MX2022006948A - Composiciones y metodos para programar celulas terapeuticas utilizando nanoportadores de acidos nucleicos dirigidos. - Google Patents

Composiciones y metodos para programar celulas terapeuticas utilizando nanoportadores de acidos nucleicos dirigidos.

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Publication number
MX2022006948A
MX2022006948A MX2022006948A MX2022006948A MX2022006948A MX 2022006948 A MX2022006948 A MX 2022006948A MX 2022006948 A MX2022006948 A MX 2022006948A MX 2022006948 A MX2022006948 A MX 2022006948A MX 2022006948 A MX2022006948 A MX 2022006948A
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Mexico
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compositions
methods
nucleic acid
therapeutic cells
targeted nucleic
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MX2022006948A
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English (en)
Inventor
Matthias Stephan
Howell F Moffett
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Hutchinson Fred Cancer Res
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Publication of MX2022006948A publication Critical patent/MX2022006948A/es

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    • C12N9/22—Ribonucleases RNAses, DNAses
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    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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Abstract

Se describen composiciones y métodos que modifican rápida y selectivamente las células madre hematopoyéticas (o células derivadas de estas) para lograr objetivos terapéuticos al proporcionar la expresión transitoria de ácidos nucleicos. La expresión transitoria produce cambios terapéuticos permanentes en las células modificadas, lo que se denomina en la presente efectos de "ataque y retirada".
MX2022006948A 2016-04-14 2018-10-12 Composiciones y metodos para programar celulas terapeuticas utilizando nanoportadores de acidos nucleicos dirigidos. MX2022006948A (es)

Applications Claiming Priority (2)

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US201662322581P 2016-04-14 2016-04-14
US201762442890P 2017-01-05 2017-01-05

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MX2022006948A true MX2022006948A (es) 2022-07-12

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MX2018012556A MX2018012556A (es) 2016-04-14 2017-04-14 Composiciones y metodos para programar celulas terapeuticas utilizando nanoportadores de acidos nucleicos dirigidos.
MX2022006948A MX2022006948A (es) 2016-04-14 2018-10-12 Composiciones y metodos para programar celulas terapeuticas utilizando nanoportadores de acidos nucleicos dirigidos.

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EP (2) EP3442585B1 (es)
JP (2) JP7118340B2 (es)
KR (2) KR102542533B1 (es)
CN (1) CN109121413A (es)
AU (2) AU2017250295B2 (es)
BR (1) BR112018071221A2 (es)
CA (1) CA3020857A1 (es)
CL (1) CL2018002905A1 (es)
CO (1) CO2018012099A2 (es)
CR (1) CR20180503A (es)
IL (2) IL300282A (es)
MX (2) MX2018012556A (es)
SG (1) SG11201807593TA (es)
WO (1) WO2017181110A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7348063B2 (ja) 2017-01-05 2023-09-20 フレッド ハッチンソン キャンサー センター ワクチン効力を改善するためのシステム及び方法
JP7275054B2 (ja) 2017-06-15 2023-05-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 標的化された非ウイルスｄｎａ挿入
CN111655719A (zh) 2017-10-27 2020-09-11 加利福尼亚大学董事会 内源性t细胞受体的靶向置换
CN108383914A (zh) * 2018-02-23 2018-08-10 北京美康基免生物科技有限公司 一种基于cd19的嵌合抗原受体及其应用
KR20210014638A (ko) * 2018-05-01 2021-02-09 프레드 헛친슨 켄서 리서치 센터 유전자 발현을 위한 나노입자 및 이의 용도
JP2022533949A (ja) * 2019-05-15 2022-07-27 ステムサイト インコーポレーテッド 高濃度細胞のパッケージングおよび輸送
CN111925448B (zh) * 2020-08-03 2022-06-21 山东大学 在体生成car-巨噬细胞的制备方法及肿瘤免疫治疗中的应用
GB202017555D0 (en) * 2020-11-06 2020-12-23 Harbour Antibodies Bv Antibody-conjugated nanoparticles
CN112870370A (zh) * 2021-03-05 2021-06-01 广州贝奥吉因生物科技股份有限公司 一种基于黑磷纳米片的靶向载药体系及其制备方法
CN114246986B (zh) * 2021-12-29 2022-08-23 中国人民解放军陆军军医大学 一种基于原位调控免疫反应的心血管植入物及其制备方法
WO2023201097A1 (en) * 2022-04-15 2023-10-19 Turn Biotechnologies, Inc. Methods and compositions for immune cell rejuvenation and therapies using rejuvenated immune cells

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US527016A (en) 1894-10-02 Worth
US1999A (en) 1841-03-12 Improvement in seed-planters
US3753357A (en) 1970-12-14 1973-08-21 Ovitron Res Corp Method and apparatus for the preservation of cells and tissues
US4078052A (en) 1976-06-30 1978-03-07 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Large unilamellar vesicles (LUV) and method of preparing same
CH621479A5 (es) 1977-08-05 1981-02-13 Battelle Memorial Institute
CH624011A5 (es) 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4241046A (en) 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4199022A (en) 1978-12-08 1980-04-22 The United States Of America As Represented By The Department Of Energy Method of freezing living cells and tissues with improved subsequent survival
US4559298A (en) 1982-11-23 1985-12-17 American National Red Cross Cryopreservation of biological materials in a non-frozen or vitreous state
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5866322A (en) * 1988-01-29 1999-02-02 Abbott Laboratories Method for performing Rubella assay
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US6291161B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
US5527894A (en) 1990-06-11 1996-06-18 Nexstar Pharmacueticals, Inc. Ligands of HIV-1 tat protein
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
WO1991019813A1 (en) 1990-06-11 1991-12-26 The University Of Colorado Foundation, Inc. Nucleic acid ligands
US5270160A (en) 1990-12-21 1993-12-14 Toray Industries, Inc. Polyester film and photosensitive material
US5756291A (en) 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
EP0737207B1 (en) 1994-01-11 2004-09-22 Dyax Corporation Inhibitors of human plasmin derived from the kunitz domains
AUPP221098A0 (en) 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
US7427394B2 (en) * 2000-10-10 2008-09-23 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US8361794B2 (en) 2004-06-29 2013-01-29 Immunocore Limited Cells expressing a modified T cell receptor
US8663599B1 (en) * 2004-10-05 2014-03-04 Gp Medical, Inc. Pharmaceutical composition of nanoparticles
KR20130105885A (ko) 2005-01-05 2013-09-26 에프-스타 비오테크놀로기쉐 포르슝스 운드 엔트비클룽스게스.엠.베.하. 상보성 결정부위와 다른 분자의 부위에서 처리된 결합성을 갖는 합성 면역글로불린 영역
GB0504767D0 (en) 2005-03-08 2005-04-13 Ares Trading Sa Lipocalin protein
EP1829895A1 (en) 2006-03-03 2007-09-05 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
KR20090021217A (ko) 2006-06-14 2009-02-27 추가이 세이야쿠 가부시키가이샤 조혈 줄기세포 증가 촉진제
US20100196492A1 (en) * 2007-03-08 2010-08-05 Green Jordan J Electrostatic coating of particles for drug delivery
US9365629B2 (en) 2007-09-24 2016-06-14 University Of Zurich Designed armadillo repeat proteins
PE20100362A1 (es) 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
US20120192298A1 (en) * 2009-07-24 2012-07-26 Sigma Aldrich Co. Llc Method for genome editing
PT2510096E (pt) * 2009-12-10 2015-02-04 Univ Iowa State Res Found Inc Modificação do adn modificada pelo efector tal
GB201006096D0 (en) * 2010-04-13 2010-05-26 Alligator Bioscience Ab Novel compositions and uses thereof
CN102851304A (zh) * 2011-06-30 2013-01-02 复旦大学 基于静电包衣的三元非病毒核酸递释系统及其制备方法
WO2014153114A1 (en) * 2013-03-14 2014-09-25 Fred Hutchinson Cancer Research Center Compositions and methods to modify cells for therapeutic objectives
US9828582B2 (en) * 2013-03-19 2017-11-28 Duke University Compositions and methods for the induction and tuning of gene expression
AU2014273091B2 (en) * 2013-05-31 2019-12-12 Cellectis A LAGLIDADG homing endonuclease cleaving the T cell receptor alpha gene and uses thereof
AU2017368320A1 (en) 2016-12-02 2019-05-02 Cartesian Therapeutics, Inc. Cancer immuno therapy with highly enriched CD8+ chimeric antigen receptor T cells
JP7348063B2 (ja) * 2017-01-05 2023-09-20 フレッド ハッチンソン キャンサー センター ワクチン効力を改善するためのシステム及び方法

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