SG11201506395RA - Antibody drug conjugates - Google Patents

Antibody drug conjugates

Info

Publication number
SG11201506395RA
SG11201506395RA SG11201506395RA SG11201506395RA SG11201506395RA SG 11201506395R A SG11201506395R A SG 11201506395RA SG 11201506395R A SG11201506395R A SG 11201506395RA SG 11201506395R A SG11201506395R A SG 11201506395RA SG 11201506395R A SG11201506395R A SG 11201506395RA
Authority
SG
Singapore
Prior art keywords
drug conjugates
antibody drug
antibody
conjugates
drug
Prior art date
Application number
SG11201506395RA
Inventor
Tinya Abrams
Steven Cohen
Christie P Fanton
Thomas Huber
Kathy Miller
Siew Ho Schleyer
Kathrin Ulrike Tissot-Daguette
Catrin Finner
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG11201506395RA publication Critical patent/SG11201506395RA/en

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    • A—HUMAN NECESSITIES
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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