JP2017121241A5 - - Google Patents

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Publication number
JP2017121241A5
JP2017121241A5 JP2017016747A JP2017016747A JP2017121241A5 JP 2017121241 A5 JP2017121241 A5 JP 2017121241A5 JP 2017016747 A JP2017016747 A JP 2017016747A JP 2017016747 A JP2017016747 A JP 2017016747A JP 2017121241 A5 JP2017121241 A5 JP 2017121241A5
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JP
Japan
Prior art keywords
polynucleotide
guanosine
composition
lipid
composition according
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JP2017016747A
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English (en)
Japanese (ja)
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JP2017121241A (ja
JP6449356B2 (ja
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Publication of JP2017121241A publication Critical patent/JP2017121241A/ja
Publication of JP2017121241A5 publication Critical patent/JP2017121241A5/ja
Priority to JP2018227745A priority Critical patent/JP6971953B6/ja
Application granted granted Critical
Publication of JP6449356B2 publication Critical patent/JP6449356B2/ja
Priority to JP2021179217A priority patent/JP2022036938A/ja
Priority to JP2023169292A priority patent/JP2023175888A/ja
Priority to JP2025170782A priority patent/JP2026004568A/ja
Active legal-status Critical Current
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JP2017016747A 2012-04-02 2017-02-01 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド Active JP6449356B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2018227745A JP6971953B6 (ja) 2012-04-02 2018-12-05 修飾ポリヌクレオチドを封入する脂質ナノ粒子を含む組成物
JP2021179217A JP2022036938A (ja) 2012-04-02 2021-11-02 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド
JP2023169292A JP2023175888A (ja) 2012-04-02 2023-09-29 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド
JP2025170782A JP2026004568A (ja) 2012-04-02 2025-10-09 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド

Applications Claiming Priority (102)

Application Number Priority Date Filing Date Title
US201261618878P 2012-04-02 2012-04-02
US201261618862P 2012-04-02 2012-04-02
US201261618957P 2012-04-02 2012-04-02
US201261618961P 2012-04-02 2012-04-02
US201261618868P 2012-04-02 2012-04-02
US201261618885P 2012-04-02 2012-04-02
US201261618945P 2012-04-02 2012-04-02
US201261618922P 2012-04-02 2012-04-02
US201261618866P 2012-04-02 2012-04-02
US201261618873P 2012-04-02 2012-04-02
US201261618896P 2012-04-02 2012-04-02
US201261618935P 2012-04-02 2012-04-02
US201261618953P 2012-04-02 2012-04-02
US201261618911P 2012-04-02 2012-04-02
US201261618870P 2012-04-02 2012-04-02
US61/618,935 2012-04-02
US61/618,957 2012-04-02
US61/618,953 2012-04-02
US61/618,911 2012-04-02
US61/618,866 2012-04-02
US61/618,868 2012-04-02
US61/618,873 2012-04-02
US61/618,885 2012-04-02
US61/618,945 2012-04-02
US61/618,870 2012-04-02
US61/618,922 2012-04-02
US61/618,878 2012-04-02
US61/618,862 2012-04-02
US61/618,896 2012-04-02
US61/618,961 2012-04-02
US201261648244P 2012-05-17 2012-05-17
US201261648286P 2012-05-17 2012-05-17
US61/648,244 2012-05-17
US61/648,286 2012-05-17
US201261668157P 2012-07-05 2012-07-05
US61/668,157 2012-07-05
US201261681667P 2012-08-10 2012-08-10
US201261681742P 2012-08-10 2012-08-10
US201261681650P 2012-08-10 2012-08-10
US201261681687P 2012-08-10 2012-08-10
US201261681645P 2012-08-10 2012-08-10
US201261681661P 2012-08-10 2012-08-10
US201261681648P 2012-08-10 2012-08-10
US201261681658P 2012-08-10 2012-08-10
US201261681720P 2012-08-10 2012-08-10
US201261681647P 2012-08-10 2012-08-10
US201261681649P 2012-08-10 2012-08-10
US201261681712P 2012-08-10 2012-08-10
US201261681675P 2012-08-10 2012-08-10
US201261681704P 2012-08-10 2012-08-10
US201261681654P 2012-08-10 2012-08-10
US201261681696P 2012-08-10 2012-08-10
US61/681,648 2012-08-10
US61/681,658 2012-08-10
US61/681,647 2012-08-10
US61/681,645 2012-08-10
US61/681,654 2012-08-10
US61/681,720 2012-08-10
US61/681,712 2012-08-10
US61/681,649 2012-08-10
US61/681,650 2012-08-10
US61/681,696 2012-08-10
US61/681,687 2012-08-10
US61/681,704 2012-08-10
US61/681,742 2012-08-10
US61/681,675 2012-08-10
US61/681,661 2012-08-10
US61/681,667 2012-08-10
US201261696381P 2012-09-04 2012-09-04
US61/696,381 2012-09-04
US201261709303P 2012-10-03 2012-10-03
US61/709,303 2012-10-03
US201261712490P 2012-10-11 2012-10-11
US61/712,490 2012-10-11
US201261737130P 2012-12-14 2012-12-14
US201261737139P 2012-12-14 2012-12-14
US201261737174P 2012-12-14 2012-12-14
US201261737155P 2012-12-14 2012-12-14
US201261737134P 2012-12-14 2012-12-14
US201261737147P 2012-12-14 2012-12-14
US201261737168P 2012-12-14 2012-12-14
US201261737184P 2012-12-14 2012-12-14
US201261737203P 2012-12-14 2012-12-14
US201261737213P 2012-12-14 2012-12-14
US201261737191P 2012-12-14 2012-12-14
US201261737160P 2012-12-14 2012-12-14
US201261737135P 2012-12-14 2012-12-14
US201261737152P 2012-12-14 2012-12-14
US61/737,135 2012-12-14
US61/737,191 2012-12-14
US61/737,213 2012-12-14
US61/737,155 2012-12-14
US61/737,174 2012-12-14
US61/737,139 2012-12-14
US61/737,184 2012-12-14
US61/737,168 2012-12-14
US61/737,130 2012-12-14
US61/737,147 2012-12-14
US61/737,160 2012-12-14
US61/737,203 2012-12-14
US61/737,134 2012-12-14
US61/737,152 2012-12-14

