JP2002515786A - 経皮輸送の超音波増強 - Google Patents
経皮輸送の超音波増強Info
- Publication number
- JP2002515786A JP2002515786A JP50444398A JP50444398A JP2002515786A JP 2002515786 A JP2002515786 A JP 2002515786A JP 50444398 A JP50444398 A JP 50444398A JP 50444398 A JP50444398 A JP 50444398A JP 2002515786 A JP2002515786 A JP 2002515786A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- transducer
- ultrasound
- ultrasonic
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150061—Means for enhancing collection
- A61B5/150083—Means for enhancing collection by vibration, e.g. ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150061—Means for enhancing collection
- A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150106—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced
- A61B5/150137—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced by vibration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15134—Bladeless capillary blood sampling devices, i.e. devices for perforating the skin in order to obtain a blood sample but not using a blade, needle, canula, or lancet, e.g. by laser perforation, suction or pressurized fluids
- A61B5/15136—Bladeless capillary blood sampling devices, i.e. devices for perforating the skin in order to obtain a blood sample but not using a blade, needle, canula, or lancet, e.g. by laser perforation, suction or pressurized fluids by use of radiation, e.g. laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.経皮輸送を増強するためのデバイスであって、 第1の直径およびエネルギーを有する超音波ビームを提供する超音波トランス デューサと、 該ビームが該第1の直径より小さい第2の直径を有し且つ該ビームが該エネル ギーの少なくとも50%を維持するように、該超音波ビームを幾何学的にチャネ リングするように構成および調節された壁を有するチャンバと、を備え、 より小さい直径を有する該超音波ビームが皮膚に適用される、 デバイス。 2.前記デバイスが、分析物回収を高めるために使用される、請求項1に記載の デバイス。 3.前記チャンバが、大開口部および小開口部を有する円錐台の形状を有し、前 記トランスデューサが、該チャンバの該大開口部に配置される、請求項1に記載 のデバイス。 4.前記チャンバが、大開口部および小開口部を持つ角の形状を有し、前記トラ ンスデューサが、該チャンバの該大開口部に配置される、請求項1に記載のデバ イス。 5.前記ビームの前記第2の直径が、約100μm〜1cmである、請求項1に 記載のデバイス。 6.前記チャンバが結合媒体を収容し、前記超音波ビームが、皮膚の透過性を増 大させるのに十分なキャビテーションをもたらす、請求項1に記載のデバイス。 7.吸引、浸透圧勾配、イオン泳動、エレクトロポレーション、磁界および機械 圧よりなる群から選択されるさらなる経皮輸送駆動力を適用する手段をさらに備 えた、請求項1に記載のデバイス。 8.前記チャネリングされた超音波ビームを皮膚に適用することによって、該皮 膚上に直径約100μm〜1cmの擦過領域が形成される、請求項1に記載のデ バイス。 9.前記トランスデューサが、前記チャンバ壁の一部を形成する、請求項1に記 載のデバイス。 10.経皮輸送を増強するために皮膚に適用するデバイスであって、 直径約100μm〜1cmの皮膚上の領域に約20kHz〜200kHzの超 音波ビームを指向するように幾何学的に構成された超音波トランスデューサと、 結合媒体を収容する、該トランスデューサと皮膚との間のキャビティと、 を備えた、デバイス。 11.前記トランスデューサの形状が半球状である、請求項10に記載のデバイ ス。 12.前記トランスデューサが半球に構成された複数のトランスデューサを含む 、請求項10に記載のデバイス。 13.経皮輸送を増強する方法であって、 約20kHz〜2MHzの周波数および第1の直径を有する超音波ビームを提 供する工程、 該第1の直径より小さい約100μm〜1cmの間の第2の直径となるように 、該超音波ビームを幾何学的にチャネリングする工程であって、該ビームのエネ ルギーが約50%よりも大きくは減少しない工程、および 該チャネリングされたビームを皮膚の領域に適用する工程、 を包含する、方法。 14.経皮輸送を増強するためのデバイスであって、 約1kHz〜100kHzの間の周波数でエネルギーを生成するトランスデュ ーサと、 該トランスデューサからエネルギーを受容し、振動を皮膚に伝達するように構 成された少なくとも1つの部材と、 を備えた、デバイス。 15.前記部材を収容するハウジングをさらに備え、該ハウジングを皮膚に当て たときに、前記少なくとも1つの部材が皮膚内に最大約150μm延びる、請求 項14に記載のデバイス。 16.前記部材を収容するハウジングをさらに備え、該ハウジングを皮膚に当て たときに、前記少なくとも1つの部材が丁度皮膚に触れる、請求項14に記載の デバイス。 17.前記少なくとも1つの部材は、約10μm〜2cmの直径を有する、請求 項14に記載のデバイス。 18.前記少なくとも1つの部材は、約100μm〜500μmの直径を有する 、請求項14に記載のデバイス。 19.前記少なくとも1つの部材および結合媒体を収容するチャンバをさらに備 えた、請求項14に記載のデバイス。 20.前記少なくとも1つの部材は中空であり、これにより、分析物を該部材の 該中空部内に収集できる、請求項14に記載のデバイス。 21.皮膚から引き出される分析物の測定を提供するセンサユニットをさらに備 えた、請求項14に記載のデバイス。 22.ハウジングをさらに備え、該ハウジングが、前記トランスデューサと、ト ランスデューサコントローラと、該トランスデューサコントローラに電力供給す るバッテリと、ディスプレイと、前記少なくとも1つの部材および前記センサユ ニットを含む使捨てユニットを取り付ける手段と、前記デバイスを皮膚に当てた ときに該部材が皮膚内に突出し得る距離を調節する手段と、を収容する、請求項 21に記載のデバイス。 23.複数の部材をさらに備えた、請求項14に記載のデバイス。 24.経皮輸送を増強する方法であって、 1kHz〜100kHzの範囲の周 波数で超音波エネルギーを送達するトランスデューサを提供する工程、 該超音波エネルギーを部材に伝送し、該部材を振動させる工程、および 該部材によって生成された該振動を皮膚に適用する工程、 を包含する、方法。 25.前記部材を直接前記皮膚に適用する工程をさらに包含する、請求項24に 記載の方法。 26.少なくとも1つの前記部材を前記皮膚から約0.1〜5mm上方に位置決 めする工程をさらに包含する、請求項24に記載の方法。 27.前記部材および前記皮膚に接触する結合媒体を提供する工程であって、該 部材が該皮膚に接触しないように該部材を位置決めし、該部材は該皮膚の透過性 を増大させるのに十分なキャビテーションをもたらす工程をさらに包含する、請 求項24に記載の方法。 28.分析物が抽出され得る穴を前記皮膚に形成する工程をさらに包含する、請 求項24に記載の方法。 29.前記穴が前記部材によって形成される、請求項28に記載の方法。 30.前記部材が横モードで振動する、請求項24に記載の方法。 31.経皮輸送を行う方法であって、 超音波を皮膚のある領域に適用して該皮膚をより透過性にする工程、 該超音波を除去する工程、および さらなる超音波、吸引、浸透圧勾配、イオン泳動、エレクトロポレーション、 磁界および機械圧よりなる群から選択される経皮輸送駆動力を適用する工程、 を包含する、方法。
Applications Claiming Priority (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2095396P | 1996-06-28 | 1996-06-28 | |
US2292396P | 1996-08-01 | 1996-08-01 | |
US2292596P | 1996-08-01 | 1996-08-01 | |
US2363696P | 1996-08-09 | 1996-08-09 | |
US2463996P | 1996-08-22 | 1996-08-22 | |
US3304796P | 1996-12-11 | 1996-12-11 | |
US3399697P | 1997-01-03 | 1997-01-03 | |
US3465797P | 1997-01-08 | 1997-01-08 | |
US60/022,925 | 1997-01-08 | ||
US60/024,639 | 1997-01-08 | ||
US60/034,657 | 1997-01-08 | ||
US60/020,953 | 1997-01-08 | ||
US60/033,047 | 1997-01-08 | ||
US60/022,923 | 1997-01-08 | ||
US60/033,996 | 1997-01-08 | ||
US60/023,636 | 1997-01-08 | ||
PCT/US1997/011559 WO1998000194A2 (en) | 1996-06-28 | 1997-06-30 | Ultrasound enhancement of transdermal transport |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2002515786A true JP2002515786A (ja) | 2002-05-28 |
Family
ID=27574056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50444398A Ceased JP2002515786A (ja) | 1996-06-28 | 1997-06-30 | 経皮輸送の超音波増強 |
Country Status (4)
Country | Link |
---|---|
US (2) | US6234990B1 (ja) |
EP (1) | EP0925088A2 (ja) |
JP (1) | JP2002515786A (ja) |
WO (1) | WO1998000194A2 (ja) |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005287776A (ja) * | 2004-03-31 | 2005-10-20 | Matsushita Electric Works Ltd | 血糖計測装置 |
JP2010158554A (ja) * | 1999-06-08 | 2010-07-22 | Altea Therapeutics Corp | 薄膜組織インターフェイスデバイスを使用する生物学的膜のミクロポレーションのための装置、およびそのための方法 |
JP2010526589A (ja) * | 2007-05-07 | 2010-08-05 | ガイデッド セラピー システムズ, エル.エル.シー. | 音響エネルギーを使用してメディカントを調節するための方法およびシステム |
JP2010527644A (ja) * | 2007-05-07 | 2010-08-19 | ガイデッド セラピー システムズ, エル.エル.シー. | カプラ部材を使用して音響エネルギーを結合し、かつ焦点に集めるための方法およびシステム |
JP2013500118A (ja) * | 2009-07-30 | 2013-01-07 | アルマ レーザー エルティーディー. | ソノトロード |
US8444562B2 (en) | 2004-10-06 | 2013-05-21 | Guided Therapy Systems, Llc | System and method for treating muscle, tendon, ligament and cartilage tissue |
US8460193B2 (en) | 2004-10-06 | 2013-06-11 | Guided Therapy Systems Llc | System and method for ultra-high frequency ultrasound treatment |
US8480585B2 (en) | 1997-10-14 | 2013-07-09 | Guided Therapy Systems, Llc | Imaging, therapy and temperature monitoring ultrasonic system and method |
US8506486B2 (en) | 2004-10-06 | 2013-08-13 | Guided Therapy Systems, Llc | Ultrasound treatment of sub-dermal tissue for cosmetic effects |
US8535228B2 (en) | 2004-10-06 | 2013-09-17 | Guided Therapy Systems, Llc | Method and system for noninvasive face lifts and deep tissue tightening |
US8636665B2 (en) | 2004-10-06 | 2014-01-28 | Guided Therapy Systems, Llc | Method and system for ultrasound treatment of fat |
US8663112B2 (en) | 2004-10-06 | 2014-03-04 | Guided Therapy Systems, Llc | Methods and systems for fat reduction and/or cellulite treatment |
US8690778B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Energy-based tissue tightening |
US8708935B2 (en) | 2004-09-16 | 2014-04-29 | Guided Therapy Systems, Llc | System and method for variable depth ultrasound treatment |
US8715186B2 (en) | 2009-11-24 | 2014-05-06 | Guided Therapy Systems, Llc | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
US8857438B2 (en) | 2010-11-08 | 2014-10-14 | Ulthera, Inc. | Devices and methods for acoustic shielding |
US8858471B2 (en) | 2011-07-10 | 2014-10-14 | Guided Therapy Systems, Llc | Methods and systems for ultrasound treatment |
US8868958B2 (en) | 2005-04-25 | 2014-10-21 | Ardent Sound, Inc | Method and system for enhancing computer peripheral safety |
US8915870B2 (en) | 2004-10-06 | 2014-12-23 | Guided Therapy Systems, Llc | Method and system for treating stretch marks |
US8932224B2 (en) | 2004-10-06 | 2015-01-13 | Guided Therapy Systems, Llc | Energy based hyperhidrosis treatment |
