DK3256577T3 - Ketoreduktase polypeptider til syntesen af chirale forbindelser - Google Patents
Ketoreduktase polypeptider til syntesen af chirale forbindelser Download PDFInfo
- Publication number
- DK3256577T3 DK3256577T3 DK16749625.6T DK16749625T DK3256577T3 DK 3256577 T3 DK3256577 T3 DK 3256577T3 DK 16749625 T DK16749625 T DK 16749625T DK 3256577 T3 DK3256577 T3 DK 3256577T3
- Authority
- DK
- Denmark
- Prior art keywords
- synthesis
- chiral compounds
- ketoreductase polypeptides
- ketoreductase
- polypeptides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562114380P | 2015-02-10 | 2015-02-10 | |
PCT/US2016/016692 WO2016130412A1 (en) | 2015-02-10 | 2016-02-05 | Ketoreductase polypeptides for the synthesis of chiral compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3256577T3 true DK3256577T3 (da) | 2020-09-14 |
Family
ID=56615088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16749625.6T DK3256577T3 (da) | 2015-02-10 | 2016-02-05 | Ketoreduktase polypeptider til syntesen af chirale forbindelser |
Country Status (5)
Country | Link |
---|---|
US (3) | US10696953B2 (da) |
EP (1) | EP3256577B1 (da) |
DK (1) | DK3256577T3 (da) |
ES (1) | ES2830725T3 (da) |
WO (1) | WO2016130412A1 (da) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2830725T3 (es) | 2015-02-10 | 2021-06-04 | Codexis Inc | Polipéptidos cetoreductasa para la síntesis de compuestos quirales |
GB201802383D0 (en) * | 2018-02-14 | 2018-03-28 | Givaudan Sa | Process |
WO2020016749A2 (en) | 2018-07-16 | 2020-01-23 | Novartis Ag | Chemical process for preparing phenylpiperidinyl indole derivatives |
CN111378695B (zh) * | 2020-04-07 | 2023-07-28 | 宁波酶赛生物工程有限公司 | 合成r-3-(2-氯-1-羟基乙基)苯酚的方法、去氧肾上腺素、滴眼剂 |
WO2024150146A1 (en) * | 2023-01-12 | 2024-07-18 | Novartis Ag | Engineered ketoreductase polypeptides |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5538867A (en) | 1988-09-13 | 1996-07-23 | Elf Aquitaine | Process for the electrochemical regeneration of pyridine cofactors |
JP3155107B2 (ja) | 1993-01-12 | 2001-04-09 | ダイセル化学工業株式会社 | 光学活性4−ハロ−3−ヒドロキシ酪酸エステルの製造方法 |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
US6309883B1 (en) | 1994-02-17 | 2001-10-30 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6995017B1 (en) | 1994-02-17 | 2006-02-07 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6395547B1 (en) | 1994-02-17 | 2002-05-28 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6406855B1 (en) | 1994-02-17 | 2002-06-18 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US20060257890A1 (en) | 1996-05-20 | 2006-11-16 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
DK0765394T3 (da) | 1994-06-03 | 2001-12-10 | Novozymes As | Oprensede Myceliopthora-laccaser og nukleinsyrer der koder for disse |
AU2705895A (en) | 1994-06-30 | 1996-01-25 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein |
JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
FI104465B (fi) | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
US6506602B1 (en) | 1996-03-25 | 2003-01-14 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6096548A (en) | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
US5891685A (en) | 1996-06-03 | 1999-04-06 | Mitsubishi Chemical Corporation | Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid |
WO1998031837A1 (en) | 1997-01-17 | 1998-07-23 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
US7148054B2 (en) | 1997-01-17 | 2006-12-12 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
US6365408B1 (en) | 1998-06-19 | 2002-04-02 | Maxygen, Inc. | Methods of evolving a polynucleotides by mutagenesis and recombination |
