ATE427992T1 - Dna-synthesepromotoren, mit dna-polymerase assoziierte faktoren und nutzung davon - Google Patents
Dna-synthesepromotoren, mit dna-polymerase assoziierte faktoren und nutzung davonInfo
- Publication number
- ATE427992T1 ATE427992T1 AT02780096T AT02780096T ATE427992T1 AT E427992 T1 ATE427992 T1 AT E427992T1 AT 02780096 T AT02780096 T AT 02780096T AT 02780096 T AT02780096 T AT 02780096T AT E427992 T1 ATE427992 T1 AT E427992T1
- Authority
- AT
- Austria
- Prior art keywords
- dna
- dna synthesis
- dna polymerase
- synthesis
- integer
- Prior art date
Links
- 230000006820 DNA synthesis Effects 0.000 title abstract 5
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 title abstract 4
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 title abstract 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000001737 promoting effect Effects 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 241000205188 Thermococcus Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6846—Common amplification features
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001349173A JP2003144169A (ja) | 2001-11-14 | 2001-11-14 | Ｄｎａ合成反応を促進する添加剤 |
| JP2002311596A JP4300321B2 (ja) | 2002-10-25 | 2002-10-25 | Ｄｎａ合成反応を促進する方法、およびそのための組成物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE427992T1 true ATE427992T1 (de) | 2009-04-15 |
Family
ID=26624518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02780096T ATE427992T1 (de) | 2001-11-14 | 2002-11-14 | Dna-synthesepromotoren, mit dna-polymerase assoziierte faktoren und nutzung davon |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7384739B2 (de) |
| EP (1) | EP1452593B1 (de) |
| AT (1) | ATE427992T1 (de) |
| DE (1) | DE60231901D1 (de) |
| WO (1) | WO2003042383A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200506052A (en) * | 2003-05-07 | 2005-02-16 | Takara Bio Inc | Method of analyzing DNA region |
| WO2005118815A1 (ja) * | 2004-06-04 | 2005-12-15 | Takara Bio Inc. | Ｄｎａポリメラーゼ活性を有するポリペプチド |
| JP4719455B2 (ja) * | 2004-12-07 | 2011-07-06 | シスメックス株式会社 | 直接核酸増幅方法用生体試料処理液および直接核酸増幅方法 |
| US8003346B2 (en) * | 2005-07-04 | 2011-08-23 | Celestar Lexico-Sciences, Inc. | Mutant PCNA |
| US9090948B2 (en) | 2008-09-30 | 2015-07-28 | Abbott Molecular Inc. | Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples |
| CA2765167A1 (en) * | 2009-06-12 | 2010-12-16 | Nanectis Biotechnologies | A highly sensitive method for detection of viral hiv dna remaining after antiretroviral therapy of aids patients |
| WO2010147111A1 (ja) | 2009-06-15 | 2010-12-23 | トヨタ自動車株式会社 | 無細胞タンパク質合成溶液、無細胞タンパク質合成キット及びタンパク質合成方法 |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2857499A1 (de) | 2010-10-01 | 2015-04-08 | Moderna Therapeutics, Inc. | Manipulierte Nukleinsäuren und Verfahren zur Verwendung davon |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| PT3682905T (pt) | 2011-10-03 | 2022-04-07 | Modernatx Inc | Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações |
| ES2923757T3 (es) | 2011-12-16 | 2022-09-30 | Modernatx Inc | Composiciones de ARNm modificado |
| WO2013115067A1 (ja) * | 2012-01-31 | 2013-08-08 | タカラバイオ株式会社 | 核酸合成反応の向上方法 |
| WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| JP6478446B2 (ja) * | 2012-09-28 | 2019-03-06 | 東洋紡株式会社 | 改変された耐熱性ｄｎａポリメラーゼ |
| BR112015008268A2 (pt) * | 2012-10-22 | 2017-11-28 | Bayer Cropscience Ag | composição de material, kit, dispositivo, cartucho e métodos para a amplificação de ácidos nucleicos |
| PT2922554T (pt) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Arn modificado nas porções terminais |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| CA2923029A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| WO2016011226A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| EP3247804B1 (de) * | 2015-01-23 | 2020-08-05 | Qiagen Sciences, LLC | Hochmultiplex-pcr mit molekularer strichcodierung |
