DK3356524T3 - Forøget genlevering til naturlige dræberceller, hæmatopoietiske stamceller og makrofager - Google Patents

Forøget genlevering til naturlige dræberceller, hæmatopoietiske stamceller og makrofager Download PDF

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Publication number
DK3356524T3
DK3356524T3 DK16852663.0T DK16852663T DK3356524T3 DK 3356524 T3 DK3356524 T3 DK 3356524T3 DK 16852663 T DK16852663 T DK 16852663T DK 3356524 T3 DK3356524 T3 DK 3356524T3
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Prior art keywords
macrophage
hematopoietic stem
natural killer
cells
stem cells
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DK16852663.0T
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English (en)
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Evren Alici
Tolga Sutlu
Adil Duru
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Vycellix Inc
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Publication of DK3356524T3 publication Critical patent/DK3356524T3/da

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K39/4614—Monocytes; Macrophages
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    • A61K39/4644—Cancer antigens
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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838—Viral antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • C12N2740/00—Reverse transcribing RNA viruses
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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Medicinal Chemistry (AREA)
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  • Epidemiology (AREA)
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  • Cell Biology (AREA)
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  • Biochemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
DK16852663.0T 2015-09-30 2016-09-30 Forøget genlevering til naturlige dræberceller, hæmatopoietiske stamceller og makrofager DK3356524T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562235427P 2015-09-30 2015-09-30
PCT/US2016/054618 WO2017059177A2 (en) 2015-09-30 2016-09-30 Enhanced gene delivery to natural killer cells, hematopoietic stem cells and macrophages

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DK3356524T3 true DK3356524T3 (da) 2021-11-15

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Country Link
US (1) US20190262309A1 (da)
EP (1) EP3356524B1 (da)
JP (1) JP7034065B2 (da)
KR (1) KR20180053757A (da)
CN (1) CN108291221B (da)
AU (2) AU2016331082B2 (da)
BR (1) BR112018006026A2 (da)
CA (1) CA2999891A1 (da)
DK (1) DK3356524T3 (da)
ES (1) ES2897599T3 (da)
HU (1) HUE056374T2 (da)
IL (1) IL258342B2 (da)
PT (1) PT3356524T (da)
WO (1) WO2017059177A2 (da)

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US10434085B2 (en) 2015-06-04 2019-10-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones
EP3487991B1 (en) * 2016-07-25 2022-09-07 The United States of America, as represented by The Secretary, Department of Health and Human Services Methods of producing modified natural killer cells and methods of use
CN109722437B (zh) * 2018-12-29 2020-01-07 广州百暨基因科技有限公司 一种通用型car-t细胞及其制备方法和用途
CN114045265A (zh) * 2021-11-17 2022-02-15 深圳知因细胞生物科技有限公司 一种慢病毒体外转染人造血干细胞的试剂和试剂盒
CN115975922A (zh) * 2022-12-15 2023-04-18 杭州师范大学 Bx795在制备nk-92细胞激活剂上的应用

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JP2002522513A (ja) 1998-08-11 2002-07-23 アメリカ合衆国 哺乳動物細胞を形質導入する方法およびそれに関連する産物
WO2001019379A2 (en) 1999-09-14 2001-03-22 Children's Medical Center Corporation, The Methods for treating muscular dystrophy with bone marrow cells
CA2597928A1 (en) * 2005-02-16 2006-08-24 Lentigen Corporation Lentiviral vectors and their use
WO2008018517A1 (fr) * 2006-08-09 2008-02-14 Zeria Pharmaceutical Co., Ltd. Agent thérapeutique et/ou préventif pour une maladie s'accompagnant d'une croissance cellulaire exagérée, et polynucléotide utile en tant que principe actif
US20130071414A1 (en) * 2011-04-27 2013-03-21 Gianpietro Dotti Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
US20140243403A1 (en) 2011-06-03 2014-08-28 The General Hospital Corporation Treating colorectal, pancreatic, and lung cancer
KR20150131218A (ko) 2013-03-14 2015-11-24 벨리쿰 파마슈티컬스, 인크. T 세포 증식의 제어 방법
WO2014172616A2 (en) * 2013-04-18 2014-10-23 President And Fellows Of Harvard College Methods, compositions and kits for promoting motor neuron survival and treating and diagnosing neurodegenerative disorders
IL247063B (en) 2013-10-07 2022-09-01 Mor Research Applic Ltd Treatments for Pi. Wee. R. (pvr)

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US20190262309A1 (en) 2019-08-29
IL258342A (en) 2018-05-31
CN108291221B (zh) 2023-01-24
KR20180053757A (ko) 2018-05-23
JP2018535661A (ja) 2018-12-06
ES2897599T3 (es) 2022-03-01
EP3356524A4 (en) 2019-07-31
WO2017059177A3 (en) 2017-07-20
BR112018006026A2 (pt) 2018-11-06
PT3356524T (pt) 2021-11-17
HUE056374T2 (hu) 2022-02-28
JP7034065B2 (ja) 2022-03-11
CA2999891A1 (en) 2017-04-06
EP3356524A2 (en) 2018-08-08
AU2023203314A1 (en) 2023-06-22
AU2016331082A1 (en) 2018-04-19
WO2017059177A2 (en) 2017-04-06
EP3356524B1 (en) 2021-08-18
CN108291221A (zh) 2018-07-17
IL258342B1 (en) 2023-01-01
AU2016331082B2 (en) 2023-12-07
IL258342B2 (en) 2023-05-01

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