MA32031B1 - Procedes et compositions faisant appel a des polypeptides de fusion klotho-fgf - Google Patents
Procedes et compositions faisant appel a des polypeptides de fusion klotho-fgfInfo
- Publication number
- MA32031B1 MA32031B1 MA33039A MA33039A MA32031B1 MA 32031 B1 MA32031 B1 MA 32031B1 MA 33039 A MA33039 A MA 33039A MA 33039 A MA33039 A MA 33039A MA 32031 B1 MA32031 B1 MA 32031B1
- Authority
- MA
- Morocco
- Prior art keywords
- compositions
- polypeptides
- cclothoff
- built
- processes
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000015834 Klotho Human genes 0.000 abstract 3
- 108050004036 Klotho Proteins 0.000 abstract 3
- 208000030159 metabolic disease Diseases 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01031—Beta-glucuronidase (3.2.1.31)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
Abstract
L'invention concerne des procédés, des trousses et des compositions destinés à prévenir ou traiter des états ou troubles métaboliques liés à l'âge. L'invention porte sur des polypeptides de fusion klotho qui comprennent au moins une protéine klotho ou un fragment actif de cette dernière. Les protéines de fusion klotho précitées sont utilisées pour traiter et prévenir une variété d'états et de troubles métaboliques liés à l'âge.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6301508P | 2008-01-28 | 2008-01-28 | |
PCT/EP2009/050850 WO2009095372A1 (fr) | 2008-01-28 | 2009-01-26 | Procédés et compositions faisant appel à des polypeptides de fusion klotho-fgf |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32031B1 true MA32031B1 (fr) | 2011-01-03 |
Family
ID=40492768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33039A MA32031B1 (fr) | 2008-01-28 | 2010-07-19 | Procedes et compositions faisant appel a des polypeptides de fusion klotho-fgf |
Country Status (21)
Country | Link |
---|---|
US (2) | US8481031B2 (fr) |
EP (1) | EP2247614B1 (fr) |
JP (1) | JP5627469B2 (fr) |
KR (1) | KR20100118126A (fr) |
CN (1) | CN102015760B (fr) |
AR (1) | AR070690A1 (fr) |
AU (1) | AU2009209696B2 (fr) |
BR (1) | BRPI0906722A2 (fr) |
CA (2) | CA2712634C (fr) |
CL (1) | CL2009000166A1 (fr) |
CO (1) | CO6300826A2 (fr) |
CR (1) | CR11580A (fr) |
EA (1) | EA201001204A1 (fr) |
EC (1) | ECSP10010372A (fr) |
ES (1) | ES2479417T3 (fr) |
IL (1) | IL207161A0 (fr) |
MA (1) | MA32031B1 (fr) |
MX (1) | MX2010008206A (fr) |
PE (1) | PE20091405A1 (fr) |
TW (1) | TW200936156A (fr) |
WO (1) | WO2009095372A1 (fr) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8420088B2 (en) * | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
EP2358749B1 (fr) | 2008-10-10 | 2018-07-18 | Amgen, Inc | Mutants fgf21 et leurs utilisations |
DK3248610T3 (da) * | 2009-05-05 | 2024-01-15 | Amgen Inc | Fgf21-mutanter og anvendelser deraf |
AU2010246038A1 (en) | 2009-05-05 | 2011-12-01 | Amgen Inc. | FGF21 mutants and uses thereof |
EP2443145A1 (fr) * | 2009-06-17 | 2012-04-25 | Amgen, Inc | Polypeptides fgf19 chimériques et leurs utilisations |
CN102656266B (zh) * | 2009-10-15 | 2016-08-03 | 霍夫曼-拉罗奇有限公司 | 具有改变的受体特异性的嵌合成纤维细胞生长因子 |
US8889621B2 (en) | 2009-10-30 | 2014-11-18 | New York University | Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia |
AU2010326024A1 (en) * | 2009-12-02 | 2012-07-05 | Amgen Inc. | Binding proteins that bind to human FGFR1c, human beta-Klotho and both human FGFR1c and human beta-Klotho |
UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
WO2011084452A1 (fr) | 2009-12-16 | 2011-07-14 | Eli Lilly And Company | Utilisations thérapeutiques de l'alpha-klotho soluble |
EP2558497A2 (fr) | 2010-04-15 | 2013-02-20 | Amgen Inc. | Protéines de liaison au récepteur de fgf humain et à beta-klotho |
