PE20399A1 - Muteina ob - Google Patents

Muteina ob

Info

Publication number
PE20399A1
PE20399A1 PE00108697A PE00108697A PE20399A1 PE 20399 A1 PE20399 A1 PE 20399A1 PE 00108697 A PE00108697 A PE 00108697A PE 00108697 A PE00108697 A PE 00108697A PE 20399 A1 PE20399 A1 PE 20399A1
Authority
PE
Peru
Prior art keywords
muteina
muteins
making
methods
relates
Prior art date
Application number
PE00108697A
Other languages
English (en)
Inventor
Yves Guisez
Rene Devos
Geert Plaetinck
Der Heyden Jose Van
Sandra Verploegen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20399A1 publication Critical patent/PE20399A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Abstract

CARACTERIZADA PORQUE COMPRENDE UNA SEQ. ID. 1, CON 146 AMINOACIDOS, EN DONDE EN LA POSICION 127 Ser ES Asp Y EN LA POSICION 128 Arg ES Gln. TAMBIEN SE REFIERE AL METODO DE PRODUCCION DE UNA MUTEINA OB, AL VECTOR DE EXPRESION QUE CODIFICA LA MUTEINA OB Y A LA CELULA HOSPEDADORA SELECCIONADA DE UNA CELULA PROCARIOTA, DE INSECTO o DE MAMIFERO; EN DONDE DICHO METODO DE PRODUCCION COMPRENDE: CULTIVAR UNA CELULA HOSPEDADORA TRANSFORMADA CON LA INSERCION DE UN VECTOR DE EXPRESION, EN UN MEDIO DE CULTIVO ADECUADO PARA LA EXPRESION DE LA MUTEINA, Y, PURIFICAR LA MUTEINA OBTENIDA. ADEMAS SE REFIERE A LOS ANTICUERPOS POLI- Y/O MONOCLONALES CONTRA UNA MUTEINA OB. LA MUTEINA OB ACTUA COMO ANTAGONISTA DE LA PROTEINA DE OBESIDAD HUMANA (LEPTINA), CAUSANDO UN AUMENTO EN EL PESO CORPORAL, SIENDO USADA SOLA O EN COMBINACION CON UN ANTICUERPO MONOCLONAL CONTRA UNA PROTEINA DE LA OBESIDAD, PARA LA PREVENCION, TRATAMIENTO Y CONTROL DE LA OBESIDAD Y DE ENFERMEDADES ASOCIADAS TALES COMO ANOREXIA, CAQUEXIA, TRASTORNOS POR DEMACRACION, ENTRE OTROS
PE00108697A 1996-12-06 1997-12-02 Muteina ob PE20399A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96119606 1996-12-06

Publications (1)

Publication Number Publication Date
PE20399A1 true PE20399A1 (es) 1999-03-05

Family

ID=8223476

Family Applications (1)

Application Number Title Priority Date Filing Date
PE00108697A PE20399A1 (es) 1996-12-06 1997-12-02 Muteina ob

Country Status (8)

Country Link
AR (1) AR010333A1 (es)
AU (1) AU5654998A (es)
CO (1) CO4930295A1 (es)
HR (1) HRP970654A2 (es)
MA (1) MA24411A1 (es)
PE (1) PE20399A1 (es)
WO (1) WO1998024896A2 (es)
ZA (1) ZA9710832B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208572B2 (en) 1998-08-21 2007-04-24 Albany Medical College Leptin-related peptides
US6777388B1 (en) 1998-08-21 2004-08-17 Clf Medical Technology Acceleration Program, Inc. Leptin-related peptides
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
US8227408B2 (en) 2005-09-07 2012-07-24 Neurotez, Inc. Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
WO2009143380A2 (en) 2008-05-21 2009-11-26 Neurotez, Inc. Methods for treating progressive cognitive disorders related to neurofibrillary tangles
CA2742600A1 (en) 2008-11-04 2010-05-14 Nikolaos Tezapsidis Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amlyoid beta
ES2630031T3 (es) 2010-09-28 2017-08-17 Aegerion Pharmaceuticals, Inc. Un polipéptido de leptina pinnípedo-humano quimérico con solubilidad aumentada

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU192989B (en) * 1983-08-17 1987-08-28 Wellcome Found Process for production of phisiologically active hormone preparatives
US6309853B1 (en) * 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
EP0725078A1 (en) * 1995-01-31 1996-08-07 Eli Lilly And Company Anti-obesity proteins
GB9509164D0 (en) * 1995-05-05 1995-06-28 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
AR010333A1 (es) 2000-06-07
CO4930295A1 (es) 2000-06-27
HRP970654A2 (en) 1998-10-31
MA24411A1 (fr) 1998-07-01
WO1998024896A3 (en) 1998-10-01
WO1998024896A2 (en) 1998-06-11
AU5654998A (en) 1998-06-29
ZA9710832B (en) 1998-06-08

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal