal enzymes |
| EP2197893B1 (de) * | 2007-09-07 | 2013-07-24 | Dyadic International, Inc. | Neue pilzenzyme |
| WO2010107303A2 (en) | 2009-03-16 | 2010-09-23 | Dyadic Nederland B.V. | New fungal production system |
| WO2010120557A1 (en) | 2009-03-31 | 2010-10-21 | Codexis, Inc. | Improved endoglucanases |
| WO2010129287A2 (en) | 2009-04-27 | 2010-11-11 | The Board Of Trustees Of The University Of Illinois | Hemicellulose-degrading enzymes |
| FI121712B (fi) * | 2009-04-30 | 2011-03-15 | Ab Enzymes Oy | Uusi sieniperäinen proteaasi ja sen käyttö |
| FI121711B (fi) | 2009-04-30 | 2011-03-15 | Ab Enzymes Oy | Sieniperäinen seriiniproteaasi ja sen käyttö |
| CA2765715A1 (en) | 2009-06-16 | 2010-12-23 | Codexis, Inc. | .beta.-glucosidase variants |
| FI121851B (fi) | 2009-07-08 | 2011-05-13 | Ab Enzymes Oy | Sieniperäinen proteaasi ja sen käyttö |
| JP5932648B2 (ja) | 2009-09-23 | 2016-06-15 | ダニスコ・ユーエス・インク | 新規なグリコシルヒドロラーゼ酵素及びその用途 |
| DK2483415T3 (en) | 2009-09-30 | 2015-02-09 | Codexis Inc | RECOMBINANT C1 B-glucosidase FOR MANUFACTURE OF sugars from cellulosic BIOMASS |
| US8652813B2 (en) | 2009-11-25 | 2014-02-18 | Codexis, Inc. | Recombinant Thermoascus aurantiacus β-glucosidase variants |
| MX2012006016A (es) | 2009-11-25 | 2012-06-25 | Codexis Inc | Variantes de beta-glucosidasa recombinante para produccion de azucares solubles de biomasa celulosica. |
| DE102009055015B4 (de) * | 2009-12-18 | 2013-12-24 | Technische Universität Dresden | Hefe-Sekretionssystem auf Basis einer Signalsequenz aus der Hydrophobin 1-Gensequenz von Trichoderma reesei |
| PH12012500999A1 (en) | 2009-12-23 | 2013-02-11 | Danisco Us Inc | Methods for improving the efficiency of simultaneous saccharification and fermentation reactions |
| FI122937B (fi) | 2009-12-30 | 2012-09-14 | Roal Oy | Menetelmä selluloosamateriaalin käsittelemiseksi sekä tässä käyttökelpoiset CBH II/Cel6A entsyymit |
| CN103080306B (zh) | 2010-08-20 | 2015-02-18 | 科德克希思公司 | 糖苷水解酶61家族蛋白在纤维素加工中的用途 |
| WO2012024662A2 (en) * | 2010-08-20 | 2012-02-23 | Codexis, Inc. | Expression constructs comprising fungal promoters |
| KR20130132416A (ko) * | 2010-10-20 | 2013-12-04 | 다니스코 유에스 인크. | 열안정성 트리코데르마 셀룰라아제 |
| FI123942B (fi) | 2010-10-29 | 2013-12-31 | Ab Enzymes Oy | Sieniperäisen seriiniproteaasin variantteja |
| ES2570382T3 (es) | 2010-11-02 | 2016-05-18 | Codexis Inc | Composiciones y métodos para la producción de azúcares fermentables |
| US9068235B2 (en) | 2010-11-02 | 2015-06-30 | Codexis, Inc. | Fungal strains |
| WO2012068236A2 (en) * | 2010-11-16 | 2012-05-24 | Dyadic International (Usa) Inc. | Novel fungal oxidoreductases |
| CN102154358B (zh) * | 2011-01-04 | 2013-07-10 | 深圳市绿微康生物工程有限公司 | 一种高效表达的产脂肪酶基因质粒的构建方法 |
| CN102154340B (zh) * | 2011-01-04 | 2013-07-10 | 深圳市绿微康生物工程有限公司 | 一种获得高效表达脂肪酶菌株的方法 |
| CN102154238A (zh) * | 2011-01-04 | 2011-08-17 | 深圳市绿微康生物工程有限公司 | 一种有效降低人体胆固醇、血脂水平的脂肪酶及其应用 |
| CN102154237A (zh) * | 2011-01-04 | 2011-08-17 | 深圳市绿微康生物工程有限公司 | 一种有效降低动物体内胆固醇、血脂水平的脂肪酶及其应用 |
| US20140073017A1 (en) | 2011-03-17 | 2014-03-13 | Danisco Us Inc. | Cellulase compositions and methods of using the same for improved conversion of lignocellulosic biomass into fermentable sugars |
| JP6290626B2 (ja) | 2011-03-17 | 2018-03-14 | ダニスコ・ユーエス・インク | 糖化プロセスにおける粘度を低下させる方法 |
| FI123425B (fi) | 2011-03-31 | 2013-04-30 | Ab Enzymes Oy | Proteaasientsyymi ja sen käytöt |
| CN103014036A (zh) * | 2011-07-01 | 2013-04-03 | 深圳市绿微康生物工程有限公司 | 改型扩展青霉脂肪酶基因及其构建和表达方法 |
| EP2748317B1 (de) | 2011-08-22 | 2017-04-19 | Codexis, Inc. | Gh61-glykosidhydrolase-proteinvarianten und kofaktoren zur verstärkung der gh61-aktivität |
| US20130084608A1 (en) | 2011-09-30 | 2013-04-04 | Codexis, Inc. | Fungal proteases |
| WO2013067026A1 (en) | 2011-10-31 | 2013-05-10 | Bp Corporation North America Inc. | Use of plant promoters in filamentous fungi |
| US20130109055A1 (en) | 2011-10-31 | 2013-05-02 | Bp Corporation North America Inc. | Use of mammalian promoters in filamentous fungi |
| US20140234897A1 (en) * | 2011-11-04 | 2014-08-21 | Novozymes Inc. | Polypeptides Having Cellobiohydrolase Activity and Polynucleotides Encoding Same |
| EP2794871A4 (de) | 2011-12-20 | 2015-12-30 | Codexis Inc | Varianten von endoglucanase-1b (eg1b) |
| US8980578B2 (en) | 2012-06-11 | 2015-03-17 | Codexis, Inc. | Fungal beta-xylosidase variants |
| US20150376590A1 (en) | 2012-11-02 | 2015-12-31 | Bp Corporation North America Inc. | Thermotolerant Beta-Glucosidase Variants |
| WO2014145768A2 (en) | 2013-03-15 | 2014-09-18 | Bp Corporation North America Inc. | Use of non-fungal 5' utrs in filamentous fungi |
| ES2521940B1 (es) | 2013-05-10 | 2015-09-09 | Abengoa Bioenergía Nuevas Tecnologías, S.A. | Variantes de beta-glucosidasa con actividad de transglicosilación reducida |
| ES2727390T3 (es) | 2013-05-20 | 2019-10-15 | Abengoa Bioenergia Nuevas Tecnologias Sa | Expresión de enzimas beta-xilosidasas recombinantes |
| ES2527368B1 (es) | 2013-07-22 | 2015-10-27 | Abengoa Bioenergía Nuevas Tecnologías, S.A. | Célula hospedadora de Myceliophthora thermophila que expresa una enzima alfa-xilosidasa heteróloga y su uso en un procedimiento de degradación de biomasa |
| EP3074513A1 (de) | 2013-11-26 | 2016-10-05 | Novozymes A/S | Enzymzusammensetzungen und verwendungen davon |
| ES2542621B1 (es) | 2014-02-07 | 2016-08-16 | Abengoa Bioenergía Nuevas Tecnologías, S.A. | Polipéptidos con actividad polisacárido monooxigenasa y su uso para la producción de azúcares fermentables |
| EP3152315B1 (de) | 2014-06-06 | 2018-08-15 | Novozymes A/S | Enzymzusammensetzungen und ihre verwendungen |
| CN108699578A (zh) | 2015-03-11 | 2018-10-23 | 杰能科国际有限公司 | 裂解性多糖单加氧酶的酶活性 |
| HUE053863T2 (hu) | 2015-05-07 | 2021-07-28 | Codexis Inc | Penicillin-G acilázok |
| US20190002846A1 (en) | 2015-06-24 | 2019-01-03 | Genencor International B.V. | Polypeptides having demethylating activity |
| BR112018001855A2 (pt) | 2015-07-29 | 2018-09-25 | Abengoa Bioenergia Nuevas Tecnologias Sa | expressão de enzimas beta-xilosidase recombinantes |
| JP2019503168A (ja) | 2015-12-02 | 2019-02-07 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | Clr2活性が低減した糸状菌においてタンパク質を生産する方法 |
| CN108291191A (zh) | 2015-12-02 | 2018-07-17 | 巴斯夫欧洲公司 | 在具有降低的clr1活性的丝状真菌中生产蛋白质的方法 |
| US11293029B2 (en) | 2015-12-07 | 2022-04-05 | Zymergen Inc. | Promoters from Corynebacterium glutamicum |
| US11208649B2 (en) | 2015-12-07 | 2021-12-28 | Zymergen Inc. | HTP genomic engineering platform |
| US9988624B2 (en) | 2015-12-07 | 2018-06-05 | Zymergen Inc. | Microbial strain improvement by a HTP genomic engineering platform |
| DK3419992T3 (da) | 2016-02-22 | 2021-02-15 | Danisco Us Inc | Svampesystem til proteinproduktion med højt udbytte |
| DK3452587T3 (da) | 2016-05-05 | 2021-10-11 | Codexis Inc | Penicillin-g-acylaser |
| ES2647322B1 (es) * | 2016-05-20 | 2018-10-05 | Abengoa Bioenergía Nuevas Tecnologías, S.A. | Célula hospedadora Myceliophthora thermophila con actividad celulolítica mejorada y composiciones enzimáticas obtenidas por la misma |
| CN109642226A (zh) | 2016-06-30 | 2019-04-16 | 丹尼斯科美国公司 | 天冬氨酸蛋白酶 |
| WO2018005655A2 (en) | 2016-06-30 | 2018-01-04 | Zymergen Inc. | Methods for generating a bacterial hemoglobin library and uses thereof |
| EP3478845A4 (de) | 2016-06-30 | 2019-07-31 | Zymergen, Inc. | Verfahren zur erzeugung einer glucose-permease-bibliothek und verwendungen davon |
| WO2018129130A1 (en) | 2017-01-05 | 2018-07-12 | Codexis, Inc. | Penicillin-g acylases |
| EP3378936B1 (de) * | 2017-03-24 | 2021-05-12 | Clariant International Ltd | Cellulase zur verwendung in waschmittelzusammensetzungen |
| WO2018226900A2 (en) | 2017-06-06 | 2018-12-13 | Zymergen Inc. | A htp genomic engineering platform for improving fungal strains |
| CN111032682B (zh) | 2017-06-14 | 2024-04-12 | 科德克希思公司 | 用于工业生物催化的工程化转氨酶多肽 |
| EP3645713A4 (de) | 2017-06-27 | 2021-06-30 | Codexis, Inc. | Penicillin-g-acylasen |
| JP2020533966A (ja) | 2017-08-21 | 2020-11-26 | ダイアディク インターナショナル インコーポレイテッド | Myceliophthora thermophila中でのフルワクチンの産生 |
| JP2021502068A (ja) | 2017-11-07 | 2021-01-28 | コデクシス, インコーポレイテッド | トランスグルタミナーゼバリアント |
| CN109988715B (zh) * | 2017-12-29 | 2022-03-01 | 青岛蔚蓝生物集团有限公司 | 一种高产木聚糖酶的突变菌株及其应用 |
| CN110093332B (zh) * | 2018-01-30 | 2021-12-28 | 青岛蔚蓝生物集团有限公司 | 一种纤维素酶突变体及其高产菌株 |
| KR20210018219A (ko) | 2018-06-06 | 2021-02-17 | 지머젠 인코포레이티드 | 발효 및 생산 중 곰팡이 형태를 제어하기 위한 신호 전달에 포함된 유전자의 조작 |
| US11274286B2 (en) | 2018-07-09 | 2022-03-15 | Codexis, Inc. | Engineered deoxyribose-phosphate aldolases |
| CN108913713A (zh) * | 2018-07-24 | 2018-11-30 | 中国农业科学院饲料研究所 | 提高里氏木霉转化效率的重组表达载体及应用 |
| EP3636735B1 (de) | 2018-10-12 | 2024-03-27 | AB Enzymes Oy | Variante einer protease und die verwendung davon |
| WO2021207200A2 (en) | 2020-04-10 | 2021-10-14 | Codexis, Inc. | Engineered transaminase polypeptides |
| WO2021220209A1 (en) | 2020-04-30 | 2021-11-04 | Dyadic International (Usa), Inc. | Nicotinamide riboside production in filamentous fungi |
| US11479779B2 (en) * | 2020-07-31 | 2022-10-25 | Zymergen Inc. | Systems and methods for high-throughput automated strain generation for non-sporulating fungi |
| CN113403209B (zh) * | 2021-07-30 | 2022-08-26 | 西南大学 | 天冬氨酸蛋白酶基因在改良球孢白僵菌菌株中的应用 |
| CN121127575A (zh) | 2022-12-19 | 2025-12-12 | 巴斯夫欧洲公司 | 用于真菌蛋白生产的新型纤维素酶启动子 |
| WO2024156593A1 (en) | 2023-01-27 | 2024-08-02 | Basf Se | New genomic integration site for fungal protein and fine chemicals production |
| WO2025262103A1 (en) | 2024-06-19 | 2025-12-26 | Basf Se | Superior promoters for fungal protein production |
Family Cites Families (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2974001A (en) * | 1957-07-20 | 1961-03-07 | Kalle Ag | Process and compositions for enzymatic desizing and bleaching of textiles |
| GB1368599A (en) | 1970-09-29 | 1974-10-02 | Unilever Ltd | Softening compositions |
| JPS5028515B2 (de) * | 1971-09-30 | 1975-09-16 | ||
| US3966543A (en) * | 1972-10-30 | 1976-06-29 | Baxter Laboratories, Inc. | Enzyme-treated paper |
| US4081328A (en) * | 1975-10-23 | 1978-03-28 | Stanford Research Institute | Production of cellulase by a thermophilic thielavia terrestris |
| DK187280A (da) * | 1980-04-30 | 1981-10-31 | Novo Industri As | Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode |
| GB2094826B (en) | 1981-03-05 | 1985-06-12 | Kao Corp | Cellulase enzyme detergent composition |
| JPS591598A (ja) * | 1982-06-25 | 1984-01-06 | 花王株式会社 | 洗浄剤組成物 |
