BR112018006026A2 - liberação de gene aperfeiçoada para células assassinas naturais, células troncos hematopoiéticas e macrófagos - Google Patents

liberação de gene aperfeiçoada para células assassinas naturais, células troncos hematopoiéticas e macrófagos

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Publication number
BR112018006026A2
BR112018006026A2 BR112018006026A BR112018006026A BR112018006026A2 BR 112018006026 A2 BR112018006026 A2 BR 112018006026A2 BR 112018006026 A BR112018006026 A BR 112018006026A BR 112018006026 A BR112018006026 A BR 112018006026A BR 112018006026 A2 BR112018006026 A2 BR 112018006026A2
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Brazil
Prior art keywords
cells
macrophages
natural killer
stem cells
haematopoietic stem
Prior art date
Application number
BR112018006026A
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English (en)
Inventor
Duru Adil
Alici Evren
Sutlu Tolga
Original Assignee
Vycellix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Vycellix Inc filed Critical Vycellix Inc
Publication of BR112018006026A2 publication Critical patent/BR112018006026A2/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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Abstract

a presente invenção refere-se a um processo de regulação descendente de defesas intracelulares através de administração de (5z)-7-oxozeaenol. isto permite aperfeiçoada liberação de vetores de gene baseados em rna para células assassinas naturais, células troncos e macrófagos. as células resultantes podem ser usadas em terapias de transferência de célula adotiva. também são providos processos de tratamento de inflamação induzida viralmente via administração de (5z)-7-oxozeaenol junto com um terapêutico antiviral.
BR112018006026A 2015-09-30 2016-09-30 liberação de gene aperfeiçoada para células assassinas naturais, células troncos hematopoiéticas e macrófagos BR112018006026A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562235427P 2015-09-30 2015-09-30
PCT/US2016/054618 WO2017059177A2 (en) 2015-09-30 2016-09-30 Enhanced gene delivery to natural killer cells, hematopoietic stem cells and macrophages

Publications (1)

Publication Number Publication Date
BR112018006026A2 true BR112018006026A2 (pt) 2018-11-06

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BR112018006026A BR112018006026A2 (pt) 2015-09-30 2016-09-30 liberação de gene aperfeiçoada para células assassinas naturais, células troncos hematopoiéticas e macrófagos

Country Status (14)

Country Link
US (1) US20190262309A1 (pt)
EP (1) EP3356524B1 (pt)
JP (1) JP7034065B2 (pt)
KR (1) KR20180053757A (pt)
CN (1) CN108291221B (pt)
AU (2) AU2016331082B2 (pt)
BR (1) BR112018006026A2 (pt)
CA (1) CA2999891A1 (pt)
DK (1) DK3356524T3 (pt)
ES (1) ES2897599T3 (pt)
HU (1) HUE056374T2 (pt)
IL (1) IL258342B2 (pt)
PT (1) PT3356524T (pt)
WO (1) WO2017059177A2 (pt)

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CA2988854A1 (en) 2015-05-08 2016-11-17 President And Fellows Of Harvard College Universal donor stem cells and related methods
WO2016196256A2 (en) 2015-06-04 2016-12-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones
EP3487991B1 (en) 2016-07-25 2022-09-07 The United States of America, as represented by The Secretary, Department of Health and Human Services Methods of producing modified natural killer cells and methods of use
CN109722437B (zh) * 2018-12-29 2020-01-07 广州百暨基因科技有限公司 一种通用型car-t细胞及其制备方法和用途
CN114045265A (zh) * 2021-11-17 2022-02-15 深圳知因细胞生物科技有限公司 一种慢病毒体外转染人造血干细胞的试剂和试剂盒
CN115975922B (zh) * 2022-12-15 2024-06-28 杭州师范大学 Bx795在制备nk-92细胞激活剂上的应用

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JP2002522513A (ja) 1998-08-11 2002-07-23 アメリカ合衆国 哺乳動物細胞を形質導入する方法およびそれに関連する産物
CA2386536A1 (en) 1999-09-14 2001-03-22 The Children's Medical Center Corporation Methods for treating muscular dystrophy with bone marrow cells
WO2006089001A2 (en) * 2005-02-16 2006-08-24 Lentigen Corporation Lentiviral vectors and their use
WO2008018517A1 (fr) * 2006-08-09 2008-02-14 Zeria Pharmaceutical Co., Ltd. Agent thérapeutique et/ou préventif pour une maladie s'accompagnant d'une croissance cellulaire exagérée, et polynucléotide utile en tant que principe actif
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CN108291221A (zh) 2018-07-17
WO2017059177A2 (en) 2017-04-06
JP7034065B2 (ja) 2022-03-11
AU2023203314A1 (en) 2023-06-22
IL258342B1 (en) 2023-01-01
CN108291221B (zh) 2023-01-24
EP3356524A4 (en) 2019-07-31
EP3356524A2 (en) 2018-08-08
WO2017059177A3 (en) 2017-07-20
IL258342B2 (en) 2023-05-01
ES2897599T3 (es) 2022-03-01
IL258342A (en) 2018-05-31
PT3356524T (pt) 2021-11-17
US20190262309A1 (en) 2019-08-29
KR20180053757A (ko) 2018-05-23
AU2016331082A1 (en) 2018-04-19
AU2016331082B2 (en) 2023-12-07
HUE056374T2 (hu) 2022-02-28
DK3356524T3 (da) 2021-11-15
EP3356524B1 (en) 2021-08-18
CA2999891A1 (en) 2017-04-06
JP2018535661A (ja) 2018-12-06

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