MX2022001711A - Receptores en la superficie celular que responden a la perdida de heterocigosidad. - Google Patents

Receptores en la superficie celular que responden a la perdida de heterocigosidad.

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Publication number
MX2022001711A
MX2022001711A MX2022001711A MX2022001711A MX2022001711A MX 2022001711 A MX2022001711 A MX 2022001711A MX 2022001711 A MX2022001711 A MX 2022001711A MX 2022001711 A MX2022001711 A MX 2022001711A MX 2022001711 A MX2022001711 A MX 2022001711A
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MX
Mexico
Prior art keywords
heterozygosity
loss
cell
surface receptors
receptors responsive
Prior art date
Application number
MX2022001711A
Other languages
English (en)
Inventor
Carl Alexander Kamb
Han Xu
Agnes Hamburger
Original Assignee
A2 Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A2 Biotherapeutics Inc filed Critical A2 Biotherapeutics Inc
Publication of MX2022001711A publication Critical patent/MX2022001711A/es

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

La descripción se relaciona con sistemas de dos receptores modificados genéticamente que tienen, cada uno, un dominio de unión al ligando, colectivamente diseñados para direccionarse a células identificadas por la pérdida de heterocigosidad y utilizadas para tratar una enfermedad o trastorno, por ejemplo, cáncer. La descripción proporciona células inmunitarias que expresan dos receptores modificados genéticamente, métodos para crearlos y polinucleótidos y vectores que los codifican.
MX2022001711A 2019-08-09 2020-08-06 Receptores en la superficie celular que responden a la perdida de heterocigosidad. MX2022001711A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962885093P 2019-08-09 2019-08-09
US202063005670P 2020-04-06 2020-04-06
PCT/US2020/045228 WO2021030149A1 (en) 2019-08-09 2020-08-06 Cell-surface receptors responsive to loss of heterozygosity

Publications (1)

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MX2022001711A true MX2022001711A (es) 2022-05-10

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EP (1) EP4010377A4 (es)
JP (1) JP2022543702A (es)
KR (1) KR20220053587A (es)
CN (1) CN114585645A (es)
AU (1) AU2020329881A1 (es)
BR (1) BR112022002465A2 (es)
CA (1) CA3150071A1 (es)
IL (1) IL290413A (es)
MX (1) MX2022001711A (es)
WO (1) WO2021030149A1 (es)

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WO2021030149A1 (en) 2021-02-18
IL290413A (en) 2022-04-01
EP4010377A1 (en) 2022-06-15
AU2020329881A8 (en) 2022-06-02
JP2022543702A (ja) 2022-10-13
CN114585645A (zh) 2022-06-03
EP4010377A4 (en) 2023-09-06
BR112022002465A2 (pt) 2022-05-03
AU2020329881A1 (en) 2022-03-24
KR20220053587A (ko) 2022-04-29

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