| US4486533A (en) * | 1982-09-02 | 1984-12-04 | St. Louis University | Filamentous fungi functional replicating extrachromosomal element |
| NL8300698A (nl) * | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| GB8306645D0 (en) * | 1983-03-10 | 1983-04-13 | Unilever Plc | Detergent compositions |
| US4462307A (en) * | 1983-05-23 | 1984-07-31 | Pet Incorporated | Humpback oven-broiler |
| GB8421800D0 (en) * | 1984-08-29 | 1984-10-03 | Unilever Plc | Detergent compositions |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4816405A (en) * | 1984-10-24 | 1989-03-28 | The Regents Of The University Of California | Vectors for transformation by ascomycetes |
| US4885249A (en) * | 1984-12-05 | 1989-12-05 | Allelix, Inc. | Aspergillus niger transformation system |
| US4610800A (en) * | 1985-01-25 | 1986-09-09 | Genex Corporation | Method for unclogging drainage pipes |
| US5198345A (en) * | 1985-04-15 | 1993-03-30 | Gist-Brocades N.V. | Vectors in use in filamentous fungi |
| US5364770A (en) * | 1985-08-29 | 1994-11-15 | Genencor International Inc. | Heterologous polypeptides expressed in aspergillus |
| EP0215594B2 (de) | 1985-08-29 | 2003-10-15 | Genencor International, Inc. | Expression von heterologen Polypeptiden in filamentösen Pilzen, Verfahren zu deren Herstellung und Vektoren zu deren Herstellung |
| DK163591C (da) | 1985-10-08 | 1992-08-24 | Novo Nordisk As | Fremgangsmaade til behandling af et tekstilstof med en cellulase |
| US4935349A (en) * | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
| US5536661A (en) * | 1987-03-10 | 1996-07-16 | Novo Nordisk A/S | Process for the production of protein products in aspergillus |
| US5766912A (en) * | 1986-03-17 | 1998-06-16 | Novo Nordisk A/S | Humicola lipase produced in aspergillus |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5763192A (en) * | 1986-11-20 | 1998-06-09 | Ixsys, Incorporated | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
| US5252726A (en) * | 1987-09-04 | 1993-10-12 | Novo Nordisk A/S | Promoters for use in aspergillus |
| US4832864A (en) * | 1987-09-15 | 1989-05-23 | Ecolab Inc. | Compositions and methods that introduce variations in color density into cellulosic fabrics, particularly indigo dyed denim |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5122159A (en) * | 1988-09-15 | 1992-06-16 | Ecolab Inc. | Cellulase compositions and methods that introduce variations in color density into cellulosic fabrics, particularly indigo dyed denim |
| US5006126A (en) * | 1988-09-15 | 1991-04-09 | Ecolab Inc. | Cellulase compositions and methods that introduce variations in color density into cellulosic fabrics, particularly indigo dyed denim |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
| AU6355190A (en) | 1989-06-13 | 1991-01-17 | Smithkline Beecham Corporation | Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages |
| ES2150188T3 (es) | 1989-07-07 | 2000-11-16 | Unilever Nv | Procedimiento para la preparacion de una proteina mediante un hongo transformado por integracion multicopia de un vector de expresion. |
| US5120463A (en) * | 1989-10-19 | 1992-06-09 | Genencor International, Inc. | Degradation resistant detergent compositions based on cellulase enzymes |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| JPH05505308A (ja) * | 1990-03-13 | 1993-08-12 | ハワイ・バイオテクノロジー・グループ・インコーポレイテツド | アオパンカビ発現システム |
| DK115890D0 (da) * | 1990-05-09 | 1990-05-09 | Novo Nordisk As | Enzym |
