WO1998013485A1 - Methods for optimization of gene therapy by recursive sequence shuffling and selection - Google Patents

Methods for optimization of gene therapy by recursive sequence shuffling and selection Download PDF

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Publication number
WO1998013485A1
WO1998013485A1 PCT/US1997/017302 US9717302W WO9813485A1 WO 1998013485 A1 WO1998013485 A1 WO 1998013485A1 US 9717302 W US9717302 W US 9717302W WO 9813485 A1 WO9813485 A1 WO 9813485A1
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WO
WIPO (PCT)
Prior art keywords
cells
gene
recombinant
recombination
dna
Prior art date
Application number
PCT/US1997/017302
Other languages
French (fr)
Inventor
Willem P. C. Stemmer
Helmuth H. G. Van Es
Original Assignee
Maxygen, Inc.
Introgene B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US3774296P priority Critical
Priority to US60/037,742 priority
Application filed by Maxygen, Inc., Introgene B.V. filed Critical Maxygen, Inc.
Publication of WO1998013485A1 publication Critical patent/WO1998013485A1/en

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