UY33204A - Metodos y composiciones usando polipeptidos de fusion de fgf23 - Google Patents

Metodos y composiciones usando polipeptidos de fusion de fgf23

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Publication number
UY33204A
UY33204A UY0001033204A UY33204A UY33204A UY 33204 A UY33204 A UY 33204A UY 0001033204 A UY0001033204 A UY 0001033204A UY 33204 A UY33204 A UY 33204A UY 33204 A UY33204 A UY 33204A
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UY
Uruguay
Prior art keywords
compositions
methods
fusion polypeptides
fgf23
fgf23 fusion
Prior art date
Application number
UY0001033204A
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English (en)
Inventor
Glass David
Shou-Ih Hu
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Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of UY33204A publication Critical patent/UY33204A/es

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Abstract

La presente divulgación se refiere a métodos, kits, y composiciones comprendiendo polipéptidos de fusión, para prevenir o tratar las condiciones relacionadas con la edad o los trastornos metabólicos. El polipéptido de fusión comprende: (a) FGF23, o una variante o un fragmento activo del mismo, (b) un fragmento Fc modificado o un polipéptido que comprende cuando menos un subdominio extracelular de una proteína Klotho, o una variante o un derivado funcionalmente activo del mismo; y, opcionalmente, (c) un enlazador.
UY0001033204A 2010-01-29 2011-01-27 Metodos y composiciones usando polipeptidos de fusion de fgf23 UY33204A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/696,693 US8420088B2 (en) 2008-01-28 2010-01-29 Methods and compositions using FGF23 fusion polypeptides

Publications (1)

Publication Number Publication Date
UY33204A true UY33204A (es) 2011-08-31

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UY0001033204A UY33204A (es) 2010-01-29 2011-01-27 Metodos y composiciones usando polipeptidos de fusion de fgf23

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US (3) US8420088B2 (es)
EP (2) EP2529016B1 (es)
JP (2) JP5964243B2 (es)
KR (1) KR20130032296A (es)
CN (3) CN103204941B (es)
AR (1) AR080043A1 (es)
AU (1) AU2011209380B2 (es)
CA (1) CA2787285A1 (es)
EA (1) EA201201047A1 (es)
ES (1) ES2605302T3 (es)
MX (1) MX336391B (es)
PL (1) PL2529016T3 (es)
PT (1) PT2529016T (es)
TW (2) TWI430805B (es)
UY (1) UY33204A (es)
WO (1) WO2011092234A1 (es)

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TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
CN105601748B (zh) 2011-07-01 2021-08-27 恩格姆生物制药公司 用于代谢病症和疾病治疗的组合物、应用和方法
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
WO2014085365A2 (en) 2012-11-28 2014-06-05 Ngm Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
CN102961739A (zh) * 2012-12-12 2013-03-13 黄曙 Klotho蛋白的用途
CN105008548B (zh) * 2012-12-27 2020-11-27 恩格姆生物制药公司 用于调节胆汁酸体内稳态以及治疗胆汁酸紊乱和疾病的方法
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US20160120959A1 (en) * 2013-03-14 2016-05-05 The Board Of Regents Of The University Of Oklahoma Use of Klotho Nucleic Acids or Proteins for Treatment of Diabetes and Diabetes-Related Conditions
KR101492710B1 (ko) * 2013-04-03 2015-02-13 중앙대학교 산학협력단 Fgf23 유전자를 이용한 전립선암 진단용 마커 및 이를 이용한 전립선암 예측 및 진단 방법
JP6159930B2 (ja) 2013-10-24 2017-07-12 地方独立行政法人東京都健康長寿医療センター 筋幹細胞又は筋芽細胞、及びそれを用いた代謝変換に関与する物質のスクリーニング方法、並びにスクリーニング方法によって得られた物質を含む医薬組成物
NZ718962A (en) 2013-10-28 2019-12-20 Ngm Biopharmaceuticals Inc Cancer models and associated methods
BR112016010716A8 (pt) 2013-11-13 2020-04-22 Novartis Ag dose de reforço imunológico, baixa, de um inibidor de mtor, seu uso, e adjuvante de vacina
ES2808340T3 (es) 2014-01-24 2021-02-26 Ngm Biopharmaceuticals Inc Anticuerpos que se unen al dominio de beta klotho 2 y procedimientos de uso de los mismos
JP6370577B2 (ja) * 2014-03-26 2018-08-08 国立大学法人京都工芸繊維大学 抗老化物質のスクリーニング方法
US10398758B2 (en) 2014-05-28 2019-09-03 Ngm Biopharmaceuticals, Inc. Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
WO2015195509A2 (en) 2014-06-16 2015-12-23 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
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