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2015504564A Division JP2015516143A (ja) 2012-04-02 2013-03-09 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018227745A Division JP6971953B6 (ja) 2012-04-02 2018-12-05 修飾ポリヌクレオチドを封入する脂質ナノ粒子を含む組成物

Publications (3)

Publication Number Publication Date
JP2017121241A JP2017121241A (ja) 2017-07-13
JP2017121241A5 true JP2017121241A5 (https=) 2017-11-16
JP6449356B2 JP6449356B2 (ja) 2019-01-09

Family

ID=49235350

Family Applications (38)

Application Number Title Priority Date Filing Date
JP2015504571A Pending JP2015518816A (ja) 2012-04-02 2013-03-09 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2015504569A Active JP6424156B2 (ja) 2012-04-02 2013-03-09 核タンパク質の産生のための修飾ポリヌクレオチド
JP2015504563A Pending JP2015513912A (ja) 2012-04-02 2013-03-09 タンパク質の産生のための修飾ポリヌクレオチド
JP2015504562A Pending JP2015518704A (ja) 2012-04-02 2013-03-09 膜タンパク質の産生のための修飾ポリヌクレオチド
JP2015504568A Active JP6189415B2 (ja) 2012-04-02 2013-03-09 細胞質および細胞骨格タンパク質の産生のための修飾ポリヌクレオチド
JP2015504567A Pending JP2015513914A (ja) 2012-04-02 2013-03-09 分泌タンパク質の産生のための修飾ポリヌクレオチド
JP2015504570A Pending JP2015517995A (ja) 2012-04-02 2013-03-09 美容タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2015504566A Pending JP2015513913A (ja) 2012-04-02 2013-03-09 修飾ポリヌクレオチド
JP2015504564A Pending JP2015516143A (ja) 2012-04-02 2013-03-09 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド
JP2015504587A Expired - Fee Related JP6348482B2 (ja) 2012-04-02 2013-03-15 タンパク質のインビボ産生
JP2017012947A Active JP6953135B6 (ja) 2012-04-02 2017-01-27 タンパク質のインビボ産生
JP2017012971A Pending JP2017121240A (ja) 2012-04-02 2017-01-27 膜タンパク質の産生のための修飾ポリヌクレオチド
JP2017016747A Active JP6449356B2 (ja) 2012-04-02 2017-02-01 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド
JP2017017429A Active JP6553104B2 (ja) 2012-04-02 2017-02-02 タンパク質の産生のための修飾ポリヌクレオチド
JP2017018385A Active JP6426217B2 (ja) 2012-04-02 2017-02-03 核タンパク質の産生のための修飾ポリヌクレオチド
JP2017023027A Withdrawn JP2017123853A (ja) 2012-04-02 2017-02-10 分泌タンパク質の産生のための修飾ポリヌクレオチド
JP2017034565A Pending JP2017141230A (ja) 2012-04-02 2017-02-27 美容タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2017093750A Withdrawn JP2017197545A (ja) 2012-04-02 2017-05-10 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2017149905A Pending JP2018023373A (ja) 2012-04-02 2017-08-02 細胞質および細胞骨格タンパク質の産生のための修飾ポリヌクレオチド
JP2018199617A Pending JP2019033757A (ja) 2012-04-02 2018-10-24 核タンパク質の産生のための修飾ポリヌクレオチド
JP2018227745A Active JP6971953B6 (ja) 2012-04-02 2018-12-05 修飾ポリヌクレオチドを封入する脂質ナノ粒子を含む組成物
JP2019039425A Pending JP2019107022A (ja) 2012-04-02 2019-03-05 タンパク質の産生のための修飾ポリヌクレオチド
JP2019145982A Active JP6946384B2 (ja) 2012-04-02 2019-08-08 脂質ナノ粒子を含む医薬組成物