JP2015042263A (ja) * | 2006-06-15 | 2015-03-05 | シーガル アイピー ピーティーワイ リミテッド | 送達システム及び方法 |
US9011337B2 (en) | 2011-07-11 | 2015-04-21 | Guided Therapy Systems, Llc | Systems and methods for monitoring and controlling ultrasound power output and stability |
US9011336B2 (en) | 2004-09-16 | 2015-04-21 | Guided Therapy Systems, Llc | Method and system for combined energy therapy profile |
US9114247B2 (en) | 2004-09-16 | 2015-08-25 | Guided Therapy Systems, Llc | Method and system for ultrasound treatment with a multi-directional transducer |
US9149658B2 (en) | 2010-08-02 | 2015-10-06 | Guided Therapy Systems, Llc | Systems and methods for ultrasound treatment |
US9263663B2 (en) | 2012-04-13 | 2016-02-16 | Ardent Sound, Inc. | Method of making thick film transducer arrays |
US9504446B2 (en) | 2010-08-02 | 2016-11-29 | Guided Therapy Systems, Llc | Systems and methods for coupling an ultrasound source to tissue |
US9510802B2 (en) | 2012-09-21 | 2016-12-06 | Guided Therapy Systems, Llc | Reflective ultrasound technology for dermatological treatments |
US9566454B2 (en) | 2006-09-18 | 2017-02-14 | Guided Therapy Systems, Llc | Method and sysem for non-ablative acne treatment and prevention |
US9694212B2 (en) | 2004-10-06 | 2017-07-04 | Guided Therapy Systems, Llc | Method and system for ultrasound treatment of skin |
JP2017136437A (ja) * | 2012-05-01 | 2017-08-10 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 経皮挿入するための先端装填型マイクロニードルアレイ |
US9827449B2 (en) | 2004-10-06 | 2017-11-28 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
JP2017537690A (ja) * | 2014-11-12 | 2017-12-21 | ミューファーマ ピーティーワイ リミテッド | 非侵襲性の薬剤塗布具 |
US9907535B2 (en) | 2000-12-28 | 2018-03-06 | Ardent Sound, Inc. | Visual imaging system for ultrasonic probe |
US10420960B2 (en) | 2013-03-08 | 2019-09-24 | Ulthera, Inc. | Devices and methods for multi-focus ultrasound therapy |
US10537304B2 (en) | 2008-06-06 | 2020-01-21 | Ulthera, Inc. | Hand wand for ultrasonic cosmetic treatment and imaging |
US10561862B2 (en) | 2013-03-15 | 2020-02-18 | Guided Therapy Systems, Llc | Ultrasound treatment device and methods of use |
US10603521B2 (en) | 2014-04-18 | 2020-03-31 | Ulthera, Inc. | Band transducer ultrasound therapy |
US10864385B2 (en) | 2004-09-24 | 2020-12-15 | Guided Therapy Systems, Llc | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
US11207548B2 (en) | 2004-10-07 | 2021-12-28 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
US11224895B2 (en) | 2016-01-18 | 2022-01-18 | Ulthera, Inc. | Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof |
US11235179B2 (en) | 2004-10-06 | 2022-02-01 | Guided Therapy Systems, Llc | Energy based skin gland treatment |
US11241218B2 (en) | 2016-08-16 | 2022-02-08 | Ulthera, Inc. | Systems and methods for cosmetic ultrasound treatment of skin |
US11724133B2 (en) | 2004-10-07 | 2023-08-15 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
US11883688B2 (en) | 2004-10-06 | 2024-01-30 | Guided Therapy Systems, Llc | Energy based fat reduction |
US11944849B2 (en) | 2018-02-20 | 2024-04-02 | Ulthera, Inc. | Systems and methods for combined cosmetic treatment of cellulite with ultrasound |
US11969609B2 (en) | 2022-12-05 | 2024-04-30 | Ulthera, Inc. | Devices and methods for multi-focus ultrasound therapy |
Families Citing this family (217)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7789841B2 (en) | 1997-02-06 | 2010-09-07 | Exogen, Inc. | Method and apparatus for connective tissue treatment |
US5913833A (en) * | 1997-02-07 | 1999-06-22 | Abbott Laboratories | Method and apparatus for obtaining biological fluids |
US5904659A (en) * | 1997-02-14 | 1999-05-18 | Exogen, Inc. | Ultrasonic treatment for wounds |
JP4441000B2 (ja) * | 1997-06-23 | 2010-03-24 | 克郎 立花 | 生体組織処理装置 |
US6575956B1 (en) * | 1997-12-31 | 2003-06-10 | Pharmasonics, Inc. | Methods and apparatus for uniform transcutaneous therapeutic ultrasound |
DE19800416C2 (de) * | 1998-01-08 | 2002-09-19 | Storz Karl Gmbh & Co Kg | Vorrichtung zur Behandlung von Körpergewebe, insbesondere von oberflächennahem Weichgewebe, mittels Ultraschall |
US8287483B2 (en) | 1998-01-08 | 2012-10-16 | Echo Therapeutics, Inc. | Method and apparatus for enhancement of transdermal transport |
US7066884B2 (en) * | 1998-01-08 | 2006-06-27 | Sontra Medical, Inc. | System, method, and device for non-invasive body fluid sampling and analysis |
US20060015058A1 (en) * | 1998-01-08 | 2006-01-19 | Kellogg Scott C | Agents and methods for enhancement of transdermal transport |
CA2317777C (en) * | 1998-01-08 | 2005-05-03 | Sontra Medical, Inc. | Sonophoretic enhanced transdermal transport |
US20020055702A1 (en) * | 1998-02-10 | 2002-05-09 | Anthony Atala | Ultrasound-mediated drug delivery |
ATE245937T1 (de) | 1998-05-13 | 2003-08-15 | Cygnus Therapeutic Systems | Überwachung physiologischer analyte |
DK1077636T3 (da) * | 1998-05-13 | 2004-05-24 | Cygnus Therapeutic Systems | Signalbehandling til måling af fysiologiske analytter |
US7344499B1 (en) | 1998-06-10 | 2008-03-18 | Georgia Tech Research Corporation | Microneedle device for extraction and sensing of bodily fluids |
US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
DE69902391T2 (de) | 1998-06-24 | 2003-03-06 | Transderm Technologies Llc San | Nichtinvasiven transdermal detektion von analyten |
GB9822150D0 (en) | 1998-10-09 | 1998-12-02 | Dignes Roy | Ultrasound driven devices for accelerated transfer of substances across porous boundaries |
DE19850517B4 (de) * | 1998-11-03 | 2004-02-12 | Lts Lohmann Therapie-Systeme Ag | Verwendung eines wirkstoffhaltigen transdermalen therapeutischen Systems in einer Kombinationsbehandlung mit und ohne Ultraschall |
US20040171980A1 (en) | 1998-12-18 | 2004-09-02 | Sontra Medical, Inc. | Method and apparatus for enhancement of transdermal transport |
CA2355184A1 (en) * | 1998-12-18 | 2000-06-22 | Sontra Medical, Inc. | Methods and apparatus for enhancement of transdermal transport |
US6620123B1 (en) * | 1999-12-17 | 2003-09-16 | Sontra Medical, Inc. | Method and apparatus for producing homogenous cavitation to enhance transdermal transport |
JP2002542841A (ja) * | 1998-12-18 | 2002-12-17 | ソントラ・メディカル・インコーポレーテッド | 経皮的移動を促進する均質空洞を製造するための方法及び装置 |
US6395096B1 (en) * | 1999-01-21 | 2002-05-28 | Uncopiers, Inc. | Single transducer ACIM method and apparatus |
US20020134402A1 (en) * | 2000-01-21 | 2002-09-26 | Madanshetty Sameer I. | Article produced by acoustic cavitation in a liquid insonification medium |
CA2361150A1 (en) * | 1999-02-22 | 2000-08-24 | Mark W. Cowan | Methods and apparatus for uniform transcutaneous therapeutic ultrasound |
US6217530B1 (en) * | 1999-05-14 | 2001-04-17 | University Of Washington | Ultrasonic applicator for medical applications |
US6666835B2 (en) * | 1999-05-14 | 2003-12-23 | University Of Washington | Self-cooled ultrasonic applicator for medical applications |
US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
CA2376128C (en) * | 1999-06-04 | 2009-01-06 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6835184B1 (en) * | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
US20030229331A1 (en) * | 1999-11-05 | 2003-12-11 | Pharmasonics, Inc. | Methods and apparatus for uniform transcutaneous therapeutic ultrasound |
JP2003527613A (ja) * | 2000-03-17 | 2003-09-16 | ソントラ・メディカル・インコーポレーテッド | 体液の非侵襲性のサンプリングおよび分析のためのシステム、方法およびデバイス |
KR100627249B1 (ko) * | 2000-06-07 | 2006-09-22 | 강형철 | 음압에 의한 약물 전달 장치 |
US20080182293A1 (en) * | 2000-07-14 | 2008-07-31 | Transform Pharmaceuticals, Inc. | Computerized control of high-throughput transdermal experimental processing and digital analysis of comparative samples |
US6852526B2 (en) * | 2000-07-14 | 2005-02-08 | Transform Pharmaceuticals, Inc. | Transdermal assay with magnetic clamp |
DE60123960T2 (de) * | 2000-07-14 | 2007-04-26 | Transform Pharmaceuticals, Inc., Lexington | System und verfahren zum optimieren des gewebebarrieretransfers von verbindungen |
