AR090825A1 - COMPUESTO DE microARN Y METODOS DE MODULACION DE LA ACTIVIDAD DE miR-21 - Google Patents

COMPUESTO DE microARN Y METODOS DE MODULACION DE LA ACTIVIDAD DE miR-21

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Publication number
AR090825A1
AR090825A1 ARP130101370A ARP130101370A AR090825A1 AR 090825 A1 AR090825 A1 AR 090825A1 AR P130101370 A ARP130101370 A AR P130101370A AR P130101370 A ARP130101370 A AR P130101370A AR 090825 A1 AR090825 A1 AR 090825A1
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AR
Argentina
Prior art keywords
nucleoside
compound
mir
activity
bicyclic
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ARP130101370A
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English (en)
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Regulus Therapeutics Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48289681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR090825(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regulus Therapeutics Inc filed Critical Regulus Therapeutics Inc
Publication of AR090825A1 publication Critical patent/AR090825A1/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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Abstract

Reivindicación 1: Un compuesto que comprende un oligonucleótido modificado que consiste en 8 a 22 nucleósidos enlazados, en donde la secuencia de nucleobases del oligonucleótido modificado es complementaria a miR-21 (SEQ ID Nº 1) y en donde el oligonucleótido modificado comprende al menos 8 nucleósidos contiguos del siguiente patrón de nucleósidos III en la orientación 5 a 3: (R)X-NB-NQ-NQ-NB-(NQ-NQ-NQ-NB)₃-NY-NZ en donde cada R es un nucleósido no bicíclico; X es de 1 a 4; cada NB es un nucleósido bicíclico; cada NQ es un nucleósido no bicíclico; NY es un nucleósido modificado o un nucleósido sin modificar; y cada NZ es un nucleósido modificado. Reivindicación 35: Un método para inhibir la actividad de miR-21 que comprende poner en contacto una célula con un compuesto de cualquiera de las reivindicaciones 1 a 34. Reivindicación 43: Un método para tratar un trastorno fibroproliferativo en un sujeto que comprende administrarle al sujeto un compuesto de cualquiera de las reivindicaciones 1 a 34. Reivindicación 60: Uso de un compuesto de cualquiera de las reivindicaciones 1 a 34 para la preparación de un medicamento. Reivindicación 64: Uso de un compuesto de cualquiera de las reivindicaciones 1 a 34 para la preparación de un medicamento para prevenir y/o retrasar el inicio de metástasis.
ARP130101370A 2012-04-25 2013-04-24 COMPUESTO DE microARN Y METODOS DE MODULACION DE LA ACTIVIDAD DE miR-21 AR090825A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261741783P 2012-04-25 2012-04-25
US201261717927P 2012-10-24 2012-10-24
US201361779913P 2013-03-13 2013-03-13

Publications (1)

Publication Number Publication Date
AR090825A1 true AR090825A1 (es) 2014-12-10

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ID=48289681

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Country Status (29)

Country Link
US (5) US8969317B2 (es)
EP (1) EP2841579B1 (es)
JP (1) JP6322189B2 (es)
KR (4) KR20230037703A (es)
CN (1) CN104254607B (es)
AR (1) AR090825A1 (es)
AU (1) AU2013251696B2 (es)
BR (1) BR112014026639A8 (es)
CA (1) CA2869639A1 (es)
CL (3) CL2014002844A1 (es)
CO (1) CO7111303A2 (es)
CR (1) CR20140524A (es)
DO (1) DOP2014000233A (es)
EA (1) EA030211B1 (es)
EC (1) ECSP14028612A (es)
GT (1) GT201400221A (es)
HK (1) HK1207115A1 (es)
IL (1) IL234904B (es)
IN (1) IN2014DN09134A (es)
MX (1) MX353562B (es)
MY (1) MY173600A (es)
NZ (1) NZ630591A (es)
PE (1) PE20142404A1 (es)
PH (1) PH12014502387A1 (es)
SG (1) SG11201406931XA (es)
TW (1) TWI647235B (es)
UA (1) UA117098C2 (es)
WO (1) WO2013163258A1 (es)
ZA (1) ZA201407228B (es)

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