| GB9015198D0 (en) * | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| KR930701625A (ko) * | 1990-07-13 | 1993-06-12 | 리처드 에프. 셀든 | 라이브러리 스크리닝 방법 |
| EP0542810A1 (de) * | 1990-08-02 | 1993-05-26 | B.R. Centre Limited | Verfahren zur herstellung von proteinen mit einer gewünschten funktion |
| JP3133774B2 (ja) * | 1990-10-04 | 2001-02-13 | 日本食品化工株式会社 | 新規な宿主−ベクター系 |
| US5290474A (en) * | 1990-10-05 | 1994-03-01 | Genencor International, Inc. | Detergent composition for treating cotton-containing fabrics containing a surfactant and a cellulase composition containing endolucanase III from trichoderma ssp |
| US5780279A (en) * | 1990-12-03 | 1998-07-14 | Genentech, Inc. | Method of selection of proteolytic cleavage sites by directed evolution and phagemid display |
| JPH06503960A (ja) * | 1990-12-10 | 1994-05-12 | ジェネンコア インターナショナル インコーポレーテッド | TRICHODERMA REESEIのβ−グルコシダーゼ遺伝子のクローニングおよび増幅によるセルロースの改良糖化 |
| GB9102635D0 (en) | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
| US5858657A (en) * | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| DE69230142T2 (de) * | 1991-05-15 | 2000-03-09 | Cambridge Antibody Technology Ltd. | Verfahren zur herstellung von spezifischen bindungspaargliedern |
| ES2136092T3 (es) * | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US5516670A (en) * | 1991-09-30 | 1996-05-14 | Kuehnle; Adelheid R. | Magnetophoretic particle delivery method and apparatus for the treatment of cells |
| BE1005432A4 (nl) | 1991-10-01 | 1993-07-20 | Dsm Nv | Expressiecassette voor heterologe eiwitten. |
| EP0672149B1 (de) * | 1991-12-09 | 2001-08-08 | Unilever Plc | Verfahren zur Herstellung/Sekretion eines Proteins durch einen transformiertenSchimmelpilz unter Verwendung von Expressions-/Sekretions- Regulationsregionenaus Aspergillus |
| CA2062023A1 (en) * | 1992-02-10 | 1993-08-11 | Jagroop S. Dahiya | Novel fungal strains and use thereof in antibiotic production |
| JPH08500733A (ja) | 1992-08-19 | 1996-01-30 | アルコ グループ リミティド | グルコースの存在下で活性的な真菌プロモーター |
| PT663953E (pt) * | 1992-09-04 | 2002-05-31 | Scripps Research Inst | Fagemideos que co-expressam um receptor de superficie e uma proteina heterologa de superficie |
| DE69332030T2 (de) | 1992-12-10 | 2002-10-02 | Dsm N.V., Heerlen | Herstellung von heterologen proteinen in filamentösen fungi |
| GB9316883D0 (en) * | 1993-08-13 | 1993-09-29 | Univ Leeds | Production of heterologous peptices |
| AU8095594A (en) * | 1993-11-02 | 1995-05-23 | Merck & Co., Inc. | Dna encoding triol polyketide synthase |
| US5605793A (en) * | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5820866A (en) * | 1994-03-04 | 1998-10-13 | National Jewish Center For Immunology And Respiratory Medicine | Product and process for T cell regulation |
| GB2289218A (en) | 1994-05-06 | 1995-11-15 | Merck & Co Inc | Inhibition of TNFalpha production with agonists of the A2b subtype of the adenosine receptor |
| AU2733895A (en) * | 1994-06-17 | 1996-01-15 | Novo Nordisk A/S | A fungus wherein the area gene has been modified and an area gene from aspergillus oryzae |
| US6060305A (en) * | 1994-06-30 | 2000-05-09 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic Fusarium expression system |
| CN101659926A (zh) * | 1994-06-30 | 2010-03-03 | 诺沃奇梅兹有限公司 | 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子 |
| WO1996002563A1 (en) | 1994-07-13 | 1996-02-01 | Cornell Research Foundation, Inc. | Epstein-barr virus nuclear antigen 1 protein and its expression and recovery |
