JP2018029594A5 - - Google Patents

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JP2018029594A5
JP2018029594A5 JP2017170459A JP2017170459A JP2018029594A5 JP 2018029594 A5 JP2018029594 A5 JP 2018029594A5 JP 2017170459 A JP2017170459 A JP 2017170459A JP 2017170459 A JP2017170459 A JP 2017170459A JP 2018029594 A5 JP2018029594 A5 JP 2018029594A5
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  1. キメラ抗原受容体（CAR）を発現するヒトT細胞の抗腫瘍的有効量の集団を含む、ヒト患者における白血病を治療するための医薬組成物であって、
    前記CARがSEQ ID NO：20のアミノ酸配列を含むCD19抗原結合ドメインと、CD8αヒンジドメインと、CD8α膜貫通ドメインと、4-1BB共刺激シグナル伝達領域と、そしてCD3ζシグナル伝達ドメインとを含む、医薬組成物。
  2. 前記T細胞の前記抗腫瘍的有効量のT細胞が、細胞10 4 〜10 9 個／kg患者体重である、請求項１に記載の医薬組成物。
  3. 前記T細胞の前記抗腫瘍的有効量のT細胞が、細胞10 5 〜10 6 個／kg患者体重である、請求項１に記載の医薬組成物。
  4. 前記CD8α膜貫通ドメインが、SEQ ID NO：22のアミノ酸配列を含む、請求項１〜３のいずれ1項に記載の医薬組成物。
  5. 前記CD8αヒンジドメインが、SEQ ID NO：21のアミノ酸配列を含む、請求項１〜３のいずれ1項に記載の医薬組成物。
  6. 前記4-1BB共刺激シグナル伝達領域が、SEQ ID NO：23のアミノ酸配列を含む、請求項１〜３のいずれ1項に記載の医薬組成物。
  7. 前記CD19抗原結合ドメインがSEQ ID NO：20のアミノ酸配列を含み、前記CD8αヒンジドメインがSEQ ID NO：21のアミノ酸配列を含み、前記CD8α膜貫通ドメインがSEQ ID NO：22のアミノ酸配列を含み、前記4-1BB共刺激シグナル伝達領域がSEQ ID NO：23のアミノ酸配列を含む、請求項１〜３のいずれ1項に記載の医薬組成物。
  8. 前記白血病が、慢性リンパ性白血病または急性リンパ性白血病である、請求項１〜７のいずれか１項に記載の医薬組成物。
  9. 前記白血病が、治療抵抗性のCD19+白血病またはリンパ腫である、請求項１〜７のいずれか1項に記載の医薬組成物。
JP2017170459A 2010-12-09 2017-09-05 癌を治療するためのキメラ抗原受容体改変ｔ細胞の使用 Active JP6588060B2 (ja)

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JP2017170459A Active JP6588060B2 (ja) 2010-12-09 2017-09-05 癌を治療するためのキメラ抗原受容体改変ｔ細胞の使用
JP2017171153A Active JP6588514B2 (ja) 2010-12-09 2017-09-06 癌を治療するためのキメラ抗原受容体改変ｔ細胞の使用
JP2019165362A Active JP6943933B2 (ja) 2010-12-09 2019-09-11 癌を治療するためのキメラ抗原受容体改変ｔ細胞の使用
JP2021146980A Active JP7426361B2 (ja) 2010-12-09 2021-09-09 癌を治療するためのキメラ抗原受容体改変ｔ細胞の使用
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AP (1) AP2013006918A0 (ja)
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DO (1) DOP2013000128A (ja)
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