| SMT202200310T1 (it) | 2015-12-23 | 2022-09-14 | Modernatx Inc | Metodi di utilizzo dei polinucleotidi codificanti il ligando di ox40 |
| US20190241658A1 (en) | 2016-01-10 | 2019-08-08 | Modernatx, Inc. | Therapeutic mRNAs encoding anti CTLA-4 antibodies |
| US10323243B2 (en) | 2016-01-19 | 2019-06-18 | Board Of Regents, The University Of Texas System | Thermostable reverse transcriptase |
| PL3458083T3 (pl) | 2016-05-18 | 2023-03-13 | Modernatx, Inc. | Polinukleotydy kodujące interleukinę-12 (il12) i ich zastosowania |
| RS63625B1 (sr) | 2016-05-18 | 2022-10-31 | Modernatx Inc | Kombinacije irnk koje kodiraju imunomodulirajuće polipeptide i njihova upotreba |
| US20200131498A1 (en) | 2017-06-14 | 2020-04-30 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
| WO2019084538A1 (en) | 2017-10-27 | 2019-05-02 | Board Of Regents, The University Of Texas System | TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5284940A (en) * | 1990-11-14 | 1994-02-08 | Hri Research, Inc. | Preparation for nucleic acid samples |
| ATE247175T1 (de) | 1994-01-31 | 2003-08-15 | Univ California | Methode zur eliminierung von sequenzierartefakten |
| DE4411588C1 (de) | 1994-03-30 | 1995-09-28 | Deutsches Rheuma Forschungszen | Puffer für DNA- und RNA-Polymerase-Reaktionen |
| US5556771A (en) * | 1995-02-10 | 1996-09-17 | Gen-Probe Incorporated | Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification |
| FR2733515B1 (fr) * | 1995-04-27 | 1997-09-05 | Cis Bio Int | Tampon, procede et methode d'evaluation des conditions optimales, d'amplification de sequences cibles d'acide nucleique, et leurs applications |
| JP3112148B2 (ja) | 1995-05-31 | 2000-11-27 | 東洋紡績株式会社 | 核酸の増幅方法およびその試薬 |
| US5773258A (en) | 1995-08-25 | 1998-06-30 | Roche Molecular Systems, Inc. | Nucleic acid amplification using a reversibly inactivated thermostable enzyme |
| US6114150A (en) | 1995-11-29 | 2000-09-05 | Yale University | Amplification of nucleic acids |
| CN1552869A (zh) * | 1995-12-27 | 2004-12-08 | 宝酒造株式会社 | 新型dna聚合酶 |
| EP0834569A1 (de) * | 1996-10-03 | 1998-04-08 | Roche Diagnostics GmbH | Thermostabile DNS Polymerase aus Carboxydothermus hydrogenoformans |
| WO1998045452A2 (en) * | 1997-04-08 | 1998-10-15 | The Rockfeller University | Enzyme derived from thermophilic organisms that functions as a chromosomal replicase, and preparation and uses thereof |
| CA2295306C (en) | 1997-06-26 | 2008-11-25 | Takara Shuzo Co., Ltd. | Dna polymerase-related factors |
| US6787305B1 (en) | 1998-03-13 | 2004-09-07 | Invitrogen Corporation | Compositions and methods for enhanced synthesis of nucleic acid molecules |
| AU6385800A (en) * | 1999-07-30 | 2001-02-19 | Stratagene | Archaeal replication accessory factors and methods of use |
| DE19937230A1 (de) * | 1999-08-06 | 2001-02-08 | Lion Bioscience Ag | Chimäre Proteine |
-
2002
- 2002-11-14 EP EP02780096A patent/EP1452593B1/de not_active Expired - Lifetime
- 2002-11-14 AT AT02780096T patent/ATE427992T1/de not_active IP Right Cessation
- 2002-11-14 US US10/495,581 patent/US7384739B2/en not_active Expired - Lifetime
- 2002-11-14 DE DE60231901T patent/DE60231901D1/de not_active Expired - Lifetime
- 2002-11-14 WO PCT/JP2002/011884 patent/WO2003042383A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003042383A1 (en) | 2003-05-22 |
| EP1452593B1 (de) | 2009-04-08 |
| US7384739B2 (en) | 2008-06-10 |
| EP1452593A1 (de) | 2004-09-01 |
| EP1452593A4 (de) | 2005-11-30 |
| US20050069887A1 (en) | 2005-03-31 |
| DE60231901D1 (de) | 2009-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |