MX367352B - Metodos para reducir el riesgo de padecer una enfermedad cardiovascular. - Google Patents

Metodos para reducir el riesgo de padecer una enfermedad cardiovascular.

Info

Publication number
MX367352B
MX367352B MX2014008180A MX2014008180A MX367352B MX 367352 B MX367352 B MX 367352B MX 2014008180 A MX2014008180 A MX 2014008180A MX 2014008180 A MX2014008180 A MX 2014008180A MX 367352 B MX367352 B MX 367352B
Authority
MX
Mexico
Prior art keywords
methods
patient
cardiovascular disease
reducing risk
ldl
Prior art date
Application number
MX2014008180A
Other languages
English (en)
Other versions
MX2014008180A (es
Inventor
L Bisgaier Charles
Original Assignee
Gemphire Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gemphire Therapeutics Inc filed Critical Gemphire Therapeutics Inc
Publication of MX2014008180A publication Critical patent/MX2014008180A/es
Publication of MX367352B publication Critical patent/MX367352B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Métodos para reducir los niveles de LDL-C en plasma en un paciente que recibe una dosis estable de estatina donde el paciente tiene un nivel de LDL-C mayor que el objetivo de tratamiento. Métodos para reducir el riesgo de un paciente de desarrollar una enfermedad cardíaca coronaria o de tener un evento cardiovascular recurrente donde el paciente está recibiendo una dosis estable de estatina y el paciente tiene un nivel de LDL-C mayor que el objetivo de tratamiento.
MX2014008180A 2012-01-06 2013-01-04 Metodos para reducir el riesgo de padecer una enfermedad cardiovascular. MX367352B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261584002P 2012-01-06 2012-01-06
PCT/US2013/020317 WO2013103842A1 (en) 2012-01-06 2013-01-04 Methods of reducing risk of cardiovascular disease

Publications (2)

Publication Number Publication Date
MX2014008180A MX2014008180A (es) 2014-10-14
MX367352B true MX367352B (es) 2019-08-16

Family

ID=48745439

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008180A MX367352B (es) 2012-01-06 2013-01-04 Metodos para reducir el riesgo de padecer una enfermedad cardiovascular.

Country Status (9)