| US5602004A (en) * | 1994-07-20 | 1997-02-11 | Novo Nordisk Biotech, Inc. | Thermophilic fungal expression system |
| US5861280A (en) | 1995-03-20 | 1999-01-19 | Novo Nordisk A/S | Host cell expressing reduced levels of a metalloprotease and methods using the host cell in protein production |
| US6046021A (en) * | 1995-04-12 | 2000-04-04 | Biolog, Inc. | Comparative phenotype analysis of two or more microorganisms using a plurality of substrates within a multiwell testing device |
| KR100501838B1 (ko) * | 1995-04-24 | 2005-07-21 | 큐비스트 파마슈티컬즈 인코포레이티드 | 새로운 대사 경로를 만들고 이를 스크리닝하는 방법 |
| US5958672A (en) * | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
| US6030779A (en) * | 1995-07-18 | 2000-02-29 | Diversa Corporation | Screening for novel bioactivities |
| US6057103A (en) * | 1995-07-18 | 2000-05-02 | Diversa Corporation | Screening for novel bioactivities |
| FI103133B (fi) | 1995-09-01 | 1999-04-30 | Valtion Teknillinen | Menetelmä glukoosirepression modifioimiseksi |
| EP0796328A2 (de) | 1995-10-13 | 1997-09-24 | Gist-Brocades B.V. | Protein-detektion |
| US5830696A (en) * | 1996-12-05 | 1998-11-03 | Diversa Corporation | Directed evolution of thermophilic enzymes |
| US5939250A (en) * | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| US5776730A (en) * | 1995-12-15 | 1998-07-07 | University Of Hawaii | Neurospora hosts for the production of recombinant proteins, and methods for producing same |
| WO1997026330A2 (en) * | 1996-01-19 | 1997-07-24 | Novo Nordisk Biotech, Inc. | Morphological mutants of filamentous fungi |
| AU1437997A (en) | 1996-01-26 | 1997-08-20 | Novo Nordisk A/S | Production of sanitary paper |
| US5753477A (en) * | 1996-03-19 | 1998-05-19 | University Technology Corporation | Magneto-biolistic methods |
| US5783431A (en) * | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| US7883872B2 (en) * | 1996-10-10 | 2011-02-08 | Dyadic International (Usa), Inc. | Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose |
| US5811381A (en) * | 1996-10-10 | 1998-09-22 | Mark A. Emalfarb | Cellulase compositions and methods of use |
| US5879921A (en) * | 1996-11-07 | 1999-03-09 | Novo Nordisk A/S | Recombinant expression of a glucose oxidase from a cladosporium strain |
| US6017731A (en) * | 1996-12-13 | 2000-01-25 | Chiron Corporation | Method for expression of heterologous proteins in yeast |
| US5989814A (en) * | 1997-04-01 | 1999-11-23 | Reagents Of The University Of California | Screening methods in eucaryotic cells |
| US6573068B1 (en) * | 1997-11-13 | 2003-06-03 | Genset, S. A. | Claudin-50 protein |
| ES2143408B1 (es) | 1998-04-02 | 2000-12-01 | Urquima Sa | Promotor y construcciones para expresion de proteinas recombinantes en hongos filamentosos. |
| US5914245A (en) | 1998-04-20 | 1999-06-22 | Kairos Scientific Inc. | Solid phase enzyme kinetics screening in microcolonies |
| US6413776B1 (en) | 1998-06-12 | 2002-07-02 | Galapagos Geonomics N.V. | High throughput screening of gene function using adenoviral libraries for functional genomics applications |
| WO1999067639A1 (en) | 1998-06-25 | 1999-12-29 | Caliper Technologies Corporation | High throughput methods, systems and apparatus for performing cell based screening assays |
| IL140100A0 (en) | 1998-06-29 | 2002-02-10 | Phylos Inc | Methods of generating highly diverse libraries |
| ATE286136T1 (de) * | 1998-10-06 | 2005-01-15 | Mark Aaron Emalfarb | Transformationsystem in filamentösen fungiziden chrysosporium-wirtszellen |
