MX366978B - Conjugados de anticuerpo - farmaco. - Google Patents

Conjugados de anticuerpo - farmaco.

Info

Publication number
MX366978B
MX366978B MX2015013203A MX2015013203A MX366978B MX 366978 B MX366978 B MX 366978B MX 2015013203 A MX2015013203 A MX 2015013203A MX 2015013203 A MX2015013203 A MX 2015013203A MX 366978 B MX366978 B MX 366978B
Authority
MX
Mexico
Prior art keywords
drug conjugates
antibody drug
antibody
cancer
treatment
Prior art date
Application number
MX2015013203A
Other languages
English (en)
Other versions
MX2015013203A (es
Inventor
Huber Thomas
Abrams Tinya
Cohen Steven
P Fanton Christie
Miller Kathy
Ho Schleyer Siew
Ulrike Tissot-Daguette Kathrin
Finner Catrin
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2015013203A publication Critical patent/MX2015013203A/es
Publication of MX366978B publication Critical patent/MX366978B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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    • A61K39/39591—Stabilisation, fragmentation
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Abstract

La presente invención se refiere a anticuerpos anti-cKIT, fragmentos de anticuerpo, conjugados anticuerpo-fármaco, y sus usos para el tratamiento del cáncer.
MX2015013203A 2013-03-15 2014-03-12 Conjugados de anticuerpo - farmaco. MX366978B (es)

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US201361793641P 2013-03-15 2013-03-15
PCT/US2014/024597 WO2014150937A1 (en) 2013-03-15 2014-03-12 Antibody drug conjugates

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AU2014235474A1 (en) 2015-08-27
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