US7172859B2 (en) * | 2000-07-14 | 2007-02-06 | Transform Pharmaceuticals, Inc. | System and method for optimizing tissue barrier transfer of compounds |
US6638249B1 (en) | 2000-07-17 | 2003-10-28 | Wisconsin Alumni Research Foundation | Ultrasonically actuated needle pump system |
US20020156415A1 (en) * | 2000-08-24 | 2002-10-24 | Redding Bruce K. | Ultrasonically enhanced substance delivery system and device |
US6964647B1 (en) * | 2000-10-06 | 2005-11-15 | Ellaz Babaev | Nozzle for ultrasound wound treatment |
US6601581B1 (en) | 2000-11-01 | 2003-08-05 | Advanced Medical Applications, Inc. | Method and device for ultrasound drug delivery |
US9302903B2 (en) | 2000-12-14 | 2016-04-05 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
WO2002050584A2 (en) | 2000-12-21 | 2002-06-27 | Biovalve Technologies, Inc. | Microneedle array systems |
US6533803B2 (en) | 2000-12-22 | 2003-03-18 | Advanced Medical Applications, Inc. | Wound treatment method and device with combination of ultrasound and laser energy |
US6761729B2 (en) | 2000-12-22 | 2004-07-13 | Advanced Medicalapplications, Inc. | Wound treatment method and device with combination of ultrasound and laser energy |
US7914470B2 (en) * | 2001-01-12 | 2011-03-29 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
US6569099B1 (en) | 2001-01-12 | 2003-05-27 | Eilaz Babaev | Ultrasonic method and device for wound treatment |
US8235919B2 (en) | 2001-01-12 | 2012-08-07 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
US6712805B2 (en) | 2001-01-29 | 2004-03-30 | Ultra Sonic Tech Llc | Method and apparatus for intradermal incorporation of microparticles containing encapsulated drugs using low frequency ultrasound |
US6960173B2 (en) * | 2001-01-30 | 2005-11-01 | Eilaz Babaev | Ultrasound wound treatment method and device using standing waves |
US6623444B2 (en) | 2001-03-21 | 2003-09-23 | Advanced Medical Applications, Inc. | Ultrasonic catheter drug delivery method and device |
US6478754B1 (en) | 2001-04-23 | 2002-11-12 | Advanced Medical Applications, Inc. | Ultrasonic method and device for wound treatment |
US7645269B2 (en) * | 2001-04-30 | 2010-01-12 | Kci Licensing, Inc. | Gradient wound treatment system and method |
NZ512367A (en) * | 2001-06-14 | 2005-05-27 | Horticulture & Food Res Inst | Non-invasive transudate extraction |
US7135029B2 (en) | 2001-06-29 | 2006-11-14 | Makin Inder Raj S | Ultrasonic surgical instrument for intracorporeal sonodynamic therapy |
US20050075598A1 (en) * | 2001-08-24 | 2005-04-07 | Redding Bruce K. | Method and apparatus for the measurement of real time drug delivery through the use of a wearable monitor and sensor attached to a transdermal drug delivery device |
US6908448B2 (en) * | 2001-08-24 | 2005-06-21 | Dermisonics, Inc. | Substance delivery device |
AU2002327675A1 (en) | 2001-09-19 | 2003-04-01 | Biovalve Technologies, Inc. | Microneedles, microneedle arrays, and systems and methods relating to same |
DE60239229D1 (de) | 2001-09-21 | 2011-03-31 | Valeritas Inc | Durch gasdruck betätigte mikronadel-anordnungen und damit zusammenhängende systeme und verfahren |
TWI220386B (en) * | 2002-01-21 | 2004-08-21 | Matsushita Electric Works Ltd | Ultrasonic transdermal permeation device |
US6887239B2 (en) * | 2002-04-17 | 2005-05-03 | Sontra Medical Inc. | Preparation for transmission and reception of electrical signals |
JP4243499B2 (ja) * | 2002-06-11 | 2009-03-25 | 富士通株式会社 | 貼合せ基板製造装置及び貼合せ基板製造方法 |
US20030233085A1 (en) | 2002-06-18 | 2003-12-18 | Pedro Giammarusti | Optimization of transcutaneous active permeation of compounds through the synergistic use of ultrasonically generated mechanical abrasion of the skin, chemical enhancers and simultaneous application of sonophoresis, iontophoresis, electroporation, mechanical vibrations and magnetophoresis through single application devices |
US20040009180A1 (en) | 2002-07-11 | 2004-01-15 | Allergan, Inc. | Transdermal botulinum toxin compositions |
DE10393505D2 (de) * | 2002-07-22 | 2005-06-23 | Hans-Werner Bender | Schallapplikator-Vorrichtung zur Verbesserung der Behandlungsbedingungen |
EP1386597A1 (en) * | 2002-07-31 | 2004-02-04 | Joan Francesc Casas Boncompte | Ultrasound endomassage device |
US20040064051A1 (en) * | 2002-09-30 | 2004-04-01 | Talish Roger J. | Ultrasound transducer coupling apparatus |
CA2500713C (en) * | 2002-10-04 | 2012-07-03 | Photokinetix, Inc. | Photokinetic delivery of biologically active substances using pulsed incoherent light |
US7449307B2 (en) * | 2002-10-28 | 2008-11-11 | Transform Pharmaceuticals, Inc. | Raised surface assay plate |
US6908760B2 (en) * | 2002-10-28 | 2005-06-21 | Transform Pharmaceuticals, Inc. | Raised surface assay plate |
US20040161362A1 (en) * | 2002-12-27 | 2004-08-19 | Bogert David L. | Audible range acoustic cleaning process for implants |
US20040267240A1 (en) * | 2003-01-29 | 2004-12-30 | Yossi Gross | Active drug delivery in the gastrointestinal tract |
EP1594477A4 (en) * | 2003-01-29 | 2009-07-15 | Pill Pharma Ltd E | ACTIVE MEDICATION CONTRIBUTION IN THE DIGESTIVE TUBE |
US20040158194A1 (en) * | 2003-02-06 | 2004-08-12 | Wolff Andy And Beiski Ben Z. | Oral devices and methods for controlled drug release |
EP1599141A2 (en) * | 2003-02-19 | 2005-11-30 | Second Stage Ventures, Inc. | Ultrasonically enhanced saline treatment for burn damaged skin |
IL155546A (en) * | 2003-04-22 | 2010-06-16 | Healfus Ltd | Apparatus for treatment of damaged tissue |
US20040253736A1 (en) * | 2003-06-06 | 2004-12-16 | Phil Stout | Analytical device with prediction module and related methods |
US20040249254A1 (en) * | 2003-06-06 | 2004-12-09 | Joel Racchini | Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein |
US7258673B2 (en) * | 2003-06-06 | 2007-08-21 | Lifescan, Inc | Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein |
US20050069925A1 (en) | 2003-08-15 | 2005-03-31 | Russell Ford | Microprocessors, devices, and methods for use in monitoring of physiological analytes |
US7189341B2 (en) * | 2003-08-15 | 2007-03-13 | Animas Technologies, Llc | Electrochemical sensor ink compositions, electrodes, and uses thereof |
US7299082B2 (en) | 2003-10-31 | 2007-11-20 | Abbott Diabetes Care, Inc. | Method of calibrating an analyte-measurement device, and associated methods, devices and systems |
MXPA06005677A (es) * | 2003-11-21 | 2006-12-14 | Johnson & Johnson | Metodo y sistema de suministro transdermico de vacuna asistido por ultrasonido. |
KR100561853B1 (ko) * | 2003-12-09 | 2006-03-16 | 삼성전자주식회사 | 휴대용 단말기를 이용한 체액 분석 장치 및 그 방법 |
MXPA06007832A (es) * | 2004-01-09 | 2007-01-26 | Johnson & Johnson | Metodo y sistema de suministro de agente transdermico asistido por frecuencia. |
US8165651B2 (en) | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
US7699964B2 (en) * | 2004-02-09 | 2010-04-20 | Abbott Diabetes Care Inc. | Membrane suitable for use in an analyte sensor, analyte sensor, and associated method |
US8235909B2 (en) | 2004-05-12 | 2012-08-07 | Guided Therapy Systems, L.L.C. | Method and system for controlled scanning, imaging and/or therapy |
US7559241B2 (en) * | 2004-05-27 | 2009-07-14 | Sulphco, Inc. | High-throughput continuous-flow ultrasound reactor |
US7794490B2 (en) * | 2004-06-22 | 2010-09-14 | Boston Scientific Scimed, Inc. | Implantable medical devices with antimicrobial and biodegradable matrices |
EP1616551A1 (fr) | 2004-07-13 | 2006-01-18 | L'oreal | Procédé de traitement cosmétique pour prévenir ou retarder les signes du vieillissement cutané |
US7356368B2 (en) * | 2004-07-21 | 2008-04-08 | Boston Scientific Scimed, Inc. | Light-activated anti-infective coatings and devices made thereof |
US7537590B2 (en) | 2004-07-30 | 2009-05-26 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
WO2006026459A2 (en) * | 2004-08-26 | 2006-03-09 | Finsterwald P Michael | Biological cell acoustic enhancement and stimulation |
