MX2019001185A - Polipeptidos inmunomoduladores y composiciones y metodos relacionados. - Google Patents
Polipeptidos inmunomoduladores y composiciones y metodos relacionados.Info
- Publication number
- MX2019001185A MX2019001185A MX2019001185A MX2019001185A MX2019001185A MX 2019001185 A MX2019001185 A MX 2019001185A MX 2019001185 A MX2019001185 A MX 2019001185A MX 2019001185 A MX2019001185 A MX 2019001185A MX 2019001185 A MX2019001185 A MX 2019001185A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- engineered
- methods
- polypeptides
- immunomodulatory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57554—Prolactin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
Abstract
En la presente se proporcionan polipéptidos inmunomoduladores que contienen una primera y una segunda subunidades de una citocina o una quimiocina conectada por una región de unión que contiene un resto dirigido que se une a una molécula objetivo. En algunos aspectos, la descripción se refiere adicionalmente a células modificadas y composiciones que comprenden los polipéptidos inmunomoduladores, así como métodos para su administración a los sujetos. En algunas modalidades, las células modificadas para contener el polipéptido inmunomodulador, tales como las células T, contienen adicionalmente un receptor de antígeno modificado genéticamente que se une específicamente a los antígenos, tal como un receptor de antígeno quimérico (CAR). En algunas modalidades, las características de los polipéptidos, las células modificadas y los métodos proporcionan un tratamiento mejorado de enfermedades o trastornos, tal como la reducción de los efectos adversos de la terapia con citocinas o quimiocinas, o el aumento de la actividad, la eficacia y/o la persistencia o la disminución de la inmunogenicidad de la terapia de células adoptivas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662369017P | 2016-07-29 | 2016-07-29 | |
PCT/US2017/044549 WO2018023093A1 (en) | 2016-07-29 | 2017-07-28 | Immunomodulatory polypeptides and related compositions and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019001185A true MX2019001185A (es) | 2019-10-21 |
Family
ID=59631857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019001185A MX2019001185A (es) | 2016-07-29 | 2017-07-28 | Polipeptidos inmunomoduladores y composiciones y metodos relacionados. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20190194283A1 (es) |
EP (1) | EP3490585B1 (es) |
JP (2) | JP7295795B2 (es) |
CN (1) | CN110087672A (es) |
AU (1) | AU2017301880C1 (es) |
CA (1) | CA3031955A1 (es) |
ES (1) | ES2951552T3 (es) |
MA (1) | MA45779A (es) |
MX (1) | MX2019001185A (es) |
WO (1) | WO2018023093A1 (es) |
Families Citing this family (22)
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WO2019010224A1 (en) | 2017-07-03 | 2019-01-10 | Torque Therapeutics, Inc. | FUSION MOLECULES TARGETING IMMUNE REGULATORY CELLS AND USES THEREOF |
CA3093791A1 (en) * | 2018-03-14 | 2019-09-19 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Il-13 receptor alpha 2 targeted, zetakine directed t cell immunotherapy |
WO2019222294A1 (en) * | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
US11319380B2 (en) | 2018-06-04 | 2022-05-03 | Precigen, Inc. | MUC16 specific chimeric antigen receptors and uses thereof |
CN109306016B (zh) * | 2018-08-15 | 2021-10-22 | 华东师范大学 | 共表达细胞因子il-7的nkg2d-car-t细胞及其用途 |
US20210340219A1 (en) * | 2018-09-07 | 2021-11-04 | Sotio, LLC | Chimeric receptor polypeptides in combination with trans metabolism molecules modulating intracellular lactate concentrations and therapeutic uses thereof |
WO2020181983A1 (zh) * | 2019-03-12 | 2020-09-17 | 重庆精准生物技术有限公司 | 缺氧调控启动子及其应用 |
CN111848811A (zh) * | 2019-04-27 | 2020-10-30 | 张晋宇 | 一种蛋白质异二聚体及其用途 |
US11512122B2 (en) | 2019-05-17 | 2022-11-29 | Xencor, Inc. | IL-7-FC-fusion proteins |
CN112294760A (zh) * | 2019-07-26 | 2021-02-02 | 张晋宇 | 一种液体制剂及其应用 |
WO2021081345A1 (en) * | 2019-10-25 | 2021-04-29 | Mayo Foundation For Medical Education And Research | Bi-peptide with affinity to extracellular matrix proteins or cells and to growth factors for tissue healing and regeneration |
WO2021115333A1 (zh) * | 2019-12-10 | 2021-06-17 | 苏州克睿基因生物科技有限公司 | 一种融合蛋白及表达此蛋白的工程化免疫细胞及其应用 |
CN111153961B (zh) * | 2020-01-08 | 2022-02-18 | 郑州大学 | 一种亲和pd-1的肽及其应用 |
AU2020425816A1 (en) * | 2020-01-30 | 2022-08-04 | Purdue Research Foundation | Ligand-mediated delivery of therapeutic proteins and the uses thereof |
CN111533785B (zh) * | 2020-02-11 | 2022-03-08 | 北京市肿瘤防治研究所 | 靶向免疫检查点tim3结合肽及其应用 |
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CN112063588A (zh) * | 2020-08-13 | 2020-12-11 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
CN114249807B (zh) * | 2021-08-13 | 2023-12-05 | 上海鑫湾生物科技有限公司 | 缺氧触发的人工转录因子、转录控制系统及其应用 |
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WO2023137069A2 (en) * | 2022-01-12 | 2023-07-20 | St. Jude Children's Research Hospital, Inc. | Bispecific chimeric antigen receptors targeting grp78 and cd123 or grp78 and b7h3 |
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-
2017
- 2017-07-28 WO PCT/US2017/044549 patent/WO2018023093A1/en unknown
- 2017-07-28 MA MA045779A patent/MA45779A/fr unknown
- 2017-07-28 CA CA3031955A patent/CA3031955A1/en active Pending
- 2017-07-28 EP EP17752521.9A patent/EP3490585B1/en active Active
- 2017-07-28 CN CN201780058404.8A patent/CN110087672A/zh active Pending
- 2017-07-28 JP JP2019504812A patent/JP7295795B2/ja active Active
- 2017-07-28 AU AU2017301880A patent/AU2017301880C1/en active Active
- 2017-07-28 ES ES17752521T patent/ES2951552T3/es active Active
- 2017-07-28 US US16/320,075 patent/US20190194283A1/en active Pending
- 2017-07-28 MX MX2019001185A patent/MX2019001185A/es unknown
-
2023
- 2023-02-20 JP JP2023024001A patent/JP2023062104A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20190194283A1 (en) | 2019-06-27 |
AU2017301880C1 (en) | 2022-04-21 |
AU2017301880A1 (en) | 2019-02-07 |
WO2018023093A1 (en) | 2018-02-01 |
ES2951552T3 (es) | 2023-10-23 |
EP3490585A1 (en) | 2019-06-05 |
EP3490585B1 (en) | 2023-05-17 |
CN110087672A (zh) | 2019-08-02 |
JP2023062104A (ja) | 2023-05-02 |
JP7295795B2 (ja) | 2023-06-21 |
AU2017301880B2 (en) | 2021-11-04 |
CA3031955A1 (en) | 2018-02-01 |
MA45779A (fr) | 2019-06-05 |
JP2019531704A (ja) | 2019-11-07 |
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