MX2022001711A - Receptores en la superficie celular que responden a la perdida de heterocigosidad. - Google Patents
Receptores en la superficie celular que responden a la perdida de heterocigosidad.Info
- Publication number
- MX2022001711A MX2022001711A MX2022001711A MX2022001711A MX2022001711A MX 2022001711 A MX2022001711 A MX 2022001711A MX 2022001711 A MX2022001711 A MX 2022001711A MX 2022001711 A MX2022001711 A MX 2022001711A MX 2022001711 A MX2022001711 A MX 2022001711A
- Authority
- MX
- Mexico
- Prior art keywords
- heterozygosity
- loss
- cell
- surface receptors
- receptors responsive
- Prior art date
Links
- 108010001857 Cell Surface Receptors Proteins 0.000 title 1
- 102000006240 membrane receptors Human genes 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 108020001756 ligand binding domains Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
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- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- A61K2239/57—Skin; melanoma
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- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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Abstract
La descripción se relaciona con sistemas de dos receptores modificados genéticamente que tienen, cada uno, un dominio de unión al ligando, colectivamente diseñados para direccionarse a células identificadas por la pérdida de heterocigosidad y utilizadas para tratar una enfermedad o trastorno, por ejemplo, cáncer. La descripción proporciona células inmunitarias que expresan dos receptores modificados genéticamente, métodos para crearlos y polinucleótidos y vectores que los codifican.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962885093P | 2019-08-09 | 2019-08-09 | |
US202063005670P | 2020-04-06 | 2020-04-06 | |
PCT/US2020/045228 WO2021030149A1 (en) | 2019-08-09 | 2020-08-06 | Cell-surface receptors responsive to loss of heterozygosity |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022001711A true MX2022001711A (es) | 2022-05-10 |
Family
ID=74571174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022001711A MX2022001711A (es) | 2019-08-09 | 2020-08-06 | Receptores en la superficie celular que responden a la perdida de heterocigosidad. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20240173352A1 (es) |
EP (1) | EP4010377A4 (es) |
JP (1) | JP2022543702A (es) |
KR (1) | KR20220053587A (es) |
CN (1) | CN114585645A (es) |
AU (1) | AU2020329881A1 (es) |
BR (1) | BR112022002465A2 (es) |
CA (1) | CA3150071A1 (es) |
IL (1) | IL290413A (es) |
MX (1) | MX2022001711A (es) |
WO (1) | WO2021030149A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3133333A1 (en) | 2019-04-30 | 2020-04-30 | Brian Scott GARRISON | Chimeric receptors and methods of use thereof |
EP4073103A1 (en) | 2019-12-11 | 2022-10-19 | A2 Biotherapeutics, Inc. | Lilrb1-based chimeric antigen receptor |
TW202144396A (zh) * | 2020-02-20 | 2021-12-01 | 美商聖堤生物科技股份有限公司 | 抑制性嵌合受體架構 |
WO2022036068A1 (en) | 2020-08-13 | 2022-02-17 | A2 Biotherapeutics, Inc. | Gene fusions for control of genetically modified cells |
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