JP2019225097A Withdrawn JP2020072670A (ja) 2012-04-02 2019-12-13 タンパク質のインビボ産生
JP2020088048A Withdrawn JP2020158508A (ja) 2012-04-02 2020-05-20 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2020204863A Pending JP2021045163A (ja) 2012-04-02 2020-12-10 タンパク質の産生のための修飾ポリヌクレオチド
JP2021149858A Pending JP2022023036A (ja) 2012-04-02 2021-09-15 分泌タンパク質の産生のための修飾ポリヌクレオチド
JP2021179217A Pending JP2022036938A (ja) 2012-04-02 2021-11-02 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド
JP2022020499A Withdrawn JP2022078081A (ja) 2012-04-02 2022-02-14 タンパク質のインビボ産生
JP2022085185A Withdrawn JP2022122923A (ja) 2012-04-02 2022-05-25 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2022191512A Pending JP2023021215A (ja) 2012-04-02 2022-11-30 タンパク質の産生のための修飾ポリヌクレオチド
JP2023121563A Pending JP2023145599A (ja) 2012-04-02 2023-07-26 分泌タンパク質の産生のための修飾ポリヌクレオチド
JP2023169292A Pending JP2023175888A (ja) 2012-04-02 2023-09-29 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド
JP2024018721A Withdrawn JP2024063025A (ja) 2012-04-02 2024-02-09 タンパク質のインビボ産生
JP2024087183A Pending JP2024123008A (ja) 2012-04-02 2024-05-29 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2024203572A Pending JP2025024198A (ja) 2012-04-02 2024-11-22 タンパク質の産生のための修飾ポリヌクレオチド
JP2025106096A Pending JP2025138725A (ja) 2012-04-02 2025-06-24 分泌タンパク質の産生のための修飾ポリヌクレオチド
JP2025170782A Pending JP2026004568A (ja) 2012-04-02 2025-10-09 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド

Family Applications Before (12)

Application Number Title Priority Date Filing Date
JP2015504571A Pending JP2015518816A (ja) 2012-04-02 2013-03-09 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2015504569A Active JP6424156B2 (ja) 2012-04-02 2013-03-09 核タンパク質の産生のための修飾ポリヌクレオチド
JP2015504563A Pending JP2015513912A (ja) 2012-04-02 2013-03-09 タンパク質の産生のための修飾ポリヌクレオチド
JP2015504562A Pending JP2015518704A (ja) 2012-04-02 2013-03-09 膜タンパク質の産生のための修飾ポリヌクレオチド
JP2015504568A Active JP6189415B2 (ja) 2012-04-02 2013-03-09 細胞質および細胞骨格タンパク質の産生のための修飾ポリヌクレオチド
JP2015504567A Pending JP2015513914A (ja) 2012-04-02 2013-03-09 分泌タンパク質の産生のための修飾ポリヌクレオチド
JP2015504570A Pending JP2015517995A (ja) 2012-04-02 2013-03-09 美容タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2015504566A Pending JP2015513913A (ja) 2012-04-02 2013-03-09 修飾ポリヌクレオチド
JP2015504564A Pending JP2015516143A (ja) 2012-04-02 2013-03-09 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド
JP2015504587A Expired - Fee Related JP6348482B2 (ja) 2012-04-02 2013-03-15 タンパク質のインビボ産生
JP2017012947A Active JP6953135B6 (ja) 2012-04-02 2017-01-27 タンパク質のインビボ産生
JP2017012971A Pending JP2017121240A (ja) 2012-04-02 2017-01-27 膜タンパク質の産生のための修飾ポリヌクレオチド