GB0422525D0 (en) | 2004-10-11 | 2004-11-10 | Luebcke Peter | Dermatological compositions and methods |
US20060094944A1 (en) * | 2004-10-28 | 2006-05-04 | Sontra Medical Corporation | System and method for analyte sampling and analysis with error correction |
JP2008522778A (ja) * | 2004-12-14 | 2008-07-03 | イー−ピル ファーマ リミティド | 電気透過性増加を用いた薬物又は物質の局所輸送 |
KR20070094950A (ko) | 2005-04-05 | 2007-09-27 | 가부시끼가이샤 제이엠에스 | 3,4-dge에서 유래하는 age에 특이적으로 반응하는항체 |
WO2006123346A2 (en) * | 2005-05-19 | 2006-11-23 | E-Pill Pharma, Ltd. | Ingestible device for nitric oxide production in tissue |
US20070106138A1 (en) * | 2005-05-26 | 2007-05-10 | Beiski Ben Z | Intraoral apparatus for non-invasive blood and saliva monitoring & sensing |
US7713218B2 (en) | 2005-06-23 | 2010-05-11 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
US7785277B2 (en) * | 2005-06-23 | 2010-08-31 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
US7955262B2 (en) * | 2005-07-26 | 2011-06-07 | Syneron Medical Ltd. | Method and apparatus for treatment of skin using RF and ultrasound energies |
US9101949B2 (en) * | 2005-08-04 | 2015-08-11 | Eilaz Babaev | Ultrasonic atomization and/or seperation system |
US20070031611A1 (en) * | 2005-08-04 | 2007-02-08 | Babaev Eilaz P | Ultrasound medical stent coating method and device |
US7896539B2 (en) * | 2005-08-16 | 2011-03-01 | Bacoustics, Llc | Ultrasound apparatus and methods for mixing liquids and coating stents |
JP4341608B2 (ja) * | 2005-11-01 | 2009-10-07 | トヨタ自動車株式会社 | エンジン音制御装置 |
US7432069B2 (en) * | 2005-12-05 | 2008-10-07 | Sontra Medical Corporation | Biocompatible chemically crosslinked hydrogels for glucose sensing |
US20080177220A1 (en) * | 2006-01-06 | 2008-07-24 | The Curators Of The University Of Missouri | Ultrasound-Mediated Transcleral Drug Delivery |
US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
WO2010029556A1 (en) * | 2008-09-12 | 2010-03-18 | Slender Medical, Ltd. | A device for ultrasound treatment and monitoring tissue treatment |
US20110251524A1 (en) * | 2006-03-09 | 2011-10-13 | Slender Medical, Ltd. | Device for ultrasound treatment and monitoring tissue treatment |
US9107798B2 (en) * | 2006-03-09 | 2015-08-18 | Slender Medical Ltd. | Method and system for lipolysis and body contouring |
US20090048514A1 (en) * | 2006-03-09 | 2009-02-19 | Slender Medical Ltd. | Device for ultrasound monitored tissue treatment |
US20090234252A1 (en) * | 2006-04-24 | 2009-09-17 | Bacoustics, Llc | Portable topical pain relief system |
DE102006022554B4 (de) * | 2006-05-15 | 2014-12-04 | Roche Diagnostics Gmbh | Verfahren und Vorrichtung zum Stimulieren eines Gewebes für die subkutane Verabreichung von Wirkstoffen |
US7431704B2 (en) * | 2006-06-07 | 2008-10-07 | Bacoustics, Llc | Apparatus and method for the treatment of tissue with ultrasound energy by direct contact |
US8562547B2 (en) | 2006-06-07 | 2013-10-22 | Eliaz Babaev | Method for debriding wounds |
WO2007144801A2 (en) * | 2006-06-14 | 2007-12-21 | Koninklijke Philips Electronics N. V. | Device for transdermal drug delivery and method of operating such a device |
EP2049173A4 (en) * | 2006-08-01 | 2013-09-11 | Agency Science Tech & Res | MICRO-NEEDLES REINFORCED BY ULTRASON |
AU2007286660A1 (en) * | 2006-08-25 | 2008-02-28 | Eilaz Babaev | Portable ultrasound device for the treatment of wounds |
US20080082039A1 (en) * | 2006-09-29 | 2008-04-03 | Eilaz Babaev | Ultrasound Liquid Delivery Device |
US8050752B2 (en) * | 2006-09-29 | 2011-11-01 | Bacoustics, Llc | Method of treating lumens, cavities, and tissues of the body with an ultrasound delivered liquid |
US20080139943A1 (en) * | 2006-12-07 | 2008-06-12 | Industrial Technology Research Institute | Ultrasonic wave device |
US20080142616A1 (en) * | 2006-12-15 | 2008-06-19 | Bacoustics Llc | Method of Producing a Directed Spray |
WO2008079379A1 (en) * | 2006-12-22 | 2008-07-03 | Celleration, Inc. | Apparatus to prevent applicator re-use |
US8491521B2 (en) | 2007-01-04 | 2013-07-23 | Celleration, Inc. | Removable multi-channel applicator nozzle |
JP5508861B2 (ja) * | 2007-03-07 | 2014-06-04 | エコー セラピューティクス, インコーポレイテッド | 経皮的被検体モニタリングシステム |
EP2152358B1 (en) | 2007-04-27 | 2011-03-02 | Echo Therapeutics, Inc. | Skin permeation device for analyte sensing or transdermal drug delivery |
US20150174388A1 (en) | 2007-05-07 | 2015-06-25 | Guided Therapy Systems, Llc | Methods and Systems for Ultrasound Assisted Delivery of a Medicant to Tissue |
US7753285B2 (en) | 2007-07-13 | 2010-07-13 | Bacoustics, Llc | Echoing ultrasound atomization and/or mixing system |
US7780095B2 (en) | 2007-07-13 | 2010-08-24 | Bacoustics, Llc | Ultrasound pumping apparatus |
US20100274161A1 (en) * | 2007-10-15 | 2010-10-28 | Slender Medical, Ltd. | Implosion techniques for ultrasound |
CN100560157C (zh) * | 2007-11-13 | 2009-11-18 | 重庆市生力医疗设备有限公司 | 超声波药贴 |
EP2230904B1 (en) | 2007-12-06 | 2020-05-20 | Measurement Specialties, Inc. | Multilayer backing absorber for ultrasonic transducer |
EP2231230A4 (en) | 2007-12-21 | 2013-01-23 | Carticept Medical Inc | ARTICULAR INJECTION SYSTEM |
US9044542B2 (en) | 2007-12-21 | 2015-06-02 | Carticept Medical, Inc. | Imaging-guided anesthesia injection systems and methods |
US8545440B2 (en) | 2007-12-21 | 2013-10-01 | Carticept Medical, Inc. | Injection system for delivering multiple fluids within the anatomy |
WO2009085739A1 (en) * | 2007-12-27 | 2009-07-09 | Tti Ellebeau, Inc. | Iontophoresis device having an active electrode unit |
WO2009085241A2 (en) * | 2007-12-28 | 2009-07-09 | Celleration, Inc. | Methods for treating inflammatory skin disorders |
US20100069726A1 (en) * | 2008-06-04 | 2010-03-18 | Seventh Sense Biosystems, Inc. | Compositions and methods for rapid one-step diagnosis |
CN102099475A (zh) * | 2008-06-04 | 2011-06-15 | 科达治疗公司 | 用间隙连接调节化合物治疗疼痛 |
WO2010029555A1 (en) * | 2008-09-12 | 2010-03-18 | Slender Medical, Ltd. | Virtual ultrasonic scissors |
WO2012018486A2 (en) | 2010-07-26 | 2012-02-09 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
US9041541B2 (en) | 2010-01-28 | 2015-05-26 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
EP2408372B1 (en) | 2009-03-02 | 2019-01-09 | Seventh Sense Biosystems, Inc. | Devices associated with blood sampling |
US20120277629A1 (en) | 2011-04-29 | 2012-11-01 | Seventh Sense Biosystems, Inc. | Systems and methods for collection and/or manipulation of blood spots or other bodily fluids |
WO2010101625A2 (en) | 2009-03-02 | 2010-09-10 | Seventh Sense Biosystems, Inc. | Oxygen sensor |
US9033898B2 (en) | 2010-06-23 | 2015-05-19 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
US9295417B2 (en) | 2011-04-29 | 2016-03-29 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
US9314421B2 (en) * | 2009-03-06 | 2016-04-19 | The Hong Kong University Of Science And Technology | Ultrasound-enhanced intrascleral delivery of macromolecules |
US20100280419A1 (en) * | 2009-05-01 | 2010-11-04 | Dimitri Donskoy | Ultrasonically Assisted Fitness Method and Apparatus |
US20110066175A1 (en) * | 2009-05-07 | 2011-03-17 | Rainbow Medical Ltd. | Gastric anchor |
US8414559B2 (en) * | 2009-05-07 | 2013-04-09 | Rainbow Medical Ltd. | Gastroretentive duodenal pill |
US20100286628A1 (en) * | 2009-05-07 | 2010-11-11 | Rainbow Medical Ltd | Gastric anchor |
US20100286587A1 (en) * | 2009-05-07 | 2010-11-11 | Yossi Gross | Sublingual electrical drug delivery |
DK2263808T3 (da) | 2009-06-19 | 2014-06-10 | Sonovia Holdings Llc | Dobbeltfrekvens-ultralydstransducer |
US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
CN103140173A (zh) * | 2010-06-24 | 2013-06-05 | 杰拓奥兹有限公司 | 水凝胶超声耦合装置 |
US20120016308A1 (en) | 2010-07-16 | 2012-01-19 | Seventh Sense Biosystems, Inc. | Low-pressure packaging for fluid devices |
EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
US20120039809A1 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
