ATE92538T1 - Verstaerkung und nachweis von nukleinsaeuresequenzen. - Google Patents

Verstaerkung und nachweis von nukleinsaeuresequenzen.

Info

Publication number
ATE92538T1
ATE92538T1 AT89902420T AT89902420T ATE92538T1 AT E92538 T1 ATE92538 T1 AT E92538T1 AT 89902420 T AT89902420 T AT 89902420T AT 89902420 T AT89902420 T AT 89902420T AT E92538 T1 ATE92538 T1 AT E92538T1
Authority
AT
Austria
Prior art keywords
nucleic acid
detection
acid sequences
amplification
methods
Prior art date
Application number
AT89902420T
Other languages
English (en)
Inventor
Harvey I Miller
Sean Johnston
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22517472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE92538(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE92538T1 publication Critical patent/ATE92538T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Testing Of Optical Devices Or Fibers (AREA)
  • Light Guides In General And Applications Therefor (AREA)
AT89902420T 1988-01-21 1989-01-12 Verstaerkung und nachweis von nukleinsaeuresequenzen. ATE92538T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14646288A 1988-01-21 1988-01-21
EP89902420A EP0359789B1 (de) 1988-01-21 1989-01-12 Verstärkung und nachweis von nukleinsäuresequenzen
PCT/US1989/000120 WO1989006700A1 (en) 1988-01-21 1989-01-12 Amplification and detection of nucleic acid sequences

Publications (1)

Publication Number Publication Date
ATE92538T1 true ATE92538T1 (de) 1993-08-15

Family

ID=22517472

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89902420T ATE92538T1 (de) 1988-01-21 1989-01-12 Verstaerkung und nachweis von nukleinsaeuresequenzen.

Country Status (10)

Country Link
EP (1) EP0359789B1 (de)
JP (3) JP2846018B2 (de)
AT (1) ATE92538T1 (de)
AU (1) AU624601B2 (de)
DE (1) DE68908054T2 (de)
DK (1) DK175944B1 (de)
ES (1) ES2010094A6 (de)
NO (1) NO300782B1 (de)
NZ (1) NZ227688A (de)
WO (1) WO1989006700A1 (de)

Families Citing this family (221)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5856092A (en) * 1989-02-13 1999-01-05 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
ATE181576T1 (de) * 1989-02-13 1999-07-15 Geneco Pty Ltd Nachweis einer nukleinsäuresequenz oder einer änderung darin
IE66597B1 (en) * 1989-05-10 1996-01-24 Akzo Nv Method for the synthesis of ribonucleic acid (RNA)
DE3929030A1 (de) * 1989-09-01 1991-03-07 Boehringer Mannheim Gmbh Verfahren zur vermehrung von nukleinsaeuren
US7049102B1 (en) * 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US5545522A (en) * 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5629153A (en) * 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
DE69131596T2 (de) 1990-01-10 1999-12-23 Chiron Diagnostics Corp., East Walpole Dns-abhängige rns-polymerase-transkripte als reportermoleküle zur signalverstärkung in nukleinsäure-hybridisierungsuntersuchungen
US7585512B1 (en) 1990-05-08 2009-09-08 Thomas Jefferson University Composition and method of using tumor cells
US5518900A (en) * 1993-01-15 1996-05-21 Molecular Tool, Inc. Method for generating single-stranded DNA molecules
WO1992020820A1 (en) * 1991-05-15 1992-11-26 Vanderbilt University Method to determine metastatic potential of tumor cells
US5169766A (en) * 1991-06-14 1992-12-08 Life Technologies, Inc. Amplification of nucleic acid molecules
EP0648281A4 (de) * 1991-09-10 1997-06-04 Jack D Love Zielgerichte amplifikation von dna und rna und signalamplifikation.
