BR112021021996A2 - Métodos para administração de imunoterapia com receptores de antígeno quimérico - Google Patents

Métodos para administração de imunoterapia com receptores de antígeno quimérico

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Publication number
BR112021021996A2
BR112021021996A2 BR112021021996A BR112021021996A BR112021021996A2 BR 112021021996 A2 BR112021021996 A2 BR 112021021996A2 BR 112021021996 A BR112021021996 A BR 112021021996A BR 112021021996 A BR112021021996 A BR 112021021996A BR 112021021996 A2 BR112021021996 A2 BR 112021021996A2
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BR
Brazil
Prior art keywords
methods
chimeric antigen
cell lymphoma
antigen receptors
immunotherapy
Prior art date
Application number
BR112021021996A
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English (en)
Inventor
Rajul JAIN
Remus Vezan
Original Assignee
Kite Pharma Inc
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Publication date
Application filed by Kite Pharma Inc filed Critical Kite Pharma Inc
Publication of BR112021021996A2 publication Critical patent/BR112021021996A2/pt

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70503—Immunoglobulin superfamily
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    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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Abstract

métodos para administração de imunoterapia com receptores de antígeno quimérico. a revelação fornece células compreendendo imunoterapia com células t autólogas geneticamente modificadas para receptor de antígeno quimérico (car) direcionadas a cd19 para o tratamento de, por exemplo, linfoma de grandes células b recidivante ou refratário, após duas ou mais linhas de terapia sistêmica, inclusive linfoma difuso de grandes células b (ldgcb) não especificado de outro modo, linfoma primário de grandes células b do mediastino, linfoma de grandes células b de alto grau, e ldgcb decorrente de linfoma folicular. alguns aspectos da revelação se referem a métodos para tratamento e monitoramento após a infusão de terapia com células t aqui fornecida.
BR112021021996A 2019-05-03 2020-05-03 Métodos para administração de imunoterapia com receptores de antígeno quimérico BR112021021996A2 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962843190P 2019-05-03 2019-05-03
US201962855828P 2019-05-31 2019-05-31
US201962868262P 2019-06-28 2019-06-28
US201962931669P 2019-11-06 2019-11-06
US201962944903P 2019-12-06 2019-12-06
PCT/US2020/031231 WO2020227177A1 (en) 2019-05-03 2020-05-03 Methods of administering chimeric antigen receptor immunotherapy

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BR112021021996A2 true BR112021021996A2 (pt) 2022-01-11

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BR112021021996A BR112021021996A2 (pt) 2019-05-03 2020-05-03 Métodos para administração de imunoterapia com receptores de antígeno quimérico

Country Status (13)

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US (2) US20200384027A1 (pt)
EP (2) EP3962490A4 (pt)
JP (1) JP2022532865A (pt)
KR (1) KR20220005075A (pt)
CN (1) CN114206346A (pt)
AU (1) AU2020267378A1 (pt)
BR (1) BR112021021996A2 (pt)
CA (1) CA3138707A1 (pt)
IL (1) IL287533A (pt)
MX (1) MX2021013394A (pt)
SG (1) SG11202112123RA (pt)
TW (1) TW202108150A (pt)
WO (1) WO2020227177A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022117799A2 (en) * 2020-12-04 2022-06-09 Morphosys Ag Anti-cd19 combination therapy
WO2022137186A1 (en) * 2020-12-23 2022-06-30 Crispr Therapeutics Ag Cancer treatment using cd38 inhibitor and/or lenalidomide and t-cells expressing a chimeric antigen receptor
CN117396607A (zh) 2020-12-30 2024-01-12 阿劳诺斯治疗公司 包含多顺反子表达盒的重组载体及其使用方法
CN113406334A (zh) * 2021-06-02 2021-09-17 浙江省人民医院 一种dlbcl相关的生物标记组合物及其应用、dlbcl预后的效果预测模型
TW202313665A (zh) * 2021-07-30 2023-04-01 美商凱特製藥公司 細胞療法誘導之毒性的監測及管理
CN113786490A (zh) * 2021-09-14 2021-12-14 华中科技大学同济医学院附属协和医院 能调控巨噬细胞表观遗传的制剂用于制备治疗噬血细胞综合征药物的应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
US6319494B1 (en) 1990-12-14 2001-11-20 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
WO1994009138A1 (en) 1992-10-20 1994-04-28 Cetus Oncology Corporation Interleukin-6 receptor antagonists
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US6406699B1 (en) 1999-10-05 2002-06-18 Gary W. Wood Composition and method of cancer antigen immunotherapy
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
ATE373078T1 (de) 2000-02-24 2007-09-15 Xcyte Therapies Inc Gleichzeitige stimulation und konzentration von zellen
GB0700058D0 (en) 2007-01-03 2007-02-07 Scancell Aps Anti-tumor vaccine based on normal cells
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
TR201808019T4 (tr) * 2010-10-27 2018-06-21 Amgen Res Munich Gmbh Dlbcl tedavisi için araçlar ve yöntemler.
JP5947311B2 (ja) 2010-12-09 2016-07-06 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 癌を治療するためのキメラ抗原受容体改変ｔ細胞の使用
US9402865B2 (en) 2011-01-18 2016-08-02 The Trustees Of The University Of Pennsylvania Compositions and methods for treating cancer
MX359513B (es) 2011-03-23 2018-10-01 Hutchinson Fred Cancer Res Metodo y composiciones para inmunoterapia celular.
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
US10421960B2 (en) 2011-09-16 2019-09-24 The Trustees Of The University Of Pennsylvania RNA engineered T cells for the treatment of cancer
US10117896B2 (en) 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
EP3102609A4 (en) 2014-02-04 2017-08-23 The United States of America, as represented by The Secretary, Department of Health and Human Services Methods for producing autologous t cells useful to treat b cell malignancies and other cancers and compositions thereof
EP3851110A1 (en) 2015-05-28 2021-07-21 Kite Pharma, Inc. Methods of conditioning patients for t cell therapy
WO2017070395A1 (en) 2015-10-20 2017-04-27 Kite Pharma, Inc. Methods of preparing t cells for t cell therapy
CN108495651A (zh) 2015-12-17 2018-09-04 诺华股份有限公司 抗pd-1的抗体分子及其用途
CN110461315A (zh) * 2016-07-15 2019-11-15 诺华股份有限公司 使用与激酶抑制剂组合的嵌合抗原受体治疗和预防细胞因子释放综合征
JOP20180042A1 (ar) * 2017-04-24 2019-01-30 Kite Pharma Inc نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام
MX2019014268A (es) * 2017-06-02 2020-08-03 Juno Therapeutics Inc Artículos de manufactura y métodos para tratamiento usando terapia celular adoptiva.
US11673962B2 (en) * 2017-10-02 2023-06-13 Humanigen, Inc. Method of increasing the efficacy of CAR-T immunotherapy using lenzilumab
SG11202003380TA (en) * 2017-10-18 2020-05-28 Kite Pharma Inc Methods of administering chimeric antigen receptor immunotherapy

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US20200384027A1 (en) 2020-12-10
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US20230270785A1 (en) 2023-08-31
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