AU2013243952A1 - Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins - Google Patents
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins Download PDFInfo
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- AU2013243952A1 AU2013243952A1 AU2013243952A AU2013243952A AU2013243952A1 AU 2013243952 A1 AU2013243952 A1 AU 2013243952A1 AU 2013243952 A AU2013243952 A AU 2013243952A AU 2013243952 A AU2013243952 A AU 2013243952A AU 2013243952 A1 AU2013243952 A1 AU 2013243952A1
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- optionally substituted
- independently
- pct
- polypeptide
- polynucleotide
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- 108091033319 polynucleotide Proteins 0.000 title claims abstract description 239
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 68
- 230000001086 cytosolic effect Effects 0.000 title description 14
- 102000010831 Cytoskeletal Proteins Human genes 0.000 title description 6
- 108010037414 Cytoskeletal Proteins Proteins 0.000 title description 6
- 238000000034 method Methods 0.000 claims abstract description 100
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- 108090000623 proteins and genes Proteins 0.000 claims description 281
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 279
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- 102000004169 proteins and genes Human genes 0.000 claims description 256
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- 125000003729 nucleotide group Chemical group 0.000 claims description 88
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- 125000000547 substituted alkyl group Chemical group 0.000 claims description 56
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- HXVVOLDXHIMZJZ-UHFFFAOYSA-N 3-[2-[2-[2-[bis[3-(dodecylamino)-3-oxopropyl]amino]ethyl-[3-(dodecylamino)-3-oxopropyl]amino]ethylamino]ethyl-[3-(dodecylamino)-3-oxopropyl]amino]-n-dodecylpropanamide Chemical compound CCCCCCCCCCCCNC(=O)CCN(CCC(=O)NCCCCCCCCCCCC)CCN(CCC(=O)NCCCCCCCCCCCC)CCNCCN(CCC(=O)NCCCCCCCCCCCC)CCC(=O)NCCCCCCCCCCCC HXVVOLDXHIMZJZ-UHFFFAOYSA-N 0.000 claims description 4
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- 125000005415 substituted alkoxy group Chemical group 0.000 claims 32
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| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
| DE102004024617A1 (de) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| US9308181B2 (en) | 2006-03-06 | 2016-04-12 | Nuvo Research Inc. | Topical formulations, systems and methods |
| US9642912B2 (en) | 2006-03-06 | 2017-05-09 | Crescita Therapeutics Inc. | Topical formulations for treating skin conditions |
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| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
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| PL2591114T3 (pl) | 2010-07-06 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Immunizacja dużych ssaków małymi dawkami rna |
| PL3243526T3 (pl) | 2010-07-06 | 2020-05-18 | Glaxosmithkline Biologicals S.A. | Dostarczanie rna w celu wyzwolenia wielu szlaków immunologicznych |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| HUE061068T2 (hu) | 2010-08-31 | 2023-05-28 | Glaxosmithkline Biologicals Sa | Pegilált liposzómák immunogént kódoló RNS szállítására |
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| EP4098324A1 (en) | 2010-10-11 | 2022-12-07 | GlaxoSmithKline Biologicals S.A. | Antigen delivery platforms |
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