DE4213029A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen vervielfaeltigung von nukleins aeuresequenzen
US5981179A (en) * 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5256555A (en) 1991-12-20 1993-10-26 Ambion, Inc. Compositions and methods for increasing the yields of in vitro RNA transcription and other polynucleotide synthetic reactions
AU681082B2 (en) * 1992-05-06 1997-08-21 Gen-Probe Incorporated Nucleic acid sequence amplification method, composition and kit
US5614389A (en) * 1992-08-04 1997-03-25 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US5834202A (en) * 1992-08-04 1998-11-10 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US5733733A (en) * 1992-08-04 1998-03-31 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
DE4238699A1 (de) * 1992-11-17 1994-05-19 Boehringer Mannheim Gmbh Einfaches Nukleinsäurevermehrungsverfahren
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5863724A (en) * 1994-04-13 1999-01-26 Baylor College Of Medicine Methods of screening for persistent hyperinsulinemic hypoglycemia of infancy
US5942391A (en) 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
US6593086B2 (en) 1996-05-20 2003-07-15 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
FR2724934B1 (fr) * 1994-09-26 1997-01-24 Bio Merieux Oligonucleotide chimere et son utilisation dans l'obtention de transcrits d'un acide nucleique
US5789169A (en) * 1994-11-03 1998-08-04 Regents Of The University Of California Methods for the diagnosis of glaucoma
US5606043A (en) * 1994-11-03 1997-02-25 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5849879A (en) * 1994-11-03 1998-12-15 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5654141A (en) * 1994-11-18 1997-08-05 Thomas Jefferson University Amplification based detection of bacterial infection
JP3453745B2 (ja) * 1995-02-02 2003-10-06 横河電機株式会社 光ファイバ検査装置
JP3453746B2 (ja) * 1995-02-09 2003-10-06 横河電機株式会社 光ファイバ検査装置
EP0754939B1 (de) * 1995-02-02 2004-03-31 Yokogawa Electric Corporation Messvorrichtung für optische fasern
US5753787A (en) * 1995-04-10 1998-05-19 Yale University Nucleic acids encoding ancylostoma secreted protein
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP2369007B1 (de) 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Erkennung von Nukleinsäuresequenz-Unterschieden mittels der gleichzeitigen Ligaseerkennungs- und Polymerasekettenreaktion
US6132954A (en) * 1996-08-20 2000-10-17 Baylor College Of Medicine Methods of screening for agents that delay a cell cycle and compositions comprising era and an analogue of wild-type era
US6043283A (en) * 1996-09-20 2000-03-28 Baylor College Of Medicine Tyramine compounds and their neuronal effects
US6071493A (en) 1996-09-20 2000-06-06 Baylor College Of Medicine Method of screening for an agent that inhibits mononuclear phagocyte-plaque component complex formation
WO1998020166A2 (en) 1996-11-06 1998-05-14 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US6635452B1 (en) 1996-12-10 2003-10-21 Sequenom Inc. Releasable nonvolatile mass label molecules
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US6475724B1 (en) 1997-01-28 2002-11-05 The Regents Of The University Of California Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US7138511B1 (en) 1997-01-28 2006-11-21 The Regents Of The University Of California Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6171788B1 (en) 1997-01-28 2001-01-09 The Regents Of The University Of California Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6262242B1 (en) 1997-01-30 2001-07-17 Board Of Regents, The University Of Texas System Tumor suppressor designated TS10Q23.3
US6482795B1 (en) 1997-01-30 2002-11-19 Myriad Genetics, Inc. Tumor suppressor designated TS10q23.3
US6713300B1 (en) 1997-02-27 2004-03-30 University Of Utah Research Foundation Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
US6117643A (en) 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
ATE555123T1 (de) 1997-12-18 2012-05-15 Monsanto Technology Llc Insektenresistente transgene pflanzen und methoden um delta-toxin aktivität gegen zielinsekten zu verbessern
US6673914B1 (en) 1998-01-22 2004-01-06 John Wayne Cancer Institute Human tumor-associated gene
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US7029861B1 (en) 1998-09-15 2006-04-18 Board Of Regents, The University Of Texas System LPS-response gene compositions and methods
WO2000029008A2 (en) 1998-11-16 2000-05-25 Board Of Regents, The University Of Texas System Hiv-specific t-cell induction
US6156515A (en) 1999-02-09 2000-12-05 Urocor, Inc. Prostate-specific gene for diagnosis, prognosis and management of prostate cancer
US7037682B2 (en) 1999-03-13 2006-05-02 Government Of The Republic Of Singapore In vitro activity assay for human hepatitis B virus (HBV) DNA polymerase, and its use for screening for inhibitors of HBV DNA polymerase
WO2000066780A2 (en) 1999-04-30 2000-11-09 University Of Florida Adeno-associated virus-delivered ribozyme compositions and methods of use
AU781802B2 (en) 1999-06-01 2005-06-16 Baylor College Of Medicine Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
EP1190097A2 (de) 1999-06-22 2002-03-27 Invitrogen Corporation Verbesserte primer und methoden zum nachweis und zur unterscheidung von nukleinsäuren
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
ATE389020T1 (de) 2000-04-21 2008-03-15 Corixa Corp Verbindungen und verfahren zur behandlung und diagnose von chlamydia-infektionen
WO2002000174A2 (en) 2000-06-28 2002-01-03 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
AU2001273337B2 (en) 2000-07-10 2006-06-29 Board Of Regents, The University Of Texas System Chromosome 3p21.3 genes are tumor suppressors
WO2002048402A2 (en) 2000-12-13 2002-06-20 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
JP3853161B2 (ja) * 2001-02-19 2006-12-06 独立行政法人科学技術振興機構 微量ｍＲＮＡ及びｃＤＮＡの増幅方法
EP1366197B1 (de) 2001-03-09 2007-05-09 Nugen Technologies, Inc. Methoden und zusammensetzungen zur vervielfältigung von rna sequenzen
WO2002089747A2 (en) 2001-05-09 2002-11-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US8137911B2 (en) 2001-05-22 2012-03-20 Cellscript, Inc. Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences
WO2002095002A2 (en) 2001-05-22 2002-11-28 University Of Chicago N4 virion single-stranded dna dependent rna polymerase
WO2004059289A2 (en) 2001-05-22 2004-07-15 Epicentre Technologies Target-dependent transcription using deletion mutants of n4 rna polymerase
ATE481497T1 (de) 2001-08-01 2010-10-15 Univ Utah Am n-terminus trunkierte isoformen von zyklischen phosphodiesterasen pde3a
EP1908851A3 (de) 2001-09-19 2008-06-25 Intergenetics Incorporated Genetische Analyse zur Stratifizierung eines Krebsrisikos
WO2003025141A2 (en) 2001-09-19 2003-03-27 Intergenetics Incorporated Genetic analysis for stratification of cancer risk
US20030165859A1 (en) 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
CN1612941B (zh) 2001-12-10 2011-11-16 诺瓦提斯公司 基于cntf基因的多态性治疗精神病和精神分裂症的方法
CA2476755C (en) 2001-12-17 2014-08-26 Corixa Corporation Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
WO2005019409A2 (en) 2002-07-15 2005-03-03 Board Of Regents, The University Of Texas System Combinatorial protein library screening by periplasmic expression
CA2494844C (en) 2002-08-12 2013-10-15 David Kirn Methods and compositions concerning poxviruses and cancer
AU2002951411A0 (en) 2002-09-16 2002-09-26 The University Of Sydney Genotype screen
EP1576188B1 (de) 2002-11-21 2008-10-15 Epicentre Technologies Verfahren zur verwendung von riboprimern zur strangverdrängungsreplikation von zielsequenzen
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
RU2389732C2 (ru) 2003-01-06 2010-05-20 Корикса Корпорейшн Некоторые аминоалкилглюкозаминидфосфатные производные и их применение
JP4480715B2 (ja) 2003-01-29 2010-06-16 ４５４ コーポレーション 二重末端シーケンシング
EP1604040B1 (de) 2003-03-07 2010-10-13 Rubicon Genomics, Inc. Amplifikation und analyse von gesamtgenom- und gesamttranskriptom- bibliotheken, die durch ein dns-polymerisierungsverfahren produziert wurden
EP1606419A1 (de) 2003-03-18 2005-12-21 Quantum Genetics Ireland Limited Systeme und methoden zur erhohung der milchproduktion in tieren
JP2006523465A (ja) 2003-04-14 2006-10-19 ニューゲン テクノロジーズ， インコーポレイテッド ランダムにプライミングされる複合プライマーを用いる大規模増幅