US20120237975A1 (en) | 2010-10-01 | 2012-09-20 | Jason Schrum | Engineered nucleic acids and methods of use thereof |
WO2012064802A1 (en) | 2010-11-09 | 2012-05-18 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
TWI511706B (zh) * | 2011-03-15 | 2015-12-11 | Crystalvue Medical Corp | 光學血糖檢測裝置及其運作方法 |
WO2012129545A1 (en) | 2011-03-23 | 2012-09-27 | Redding Bruce K | Systems and methods for enhancing the delivery of compounds to skin pores using ultrasonic waveforms |
EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
ES2597081T3 (es) | 2011-04-29 | 2017-01-13 | Seventh Sense Biosystems, Inc. | Entrega y/o recepción de fluidos |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
CA2850624A1 (en) | 2011-10-03 | 2013-04-11 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
US9569566B2 (en) | 2011-12-12 | 2017-02-14 | Zam Research Llc | Simulation and control system and method using contact, pressure waves and factor controls for cell regeneration, tissue closure and related applications |
KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
US9849270B2 (en) | 2011-12-16 | 2017-12-26 | 3M Innovative Properties Company | Foldable adhesive composite dressing |
EP2816950A4 (en) * | 2012-02-22 | 2015-10-28 | Aclaris Medical Llc | DEVICE AND SYSTEM FOR DETECTING PHYSIOLOGICAL SIGNALS |
US9588113B2 (en) | 2012-02-22 | 2017-03-07 | Church & Dwight Co., Inc. | Methods for electronic analyte assaying |
EP2831233A1 (en) | 2012-03-27 | 2015-02-04 | CoDa Therapeutics, Inc. | Compositions and treatments based on cadherin modulation |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
CA2868398A1 (en) | 2012-04-02 | 2013-10-10 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
CN104768567B (zh) | 2012-05-18 | 2017-07-11 | 奥塔哥创业有限公司 | 用于伤口愈合的联合治疗和组合物 |
US20140066837A1 (en) | 2012-07-26 | 2014-03-06 | Ronald L. Moy | Skin care compositions and methods |
TW201416140A (zh) | 2012-10-31 | 2014-05-01 | Ind Tech Res Inst | 可撓式超音波致動裝置 |
JP6144355B2 (ja) | 2012-11-26 | 2017-06-07 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | 化学修飾mRNA |
CA2897941A1 (en) | 2013-01-17 | 2014-07-24 | Moderna Therapeutics, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
US9682217B2 (en) | 2013-02-26 | 2017-06-20 | Prytime Medical Devices, Inc. | Vascular access systems and methods of use |
US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
JP6845009B2 (ja) | 2013-03-15 | 2021-03-17 | ケアウェア コーポレイション | 光及び超音波トランスデューサデバイス |
DK3019619T3 (da) | 2013-07-11 | 2021-10-11 | Modernatx Inc | Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder |
US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
WO2015034928A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
EP3074089A4 (en) | 2013-11-26 | 2017-07-26 | Alliqua Biomedical, Inc. | Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing |
WO2015102745A1 (en) | 2013-12-31 | 2015-07-09 | Abbott Diabetes Care Inc. | Self-powered analyte sensor and devices using the same |
EP4039322B1 (en) | 2014-02-24 | 2023-09-06 | Element Science, Inc. | External defibrillator |
CN112121302A (zh) * | 2014-05-06 | 2020-12-25 | 穆医药有限公司 | 非侵入性剂施用器 |
EP3169693B1 (en) | 2014-07-16 | 2022-03-09 | ModernaTX, Inc. | Chimeric polynucleotides |
WO2016149673A1 (en) | 2015-03-18 | 2016-09-22 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
JP2018522657A (ja) * | 2015-07-29 | 2018-08-16 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 育毛の促進 |
CA2994436A1 (en) | 2015-08-26 | 2017-03-02 | Element Science, Inc. | Wearable devices |
US11684763B2 (en) | 2015-10-16 | 2023-06-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices |
WO2017079761A1 (en) * | 2015-11-06 | 2017-05-11 | Bkr Ip Holdco Llc | Ultrasonic transducers suitable for ultrasonic drug delivery via a system, which is portable and wearable by the patient |
US11744889B2 (en) | 2016-01-05 | 2023-09-05 | University of Pittsburgh—of the Commonwealth System of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
JP3223608U (ja) | 2016-05-26 | 2019-10-24 | サンディエゴ ステイト ユニバーシティ リサーチ ファンデーション | パルス状紫色光又は青色光を用いる微生物の光による死滅 |
US10806903B2 (en) | 2016-06-22 | 2020-10-20 | Prytime Medical Devices, Inc. | Handheld multi-needle vascular access device |
CN106199466B (zh) * | 2016-06-30 | 2019-05-21 | 重庆大学 | 一种舰艇监测磁场传感器 |
CN109982649B (zh) | 2016-07-01 | 2022-09-16 | 天鹅细胞学股份有限公司 | 提取和递送实体的方法和装置 |
WO2019005808A1 (en) | 2017-06-26 | 2019-01-03 | Align Technology, Inc. | BIOCAPTOR PERFORMANCE INDICATOR FOR INTRABUCCAL DEVICES |
US20190099129A1 (en) * | 2017-10-04 | 2019-04-04 | Align Technology, Inc. | Intraoral appliances for sampling soft-tissue |
US11020605B2 (en) | 2018-05-29 | 2021-06-01 | Carewear Corp. | Method and system for irradiating tissue with pulsed blue and red light to reduce muscle fatigue, enhance wound healing and tissue repair, and reduce pain |
SI3860687T1 (sl) | 2018-10-03 | 2022-10-28 | Eli Lilly And Company | Sistemi za zazanavanja stanja znotraj sestave naprave za vbrizganje |
JP2022504629A (ja) | 2018-10-10 | 2022-01-13 | エレメント サイエンス,インク | 使い捨て部品と再使用可能部品を備えたウェアラブル医療機器 |
PL3909508T3 (pl) * | 2020-05-12 | 2024-01-03 | Medicsensors Limited | Urządzenie nadające się do noszenia do przezskórnego dostarczania produktu |
CN115400340B (zh) * | 2022-08-29 | 2023-10-13 | 广东工业大学 | 一种结合功率超声与微针的超声装置 |
Family Cites Families (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3551554A (en) | 1968-08-16 | 1970-12-29 | Crown Zellerbach Corp | Enhancing tissue penetration of physiologically active agents with dmso |
US3711606A (en) | 1970-09-02 | 1973-01-16 | Crown Zellerbach Corp | Enhancing tissue penetration of physiologically active steroidal agents with dmso |
US3711602A (en) | 1970-10-30 | 1973-01-16 | Crown Zellerbach Corp | Compositions for topical application for enhancing tissue penetration of physiologically active agents with dmso |
US4002221A (en) | 1972-09-19 | 1977-01-11 | Gilbert Buchalter | Method of transmitting ultrasonic impulses to surface using transducer coupling agent |
SU445433A1 (ru) | 1973-03-22 | 1974-10-05 | Центральный Научно-Исследовательский Институт Курортологии И Физиотерапии | Способ физиотерапевтического лечени больных с заболевани ми опорно-двигательного аппарата обменного характера |
SU506421A1 (ru) | 1974-08-06 | 1978-03-05 | Московское Ордена Ленина И Ордена Трудового Красного Знамени Высшее Техническое Училище Имени Н.Э.Баумана | Способ лечени инфицированных ран |
US4144646A (en) | 1975-12-05 | 1979-03-20 | Lion Hamigaki Kabushiki Kaisha | Torsional ultrasonic vibrators |
US4127125A (en) | 1975-12-22 | 1978-11-28 | Lion Hamigaki Kabushiki Kaisha | Devices for transmitting ultrasonic waves to teeth |
SU556805A1 (ru) | 1976-01-23 | 1977-05-05 | Каунасский Медицинский Институт | Способ введени лекарственных веществ |
US4309989A (en) | 1976-02-09 | 1982-01-12 | The Curators Of The University Of Missouri | Topical application of medication by ultrasound with coupling agent |
CA1083040A (en) | 1976-02-09 | 1980-08-05 | Mostafa Fahim | Topical application of medication by ultrasound with coupling agent |
SU591186A1 (ru) | 1976-07-23 | 1978-02-05 | Serov Vilenin Nikolaevich | Устройство дл лечени заболеваний глаз |
DE2756460A1 (de) | 1977-12-17 | 1979-06-21 | Fraunhofer Ges Forschung | Verfahren zur lokal begrenzten applikation von therpeutika durch die oberflaeche von lebenden koerpern oder koerperorganen |
US4176664A (en) | 1978-03-13 | 1979-12-04 | Stanley Kalish | Impregnated bandage |
US4280494A (en) | 1979-06-26 | 1981-07-28 | Cosgrove Robert J Jun | System for automatic feedback-controlled administration of drugs |
US4249531A (en) | 1979-07-05 | 1981-02-10 | Alza Corporation | Bioerodible system for delivering drug manufactured from poly(carboxylic acid) |
SU910157A1 (ru) | 1980-02-29 | 1982-03-07 | Московское Ордена Ленина,Ордена Трудового Красного Знамени Высшее Техническое Училище Им.Баумана | Способ лечени инфицированных ран |