US6495023B1 (en) | 1998-07-09 | 2002-12-17 | Michigan State University | Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration |
DE19857302C2 (de) | 1998-12-14 | 2000-10-26 | Forschungszentrum Juelich Gmbh | Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester |
JP4221100B2 (ja) | 1999-01-13 | 2009-02-12 | エルピーダメモリ株式会社 | 半導体装置 |
US6368861B1 (en) | 1999-01-19 | 2002-04-09 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6436675B1 (en) | 1999-09-28 | 2002-08-20 | Maxygen, Inc. | Use of codon-varied oligonucleotide synthesis for synthetic shuffling |
US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6917882B2 (en) | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US7702464B1 (en) | 2001-08-21 | 2010-04-20 | Maxygen, Inc. | Method and apparatus for codon determining |
US7024312B1 (en) | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US6961664B2 (en) | 1999-01-19 | 2005-11-01 | Maxygen | Methods of populating data structures for use in evolutionary simulations |
IL138002A0 (en) | 1999-01-19 | 2001-10-31 | Maxygen Inc | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US6365377B1 (en) | 1999-03-05 | 2002-04-02 | Maxygen, Inc. | Recombination of insertion modified nucleic acids |
EP1181356B1 (en) | 1999-03-11 | 2005-12-07 | Eastman Chemical Company | Phosphine stabilizers for oxidoreductase enzymes |
US7430477B2 (en) | 1999-10-12 | 2008-09-30 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
US6519065B1 (en) | 1999-11-05 | 2003-02-11 | Jds Fitel Inc. | Chromatic dispersion compensation device |
CZ20012792A3 (cs) | 1999-12-03 | 2002-03-13 | Kaneka Corporation | Polypeptid, polynukleotid kódující polypeptid, expresní vektor, transformant a způsob přípravy |
AU4964101A (en) | 2000-03-30 | 2001-10-15 | Maxygen Inc | In silico cross-over site selection |
CN1498273A (zh) | 2001-03-22 | 2004-05-19 | ����˹�ж�-����˹˹������˾ | 取代乙酰苯的立体选择还原 |
EP2390803B1 (en) | 2002-03-01 | 2013-11-20 | Codexis Mayflower Holdings, LLC | Methods, systems, and software for identifying functional biomolecules |
US7747391B2 (en) | 2002-03-01 | 2010-06-29 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
WO2003078583A2 (en) | 2002-03-09 | 2003-09-25 | Maxygen, Inc. | Optimization of crossover points for directed evolution |
US7132267B2 (en) | 2002-08-09 | 2006-11-07 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters |
JP2007502124A (ja) | 2003-08-11 | 2007-02-08 | コデクシス, インコーポレイテッド | 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド |
SG148180A1 (en) | 2003-08-11 | 2008-12-31 | Codexis Inc | Improved halohydrin dehalogenases and related polynucleotides |
WO2005045016A2 (en) | 2003-08-11 | 2005-05-19 | Codexis, Inc. | Improved glucose dehydrogenase polypeptides and related polynucleotides |
EP1712633A1 (en) | 2003-12-02 | 2006-10-18 | Mercian Corporation | Process for producing optically active tetrahydrothiophene derivative and method of crystallizing optically active tetrahydrothiophen-3-ol |
WO2006130657A2 (en) | 2005-05-31 | 2006-12-07 | Bristol-Myers Squibb Company | Stereoselective reduction process for the preparation of pyrrolotriazine compounds |
WO2008042876A2 (en) | 2006-10-02 | 2008-04-10 | Codexis, Inc. | Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor |
KR101586503B1 (ko) * | 2007-09-13 | 2016-01-18 | 코덱시스, 인코포레이티드 | 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드 |
WO2009046153A1 (en) * | 2007-10-01 | 2009-04-09 | Codexis, Inc. | Ketoreductase polypeptides for the production of azetidinone |