CN1878866B (zh) 2003-07-25 2012-08-01 安比恩股份有限公司 用于从固定的样品中制备rna的方法和组合物
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
DE602004030271D1 (de) 2003-09-12 2011-01-05 Univ Cincinnati Verfahren zur risikobeurteilung, überlebensvorhersage und behandlung von herzversagen und anderen leiden auf der grundlage von polymorphismen adrenerger rezeptoren
EP1718770B1 (de) 2004-02-19 2011-05-25 The Governors of the University of Alberta Leptinpromotor-polymorphismen und verwendungen davon
CN102453763A (zh) 2004-06-03 2012-05-16 阿什洛米克斯控股有限公司 诊断应激的药物和方法
AU2005284822B2 (en) 2004-09-14 2011-03-24 Regents Of The University Of Colorado Method for treatment with bucindolol based on genetic targeting
WO2006090987A1 (en) 2005-02-28 2006-08-31 Bioquest, Inc. Methods for performing direct enzymatic reactions involving nucleic acid molecules
WO2006095941A1 (en) 2005-03-05 2006-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
EP2365079A1 (de) 2005-03-05 2011-09-14 Seegene, Inc. Verfahren mit dualspezifischem Oligonukleotid sowie dualspezifisches Oligonukleotid
AU2006269820B2 (en) 2005-07-07 2012-01-19 Athlomics Pty Ltd Polynucleotide marker genes and their expression, for diagnosis of endotoxemia
US7494788B2 (en) 2005-07-11 2009-02-24 Molecular Kinetics, Inc. Entropic bristle domain sequences and their use in recombinant protein production
US7838646B2 (en) 2005-08-18 2010-11-23 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
EP1929046B1 (de) 2005-09-07 2012-07-11 Nugen Technologies, Inc. Verbessertes nukleinsäureamplifikationsverfahren
JP5237817B2 (ja) 2005-10-21 2013-07-17 ジーンニュース インコーポレーティッド バイオマーカー産物レベルを疾患に相関させるための方法および装置
CA2626325A1 (en) 2005-10-28 2007-05-10 Praecis Pharmaceuticals Incorporated Methods for identifying compounds of interest using encoded libraries
WO2007057395A2 (en) 2005-11-16 2007-05-24 Novartis Ag Biomarkers for anti-nogo-a antibody treatment in spinal cord injury
US8014957B2 (en) 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
WO2007106580A2 (en) 2006-03-15 2007-09-20 Micronics, Inc. Rapid magnetic flow assays
US7951998B2 (en) 2006-05-25 2011-05-31 Monsanto Technology Llc Method to identify disease resistant quantitative trait loci in soybean and compositions thereof
CA2663034C (en) 2006-09-15 2016-05-03 Ottawa Health Research Institute Oncolytic rhabdovirus
KR100823642B1 (ko) * 2006-09-26 2008-04-21 고려대학교 산학협력단 큐티나아제 생산 균주, 그 선별 방법, 상기 균주에 의해생산된 큐티나아제 및 상기 큐티나아제를 포함하는 조성물
US8067179B2 (en) 2006-11-30 2011-11-29 Research Development Foundation Immunoglobulin libraries
EP3121286B1 (de) * 2006-12-21 2019-11-20 Gen-Probe Incorporated Verfahren und zusammensetzungen zur erweiterung von nukleinsäuren
US7794937B2 (en) 2006-12-22 2010-09-14 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
PL2191001T4 (pl) 2007-04-09 2017-01-31 University Of Florida Research Foundation, Inc. Kompozycje wektora RAAV mające białka kapsydu zmodyfikowane tyrozyną i sposoby ich zastosowania
WO2008137475A2 (en) 2007-05-01 2008-11-13 Research Development Foundation Immunoglobulin fc libraries
CA2707436C (en) 2007-06-29 2014-01-28 Epicentre Technologies Corporation Copy dna and sense rna
US8634713B2 (en) * 2008-08-29 2014-01-21 Telefonaktiebolaget Lm Ericsson (Publ) Fibre monitoring in optical networks
KR101833701B1 (ko) 2009-04-22 2018-02-28 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 만성 폐쇄성 폐질환 및 천식의 치료에 사용하기 위한 조성물
EP2449104B1 (de) 2009-06-29 2014-06-04 Luminex Corporation Chimäre primer mit haarnadel-konformationen und verwendungsverfahren dafür
EP2449132B1 (de) 2009-07-01 2015-05-13 Gen-Probe Incorporated Verfahren und zusammensetzungen zur erweiterung von nukleinsäuren
KR20220002712A (ko) 2009-07-17 2022-01-06 바이오아트라, 인코퍼레이티드 생산 숙주에서 항체/단백질 성능과 발현을 동시에 통합 선택하고 진화시키는 방법
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
ES2671570T3 (es) 2009-09-14 2018-06-07 Sillajen Biotherapeutics, Inc. Terapia combinada contra el cáncer con virus oncolítico de vaccinia
KR20110050327A (ko) 2009-11-07 2011-05-13 주식회사 씨젠 Ｔｈｄ 프라이머 타겟 검출
MX365946B (es) 2009-12-10 2019-06-19 Turnstone Lp Rabdovirus oncolitico.
AU2010336137B2 (en) 2009-12-21 2015-08-06 Seegene, Inc. TSG primer target detection
WO2011079273A2 (en) 2009-12-23 2011-06-30 Arca Biopharma, Inc. Methods and compositions for cardiovascular diseases and conditions
JP5791634B2 (ja) 2010-01-29 2015-10-07 マイクロニクス， インコーポレイテッド サンプル−回答型のマイクロ流体カートリッジ
US11225655B2 (en) 2010-04-16 2022-01-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
CA2796399C (en) 2010-04-23 2021-08-24 Shannon Elizabeth Boye Raav-guanylate cyclase compositions and methods for treating leber congenital amaurosis-1 (lca1)
KR101223660B1 (ko) 2010-05-20 2013-01-17 광주과학기술원 ＨＩＦ－２α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물
KR101176139B1 (ko) 2010-05-20 2012-08-22 광주과학기술원 관절염 동물모델로서 연골 특이적 ＨＩＦ?２α 형질전환 마우스 및 이의 용도
EP2913402B1 (de) 2010-07-16 2017-10-18 Tocagen Inc. Retrovirusdetektion
ES2741175T3 (es) 2010-07-16 2020-02-10 Bioatla Llc Nuevos métodos de evolución de proteínas
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
MX2013003681A (es) 2010-10-01 2013-11-20 Moderna Therapeutics Inc Ácidos nucleicos manipulados y métodos de uso de los mismos.
WO2012090073A2 (en) 2010-12-30 2012-07-05 The Netherlands Cancer Institute Methods and compositions for predicting chemotherapy sensitivity
CA2824277C (en) 2011-01-04 2021-08-31 Jennerex, Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
US8952132B2 (en) 2011-02-07 2015-02-10 Research Development Foundation Engineered immunoglobulin FC polypeptides
WO2012158238A2 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
EP2683835B1 (de) 2011-03-08 2017-01-11 King Abdullah University Of Science And Technology Molekulares biomarker-set zur früherkennung von eierstockkrebs
DE12722942T1 (de) 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
US20140287931A1 (en) 2011-04-04 2014-09-25 Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis Methods and compositions for predicting resistance to anticancer treatment
KR101291668B1 (ko) 2011-04-21 2013-08-01 서울대학교산학협력단 미코박테리아―대장균용 셔틀 벡터 및 이의 용도
CN103945864A (zh) 2011-04-25 2014-07-23 先进生物学实验室股份有限公司 截短的hiv包膜蛋白(env)、其相关方法和组合物
CA2872045A1 (en) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
MX2013013627A (es) 2011-06-21 2014-04-25 Oncofactor Corp Composiciones y metodos para la terapia y diagnostico de cancer.
