MX2022010944A - Inhibidores del factor de iniciacion de traduccion eucariotica 4e (eif4e) y sus usos. - Google Patents
Inhibidores del factor de iniciacion de traduccion eucariotica 4e (eif4e) y sus usos.Info
- Publication number
- MX2022010944A MX2022010944A MX2022010944A MX2022010944A MX2022010944A MX 2022010944 A MX2022010944 A MX 2022010944A MX 2022010944 A MX2022010944 A MX 2022010944A MX 2022010944 A MX2022010944 A MX 2022010944A MX 2022010944 A MX2022010944 A MX 2022010944A
- Authority
- MX
- Mexico
- Prior art keywords
- eif4e inhibitors
- eif4e
- inhibitors
- compositions
- methods
- Prior art date
Links
- 101100286531 Drosophila melanogaster eIF4E1 gene Proteins 0.000 title 1
- 101150114135 eIF4E gene Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención proporciona compuestos que inhiben la actividad de eIF4E, y composiciones y métodos de uso de ellos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062984543P | 2020-03-03 | 2020-03-03 | |
PCT/US2021/020597 WO2021178488A1 (en) | 2020-03-03 | 2021-03-03 | Eif4e inhibitors and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022010944A true MX2022010944A (es) | 2022-11-09 |
Family
ID=75173469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022010944A MX2022010944A (es) | 2020-03-03 | 2021-03-03 | Inhibidores del factor de iniciacion de traduccion eucariotica 4e (eif4e) y sus usos. |
Country Status (15)
Country | Link |
---|---|
US (2) | US11753403B2 (es) |
EP (1) | EP4114529A1 (es) |
JP (1) | JP2023515888A (es) |
KR (1) | KR20220164706A (es) |
CN (1) | CN115515685A (es) |
AR (1) | AR121506A1 (es) |
AU (1) | AU2021230289A1 (es) |
BR (1) | BR112022017727A2 (es) |
CA (1) | CA3170411A1 (es) |
CL (1) | CL2022002402A1 (es) |
CO (1) | CO2022012594A2 (es) |
IL (1) | IL296139A (es) |
MX (1) | MX2022010944A (es) |
TW (1) | TW202146393A (es) |
WO (1) | WO2021178488A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220164706A (ko) | 2020-03-03 | 2022-12-13 | 피아이씨 테라퓨틱스 인코포레이티드 | Eif4e 억제제 및 이의 용도 |
EP4253383A1 (en) * | 2020-12-31 | 2023-10-04 | Tsinghua University | Pyridine-2-amine derivative and pharmaceutical composition and use thereof |
WO2023028235A1 (en) * | 2021-08-25 | 2023-03-02 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
US20230134932A1 (en) * | 2021-08-25 | 2023-05-04 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
GB2615307A (en) * | 2022-01-28 | 2023-08-09 | Adorx Therapeutics Ltd | Antagonist compounds |
US20240208961A1 (en) * | 2022-11-22 | 2024-06-27 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
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-
2021
- 2021-03-03 KR KR1020227033872A patent/KR20220164706A/ko unknown
- 2021-03-03 EP EP21714071.4A patent/EP4114529A1/en active Pending
- 2021-03-03 TW TW110107613A patent/TW202146393A/zh unknown
- 2021-03-03 MX MX2022010944A patent/MX2022010944A/es unknown
- 2021-03-03 AR ARP210100559A patent/AR121506A1/es unknown
- 2021-03-03 IL IL296139A patent/IL296139A/en unknown
- 2021-03-03 US US17/191,072 patent/US11753403B2/en active Active
- 2021-03-03 WO PCT/US2021/020597 patent/WO2021178488A1/en unknown
- 2021-03-03 AU AU2021230289A patent/AU2021230289A1/en active Pending
- 2021-03-03 BR BR112022017727A patent/BR112022017727A2/pt unknown
- 2021-03-03 CA CA3170411A patent/CA3170411A1/en active Pending
- 2021-03-03 CN CN202180032438.6A patent/CN115515685A/zh active Pending
- 2021-03-03 JP JP2022552792A patent/JP2023515888A/ja active Pending
-
2022
- 2022-09-02 CO CONC2022/0012594A patent/CO2022012594A2/es unknown
- 2022-09-02 CL CL2022002402A patent/CL2022002402A1/es unknown
-
2023
- 2023-06-15 US US18/210,306 patent/US20230399322A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
IL296139A (en) | 2022-11-01 |
AR121506A1 (es) | 2022-06-08 |
CL2022002402A1 (es) | 2023-04-21 |
AU2021230289A1 (en) | 2022-09-29 |
KR20220164706A (ko) | 2022-12-13 |
BR112022017727A2 (pt) | 2022-11-16 |
CA3170411A1 (en) | 2021-09-10 |
US20230399322A1 (en) | 2023-12-14 |
CO2022012594A2 (es) | 2022-09-09 |
WO2021178488A1 (en) | 2021-09-10 |
US20220356178A1 (en) | 2022-11-10 |
JP2023515888A (ja) | 2023-04-14 |
US11753403B2 (en) | 2023-09-12 |
CN115515685A (zh) | 2022-12-23 |
TW202146393A (zh) | 2021-12-16 |
EP4114529A1 (en) | 2023-01-11 |
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