| US6518042B1 (en) * | 1999-02-24 | 2003-02-11 | Novozymes A/S | Process for making DNA libraries in filamentous fungal cells using a novel cloned gene involved in the mismatch repair system of filamentous fungal cells |
| EP2278016B1 (de) | 1999-03-22 | 2012-09-26 | Novozymes Inc. | Promotorsequenzen von Fusarium Venenatum und deren Verwendungen |
| US6121034A (en) * | 1999-05-13 | 2000-09-19 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Coniothyrium minitans xylanase gene Cxy1 |
| AU4352700A (en) | 1999-10-06 | 2001-05-10 | Mark Aaron Emalfarb | High-throughput screening of expressed dna libraries in filamentous fungi |
| US7122330B2 (en) * | 2000-04-13 | 2006-10-17 | Mark Aaron Emalfarb | High-throughput screening of expressed DNA libraries in filamentous fungi |
| CN1380905A (zh) | 2000-04-13 | 2002-11-20 | 马克·阿龙·埃马尔法尔布 | 丝状真菌中dna表达文库的高通量筛选 |
| AU782105B2 (en) * | 2000-04-13 | 2005-07-07 | Dyadic International (Usa), Inc. | Novel expression-regulating sequences and expression products in the field of filamentous fungi |
| AU2002243972A1 (en) * | 2001-02-13 | 2002-08-28 | Diadexus, Inc. | Compositions and methods relating to breast specific genes and proteins |
| US7205110B2 (en) | 2002-10-07 | 2007-04-17 | Zymogenetics, Inc. | Uses of human Zven antagonists |
| ES2331067T5 (es) * | 2002-12-20 | 2013-12-26 | Novozymes A/S | Polipéptidos que tienen actividad celobiohidrolasa II y polinucleótidos para su codificación |
| ES2468366T3 (es) * | 2004-01-30 | 2014-06-16 | Novozymes Inc. | Polip�ptidos con actividad de mejora celulol�tica y polinucle�tidos que los codifican |
| WO2005074656A2 (en) * | 2004-02-06 | 2005-08-18 | Novozymes, Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| US7332319B2 (en) * | 2004-05-27 | 2008-02-19 | Genencor International, Inc. | Heterologous alpha amylase expression in Aspergillus |
| US20060105361A1 (en) * | 2004-08-24 | 2006-05-18 | Rothstein Rodney J | Donor yeast strain for transfer of genetic material |
| CN101137750B (zh) * | 2005-01-06 | 2014-05-21 | 诺维信股份有限公司 | 具有纤维二糖水解酶活性的多肽和编码它的多核苷酸 |
| BRPI0616721A2 (pt) * | 2005-09-30 | 2011-06-28 | Novozymes Inc | métodos para degradar ou converter um material celulósico e para produzir uma substáncia, e, composição detergente |
| US7923236B2 (en) * | 2007-08-02 | 2011-04-12 | Dyadic International (Usa), Inc. | Fungal enzymes |
-
1999
- 1999-10-06 AT AT99949459T patent/ATE286136T1/de not_active IP Right Cessation
- 1999-10-06 BR BRPI9914278A patent/BRPI9914278B1/pt not_active IP Right Cessation
- 1999-10-06 CA CA2345356A patent/CA2345356C/en not_active Expired - Lifetime
- 1999-10-06 DK DK99949459T patent/DK1117808T3/da active
- 1999-10-06 ES ES99949459T patent/ES2237159T3/es not_active Expired - Lifetime
- 1999-10-06 WO PCT/NL1999/000618 patent/WO2000020555A2/en not_active Ceased
- 1999-10-06 AU AU62326/99A patent/AU771539C/en not_active Ceased
- 1999-10-06 EA EA200100419A patent/EA005682B1/ru not_active IP Right Cessation
- 1999-10-06 DE DE69922978T patent/DE69922978T2/de not_active Expired - Lifetime
- 1999-10-06 CN CNB99814133XA patent/CN1230546C/zh not_active Expired - Lifetime
- 1999-10-06 EP EP99949459A patent/EP1117808B1/de not_active Expired - Lifetime
- 1999-10-06 KR KR1020017004377A patent/KR100618495B1/ko not_active Expired - Fee Related
-
2000
- 2000-04-13 US US09/548,938 patent/US6573086B1/en not_active Expired - Lifetime
-
2003
- 2003-03-21 US US10/394,568 patent/US7399627B2/en not_active Expired - Fee Related
-
2008
