SG10201811816RA - Chimeric antigen receptors and methods of making - Google Patents

Chimeric antigen receptors and methods of making

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Publication number
SG10201811816RA
SG10201811816RA SG10201811816RA SG10201811816RA SG10201811816RA SG 10201811816R A SG10201811816R A SG 10201811816RA SG 10201811816R A SG10201811816R A SG 10201811816RA SG 10201811816R A SG10201811816R A SG 10201811816RA SG 10201811816R A SG10201811816R A SG 10201811816RA
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SG
Singapore
Prior art keywords
methods
chimeric antigen
antigen receptors
making
car
Prior art date
Application number
SG10201811816RA
Inventor
Laurence Cooper
Ana Korngold
Brian Rabinovich
Harjeet Singh
Simon Olivares
Original Assignee
Univ Texas
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Application filed by Univ Texas filed Critical Univ Texas
Publication of SG10201811816RA publication Critical patent/SG10201811816RA/en

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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/46—Cellular immunotherapy
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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    • A61K39/464416—Receptors for cytokines
    • A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/1034—Isolating an individual clone by screening libraries
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    • C12N9/10—Transferases (2.)
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Abstract

CHIMERIC ANTIGEN RECEPTORS AND METHODS OF MAKING Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding the CAR from random attachment of vectors from libraries of vectors encoding antigen-binding domains (e.g ., scFv regions), hinge regions, and endodomains. In some embodiments, the vectors contain a transposon. [No suitable figure]
SG10201811816RA 2014-02-14 2015-02-16 Chimeric antigen receptors and methods of making SG10201811816RA (en)

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US201461940339P 2014-02-14 2014-02-14

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EP (2) EP3656864A1 (en)
JP (2) JP6640726B2 (en)
KR (1) KR102375998B1 (en)
CN (2) CN106414748B (en)
AU (2) AU2015218239B2 (en)
CA (2) CA2938887C (en)
DK (1) DK3105335T3 (en)
ES (1) ES2764471T3 (en)
IL (3) IL247208B (en)
MX (2) MX369513B (en)
RU (2) RU2753965C2 (en)
SG (2) SG10201811816RA (en)
WO (1) WO2015123642A1 (en)
ZA (1) ZA201605655B (en)

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