BR112015021866A2 - Domínios de gla como agentes direcionadores - Google Patents
Domínios de gla como agentes direcionadoresInfo
- Publication number
- BR112015021866A2 BR112015021866A2 BR112015021866A BR112015021866A BR112015021866A2 BR 112015021866 A2 BR112015021866 A2 BR 112015021866A2 BR 112015021866 A BR112015021866 A BR 112015021866A BR 112015021866 A BR112015021866 A BR 112015021866A BR 112015021866 A2 BR112015021866 A2 BR 112015021866A2
- Authority
- BR
- Brazil
- Prior art keywords
- ptds
- gla domains
- phosphatidylserine
- driving agents
- cells
- Prior art date
Links
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 abstract 4
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
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Abstract
MÉTODO DE DIRECIONAMENTO DA MEMBRANA CELULAR FOSFATIDILSERINA (PTDS) E USOS DE POLIPEPTÍDEO ISOLADO. A presente invenção refere-se às proteínas de domínio de Gla recombinantes e seu uso direcionado às porções de fosfatidilserina (PtdS) na superfície das células, particularmente, aquelas que expressam níveis elevados de PtdS, tais como células que sofrem apoptose.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201361787753P | 2013-03-15 | 2013-03-15 | |
US201361791537P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/026237 WO2014151683A1 (en) | 2013-03-15 | 2014-03-13 | Gla domains as targeting agents |
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BR112015021866A2 true BR112015021866A2 (pt) | 2017-08-29 |
Family
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Family Applications (2)
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BR112015021866A BR112015021866A2 (pt) | 2013-03-15 | 2014-03-13 | Domínios de gla como agentes direcionadores |
BR112015021869A BR112015021869A2 (pt) | 2013-03-15 | 2014-03-13 | Domínios gla como agentes alvo |
Family Applications After (1)
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BR112015021869A BR112015021869A2 (pt) | 2013-03-15 | 2014-03-13 | Domínios gla como agentes alvo |
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US (6) | US10894075B2 (pt) |
EP (5) | EP2970442B1 (pt) |
JP (4) | JP6595977B2 (pt) |
CN (2) | CN105164152B (pt) |
AU (2) | AU2014233885B2 (pt) |
BR (2) | BR112015021866A2 (pt) |
CA (3) | CA2905986A1 (pt) |
CY (2) | CY1126074T1 (pt) |
DK (4) | DK3524617T3 (pt) |
ES (4) | ES2756532T3 (pt) |
FI (2) | FI3524617T3 (pt) |
HK (2) | HK1215263A1 (pt) |
HR (2) | HRP20230632T1 (pt) |
HU (2) | HUE062055T2 (pt) |
IL (3) | IL240530B (pt) |
MX (3) | MX2015011409A (pt) |
MY (2) | MY176901A (pt) |
PE (2) | PE20152020A1 (pt) |
PL (3) | PL3524617T3 (pt) |
PT (2) | PT3524617T (pt) |
RU (3) | RU2705786C2 (pt) |
SA (1) | SA515361061B1 (pt) |
SG (3) | SG11201506880WA (pt) |
WO (2) | WO2014151683A1 (pt) |
ZA (2) | ZA201507670B (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2756532T3 (es) * | 2013-03-15 | 2020-04-27 | Gladiator Biosciences Inc | Dominios de Gla como agentes de direccionamiento |
WO2015170778A1 (ja) * | 2014-05-08 | 2015-11-12 | 学校法人日本大学 | ホスファチジルセリンの細胞表面への表出促進剤又は表出抑制剤、及び脂質ラフトのクラスター形成抑制剤 |
CN104745649B (zh) * | 2015-02-28 | 2018-03-09 | 苏州汉酶生物技术有限公司 | 一种福沙那韦中间体的生物制备方法 |
CN104784179A (zh) * | 2015-04-01 | 2015-07-22 | 重庆理工大学 | 替拉那韦在抗乳腺癌药物中的应用及抗乳腺癌药物 |
US11820833B2 (en) * | 2016-06-05 | 2023-11-21 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Peptides that inhibit binding of EPCR to its ligand to treat inflammation |
US11352404B2 (en) | 2017-07-24 | 2022-06-07 | Rutgers, The State University Of New Jersey | Phosphatidylserine targeting fusion molecules and methods for their use |
CN111051500A (zh) * | 2017-09-05 | 2020-04-21 | 角斗士生物科学公司 | 有效载荷递送至干细胞 |
CN108159421B (zh) * | 2018-02-05 | 2021-05-18 | 苏州大学 | 磷脂酰丝氨酸阻断剂在制备治疗血小板数量减少相关疾病药物中的用途 |
JP2021514402A (ja) * | 2018-02-20 | 2021-06-10 | プロミネント メディカル インコーポレイテッドProminent Medical Inc. | 酸化アルミニウム表面及び界面分子 |
CA3177374A1 (en) * | 2018-10-22 | 2020-04-30 | Asahi Kasei Pharma Corporation | Medicament for therapeutic treatment and/or improvement of sepsis accompanied by coagulopathy |
CN113061169B (zh) * | 2020-03-24 | 2022-09-27 | 江南大学 | 一种转录调控蛋白及其在共轭亚油酸生产中的应用 |
CN112057623A (zh) * | 2020-06-03 | 2020-12-11 | 江苏靶标生物医药研究所有限公司 | 一种磷脂酰丝氨酸在制备治疗炎症性肠病药物中的应用 |
RU2768194C1 (ru) * | 2021-08-02 | 2022-03-23 | федеральное государственное бюджетное образовательное учреждение высшего образования "Нижегородский государственный технический университет им. Р.Е. Алексеева" (НГТУ) | Способ оценки степени экстернализации фосфатидилсерина на поверхность мембран эритроцитов |
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