- 2008-03-13 US US12/047,709 patent/US8268585B2/en not_active Expired - Fee Related
-
2012
- 2012-09-17 US US13/621,507 patent/US8871493B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000020555A2 (en) | 2000-04-13 |
| KR20010103596A (ko) | 2001-11-23 |
| BR9914278A (pt) | 2001-06-19 |
| US8871493B2 (en) | 2014-10-28 |
| EP1117808A2 (de) | 2001-07-25 |
| KR100618495B1 (ko) | 2006-08-31 |
| US6573086B1 (en) | 2003-06-03 |
| EA005682B1 (ru) | 2005-04-28 |
| DE69922978T2 (de) | 2005-12-08 |
| AU6232699A (en) | 2000-04-26 |
| DE69922978D1 (de) | 2005-02-03 |
| WO2000020555A3 (en) | 2000-10-05 |
| US7399627B2 (en) | 2008-07-15 |
| CN1330717A (zh) | 2002-01-09 |
| US20080194005A1 (en) | 2008-08-14 |
| AU771539C (en) | 2005-01-13 |
| CN1230546C (zh) | 2005-12-07 |
| ES2237159T3 (es) | 2005-07-16 |
| BRPI9914278B1 (pt) | 2016-03-08 |
| EA200100419A1 (ru) | 2001-10-22 |
| US20140127788A1 (en) | 2014-05-08 |
| EP1117808B1 (de) | 2004-12-29 |
| AU771539B2 (en) | 2004-03-25 |
| US20040002136A1 (en) | 2004-01-01 |
| CA2345356A1 (en) | 2000-04-13 |
| CA2345356C (en) | 2012-10-02 |
| DK1117808T3 (da) | 2005-04-25 |
| US8268585B2 (en) | 2012-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE286136T1 (de) | Transformationsystem in filamentösen fungiziden chrysosporium-wirtszellen | |
| CA2324993A1 (en) | Tadg-15: an extracellular serine protease overexpressed in breast and ovarian carcinomas | |
| WO1995033818A3 (en) | Genes for the synthesis of antipathogenic substances | |
| WO2002031134A3 (en) | Novel serine protease genes related to dppiv | |
| WO1998056927A3 (en) | Nucleic acids encoding polypeptide having protease activity | |
| ATE386126T1 (de) | Verbesserte expressionsvektoren | |
| DK82393A (da) | Fremgangsmaade til frembringelse af mutationer ved hvert enkelt sted i kodeomraadet for et protein og til udtrykkelse af de dannede mutant-dna-dele under opnaaelse af mutantproteiner. | |
| WO2000075350A3 (en) | Nucleic acid sequences encoding proteins involved in fatty acid beta-oxidation and methods of use | |
| AU2590901A (en) | Il-17 homologous polypeptides and therapeutic uses thereof | |
| AU7599500A (en) | Novel gl50 molecules and uses therefor | |
| EP0804609A4 (de) | NEUARTIGE AUF p53 ANSPRECHENDE GENE | |
| CA2153068A1 (en) | Enhancer sequence for modulating expression in epithelial cells | |
| CA2249233A1 (en) | Mch4 and mch5, apoptotic protease, nucleic acids encoding and methods of use | |
| AU3802595A (en) | Tripeptidyl aminopeptidase | |
| AU7093601A (en) | Nucleic acid molecules encoding plant cell cycle proteins and uses therefor | |
| WO1995015391A3 (en) | Aspergillus expression system | |
| WO2000068247A3 (en) | Serine proteases | |
| WO2001090326A3 (en) | Novel matrix metalloproteinases | |
| DE69634757D1 (de) | Vektor zur expression von n-terminal verlängerten proteinen in hefezellen | |
| AU2001238064A1 (en) | 18477, a human protein kinase and uses therefor | |
| AU5727099A (en) | A 2,6-beta-d-fructan hydrolase enzyme and processes for using the enzyme | |
| DE69834046D1 (de) | Extrazelluläre serinprotease | |
| WO1990014426A3 (en) | Saf polypeptide, gene, promoter and use for expression in streptomyces | |
| AU6134596A (en) | Enamel matrix related polypeptide | |
| WO2002002771A3 (en) | Human sparc-homologous (hsparc-h1) gene and methods and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1117808 Country of ref document: EP |
|
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |