DOP2014000233A - Compuestos de microarn y métodos de modulación de la actividad de mir-21 - Google Patents

Compuestos de microarn y métodos de modulación de la actividad de mir-21

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Publication number
DOP2014000233A
DOP2014000233A DO2014000233A DO2014000233A DOP2014000233A DO P2014000233 A DOP2014000233 A DO P2014000233A DO 2014000233 A DO2014000233 A DO 2014000233A DO 2014000233 A DO2014000233 A DO 2014000233A DO P2014000233 A DOP2014000233 A DO P2014000233A
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Dominican Republic
Prior art keywords
mir
microarn
compounds
modulation methods
activity modulation
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DO2014000233A
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English (en)
Inventor
Balkrishen Bhat
Eric Marcusson
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Regulus Therapeutics Inc
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Application filed by Regulus Therapeutics Inc filed Critical Regulus Therapeutics Inc
Publication of DOP2014000233A publication Critical patent/DOP2014000233A/es

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Abstract

Se describen en la presente composiciones y métodos para la inhibición de la actividad de miR-21. Las composiciones tienen ciertos patrones de modificación de nucleósidos que proporcionan inhibidores potentes de la actividad de miR-21. Las composiciones también pueden utilizarse para inhibir miR-21 y también para tratar enfermedades asociadas con la expresión anormal de miR-21, tales como fibrosis y cáncer. CIP: C12N 15/113
DO2014000233A 2012-04-25 2014-10-16 Compuestos de microarn y métodos de modulación de la actividad de mir-21 DOP2014000233A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261741783P 2012-04-25 2012-04-25
US201261717927P 2012-10-24 2012-10-24
US201361779913P 2013-03-13 2013-03-13

Publications (1)

Publication Number Publication Date
DOP2014000233A true DOP2014000233A (es) 2014-12-31

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ID=48289681

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Application Number Title Priority Date Filing Date
DO2014000233A DOP2014000233A (es) 2012-04-25 2014-10-16 Compuestos de microarn y métodos de modulación de la actividad de mir-21

Country Status (29)

Country Link
US (5) US8969317B2 (es)
EP (1) EP2841579B1 (es)
JP (1) JP6322189B2 (es)
KR (4) KR20220028183A (es)
CN (1) CN104254607B (es)
AR (1) AR090825A1 (es)
AU (1) AU2013251696B2 (es)
BR (1) BR112014026639A8 (es)
CA (1) CA2869639A1 (es)
CL (3) CL2014002844A1 (es)
CO (1) CO7111303A2 (es)
CR (1) CR20140524A (es)
DO (1) DOP2014000233A (es)
EA (1) EA030211B1 (es)
EC (1) ECSP14028612A (es)
GT (1) GT201400221A (es)
HK (1) HK1207115A1 (es)
IL (1) IL234904B (es)
IN (1) IN2014DN09134A (es)
MX (1) MX353562B (es)
MY (1) MY173600A (es)
NZ (1) NZ630591A (es)
PE (1) PE20142404A1 (es)
PH (1) PH12014502387A1 (es)
SG (1) SG11201406931XA (es)
TW (1) TWI647235B (es)
UA (1) UA117098C2 (es)
WO (1) WO2013163258A1 (es)
ZA (1) ZA201407228B (es)

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EP3060664B1 (en) * 2013-10-25 2021-07-07 Sanofi Microrna compounds and methods for modulating mir-21 activity
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US11236337B2 (en) 2016-11-01 2022-02-01 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
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