CL2018002905A1 - Composiciones y métodos para programar células terapéuticas utilizando nanoportadores de ácidos nucléicos dirigidos. - Google Patents
Composiciones y métodos para programar células terapéuticas utilizando nanoportadores de ácidos nucléicos dirigidos.Info
- Publication number
- CL2018002905A1 CL2018002905A1 CL2018002905A CL2018002905A CL2018002905A1 CL 2018002905 A1 CL2018002905 A1 CL 2018002905A1 CL 2018002905 A CL2018002905 A CL 2018002905A CL 2018002905 A CL2018002905 A CL 2018002905A CL 2018002905 A1 CL2018002905 A1 CL 2018002905A1
- Authority
- CL
- Chile
- Prior art keywords
- compositions
- methods
- nanocarriers
- nucleic acids
- therapeutic cells
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000002539 nanocarrier Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
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- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
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- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- C07K2317/00—Immunoglobulins specific features
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- C—CHEMISTRY; METALLURGY
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- Proteomics, Peptides & Aminoacids (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE DESCRIBEN COMPOSICIONES Y MÉTODOS QUE MODIFICAN RÁPIDA Y SELECTIVAMENTE LAS CÉLULAS MADRE HEMATOPOYÉTICAS (O CÉLULAS DERIVADAS DE ESTAS) PARA LOGRAR OBJETIVOS TERAPÉUTICOS AL PROPORCIONAR LA EXPRESIÓN TRANSITORIA DE ÁCIDOS NUCLÉICOS. LA EXPRESIÓN TRANSITORIA PRODUCE CAMBIOS TERAPÉUTICOS PERMANENTES EN LAS CÉLULAS MODIFICADAS, LO QUE SE DENOMINA EN LA PRESENTE EFECTOS DE “ATAQUE Y RETIRADA”.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662322581P | 2016-04-14 | 2016-04-14 | |
US201762442890P | 2017-01-05 | 2017-01-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2018002905A1 true CL2018002905A1 (es) | 2019-02-08 |
Family
ID=60042027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018002905A CL2018002905A1 (es) | 2016-04-14 | 2018-10-11 | Composiciones y métodos para programar células terapéuticas utilizando nanoportadores de ácidos nucléicos dirigidos. |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP4166161A1 (es) |
JP (2) | JP7118340B2 (es) |
KR (2) | KR102542533B1 (es) |
CN (1) | CN109121413A (es) |
AU (2) | AU2017250295B2 (es) |
BR (1) | BR112018071221A2 (es) |
CA (1) | CA3020857A1 (es) |
CL (1) | CL2018002905A1 (es) |
CO (1) | CO2018012099A2 (es) |
CR (1) | CR20180503A (es) |
IL (2) | IL300282A (es) |
MX (2) | MX2018012556A (es) |
SG (1) | SG11201807593TA (es) |
WO (1) | WO2017181110A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3565535A4 (en) | 2017-01-05 | 2020-12-30 | Fred Hutchinson Cancer Research Center | SYSTEMS AND METHODS FOR IMPROVING THE EFFECTIVENESS OF A VACCINE |
AU2018283405A1 (en) | 2017-06-15 | 2020-01-16 | The Regents Of The University Of California | Targeted non-viral DNA insertions |
AU2018355587B2 (en) | 2017-10-27 | 2023-02-02 | The Regents Of The University Of California | Targeted replacement of endogenous T cell receptors |
CN108383914A (zh) * | 2018-02-23 | 2018-08-10 | 北京美康基免生物科技有限公司 | 一种基于cd19的嵌合抗原受体及其应用 |
WO2019213308A1 (en) * | 2018-05-01 | 2019-11-07 | Fred Hutchinson Cancer Research Center | Nanoparticles for gene expression and uses thereof |
