EA201201047A1 - Способы и композиции, в которых применяют слитые полипептиды fgf 23 - Google Patents

Способы и композиции, в которых применяют слитые полипептиды fgf 23

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Publication number
EA201201047A1
EA201201047A1 EA201201047A EA201201047A EA201201047A1 EA 201201047 A1 EA201201047 A1 EA 201201047A1 EA 201201047 A EA201201047 A EA 201201047A EA 201201047 A EA201201047 A EA 201201047A EA 201201047 A1 EA201201047 A1 EA 201201047A1
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Prior art keywords
fgf23
derivative
functionally active
active variant
fragment
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EA201201047A
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English (en)
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Дейвид Гласс
Шоуи Сюй
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Новартис Аг
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Publication of EA201201047A1 publication Critical patent/EA201201047A1/ru

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Abstract

В заявке описаны способы, наборы и композиции, предназначенные для предупреждения или лечения связанных с возрастом состояний или метаболических нарушений. Слитые полипептиды, предлагаемые в изобретении, включают FGF23 или его активный фрагмент. В одном из вариантов осуществления изобретения слитый полипептид содержит: (а) полипептид, включающий фактор роста фибробластов-23 (FGF23) или его функционально активный вариант или производное, где FGF23 имеет мутацию в одном или нескольких положениях, выбранных из Q156, С206 и С244; и (б) либо модифицированный Fc-фрагмент, который обладает пониженной аффинностью к Fc-гамма-рецептору и/или удлиненным временем полужизни в сыворотке, либо полипептид, включающий по меньшей мере один внеклеточный субдомен белка Klotho или его функционально активный вариант или производное; и необязательно (в) линкер. Слитые белки Klotho можно применять для лечения и предупреждения различных связанных с возрастом состояний и метаболических нарушений. В другом варианте осуществления изобретения слитый полипептид содержит FGF (такой как FGF23) или его функционально активный вариант или производное; и модифицированный Fc-фрагмент или его функционально активный вариант или производное. В различных вариантах слитых полипептидов FGF23 имеет мутации, которые снижают агрегацию и опосредуемое протеазой расщепление.
EA201201047A 2010-01-29 2011-01-27 Способы и композиции, в которых применяют слитые полипептиды fgf 23 EA201201047A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/696,693 US8420088B2 (en) 2008-01-28 2010-01-29 Methods and compositions using FGF23 fusion polypeptides
PCT/EP2011/051112 WO2011092234A1 (en) 2010-01-29 2011-01-27 Methods and compositions using fgf23 fusion polypeptides

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EA201201047A1 true EA201201047A1 (ru) 2013-02-28

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US (3) US8420088B2 (ru)
EP (2) EP2529016B1 (ru)
JP (2) JP5964243B2 (ru)
KR (1) KR20130032296A (ru)
CN (3) CN103204941B (ru)
AR (1) AR080043A1 (ru)
AU (1) AU2011209380B2 (ru)
CA (1) CA2787285A1 (ru)
EA (1) EA201201047A1 (ru)
ES (1) ES2605302T3 (ru)
MX (1) MX336391B (ru)
PL (1) PL2529016T3 (ru)
PT (1) PT2529016T (ru)
TW (2) TWI569805B (ru)
UY (1) UY33204A (ru)
WO (1) WO2011092234A1 (ru)

Families Citing this family (33)

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Publication number Priority date Publication date Assignee Title
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8951966B2 (en) 2011-07-01 2015-02-10 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
ES2828505T3 (es) 2012-11-28 2021-05-26 Ngm Biopharmaceuticals Inc Composiciones y métodos para el tratamiento de trastornos y enfermedades metabólicos
CN102961739A (zh) * 2012-12-12 2013-03-13 黄曙 Klotho蛋白的用途
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
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