BR112014026639A8 - compostos , métodos de inibição da atividade de mir-21 , método para diminuir a expressão de colágeno , método para tratar , prevenir ou atrasar o início de uma doença , método de tratamento de um distúrbio fibroproliferativo e usos de um composto. - Google Patents
compostos , métodos de inibição da atividade de mir-21 , método para diminuir a expressão de colágeno , método para tratar , prevenir ou atrasar o início de uma doença , método de tratamento de um distúrbio fibroproliferativo e usos de um composto. Download PDFInfo
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A61P37/02—Immunomodulators
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
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- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
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- C12N2310/322—2'-R Modification
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- C12N2310/3341—5-Methylcytosine
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- C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261741783P | 2012-04-25 | 2012-04-25 | |
US201261717927P | 2012-10-24 | 2012-10-24 | |
US201361779913P | 2013-03-13 | 2013-03-13 | |
PCT/US2013/037913 WO2013163258A1 (en) | 2012-04-25 | 2013-04-24 | Microrna compounds and methods for modulating mir-21 activity |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014026639A2 BR112014026639A2 (pt) | 2017-06-27 |
BR112014026639A8 true BR112014026639A8 (pt) | 2018-01-16 |
Family
ID=48289681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014026639A BR112014026639A8 (pt) | 2012-04-25 | 2013-04-24 | compostos , métodos de inibição da atividade de mir-21 , método para diminuir a expressão de colágeno , método para tratar , prevenir ou atrasar o início de uma doença , método de tratamento de um distúrbio fibroproliferativo e usos de um composto. |
Country Status (29)
Country | Link |
---|---|
US (5) | US8969317B2 (pt) |
EP (1) | EP2841579B1 (pt) |
JP (1) | JP6322189B2 (pt) |
KR (4) | KR102369722B1 (pt) |
CN (1) | CN104254607B (pt) |
AR (1) | AR090825A1 (pt) |
AU (1) | AU2013251696B2 (pt) |
BR (1) | BR112014026639A8 (pt) |
CA (1) | CA2869639A1 (pt) |
CL (3) | CL2014002844A1 (pt) |
CO (1) | CO7111303A2 (pt) |
CR (1) | CR20140524A (pt) |
DO (1) | DOP2014000233A (pt) |
EA (1) | EA030211B1 (pt) |
EC (1) | ECSP14028612A (pt) |
GT (1) | GT201400221A (pt) |
HK (1) | HK1207115A1 (pt) |
IL (1) | IL234904B (pt) |
IN (1) | IN2014DN09134A (pt) |
MX (1) | MX353562B (pt) |
MY (1) | MY173600A (pt) |
NZ (1) | NZ630591A (pt) |
PE (1) | PE20142404A1 (pt) |
PH (1) | PH12014502387A1 (pt) |
SG (1) | SG11201406931XA (pt) |
TW (1) | TWI647235B (pt) |
UA (1) | UA117098C2 (pt) |
WO (1) | WO2013163258A1 (pt) |
ZA (1) | ZA201407228B (pt) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
CA3162352A1 (en) | 2010-10-01 | 2012-04-05 | Modernatx, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
LT3211082T (lt) | 2011-04-25 | 2021-05-10 | Sanofi | Mikro rnr junginiai ir būdai mir-21 aktyvumui moduliuoti |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
PT3682905T (pt) | 2011-10-03 | 2022-04-07 | Modernatx Inc | Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações |
LT2791160T (lt) | 2011-12-16 | 2022-06-10 | Modernatx, Inc. | Modifikuotos mrnr sudėtys |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
CA2868996A1 (en) | 2012-04-02 | 2013-10-10 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
EP2836219A1 (en) * | 2012-04-10 | 2015-02-18 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of nonalcoholic steatohepatitis |
AU2013251696B2 (en) | 2012-04-25 | 2018-11-15 | Sanofi | MicroRNA compounds and methods for modulating miR-21 activity |
UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Способи лікування синдрому альпорта |
DK2906256T3 (en) * | 2012-10-12 | 2018-11-19 | Ionis Pharmaceuticals Inc | SELECTIVE ANTISENSE COMPOUNDS AND APPLICATIONS THEREOF |
PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
US9994846B2 (en) | 2013-10-25 | 2018-06-12 | Regulus Therapeutics Inc. | MicroRNA compounds and methods for modulating miR-21 activity |
US20160289678A1 (en) * | 2013-11-22 | 2016-10-06 | Dcb-Usa Llc | Use of microrna 146-a in the diagnosis, treatment and prevention of picornavirus infection and microrna 146-a antagonists |
JP2017511694A (ja) * | 2014-02-12 | 2017-04-27 | トーマス・ジェファーソン・ユニバーシティ | マイクロrna阻害剤を使用するための組成物および方法 |
US9833416B2 (en) * | 2014-04-04 | 2017-12-05 | Ohio State Innovation Foundation | Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same |
CN105087477A (zh) * | 2015-05-21 | 2015-11-25 | 王松灵 | miR-21反义核苷酸修饰的骨髓间充质干细胞的用途 |
US11236337B2 (en) | 2016-11-01 | 2022-02-01 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
CN110177544A (zh) | 2016-11-29 | 2019-08-27 | 普尔泰克健康有限公司 | 用于递送治疗剂的外泌体 |
CN116585344A (zh) * | 2017-05-04 | 2023-08-15 | 赛诺菲 | 用于治疗奥尔波特综合征的方法 |
JP2021534759A (ja) | 2018-08-23 | 2021-12-16 | ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S | Microrna−134バイオマーカー |
CA3117981A1 (en) * | 2018-11-13 | 2020-05-22 | Regulus Therapeutics Inc. | Microrna compounds and methods for modulating mir-10b activity |
EP4005602A1 (en) | 2019-07-30 | 2022-06-01 | Shionogi & Co., Ltd | Nucleic acid drug targeting murf1 |
KR102293777B1 (ko) * | 2019-12-31 | 2021-08-25 | 연세대학교 산학협력단 | 신규한 UQCRB-관련 순환 miRNA 바이오 마커 및 이를 이용한 대장암의 진단 방법 |
MX2022012544A (es) * | 2020-04-09 | 2022-11-07 | Univ Muenchen Tech | Liberacion dirigida de un inhibidor de mir-21 a macrofagos para el tratamiento de la fibrosis pulmonar. |
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