MX2020001358A - Celulas t que redirigen el receptor del antigeno quimerico especifico cd123 y metodos de su uso. - Google Patents

Celulas t que redirigen el receptor del antigeno quimerico especifico cd123 y metodos de su uso.

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Publication number
MX2020001358A
MX2020001358A MX2020001358A MX2020001358A MX2020001358A MX 2020001358 A MX2020001358 A MX 2020001358A MX 2020001358 A MX2020001358 A MX 2020001358A MX 2020001358 A MX2020001358 A MX 2020001358A MX 2020001358 A MX2020001358 A MX 2020001358A
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Prior art keywords
cells
chimeric antigen
aml
substitution
cd123car
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MX2020001358A
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English (en)
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Stephen Forman
Armen Mardiros
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Publication of MX2020001358A publication Critical patent/MX2020001358A/es

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464416—Receptors for cytokines
    • A61K39/464419—Receptors for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0634—Cells from the blood or the immune system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/17—Hinge-spacer domain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2510/00—Genetically modified cells

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  • Immunology (AREA)
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Abstract

Se desarrolló una familia de receptores de antígeno quimérico (CARs) que contiene scFv específico CD123 para dirigir diferentes epítopos en CD123. En algunas modalidades, tal gen del receptor de antígeno quimérico CD123 (CD123CAR) incluye una región scFv anti-CD123 fusionada en el marco a una región de bisagra IgG4 modificada que comprende una sustitución S228P, una sustitución L235E, y opcionalmente una sustitución N297Q; un dominio de señalización coestimulante; y un dominio de señalización de cadena zeta del receptor de célula T (TCR). Cuando se expresan en células T de donador saludable (CD4/CD8), los CD123CARs redirigen la especificidad de la célula T y median la actividad efectora potente contra las líneas de célula CD123+ así como muestras de paciente AML primarias. Además, las células T obtenidas de pacientes con AML activo, pueden modificarse para expresar genes CD123CAR y son capaces de lisar blastos AML autólogos in vitro. Finalmente, una dosis sencilla de 5.0 x 106 células T CAR123 resulta en un progreso leucémico significativamente retardado en ratones. Estos resultados sugieren que las células T transducidas con CD123CAR pueden usarse como una inmunoterapia para el tratamiento de AML de alto riesgo.
MX2020001358A 2013-03-15 2015-09-15 Celulas t que redirigen el receptor del antigeno quimerico especifico cd123 y metodos de su uso. MX2020001358A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13/844,048 US9657105B2 (en) 2013-03-15 2013-03-15 CD123-specific chimeric antigen receptor redirected T cells and methods of their use

Publications (1)

Publication Number Publication Date
MX2020001358A true MX2020001358A (es) 2020-08-20

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ID=51527938

Family Applications (2)

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MX2015013195A MX2015013195A (es) 2013-03-15 2014-03-14 Celulas t que redirigen el receptor del antigeno quimerico especifico cd123 y metodos de su uso.
MX2020001358A MX2020001358A (es) 2013-03-15 2015-09-15 Celulas t que redirigen el receptor del antigeno quimerico especifico cd123 y metodos de su uso.

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MX2015013195A MX2015013195A (es) 2013-03-15 2014-03-14 Celulas t que redirigen el receptor del antigeno quimerico especifico cd123 y metodos de su uso.

Country Status (16)

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US (3) US9657105B2 (es)
EP (2) EP3626247B1 (es)
JP (4) JP6588004B2 (es)
KR (4) KR102416258B1 (es)
CN (2) CN105392887B (es)
AU (3) AU2014228911A1 (es)
BR (1) BR112015023701B1 (es)
CA (1) CA2907216C (es)
DK (1) DK2968415T3 (es)
ES (1) ES2747099T3 (es)
HK (1) HK1222677A1 (es)
IL (4) IL298332A (es)
MX (2) MX2015013195A (es)
NZ (1) NZ712351A (es)
RU (1) RU2711114C2 (es)
WO (1) WO2014144622A2 (es)

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