US10040853B2 (en) 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
SI3682905T1 (sl) 2011-10-03 2022-04-29 Modernatx, Inc. Modificirani nukleozidi, nukleotidi in nukleinske kisline ter njihove uporabe
CA2855640C (en) 2011-11-14 2020-03-10 The General Hospital Corporation Assays and methods for selecting a treatment regimen for a subject with depression
US20130156849A1 (en) 2011-12-16 2013-06-20 modeRNA Therapeutics Modified nucleoside, nucleotide, and nucleic acid compositions
WO2013093629A2 (en) 2011-12-20 2013-06-27 Netherlands Cancer Institute Modular vaccines, methods and compositions related thereto
WO2013116698A2 (en) 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
NZ628596A (en) 2012-03-29 2015-10-30 Novartis Ag Pharmaceutical diagnostics for treatment of cancer in subjects having pi3k mutation
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
HK1206601A1 (en) 2012-04-02 2016-01-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
SI2922554T1 (sl) 2012-11-26 2022-06-30 Modernatx, Inc. Terminalno modificirana RNA
EP2740805B1 (de) 2012-12-07 2019-02-20 SuppreMol GmbH Stratifizierung und Behandlung von Patienten, die an idiopathischer thrombozytopenischer Purpura leiden
US10518262B2 (en) 2012-12-21 2019-12-31 Perkinelmer Health Sciences, Inc. Low elasticity films for microfluidic use
JP2016509206A (ja) 2012-12-21 2016-03-24 マイクロニクス， インコーポレイテッド 携帯型蛍光検出システムおよびマイクロアッセイカートリッジ
WO2014100732A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Fluidic circuits and related manufacturing methods
WO2014116721A1 (en) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
WO2014127478A1 (en) 2013-02-21 2014-08-28 Children's Hospital Of Eastern Ontario Research Institute Inc. Vaccine composition
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
KR101403507B1 (ko) 2013-03-21 2014-06-09 주식회사 현일바이오 결핵균 및 비결핵 마이코박테리아의 선택적 검출 방법, 그리고 이를 이용한 키트
KR101507505B1 (ko) 2013-04-18 2015-04-07 사회복지법인 삼성생명공익재단 제 1 형 근긴장성 이영양증의 진단 방법
WO2014182844A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
CA2911308C (en) 2013-05-07 2021-10-19 Micronics, Inc. Device for preparation and analysis of nucleic acids
US10190153B2 (en) 2013-05-07 2019-01-29 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
WO2014183023A1 (en) 2013-05-09 2014-11-13 Trustees Of Boston University Using plexin-a4 as a biomarker and therapeutic target for alzheimer's disease
EP3052106A4 (de) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynukleotide zur codierung immunmodulierender polypeptide
WO2015051110A1 (en) 2013-10-03 2015-04-09 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
SG11201602503TA (en) 2013-10-03 2016-04-28 Moderna Therapeutics Inc Polynucleotides encoding low density lipoprotein receptor
WO2015105888A1 (en) 2014-01-07 2015-07-16 Bioatla, Llc Proteins targeting orthologs
CN106795473A (zh) 2014-06-11 2017-05-31 精密公司 用于核酸分析的具有集成的测定对照的微流体盒及设备
WO2016086227A2 (en) 2014-11-26 2016-06-02 The Regents Of The University Of California Therapeutic compositions comprising transcription factors and methods of making and using the same
WO2016094425A1 (en) 2014-12-08 2016-06-16 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
KR101718800B1 (ko) 2015-01-21 2017-03-24 주식회사 디알나노 약물 및 ｓｉＲＮＡ의 공동―운반용 나노복합체 및 이의 용도
AU2016219511B2 (en) 2015-02-09 2020-11-12 Research Development Foundation Engineered immunoglobulin Fc polypeptides displaying improved complement activation
US10894980B2 (en) 2015-07-17 2021-01-19 President And Fellows Of Harvard College Methods of amplifying nucleic acid sequences mediated by transposase/transposon DNA complexes
US9789087B2 (en) 2015-08-03 2017-10-17 Thomas Jefferson University PAR4 inhibitor therapy for patients with PAR4 polymorphism
WO2017040380A2 (en) 2015-08-28 2017-03-09 Research Development Foundation Engineered antibody fc variants
KR101651817B1 (ko) 2015-10-28 2016-08-29 대한민국 Ngs 라이브러리 제작용 프라이머 세트 및 이를 이용한 ngs 라이브러리 제작방법 및 키트
KR101845957B1 (ko) 2016-02-23 2018-04-05 전남대학교기술지주회사(주) 프로히비틴 유전자 타깃 백혈병 진단용 키트 및 이를 이용한 진단 방법