CA1165240A (en) | 1980-07-09 | 1984-04-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
US4372296A (en) | 1980-11-26 | 1983-02-08 | Fahim Mostafa S | Treatment of acne and skin disorders and compositions therefor |
US4537776A (en) | 1983-06-21 | 1985-08-27 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone |
US4563184A (en) | 1983-10-17 | 1986-01-07 | Bernard Korol | Synthetic resin wound dressing and method of treatment using same |
US4557943A (en) | 1983-10-31 | 1985-12-10 | Advanced Semiconductor Materials America, Inc. | Metal-silicide deposition using plasma-enhanced chemical vapor deposition |
US4646725A (en) | 1983-11-16 | 1987-03-03 | Manoutchehr Moasser | Method for treating herpes lesions and other infectious skin conditions |
US4605670A (en) | 1984-02-01 | 1986-08-12 | Nitto Electric Industrial Co., Ltd. | Method for percutaneously administering metoclopramide |
DK8601218A (ja) | 1984-07-18 | 1986-03-17 | ||
US4732153A (en) | 1984-07-18 | 1988-03-22 | Michael Phillips | Transdermal dosimeter |
US4834978A (en) | 1984-10-01 | 1989-05-30 | Biotek, Inc. | Method of transdermal drug delivery |
US4698058A (en) | 1985-10-15 | 1987-10-06 | Albert R. Greenfeld | Ultrasonic self-cleaning catheter system for indwelling drains and medication supply |
US4948587A (en) | 1986-07-08 | 1990-08-14 | Massachusetts Institute Of Technology | Ultrasound enhancement of transbuccal drug delivery |
US4767402A (en) | 1986-07-08 | 1988-08-30 | Massachusetts Institute Of Technology | Ultrasound enhancement of transdermal drug delivery |
JPS6336172A (ja) * | 1986-07-29 | 1988-02-16 | Toshiba Corp | 超音波カプラ |
US4863970A (en) | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
JPS63132889A (ja) | 1986-11-21 | 1988-06-04 | Tanabe Seiyaku Co Ltd | キナゾリノン誘導体 |
JPS63135179A (ja) | 1986-11-26 | 1988-06-07 | 立花 俊郎 | 薬物の経皮投与具 |
US5006342A (en) | 1986-12-22 | 1991-04-09 | Cygnus Corporation | Resilient transdermal drug delivery device |
EP0278599A3 (en) | 1987-02-02 | 1988-12-07 | Seiko Epson Corporation | Photographic transfer type image forming apparatus |
US4787888A (en) | 1987-06-01 | 1988-11-29 | University Of Connecticut | Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a) |
US4780212A (en) | 1987-07-31 | 1988-10-25 | Massachusetts Institute Of Technology | Ultrasound enchancement of membrane permeability |
US4821733A (en) | 1987-08-18 | 1989-04-18 | Dermal Systems International | Transdermal detection system |
US4820720A (en) | 1987-08-24 | 1989-04-11 | Alza Corporation | Transdermal drug composition with dual permeation enhancers |
US5078144A (en) * | 1988-08-19 | 1992-01-07 | Olympus Optical Co. Ltd. | System for applying ultrasonic waves and a treatment instrument to a body part |
US5076273A (en) | 1988-09-08 | 1991-12-31 | Sudor Partners | Method and apparatus for determination of chemical species in body fluid |
DE3907618A1 (de) | 1989-03-09 | 1990-09-20 | Braun Melsungen Ag | Katheter |
US5139023A (en) | 1989-06-02 | 1992-08-18 | Theratech Inc. | Apparatus and method for noninvasive blood glucose monitoring |
WO1990015568A2 (en) | 1989-06-02 | 1990-12-27 | Stanley Theodore H | Apparatus and methods for noninvasive blood glucose monitoring |
JP2788307B2 (ja) | 1989-11-30 | 1998-08-20 | 住友ベークライト株式会社 | 薬剤投与器 |
US5140985A (en) | 1989-12-11 | 1992-08-25 | Schroeder Jon M | Noninvasive blood glucose measuring device |
US5016615A (en) * | 1990-02-20 | 1991-05-21 | Riverside Research Institute | Local application of medication with ultrasound |
US5115805A (en) | 1990-02-23 | 1992-05-26 | Cygnus Therapeutic Systems | Ultrasound-enhanced delivery of materials into and through the skin |
US5231975A (en) | 1990-02-23 | 1993-08-03 | Cygnus Therapeutic Systems | Ultrasound-enhanced delivery of materials into and through the skin |
US5197946A (en) | 1990-06-27 | 1993-03-30 | Shunro Tachibana | Injection instrument with ultrasonic oscillating element |
EP0504881B2 (en) | 1991-03-22 | 2000-11-08 | Katsuro Tachibana | Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same |
JP3181071B2 (ja) | 1991-06-28 | 2001-07-03 | 俊郎 立花 | 血液処理装置 |
US5171215A (en) * | 1991-08-22 | 1992-12-15 | Flanagan Dennis F | Endermic method and apparatus |
US5230334A (en) * | 1992-01-22 | 1993-07-27 | Summit Technology, Inc. | Method and apparatus for generating localized hyperthermia |
US5165418B1 (en) | 1992-03-02 | 1999-12-14 | Nikola I Tankovich | Blood sampling device and method using a laser |
US5405614A (en) | 1992-04-08 | 1995-04-11 | International Medical Associates, Inc. | Electronic transdermal drug delivery system |
NL9200731A (nl) | 1992-04-22 | 1993-11-16 | Jacob Korf | Werkwijze en inrichting voor het niet-invasief bewaken van de concentratie van stoffen in bloed. |
US5421816A (en) | 1992-10-14 | 1995-06-06 | Endodermic Medical Technologies Company | Ultrasonic transdermal drug delivery system |
US5386837A (en) | 1993-02-01 | 1995-02-07 | Mmtc, Inc. | Method for enhancing delivery of chemotherapy employing high-frequency force fields |
US5267985A (en) | 1993-02-11 | 1993-12-07 | Trancell, Inc. | Drug delivery by multiple frequency phonophoresis |
CA2114968A1 (en) | 1993-02-25 | 1994-08-26 | John Wille | Transdermal treatment with mast cell degranulating agents for drug-induced hypersensitivity |
US5415629A (en) | 1993-09-15 | 1995-05-16 | Henley; Julian L. | Programmable apparatus for the transdermal delivery of drugs and method |
US5458140A (en) | 1993-11-15 | 1995-10-17 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers |
US5445611A (en) * | 1993-12-08 | 1995-08-29 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal delivery with ultrasound and chemical enhancers |
US5443080A (en) | 1993-12-22 | 1995-08-22 | Americate Transtech, Inc. | Integrated system for biological fluid constituent analysis |
JP3170172B2 (ja) | 1995-03-30 | 2001-05-28 | ティーディーケイ株式会社 | チップ部品供給装置及び該装置に用いるチップ部品供給ケース |
US5626554A (en) * | 1995-02-21 | 1997-05-06 | Exogen, Inc. | Gel containment structure |
DE69624668T2 (de) | 1995-07-25 | 2003-08-28 | Massachusetts Inst Technology | Verbesserter transdermaler transport unter verwendung von ultraschall |
US5618275A (en) * | 1995-10-27 | 1997-04-08 | Sonex International Corporation | Ultrasonic method and apparatus for cosmetic and dermatological applications |
US5656016A (en) * | 1996-03-18 | 1997-08-12 | Abbott Laboratories | Sonophoretic drug delivery system |
-
1997
- 1997-06-30 JP JP50444398A patent/JP2002515786A/ja not_active Ceased
- 1997-06-30 EP EP97933255A patent/EP0925088A2/en not_active Withdrawn
- 1997-06-30 WO PCT/US1997/011559 patent/WO1998000194A2/en active Application Filing
- 1997-06-30 US US08/885,931 patent/US6234990B1/en not_active Expired - Fee Related
-
2001
- 2001-05-21 US US09/861,924 patent/US6491657B2/en not_active Expired - Fee Related
Cited By (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8480585B2 (en) | 1997-10-14 | 2013-07-09 | Guided Therapy Systems, Llc | Imaging, therapy and temperature monitoring ultrasonic system and method |
US9272162B2 (en) | 1997-10-14 | 2016-03-01 | Guided Therapy Systems, Llc | Imaging, therapy, and temperature monitoring ultrasonic method |
JP2010158554A (ja) * | 1999-06-08 | 2010-07-22 | Altea Therapeutics Corp | 薄膜組織インターフェイスデバイスを使用する生物学的膜のミクロポレーションのための装置、およびそのための方法 |
US9907535B2 (en) | 2000-12-28 | 2018-03-06 | Ardent Sound, Inc. | Visual imaging system for ultrasonic probe |
JP2005287776A (ja) * | 2004-03-31 | 2005-10-20 | Matsushita Electric Works Ltd | 血糖計測装置 |
JP4599872B2 (ja) * | 2004-03-31 | 2010-12-15 | パナソニック電工株式会社 | 血糖計測装置 |
US10039938B2 (en) | 2004-09-16 | 2018-08-07 | Guided Therapy Systems, Llc | System and method for variable depth ultrasound treatment |
US8708935B2 (en) | 2004-09-16 | 2014-04-29 | Guided Therapy Systems, Llc | System and method for variable depth ultrasound treatment |
