MX364707B - Conjugados de proteina-agente activo y método para su preparación. - Google Patents
Conjugados de proteina-agente activo y método para su preparación.Info
- Publication number
- MX364707B MX364707B MX2013013069A MX2013013069A MX364707B MX 364707 B MX364707 B MX 364707B MX 2013013069 A MX2013013069 A MX 2013013069A MX 2013013069 A MX2013013069 A MX 2013013069A MX 364707 B MX364707 B MX 364707B
- Authority
- MX
- Mexico
- Prior art keywords
- active agent
- conjugates
- protein
- preparing
- same
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Peptides Or Proteins (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La invención proporciona conjugados de agente proteína activo que tienen un motivo aminoácido que se puede reconocer por una isoprenoide transferasa. La invención también proorciona composiciones que contienen los conjugados así como métodos para elaborar los conjugados y composiciones. La invención proporciona además métodos para utilizar los conjugados para suministrar el agente activo a una célula objetivo, así como métodos para utilizar los conjugados para tratar a un sujeto en necesidad del mismo (por ejemplo, un sujeto en necesidad del agente activo).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161483698P | 2011-05-08 | 2011-05-08 | |
PCT/IB2012/001065 WO2012153193A2 (en) | 2011-05-08 | 2012-05-08 | Protein-active agent conjugates and method for preparing the same |
Publications (2)
Publication Number | Publication Date |
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MX2013013069A MX2013013069A (es) | 2014-01-31 |
MX364707B true MX364707B (es) | 2019-05-06 |
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Family Applications (2)
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