BR112015002816A8 - Método e composições para imunoterapia celular - Google Patents

Método e composições para imunoterapia celular

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Publication number
BR112015002816A8
BR112015002816A8 BR112015002816A BR112015002816A BR112015002816A8 BR 112015002816 A8 BR112015002816 A8 BR 112015002816A8 BR 112015002816 A BR112015002816 A BR 112015002816A BR 112015002816 A BR112015002816 A BR 112015002816A BR 112015002816 A8 BR112015002816 A8 BR 112015002816A8
Authority
BR
Brazil
Prior art keywords
cells
polynucleotide
compositions
chimeric receptor
cellular immunotherapy
Prior art date
Application number
BR112015002816A
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English (en)
Other versions
BR112015002816A2 (pt
Inventor
Jensen Michael
R Riddell Stanley
Hudecek Michael
Original Assignee
Hutchinson Fred Cancer Res
Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Fred Hutchinson Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49054932&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015002816(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hutchinson Fred Cancer Res, Seattle Childrens Hospital Dba Seattle Childrens Res Inst, Fred Hutchinson Cancer Center filed Critical Hutchinson Fred Cancer Res
Publication of BR112015002816A2 publication Critical patent/BR112015002816A2/pt
Publication of BR112015002816A8 publication Critical patent/BR112015002816A8/pt

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Abstract

MÉTODO E COMPOSIÇÕES PARA IMUNOTERAPIA CELULAR. A presente invenção proporciona ácidos nucleicos, vetores, células hospedeiras, métodos e composições para conferir e/ou aumentar as respostas imunes mediadas por imunoterapia celular, tal como por adotivamente transferir as células T CDS+ da memória central ou combinações de células T da memória central com células T CD4+ que são geneticamente modificadas para expressar um receptor quimérico. Nas modalidades a célula hospedeira geneticamente modificada compreende um ácido nucleico compreendendo um polinucleotídeo que codifica para um domínio de ligação ao ligante, um polinucleotídeo compreendendo uma região de espaçamento personalizada, um polinucleotídeo compreendendo um domínio transmembranar, e um polinucleotídeo compreendendo um domínio de sinalização intracelular. Foi surpreendentemente verificado que o comprimento da região de espaçamento pode afetar a capacidade das células T modificadas com receptor quimérico para reconhecer as células-alvo in vitro, e afeta a eficácia in vivo das células T modificadas com receptor quimérico. As formulações farmacêuticas produzidas pelo método, e os métodos de utilização das mesmas, também são descritos.
BR112015002816A 2012-08-20 2013-08-20 Método e composições para imunoterapia celular BR112015002816A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261691117P 2012-08-20 2012-08-20
PCT/US2013/055862 WO2014031687A1 (en) 2012-08-20 2013-08-20 Method and compositions for cellular immunotherapy

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BR112015002816A2 BR112015002816A2 (pt) 2017-11-28
BR112015002816A8 true BR112015002816A8 (pt) 2023-04-18

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US (4) US10780118B2 (pt)
EP (2) EP3824905A1 (pt)
JP (4) JP6574381B2 (pt)
KR (4) KR102264290B1 (pt)
CN (1) CN104780939B (pt)
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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B25A Requested transfer of rights approved

Owner name: SEATTLE CHILDREN'S HOSPITAL, DBA SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) ; FRED HUTCHINSON CANCER CENTER (US)