Country Link
US (2) US10028926B2 (es)
EP (2) EP3735967A1 (es)
JP (2) JP6295205B2 (es)
CN (2) CN104136023A (es)
AU (1) AU2013207423B2 (es)
CA (1) CA2861643C (es)
HK (1) HK1201452A1 (es)
MX (1) MX367352B (es)
WO (1) WO2013103842A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
MX2013003681A (es) 2010-10-01 2013-11-20 Moderna Therapeutics Inc Ácidos nucleicos manipulados y métodos de uso de los mismos.
DE12722942T1 (de) 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
SI3682905T1 (sl) 2011-10-03 2022-04-29 Modernatx, Inc. Modificirani nukleozidi, nukleotidi in nukleinske kisline ter njihove uporabe
US20130156849A1 (en) 2011-12-16 2013-06-20 modeRNA Therapeutics Modified nucleoside, nucleotide, and nucleic acid compositions
US9440754B2 (en) 2012-03-29 2016-09-13 R.P. Scherer Technologies, Llc Three circuit fill system for blow fill seal containers
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
HK1206601A1 (en) 2012-04-02 2016-01-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
SI2922554T1 (sl) 2012-11-26 2022-06-30 Modernatx, Inc. Terminalno modificirana RNA
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
JP2016516804A (ja) 2013-04-17 2016-06-09 ファイザー・インク 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体
SG11201602503TA (en) 2013-10-03 2016-04-28 Moderna Therapeutics Inc Polynucleotides encoding low density lipoprotein receptor
BR112017009876A2 (pt) 2014-11-14 2017-12-19 Gemphire Therapeutics Inc processos e intermediários para a preparação de éteres de dialcano terminados em ácido alfa,ômega-dicarboxílico
WO2016149191A1 (en) * 2015-03-13 2016-09-22 Esperion Therapeutics, Inc. Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease
MA41793A (fr) * 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
CA3001627A1 (en) * 2015-11-06 2017-05-11 Gemphire Therapeutics, Inc. Treatment of mixed dyslipidemia
SG10201912756XA (en) * 2016-02-26 2020-02-27 Gemphire Therapeutics Inc Treatment of patients with homozygous familial hypercholesterolemia on lipid lowering therapy
EP3579827A4 (en) * 2017-02-08 2021-01-06 Esperion Therapeutics, Inc. FORMULATIONS OF ASSOCIATIONS OF THREE ACTIVE INGREDIENTS AND METHODS OF TREATMENT OR REDUCING THE RISK OF CARDIOVASCULAR DISEASE
KR20200054910A (ko) * 2017-04-18 2020-05-20 젬파이어 세러퓨틱스 인코포레이티드 젬카빈, 이의 약학적으로 허용 가능한 염, 조성물 및 이의 사용 방법
WO2018209257A1 (en) * 2017-05-11 2018-11-15 Gemphire Therapeutics Inc. Gemcabene compositions and methods of use thereof
CN109666727B (zh) * 2018-12-29 2020-11-06 中国药科大学 一种高活性抑制pcsk9表达的微小rna的用途
WO2020257571A1 (en) 2019-06-21 2020-12-24 Esperion Therapeutics, Inc. Methods of making bempedoic acid and compositions of the same
CN113134086B (zh) * 2020-01-20 2024-05-24 深圳市长卿医学研究院 一种降血脂的药物组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648387A (en) * 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
US20020103252A1 (en) 1997-12-12 2002-08-01 Bisgaier Charles Larry Statin-carboxyalkylether combinations
NZ503982A (en) * 1997-12-12 2002-03-28 Warner Lambert Co Statin-carboxyalkylether combinations useful for treating vascular disorders and diabetes mellitus
US6861555B2 (en) 2000-01-25 2005-03-01 Warner-Lambert Company Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
HK1047082B (zh) 1999-04-01 2008-06-06 埃斯佩里安医疗公司 醚化合物，及其组合物和用途
MXPA03003021A (es) 2000-10-11 2003-07-14 Esperion Therapeutics Inc Compuestos de eter y composiciones para el control del colesterol y usos relacionados.
US6645170B2 (en) 2001-03-05 2003-11-11 Bioject Medical Technologies, Inc. Simplified disposable needle-free injection apparatus and method
US20040229954A1 (en) * 2003-05-16 2004-11-18 Macdougall Diane Elaine Selective manipulation of triglyceride, HDL and LDL parameters with 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt
US7345190B2 (en) 2003-11-12 2008-03-18 Ssv Therapeutics, Inc. Carnitine conjugates as dual prodrugs and uses thereof
US7579504B2 (en) 2005-12-07 2009-08-25 Gilead Sciences, Inc. ABCA1 elevating compounds
AU2007281212B8 (en) * 2006-08-03 2013-02-28 Trustees Of Tufts College Non-flushing niacin analogues, and methods of use thereof

Also Published As

Publication number Publication date
US10028926B2 (en) 2018-07-24
EP2800564A1 (en) 2014-11-12
AU2013207423B2 (en) 2017-10-12
EP2800564B1 (en) 2020-05-06
WO2013103842A1 (en) 2013-07-11
US10709678B2 (en) 2020-07-14
EP2800564A4 (en) 2015-07-22
CN104136023A (zh) 2014-11-05
US20150005386A1 (en) 2015-01-01
CA2861643C (en) 2020-10-06
AU2013207423A1 (en) 2014-07-24
JP6295205B2 (ja) 2018-03-14
JP2015503588A (ja) 2015-02-02
JP2018104452A (ja) 2018-07-05
MX2014008180A (es) 2014-10-14
CN110025608A (zh) 2019-07-19
US20180303779A1 (en) 2018-10-25
CA2861643A1 (en) 2013-07-11
EP3735967A1 (en) 2020-11-11
HK1201452A1 (en) 2015-09-04

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Legal Events

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GB Transfer or rights

Owner name: GEMPHIRE THERAPEUTICS, INC.

FG Grant or registration