ES2575005T3 (es) | 2008-06-13 | 2016-06-23 | Codexis, Inc. | Método de síntesis de variantes de polinucleótidos |
US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
US8426178B2 (en) * | 2008-08-27 | 2013-04-23 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
WO2013074650A1 (en) * | 2011-11-18 | 2013-05-23 | Codexis, Inc. | Biocatalysts for the preparation of hydroxy substituted carbamates |
CN105339382A (zh) * | 2013-05-21 | 2016-02-17 | 雷迪博士实验室有限公司 | 脱氢表雄酮及其中间体的制备方法 |
ES2830725T3 (es) | 2015-02-10 | 2021-06-04 | Codexis Inc | Polipéptidos cetoreductasa para la síntesis de compuestos quirales |
-
2016
- 2016-02-05 ES ES16749625T patent/ES2830725T3/es active Active
- 2016-02-05 DK DK16749625.6T patent/DK3256577T3/da active
- 2016-02-05 EP EP16749625.6A patent/EP3256577B1/en active Active
- 2016-02-05 US US15/543,535 patent/US10696953B2/en active Active
- 2016-02-05 WO PCT/US2016/016692 patent/WO2016130412A1/en active Application Filing
-
2020
- 2020-05-14 US US16/874,574 patent/US11236308B2/en active Active
-
2021
- 2021-12-16 US US17/553,455 patent/US20220106575A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US10696953B2 (en) | 2020-06-30 |
US11236308B2 (en) | 2022-02-01 |
ES2830725T3 (es) | 2021-06-04 |
EP3256577B1 (en) | 2020-08-26 |
WO2016130412A1 (en) | 2016-08-18 |
US20220106575A1 (en) | 2022-04-07 |
US20200347365A1 (en) | 2020-11-05 |
US20180002676A1 (en) | 2018-01-04 |
EP3256577A4 (en) | 2018-10-17 |
EP3256577A1 (en) | 2017-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL255817A (en) | Synthesis of heterocyclic compounds | |
DK3192902T3 (da) | Fremgangsmåde til fremstilling af graphenholdige viscosefibre | |
DK3096741T3 (da) | Fremgangsmåde til fremstillingen af hybridosomer | |
DK3294720T3 (da) | Fremgangsmåde til fremstilling af terpinolenepoxid | |
DK3325443T3 (da) | Fremgangsmåde til fremstilling af pridopidin | |
DK3174858T3 (da) | Fremgangsmåde til fremstilling af pyrazoler | |
DK3234131T3 (da) | Fremgangsmåde til screening af kiral toksicitet | |
DK3372584T3 (da) | Fremgangsmåde til fremstillingen af en diarylthiohydantoin-forbindelse | |
DK3481838T3 (da) | Nye fremgangsmåder til fremstillingen af oligonukleotider | |
DK3294700T3 (da) | Fremgangsmåde til fremstilling af limonen-4-ol | |
DK3180331T3 (da) | Polymorfer af selinexor | |
DK3307271T3 (da) | Fremgangsmåder til anvendelse af pyruvatkinase-aktivatorer | |
DK3186244T3 (da) | Dioxolananaloger af uridin til behandling af cancer | |
DK3233813T3 (da) | Fremgangsmåder til fremstilling af oxathiazin-lignende forbindelser | |
DK3529233T3 (da) | Fremgangsmåde til fremstilling af 3-alkylsulfanyl-2-chlor-n-(1-alkyl-1h-tetrazol-5-yl)-4-trifluoromethyl-benzamider | |
DK3280408T3 (da) | Fremgangsmåde til fremstilling af dicycloplatin | |
DK3390407T3 (da) | Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser | |
DK3274143T3 (da) | Fremgangsmåde til fremstilling af lignocellulosematerialer | |
DK3256577T3 (da) | Ketoreduktase polypeptider til syntesen af chirale forbindelser | |
DK3152177T3 (da) | Fremgangsmåde til ekspansion af sandkornformigt råmateriale | |
DK2910535T3 (da) | Sammensætning til anvendelse af ekspanderet perlit | |
DK3137449T3 (da) | Fremgangsmåder til fremstilling af substituerede cycloseriner | |
DK3507282T3 (da) | Fremgangsmåde til fremstilling af indolcarboxamidforbindelser | |
DK3120153T3 (da) | Cellulær-baseret fremgangsmåde til bestemmelse af muligheden for defibrotid | |
DK3325453T3 (da) | Fremgangsmåder til kemisk syntese af substituerede 10H-phenothiazin-3,7-diamin-forbindelser |