MX2012004029A - Polipeptidos que contienen la region fc que exhiben funcion efectora mejorada debido a alteraciones del grado de fucosilacion, y metodos para su uso. - Google Patents
Polipeptidos que contienen la region fc que exhiben funcion efectora mejorada debido a alteraciones del grado de fucosilacion, y metodos para su uso.Info
- Publication number
- MX2012004029A MX2012004029A MX2012004029A MX2012004029A MX2012004029A MX 2012004029 A MX2012004029 A MX 2012004029A MX 2012004029 A MX2012004029 A MX 2012004029A MX 2012004029 A MX2012004029 A MX 2012004029A MX 2012004029 A MX2012004029 A MX 2012004029A
- Authority
- MX
- Mexico
- Prior art keywords
- region
- fucosylation
- methods
- containing polypeptides
- alterations
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a polipéptidos que contienen de la región Fc que exhiben función efectora mejorada debido a alteraciones del grado de fucosilación, y a métodos para usar estos polipéptidos para tratar o prevenir cáncer y otras enfermedades. Los polipéptidos que contienen la región Fc de la presente invención son preferentemente inmunoglobulinas (por ejemplo, anticuerpos), en los cuales la región Fc comprenden al menos una sustitución de aminoácido con relación a la correspondiente secuencia de aminoácidos de una región Fc tipo silvestre, y que es suficiente para atenuar la fucosilación pos-trasduccional y mediar la unión mejorada a un receptor activador de Fc y reducir la unión a un receptor inhibitorio de Fc. Los métodos de la invención son particularmente útiles en la prevención, tratamiento o mejora de uno o más síntomas asociados con una enfermedad, trastorno, o infección donde ya sea, se desea una eficiencia mejorada de la función celular efectora mediada por FcyR (por ejemplo, cáncer, enfermedad infecciosa) o una respuesta celular efectora inhibida mediada por FcyR se desea (por ejemplo inflamación, enfermedad autoinmunitaria.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24951009P | 2009-10-07 | 2009-10-07 | |
PCT/US2010/051831 WO2011044368A1 (en) | 2009-10-07 | 2010-10-07 | Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012004029A true MX2012004029A (es) | 2012-05-08 |
Family
ID=43857148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012004029A MX2012004029A (es) | 2009-10-07 | 2010-10-07 | Polipeptidos que contienen la region fc que exhiben funcion efectora mejorada debido a alteraciones del grado de fucosilacion, y metodos para su uso. |
Country Status (22)
Country | Link |
---|---|
US (1) | US9096877B2 (es) |
EP (1) | EP2486141B1 (es) |
JP (1) | JP5898082B2 (es) |
KR (1) | KR101808602B1 (es) |
CN (1) | CN102666874B (es) |
AU (1) | AU2010303415B2 (es) |
BR (1) | BR112012007760A2 (es) |
CA (1) | CA2776385C (es) |
DK (1) | DK2486141T3 (es) |
ES (1) | ES2672121T3 (es) |
HR (1) | HRP20180574T1 (es) |
HU (1) | HUE036549T2 (es) |
IL (1) | IL219059B (es) |
LT (1) | LT2486141T (es) |
MX (1) | MX2012004029A (es) |
NO (1) | NO2486141T3 (es) |
PL (1) | PL2486141T3 (es) |
PT (1) | PT2486141T (es) |
RU (1) | RU2583298C2 (es) |
SI (1) | SI2486141T1 (es) |
TR (1) | TR201804897T4 (es) |
WO (1) | WO2011044368A1 (es) |
Families Citing this family (93)
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US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US11254748B2 (en) | 2005-04-15 | 2022-02-22 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
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ES2568436T3 (es) | 2006-03-31 | 2016-04-29 | Chugai Seiyaku Kabushiki Kaisha | Procedimiento para controlar la farmacocinética en sangre de anticuerpos |
CN106519025B (zh) | 2007-09-26 | 2021-04-23 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
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RU2012118865A (ru) | 2013-11-20 |
ES2672121T3 (es) | 2018-06-12 |
AU2010303415B2 (en) | 2015-02-19 |
HRP20180574T1 (hr) | 2018-06-01 |
PT2486141T (pt) | 2018-05-09 |
CN102666874B (zh) | 2016-06-01 |
EP2486141A1 (en) | 2012-08-15 |
US9096877B2 (en) | 2015-08-04 |
PL2486141T3 (pl) | 2018-07-31 |
NO2486141T3 (es) | 2018-06-09 |
DK2486141T3 (en) | 2018-04-23 |
KR20140015138A (ko) | 2014-02-06 |
HUE036549T2 (hu) | 2018-07-30 |
LT2486141T (lt) | 2018-05-25 |
BR112012007760A2 (pt) | 2015-08-25 |
US20120219551A1 (en) | 2012-08-30 |
IL219059A0 (en) | 2012-06-28 |
EP2486141B1 (en) | 2018-01-10 |
RU2583298C2 (ru) | 2016-05-10 |
EP2486141A4 (en) | 2013-04-17 |
JP2013507128A (ja) | 2013-03-04 |
KR101808602B1 (ko) | 2017-12-13 |
JP5898082B2 (ja) | 2016-04-06 |
CN102666874A (zh) | 2012-09-12 |
CA2776385A1 (en) | 2011-04-14 |
SI2486141T1 (en) | 2018-06-29 |
WO2011044368A1 (en) | 2011-04-14 |
CA2776385C (en) | 2019-04-09 |
AU2010303415A1 (en) | 2012-04-19 |
IL219059B (en) | 2018-06-28 |
TR201804897T4 (tr) | 2018-06-21 |
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