US20220175674A1 (en) * | 2019-05-15 | 2022-06-09 | Stemcyte Inc. | High concentration cell packaging and shipping |
SE544015C2 (en) * | 2019-06-18 | 2021-11-02 | Tx Medic Ab | Allogenic car-t cell therapy |
CN111925448B (zh) * | 2020-08-03 | 2022-06-21 | 山东大学 | 在体生成car-巨噬细胞的制备方法及肿瘤免疫治疗中的应用 |
GB202017555D0 (en) * | 2020-11-06 | 2020-12-23 | Harbour Antibodies Bv | Antibody-conjugated nanoparticles |
CN112870370A (zh) * | 2021-03-05 | 2021-06-01 | 广州贝奥吉因生物科技股份有限公司 | 一种基于黑磷纳米片的靶向载药体系及其制备方法 |
CN114246986B (zh) * | 2021-12-29 | 2022-08-23 | 中国人民解放军陆军军医大学 | 一种基于原位调控免疫反应的心血管植入物及其制备方法 |
WO2023201097A1 (en) * | 2022-04-15 | 2023-10-19 | Turn Biotechnologies, Inc. | Methods and compositions for immune cell rejuvenation and therapies using rejuvenated immune cells |
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WO2008109806A2 (en) | 2007-03-08 | 2008-09-12 | Massachusetts Institute Of Technology | Electrostatic coating of particles for drug delivery |
WO2009040338A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zürich | Designed armadillo repeat proteins |
PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
US20120192298A1 (en) * | 2009-07-24 | 2012-07-26 | Sigma Aldrich Co. Llc | Method for genome editing |
AU2010327998B2 (en) * | 2009-12-10 | 2015-11-12 | Iowa State University Research Foundation, Inc. | TAL effector-mediated DNA modification |
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CN102851304A (zh) * | 2011-06-30 | 2013-01-02 | 复旦大学 | 基于静电包衣的三元非病毒核酸递释系统及其制备方法 |
WO2014153114A1 (en) * | 2013-03-14 | 2014-09-25 | Fred Hutchinson Cancer Research Center | Compositions and methods to modify cells for therapeutic objectives |
US9828582B2 (en) * | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
DK3004338T3 (en) * | 2013-05-31 | 2019-04-08 | Cellectis Sa | LAGLIDADG HOMING ENDONUCLEASE DIVERSE T-CELL RECEPTOR ALPHA GENET AND APPLICATIONS THEREOF |
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EP3565535A4 (en) | 2017-01-05 | 2020-12-30 | Fred Hutchinson Cancer Research Center | SYSTEMS AND METHODS FOR IMPROVING THE EFFECTIVENESS OF A VACCINE |
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2017
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- 2017-04-14 KR KR1020237019209A patent/KR20230088514A/ko not_active Application Discontinuation
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CO2018012099A2 (es) | 2018-12-14 |
CR20180503A (es) | 2018-12-21 |
KR20180133480A (ko) | 2018-12-14 |
IL262361B2 (en) | 2023-07-01 |
MX2022006948A (es) | 2022-07-12 |
AU2022275453A1 (en) | 2023-02-23 |
AU2017250295B2 (en) | 2022-08-25 |
EP3442585B1 (en) | 2022-11-09 |
KR20230088514A (ko) | 2023-06-19 |
IL262361A (en) | 2018-11-29 |
JP2022130552A (ja) | 2022-09-06 |
JP7118340B2 (ja) | 2022-08-16 |
WO2017181110A1 (en) | 2017-10-19 |
EP4166161A1 (en) | 2023-04-19 |
MX2018012556A (es) | 2019-09-06 |
JP2019511234A (ja) | 2019-04-25 |
IL300282A (en) | 2023-04-01 |
CA3020857A1 (en) | 2017-10-19 |
CN109121413A (zh) | 2019-01-01 |
AU2017250295A1 (en) | 2018-12-06 |
BR112018071221A2 (pt) | 2019-02-05 |
EP3442585A4 (en) | 2019-09-25 |
IL262361B1 (en) | 2023-03-01 |
SG11201807593TA (en) | 2018-10-30 |
EP3442585A1 (en) | 2019-02-20 |
KR102542533B1 (ko) | 2023-06-13 |
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