Family Applications After (25)

Application Number Title Priority Date Filing Date
JP2017017429A Active JP6553104B2 (ja) 2012-04-02 2017-02-02 タンパク質の産生のための修飾ポリヌクレオチド
JP2017018385A Active JP6426217B2 (ja) 2012-04-02 2017-02-03 核タンパク質の産生のための修飾ポリヌクレオチド
JP2017023027A Withdrawn JP2017123853A (ja) 2012-04-02 2017-02-10 分泌タンパク質の産生のための修飾ポリヌクレオチド
JP2017034565A Pending JP2017141230A (ja) 2012-04-02 2017-02-27 美容タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2017093750A Withdrawn JP2017197545A (ja) 2012-04-02 2017-05-10 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2017149905A Pending JP2018023373A (ja) 2012-04-02 2017-08-02 細胞質および細胞骨格タンパク質の産生のための修飾ポリヌクレオチド
JP2018199617A Pending JP2019033757A (ja) 2012-04-02 2018-10-24 核タンパク質の産生のための修飾ポリヌクレオチド
JP2018227745A Active JP6971953B6 (ja) 2012-04-02 2018-12-05 修飾ポリヌクレオチドを封入する脂質ナノ粒子を含む組成物
JP2019039425A Pending JP2019107022A (ja) 2012-04-02 2019-03-05 タンパク質の産生のための修飾ポリヌクレオチド
JP2019145982A Active JP6946384B2 (ja) 2012-04-02 2019-08-08 脂質ナノ粒子を含む医薬組成物
JP2019225097A Withdrawn JP2020072670A (ja) 2012-04-02 2019-12-13 タンパク質のインビボ産生
JP2020088048A Withdrawn JP2020158508A (ja) 2012-04-02 2020-05-20 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2020204863A Pending JP2021045163A (ja) 2012-04-02 2020-12-10 タンパク質の産生のための修飾ポリヌクレオチド
JP2021149858A Pending JP2022023036A (ja) 2012-04-02 2021-09-15 分泌タンパク質の産生のための修飾ポリヌクレオチド
JP2021179217A Pending JP2022036938A (ja) 2012-04-02 2021-11-02 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド
JP2022020499A Withdrawn JP2022078081A (ja) 2012-04-02 2022-02-14 タンパク質のインビボ産生
JP2022085185A Withdrawn JP2022122923A (ja) 2012-04-02 2022-05-25 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2022191512A Pending JP2023021215A (ja) 2012-04-02 2022-11-30 タンパク質の産生のための修飾ポリヌクレオチド
JP2023121563A Pending JP2023145599A (ja) 2012-04-02 2023-07-26 分泌タンパク質の産生のための修飾ポリヌクレオチド
JP2023169292A Pending JP2023175888A (ja) 2012-04-02 2023-09-29 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド
JP2024018721A Withdrawn JP2024063025A (ja) 2012-04-02 2024-02-09 タンパク質のインビボ産生
JP2024087183A Pending JP2024123008A (ja) 2012-04-02 2024-05-29 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2024203572A Pending JP2025024198A (ja) 2012-04-02 2024-11-22 タンパク質の産生のための修飾ポリヌクレオチド
JP2025106096A Pending JP2025138725A (ja) 2012-04-02 2025-06-24 分泌タンパク質の産生のための修飾ポリヌクレオチド
JP2025170782A Pending JP2026004568A (ja) 2012-04-02 2025-10-09 ヒト疾患に関連するタンパク質の産生のための修飾ポリヌクレオチド

Country Status (9)

Country Link
US (40) US9192651B2 (https=)
EP (16) EP3520821A1 (https=)
JP (38) JP2015518816A (https=)
CN (2) CN104870022B (https=)
AU (22) AU2013243948A1 (https=)
CA (10) CA2868393A1 (https=)
DE (2) DE18203666T1 (https=)
HK (8) HK1206780A1 (https=)
WO (10) WO2013151663A1 (https=)

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