EA201001204A1 - Методы и композиции, в которых применяют слитые полипептиды klotho-fgf - Google Patents

Методы и композиции, в которых применяют слитые полипептиды klotho-fgf

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Publication number
EA201001204A1
EA201001204A1 EA201001204A EA201001204A EA201001204A1 EA 201001204 A1 EA201001204 A1 EA 201001204A1 EA 201001204 A EA201001204 A EA 201001204A EA 201001204 A EA201001204 A EA 201001204A EA 201001204 A1 EA201001204 A1 EA 201001204A1
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Eurasian Patent Office
Prior art keywords
klotho
compositions
methods
apply
polypeptides fused
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EA201001204A
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English (en)
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Дейвид Гласс
Шуи Сю
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Новартис Аг
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Publication of EA201001204A1 publication Critical patent/EA201001204A1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
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Abstract

В заявке описаны способы, наборы и композиции, предназначенные для предупреждения или лечения связанных с возрастом состояний или метаболических нарушений. Слитые полипептиды Klotho, предлагаемые в изобретении, включают по меньшей мере белок Klotho или его активный фрагмент. Слитые белки Klotho можно применять для лечения и предупреждения различных связанных с возрастом состояний и метаболических нарушений.
EA201001204A 2008-01-28 2009-01-26 Методы и композиции, в которых применяют слитые полипептиды klotho-fgf EA201001204A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6301508P 2008-01-28 2008-01-28
PCT/EP2009/050850 WO2009095372A1 (en) 2008-01-28 2009-01-26 Methods and compositions using klotho-fgf fusion polypeptides

Publications (1)

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EA201001204A1 true EA201001204A1 (ru) 2011-02-28

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EA201001204A EA201001204A1 (ru) 2008-01-28 2009-01-26 Методы и композиции, в которых применяют слитые полипептиды klotho-fgf

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US (2) US8481031B2 (ru)
EP (1) EP2247614B1 (ru)
JP (1) JP5627469B2 (ru)
KR (1) KR20100118126A (ru)
CN (1) CN102015760B (ru)
AR (1) AR070690A1 (ru)
AU (1) AU2009209696B2 (ru)
BR (1) BRPI0906722A2 (ru)
CA (2) CA2854933A1 (ru)
CL (1) CL2009000166A1 (ru)
CO (1) CO6300826A2 (ru)
CR (1) CR11580A (ru)
EA (1) EA201001204A1 (ru)
EC (1) ECSP10010372A (ru)
ES (1) ES2479417T3 (ru)
IL (1) IL207161A0 (ru)
MA (1) MA32031B1 (ru)
MX (1) MX2010008206A (ru)
PE (1) PE20091405A1 (ru)
TW (1) TW200936156A (ru)
WO (1) WO2009095372A1 (ru)

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RU2675514C2 (ru) * 2012-12-27 2018-12-19 ЭнДжиЭм БАЙОФАРМАСЬЮТИКАЛЗ, ИНК. Способы модуляции гомеостаза желчных кислот и лечение расстройств и заболеваний, ассоциированных с желчными кислотами
US10369199B2 (en) 2013-10-28 2019-08-06 Ngm Biopharmaceuticals, Inc. Methods of using variants of FGF19 polypeptides for the treatment of cancer
US10398758B2 (en) 2014-05-28 2019-09-03 Ngm Biopharmaceuticals, Inc. Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
US10413590B2 (en) 2011-07-01 2019-09-17 Ngm Biopharmaceuticals, Inc. Methods of using compositions comprising variants of FGF19 polypeptides for reducing body mass in a subject
US10434144B2 (en) 2014-11-07 2019-10-08 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
US10456449B2 (en) 2014-06-16 2019-10-29 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US10517929B2 (en) 2014-10-23 2019-12-31 Ngm Biopharmaceuticals, Inc. Pharmaceutical compositions comprising FGF19 variants
US10744185B2 (en) 2015-11-09 2020-08-18 Ngm Biopharmaceuticals, Inc. Methods of using variants of FGF19 polypeptides for the treatment of pruritus
US10758590B2 (en) 2012-11-28 2020-09-01 Ngm Biopharmaceuticals, Inc. Methods of using compositions comprising variants and fusions of FGF 19 polypeptides for treating diabetes
US11066454B2 (en) 2012-11-28 2021-07-20 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
US11103554B2 (en) 2012-12-27 2021-08-31 Ngm Biopharmaceuticals, Inc. Methods of using compositions comprising variants of FGF19 polypeptides for reducing bile acid synthesis in a subject having cirrhosis
US11370841B2 (en) 2016-08-26 2022-06-28 Ngm Biopharmaceuticals, Inc. Methods of treating fibroblast growth factor 19-mediated cancers and tumors

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UA109888C2 (uk) * 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
CA2783555A1 (en) 2009-12-16 2011-07-14 Eli Lilly And Company Therapeutic uses of soluble alpha-klotho
JP2013523184A (ja) 2010-04-15 2013-06-17 アムジエン・インコーポレーテツド ヒトＦＧＦ受容体およびβ−ＫＬＯＴＨＯ結合性タンパク質
EP2571510B1 (en) * 2010-05-21 2018-08-08 XL-protein GmbH Biosynthetic proline/alanine random coil polypeptides and their uses
HUE055963T2 (hu) * 2010-06-25 2022-01-28 Shire Human Genetic Therapies Eljárások és kompozíciók iduronát-2-szulfáz központi idegrendszerbe történõ leadásához
CN102465182A (zh) * 2010-10-29 2012-05-23 株式会社爱茉莉太平洋 检测皮肤活性物质的检测试剂盒和检测皮肤活性物质的方法
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CN105838661B (zh) * 2014-12-30 2020-11-10 深圳市第二人民医院 Klotho基因编辑在异种肾脏移植中的应用
CN107405382A (zh) * 2015-02-06 2017-11-28 加利福尼亚大学董事会 用于改善认知的方法和组合物
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KR20230093531A (ko) * 2016-11-22 2023-06-27 클로토 테라퓨틱스, 아이엔씨. 신규한 재조합 클로토 단백질 및 이를 수반하는 조성물 및 방법
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EP3720474A4 (en) * 2017-12-06 2021-12-29 Klotho Therapeutics, Inc. Products and methods for assessing and increasing klotho protein levels
AU2018384735A1 (en) * 2017-12-13 2020-06-25 Icahn School Of Medicine At Mount Sinai Compositions and methods for treating or preventing endocrine FGF23-linked diseases
CN108434441A (zh) * 2018-04-17 2018-08-24 哈尔滨博翱生物医药技术开发有限公司 新型成纤维细胞生长因子-21类似物在治疗弥漫性间质性肺脏疾病中的应用
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