US9114247B2 (en) | 2004-09-16 | 2015-08-25 | Guided Therapy Systems, Llc | Method and system for ultrasound treatment with a multi-directional transducer |
US9011336B2 (en) | 2004-09-16 | 2015-04-21 | Guided Therapy Systems, Llc | Method and system for combined energy therapy profile |
US10864385B2 (en) | 2004-09-24 | 2020-12-15 | Guided Therapy Systems, Llc | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
US9895560B2 (en) | 2004-09-24 | 2018-02-20 | Guided Therapy Systems, Llc | Methods for rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
US9095697B2 (en) | 2004-09-24 | 2015-08-04 | Guided Therapy Systems, Llc | Methods for preheating tissue for cosmetic treatment of the face and body |
US10328289B2 (en) | 2004-09-24 | 2019-06-25 | Guided Therapy Systems, Llc | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
US11590370B2 (en) | 2004-09-24 | 2023-02-28 | Guided Therapy Systems, Llc | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
US9320537B2 (en) | 2004-10-06 | 2016-04-26 | Guided Therapy Systems, Llc | Methods for noninvasive skin tightening |
US10888718B2 (en) | 2004-10-06 | 2021-01-12 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
US8690780B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Noninvasive tissue tightening for cosmetic effects |
US8690778B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Energy-based tissue tightening |
US11697033B2 (en) | 2004-10-06 | 2023-07-11 | Guided Therapy Systems, Llc | Methods for lifting skin tissue |
US8672848B2 (en) | 2004-10-06 | 2014-03-18 | Guided Therapy Systems, Llc | Method and system for treating cellulite |
US11400319B2 (en) | 2004-10-06 | 2022-08-02 | Guided Therapy Systems, Llc | Methods for lifting skin tissue |
US11338156B2 (en) | 2004-10-06 | 2022-05-24 | Guided Therapy Systems, Llc | Noninvasive tissue tightening system |
US11883688B2 (en) | 2004-10-06 | 2024-01-30 | Guided Therapy Systems, Llc | Energy based fat reduction |
US8915853B2 (en) | 2004-10-06 | 2014-12-23 | Guided Therapy Systems, Llc | Methods for face and neck lifts |
US8915870B2 (en) | 2004-10-06 | 2014-12-23 | Guided Therapy Systems, Llc | Method and system for treating stretch marks |
US8915854B2 (en) | 2004-10-06 | 2014-12-23 | Guided Therapy Systems, Llc | Method for fat and cellulite reduction |
US8920324B2 (en) | 2004-10-06 | 2014-12-30 | Guided Therapy Systems, Llc | Energy based fat reduction |
US8932224B2 (en) | 2004-10-06 | 2015-01-13 | Guided Therapy Systems, Llc | Energy based hyperhidrosis treatment |
US8663112B2 (en) | 2004-10-06 | 2014-03-04 | Guided Therapy Systems, Llc | Methods and systems for fat reduction and/or cellulite treatment |
US11235179B2 (en) | 2004-10-06 | 2022-02-01 | Guided Therapy Systems, Llc | Energy based skin gland treatment |
US8641622B2 (en) | 2004-10-06 | 2014-02-04 | Guided Therapy Systems, Llc | Method and system for treating photoaged tissue |
US11235180B2 (en) | 2004-10-06 | 2022-02-01 | Guided Therapy Systems, Llc | System and method for noninvasive skin tightening |
US9039619B2 (en) | 2004-10-06 | 2015-05-26 | Guided Therapy Systems, L.L.C. | Methods for treating skin laxity |
US8636665B2 (en) | 2004-10-06 | 2014-01-28 | Guided Therapy Systems, Llc | Method and system for ultrasound treatment of fat |
US8535228B2 (en) | 2004-10-06 | 2013-09-17 | Guided Therapy Systems, Llc | Method and system for noninvasive face lifts and deep tissue tightening |
US11207547B2 (en) | 2004-10-06 | 2021-12-28 | Guided Therapy Systems, Llc | Probe for ultrasound tissue treatment |
US10265550B2 (en) | 2004-10-06 | 2019-04-23 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
US11179580B2 (en) | 2004-10-06 | 2021-11-23 | Guided Therapy Systems, Llc | Energy based fat reduction |
US8506486B2 (en) | 2004-10-06 | 2013-08-13 | Guided Therapy Systems, Llc | Ultrasound treatment of sub-dermal tissue for cosmetic effects |
US9283409B2 (en) | 2004-10-06 | 2016-03-15 | Guided Therapy Systems, Llc | Energy based fat reduction |
US9283410B2 (en) | 2004-10-06 | 2016-03-15 | Guided Therapy Systems, L.L.C. | System and method for fat and cellulite reduction |
US10525288B2 (en) | 2004-10-06 | 2020-01-07 | Guided Therapy Systems, Llc | System and method for noninvasive skin tightening |
US11167155B2 (en) | 2004-10-06 | 2021-11-09 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
US9421029B2 (en) | 2004-10-06 | 2016-08-23 | Guided Therapy Systems, Llc | Energy based hyperhidrosis treatment |
US9427600B2 (en) | 2004-10-06 | 2016-08-30 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
US9427601B2 (en) | 2004-10-06 | 2016-08-30 | Guided Therapy Systems, Llc | Methods for face and neck lifts |
US9440096B2 (en) | 2004-10-06 | 2016-09-13 | Guided Therapy Systems, Llc | Method and system for treating stretch marks |
US10960236B2 (en) | 2004-10-06 | 2021-03-30 | Guided Therapy Systems, Llc | System and method for noninvasive skin tightening |
US10888717B2 (en) | 2004-10-06 | 2021-01-12 | Guided Therapy Systems, Llc | Probe for ultrasound tissue treatment |
US8690779B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Noninvasive aesthetic treatment for tightening tissue |
US9522290B2 (en) | 2004-10-06 | 2016-12-20 | Guided Therapy Systems, Llc | System and method for fat and cellulite reduction |
US9533175B2 (en) | 2004-10-06 | 2017-01-03 | Guided Therapy Systems, Llc | Energy based fat reduction |
US10888716B2 (en) | 2004-10-06 | 2021-01-12 | Guided Therapy Systems, Llc | Energy based fat reduction |
US8460193B2 (en) | 2004-10-06 | 2013-06-11 | Guided Therapy Systems Llc | System and method for ultra-high frequency ultrasound treatment |
US9694211B2 (en) | 2004-10-06 | 2017-07-04 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
US9694212B2 (en) | 2004-10-06 | 2017-07-04 | Guided Therapy Systems, Llc | Method and system for ultrasound treatment of skin |
US9700340B2 (en) | 2004-10-06 | 2017-07-11 | Guided Therapy Systems, Llc | System and method for ultra-high frequency ultrasound treatment |
US9707412B2 (en) | 2004-10-06 | 2017-07-18 | Guided Therapy Systems, Llc | System and method for fat and cellulite reduction |
US9713731B2 (en) | 2004-10-06 | 2017-07-25 | Guided Therapy Systems, Llc | Energy based fat reduction |
US10610705B2 (en) | 2004-10-06 | 2020-04-07 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
US10610706B2 (en) | 2004-10-06 | 2020-04-07 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
US9827449B2 (en) | 2004-10-06 | 2017-11-28 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
US9827450B2 (en) | 2004-10-06 | 2017-11-28 | Guided Therapy Systems, L.L.C. | System and method for fat and cellulite reduction |
US9833639B2 (en) | 2004-10-06 | 2017-12-05 | Guided Therapy Systems, L.L.C. | Energy based fat reduction |
US9833640B2 (en) | 2004-10-06 | 2017-12-05 | Guided Therapy Systems, L.L.C. | Method and system for ultrasound treatment of skin |
US10603519B2 (en) | 2004-10-06 | 2020-03-31 | Guided Therapy Systems, Llc | Energy based fat reduction |
US8444562B2 (en) | 2004-10-06 | 2013-05-21 | Guided Therapy Systems, Llc | System and method for treating muscle, tendon, ligament and cartilage tissue |
US11717707B2 (en) | 2004-10-06 | 2023-08-08 | Guided Therapy Systems, Llc | System and method for noninvasive skin tightening |
US9974982B2 (en) | 2004-10-06 | 2018-05-22 | Guided Therapy Systems, Llc | System and method for noninvasive skin tightening |
US10010726B2 (en) | 2004-10-06 | 2018-07-03 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
US10010724B2 (en) | 2004-10-06 | 2018-07-03 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
US10010721B2 (en) | 2004-10-06 | 2018-07-03 | Guided Therapy Systems, L.L.C. | Energy based fat reduction |
US10010725B2 (en) | 2004-10-06 | 2018-07-03 | Guided Therapy Systems, Llc | Ultrasound probe for fat and cellulite reduction |