EP3465200A4 (de) 2016-06-05 2020-07-08 Berg LLC Systeme und verfahren zur patientenstratifizierung und identifizierung von potenziellen biomarkern
EP3562958B1 (de) 2016-12-29 2021-11-03 Seegene, Inc. Verfahren zur reduzierung des primer-dimer-bildung und erhöhung des amplifikationswirkungsgrades
KR101936799B1 (ko) 2017-01-09 2019-01-11 주식회사 엠이티라이프사이언스 구강전암의 치료용 약학 조성물 및 구강전암 또는 구강암의 예측 또는 진단 방법
EP3574114B1 (de) 2017-01-26 2022-06-29 Oklahoma Medical Research Foundation Biomarker für die krankheitsaktivität, die intensität und das auftreten von systemischem lupus erythematodes
US12140592B2 (en) 2017-06-16 2024-11-12 Oklahoma Medical Research Foundation Biomarkers for assessing risk of transitioning to systemic lupus erythematosus classification and disease pathogenesis
KR101956315B1 (ko) 2017-07-19 2019-03-08 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miR494 및 이를 이용한 진단키트
WO2019017680A2 (ko) 2017-07-19 2019-01-24 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miRNA 및 이를 이용한 진단키트
EP3691635B1 (de) 2018-05-25 2023-07-05 Arca Biopharma, Inc. Verfahren und zusammensetzungen mit bucindolol zur behandlung von vorhofflimmern
EP4439066A2 (de) 2018-10-31 2024-10-02 Arizona Board Of Regents On Behalf Of The University Of Arizona Biomarker und verfahren zur verwendung für strahlungsinduzierte lungenläsion
AU2020265250A1 (en) 2019-04-30 2021-11-18 Larimar Therapeutics, Inc. Frataxin-sensitive markers for determining effectiveness of frataxin replacement therapy
JP7353396B2 (ja) 2019-06-14 2023-09-29 シージーン アイエヌシー ターゲット核酸検出用試薬の協業開発のためのコンピュータ処理方法
EP4031118B1 (de) 2019-09-16 2026-01-28 The Children's Hospital of Philadelphia Mithramycinanalog zur behandlung von mutierten swi-snf-tumoren
JP2023526670A (ja) 2020-05-22 2023-06-22 インシトロ インコーポレイテッド 機械学習モデルを使用した疾患の転帰の予測
EP4163397A4 (de) 2020-06-05 2024-08-28 Seegene, Inc. Probentransportkit zum nachweis von atemwegspathogenen und verfahren zum nachweis von atemwegspathogenen damit
US20230266325A1 (en) 2020-06-30 2023-08-24 Lunglife Ai, Inc. Methods for detecting lung cancer
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
EP4320443A1 (de) 2021-04-06 2024-02-14 BPGbio, Inc. Proteinmarker zur prognose der brustkrebsprogression
EP4320441A1 (de) 2021-04-06 2024-02-14 BPGbio, Inc. Proteinmarker für östrogenrezeptor (er)-positiv- und östrogenrezeptor (er)-negativ-ähnlichen brustkrebs
EP4320440A1 (de) 2021-04-06 2024-02-14 BPGbio, Inc. Proteinmarker für östrogenrezeptor (er)-positiven luminalen a(la)-ähnlichen und luminalen b1 (lb1)-ähnlichen brustkrebs
IL310256A (en) 2021-07-21 2024-03-01 Seegene Inc Complex analysis system, method and computer-readable recording means
US20240392360A1 (en) * 2021-09-23 2024-11-28 miDiagnostics NV Nucleic acid detection
WO2023054848A1 (ko) 2021-09-30 2023-04-06 주식회사 씨젠 분자진단 시스템의 샘플 처리 및 분석 방법
US20240398393A1 (en) 2021-10-29 2024-12-05 Seegene, Inc. Sample collecting swab tool and method for detection of respiratory pathogen
CA3247402A1 (en) 2022-04-06 2023-10-12 Larimar Therapeutics, Inc. FRATAXIN-SENSITIVE MARKERS FOR MONITORING FRATAXIN REPLACEMENT THERAPY
EP4532772A1 (de) 2022-05-24 2025-04-09 Lunglife Ai, Inc. Verfahren zum nachweis zirkulierender genetisch abnormaler zellen
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
IL317568A (en) 2022-06-10 2025-02-01 Res Found Dev Engineered FCRIIB Selective IgG1 FC Variants, and Their Uses
KR102559124B1 (ko) 2022-08-25 2023-07-26 주식회사 엔젠바이오 Flt3 유전자 증폭용 조성물 및 이의 용도
WO2025155991A2 (en) 2024-01-19 2025-07-24 Bpgbio, Inc. Predictive biomarkers for response to coenzyme q10 treatment in pancreatic cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
US4819269A (en) * 1987-07-21 1989-04-04 Hughes Aircraft Company Extended imaging split mode loudspeaker system
JP2774121B2 (ja) * 1987-07-31 1998-07-09 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 標的ポリヌクレオチド配列の選択的増幅
AU618965B2 (en) * 1987-07-31 1992-01-16 Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences

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