US10252086B2 (en) | 2004-10-06 | 2019-04-09 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
US10046181B2 (en) | 2004-10-06 | 2018-08-14 | Guided Therapy Systems, Llc | Energy based hyperhidrosis treatment |
US10046182B2 (en) | 2004-10-06 | 2018-08-14 | Guided Therapy Systems, Llc | Methods for face and neck lifts |
US10603523B2 (en) | 2004-10-06 | 2020-03-31 | Guided Therapy Systems, Llc | Ultrasound probe for tissue treatment |
US10238894B2 (en) | 2004-10-06 | 2019-03-26 | Guided Therapy Systems, L.L.C. | Energy based fat reduction |
US10532230B2 (en) | 2004-10-06 | 2020-01-14 | Guided Therapy Systems, Llc | Methods for face and neck lifts |
US10245450B2 (en) | 2004-10-06 | 2019-04-02 | Guided Therapy Systems, Llc | Ultrasound probe for fat and cellulite reduction |
US11724133B2 (en) | 2004-10-07 | 2023-08-15 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
US11207548B2 (en) | 2004-10-07 | 2021-12-28 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
US8868958B2 (en) | 2005-04-25 | 2014-10-21 | Ardent Sound, Inc | Method and system for enhancing computer peripheral safety |
JP2015042263A (ja) * | 2006-06-15 | 2015-03-05 | シーガル アイピー ピーティーワイ リミテッド | 送達システム及び方法 |
US9566454B2 (en) | 2006-09-18 | 2017-02-14 | Guided Therapy Systems, Llc | Method and sysem for non-ablative acne treatment and prevention |
JP2010526589A (ja) * | 2007-05-07 | 2010-08-05 | ガイデッド セラピー システムズ, エル.エル.シー. | 音響エネルギーを使用してメディカントを調節するための方法およびシステム |
JP2010527644A (ja) * | 2007-05-07 | 2010-08-19 | ガイデッド セラピー システムズ, エル.エル.シー. | カプラ部材を使用して音響エネルギーを結合し、かつ焦点に集めるための方法およびシステム |
US9216276B2 (en) | 2007-05-07 | 2015-12-22 | Guided Therapy Systems, Llc | Methods and systems for modulating medicants using acoustic energy |
US8764687B2 (en) | 2007-05-07 | 2014-07-01 | Guided Therapy Systems, Llc | Methods and systems for coupling and focusing acoustic energy using a coupler member |
JP2017086983A (ja) * | 2007-05-07 | 2017-05-25 | ガイデッド セラピー システムズ, エル.エル.シー. | 音響エネルギーを使用してメディカントを調節するための方法およびシステム |
US10537304B2 (en) | 2008-06-06 | 2020-01-21 | Ulthera, Inc. | Hand wand for ultrasonic cosmetic treatment and imaging |
US11123039B2 (en) | 2008-06-06 | 2021-09-21 | Ulthera, Inc. | System and method for ultrasound treatment |
US11723622B2 (en) | 2008-06-06 | 2023-08-15 | Ulthera, Inc. | Systems for ultrasound treatment |
US10238849B2 (en) | 2009-07-30 | 2019-03-26 | Alma Lasers Ltd. | Sonotrode |
JP2013500118A (ja) * | 2009-07-30 | 2013-01-07 | アルマ レーザー エルティーディー. | ソノトロード |
US8715186B2 (en) | 2009-11-24 | 2014-05-06 | Guided Therapy Systems, Llc | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
US9039617B2 (en) | 2009-11-24 | 2015-05-26 | Guided Therapy Systems, Llc | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
US9345910B2 (en) | 2009-11-24 | 2016-05-24 | Guided Therapy Systems Llc | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
US9504446B2 (en) | 2010-08-02 | 2016-11-29 | Guided Therapy Systems, Llc | Systems and methods for coupling an ultrasound source to tissue |
US9149658B2 (en) | 2010-08-02 | 2015-10-06 | Guided Therapy Systems, Llc | Systems and methods for ultrasound treatment |
US10183182B2 (en) | 2010-08-02 | 2019-01-22 | Guided Therapy Systems, Llc | Methods and systems for treating plantar fascia |
US8857438B2 (en) | 2010-11-08 | 2014-10-14 | Ulthera, Inc. | Devices and methods for acoustic shielding |
US9452302B2 (en) | 2011-07-10 | 2016-09-27 | Guided Therapy Systems, Llc | Systems and methods for accelerating healing of implanted material and/or native tissue |
US8858471B2 (en) | 2011-07-10 | 2014-10-14 | Guided Therapy Systems, Llc | Methods and systems for ultrasound treatment |
US9011337B2 (en) | 2011-07-11 | 2015-04-21 | Guided Therapy Systems, Llc | Systems and methods for monitoring and controlling ultrasound power output and stability |
US9263663B2 (en) | 2012-04-13 | 2016-02-16 | Ardent Sound, Inc. | Method of making thick film transducer arrays |
JP2017136437A (ja) * | 2012-05-01 | 2017-08-10 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 経皮挿入するための先端装填型マイクロニードルアレイ |
US9802063B2 (en) | 2012-09-21 | 2017-10-31 | Guided Therapy Systems, Llc | Reflective ultrasound technology for dermatological treatments |
US9510802B2 (en) | 2012-09-21 | 2016-12-06 | Guided Therapy Systems, Llc | Reflective ultrasound technology for dermatological treatments |
US10420960B2 (en) | 2013-03-08 | 2019-09-24 | Ulthera, Inc. | Devices and methods for multi-focus ultrasound therapy |
US11517772B2 (en) | 2013-03-08 | 2022-12-06 | Ulthera, Inc. | Devices and methods for multi-focus ultrasound therapy |
US10561862B2 (en) | 2013-03-15 | 2020-02-18 | Guided Therapy Systems, Llc | Ultrasound treatment device and methods of use |
US11351401B2 (en) | 2014-04-18 | 2022-06-07 | Ulthera, Inc. | Band transducer ultrasound therapy |
US10603521B2 (en) | 2014-04-18 | 2020-03-31 | Ulthera, Inc. | Band transducer ultrasound therapy |
JP2020195881A (ja) * | 2014-11-12 | 2020-12-10 | ミューファーマ ピーティーワイ リミテッド | 非侵襲性の薬剤塗布具 |
JP2017537690A (ja) * | 2014-11-12 | 2017-12-21 | ミューファーマ ピーティーワイ リミテッド | 非侵襲性の薬剤塗布具 |
JP7035141B2 (ja) | 2014-11-12 | 2022-03-14 | ミューファーマ ピーティーワイ リミテッド | 非侵襲性の薬剤塗布具 |
US11224895B2 (en) | 2016-01-18 | 2022-01-18 | Ulthera, Inc. | Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof |
US11241218B2 (en) | 2016-08-16 | 2022-02-08 | Ulthera, Inc. | Systems and methods for cosmetic ultrasound treatment of skin |
US11944849B2 (en) | 2018-02-20 | 2024-04-02 | Ulthera, Inc. | Systems and methods for combined cosmetic treatment of cellulite with ultrasound |
US11969609B2 (en) | 2022-12-05 | 2024-04-30 | Ulthera, Inc. | Devices and methods for multi-focus ultrasound therapy |
Also Published As
Publication number | Publication date |
---|---|
WO1998000194A3 (en) | 1998-04-16 |
EP0925088A2 (en) | 1999-06-30 |
US6491657B2 (en) | 2002-12-10 |
US6234990B1 (en) | 2001-05-22 |
WO1998000194A2 (en) | 1998-01-08 |
US20020045850A1 (en) | 2002-04-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6491657B2 (en) | Ultrasound enhancement of transdermal transport | |
US8870810B2 (en) | Method and apparatus for enhancement of transdermal transport | |
US8287483B2 (en) | Method and apparatus for enhancement of transdermal transport | |
US6190315B1 (en) | Sonophoretic enhanced transdermal transport | |
US5913833A (en) | Method and apparatus for obtaining biological fluids | |
EP0781150B1 (en) | Enhanced transdermal transport using ultrasound | |
Prausnitz et al. | Current status and future potential of transdermal drug delivery | |
US6041253A (en) | Effect of electric field and ultrasound for transdermal drug delivery | |
Joshi et al. | Sonicated transdermal drug transport | |
US20060015058A1 (en) | Agents and methods for enhancement of transdermal transport | |
US6620123B1 (en) | Method and apparatus for producing homogenous cavitation to enhance transdermal transport | |
JP2002532130A (ja) | 経皮輸送の改善の方法および装置 | |
Sivakumar et al. | Transdermal drug delivery using ultrasound-theory, understanding and critical analysis | |
AU768190B2 (en) | Method and apparatus for producing homogenous cavitation to enhance transdermal transport | |
AU2012213974A1 (en) | Agents and methods for enhancement of transdermal transport |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040630 |
|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20040630 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20040630 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20051013 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070227 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070301 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070416 |
|
A313 | Final decision of rejection without a dissenting response from the applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A313 Effective date: 20071010 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20071120 |