SI2571510T1 (sl) * | 2010-05-21 | 2019-02-28 | Xl-Protein Gmbh | Biosintetični prolin/alaninski naključno zviti polipeptidi in njihove uporabe |
PT3626258T (pt) * | 2010-06-25 | 2021-10-19 | Shire Human Genetic Therapies | Métodos e composições para fornecimento ao snc de iduronato-2-sulfatase |
CN102465182A (zh) * | 2010-10-29 | 2012-05-23 | 株式会社爱茉莉太平洋 | 检测皮肤活性物质的检测试剂盒和检测皮肤活性物质的方法 |
KR102077721B1 (ko) | 2011-07-01 | 2020-02-14 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 대사성 장애 및 질환의 치료를 위한 조성물, 용도 및 방법 |
WO2013027191A1 (fr) * | 2011-08-25 | 2013-02-28 | Novartis Ag | Procédés et compositions utilisant des polypeptides de fusion fgf23 |
TWI478002B (zh) * | 2012-02-09 | 2015-03-21 | Univ Nat Sun Yat Sen | 一種篩選治療或預防帕金森氏症及其併發症之候選藥物的方法 |
US9657075B2 (en) | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
WO2014085365A2 (fr) | 2012-11-28 | 2014-06-05 | Ngm Biopharmaceuticals, Inc. | Compositions et méthodes de traitement de troubles et maladies métaboliques |
US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
CN108888757A (zh) * | 2012-12-27 | 2018-11-27 | 恩格姆生物制药公司 | 用于调节胆汁酸体内稳态及治疗胆汁酸紊乱和疾病的方法 |
JP6159930B2 (ja) * | 2013-10-24 | 2017-07-12 | 地方独立行政法人東京都健康長寿医療センター | 筋幹細胞又は筋芽細胞、及びそれを用いた代謝変換に関与する物質のスクリーニング方法、並びにスクリーニング方法によって得られた物質を含む医薬組成物 |
WO2015065897A1 (fr) | 2013-10-28 | 2015-05-07 | Ngm Biopharmaceuticals, Inc. | Modèles de cancer et procédés associés |
RU2701434C2 (ru) | 2014-01-24 | 2019-09-26 | Нгм Биофармасьютикалс, Инк. | Связывающие белки и способы их применения |
CN106456714A (zh) | 2014-03-28 | 2017-02-22 | 纽约大学 | Fgf23融合蛋白 |
US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
WO2015195509A2 (fr) | 2014-06-16 | 2015-12-23 | Ngm Biopharmaceuticals, Inc. | Procédés et utilisations pour la modulation de l'homéostasie de l'acide biliaire et le traitement de troubles et maladies de l'acide biliaire |
US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
EP3209681A4 (fr) | 2014-10-23 | 2018-10-31 | NGM Biopharmaceuticals, Inc. | Compositions pharmaceutiques comprenant des variants de peptide et leurs procédés d'utilisation |
WO2016073855A1 (fr) | 2014-11-07 | 2016-05-12 | Ngm Biopharmaceuticals, Inc. | Procédés de traitement de troubles liés à l'acide biliaire et prédiction de la sensibilité clinique au traitement de troubles liés aux acides biliaires |
WO2016088059A1 (fr) * | 2014-12-04 | 2016-06-09 | Novartis Ag | Procédés et compositions employant des polypeptides variants de klotho |
CN105838661B (zh) * | 2014-12-30 | 2020-11-10 | 深圳市第二人民医院 | Klotho基因编辑在异种肾脏移植中的应用 |
US10632180B2 (en) | 2015-02-06 | 2020-04-28 | The Regents Of The University Of California | Methods and compositions for improved cognition |
WO2016135295A1 (fr) * | 2015-02-27 | 2016-09-01 | Apceth Gmbh & Co. Kg | Cellule souche mésenchymateuse génétiquement modifiée exprimant klotho |
US11491115B2 (en) * | 2015-07-09 | 2022-11-08 | The Board Of Regents Of The University Of Texas System | Nanoparticles containing extracellular matrix for drug delivery |
WO2017019957A2 (fr) | 2015-07-29 | 2017-02-02 | Ngm Biopharmaceuticals, Inc. | Protéines de liaison et leurs procédés d'utilisation |
US10744185B2 (en) | 2015-11-09 | 2020-08-18 | Ngm Biopharmaceuticals, Inc. | Methods of using variants of FGF19 polypeptides for the treatment of pruritus |
CN116478907A (zh) * | 2016-06-02 | 2023-07-25 | 克洛索治疗有限公司 | 治疗性重组klotho蛋白及其组合物和方法 |
WO2018039557A1 (fr) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Méthodes de traitement de cancers et de tumeurs à médiation assurée par le facteur de croissance des fibroblastes 19 |
KR20230093531A (ko) | 2016-11-22 | 2023-06-27 | 클로토 테라퓨틱스, 아이엔씨. | 신규한 재조합 클로토 단백질 및 이를 수반하는 조성물 및 방법 |
US11365228B2 (en) | 2017-07-06 | 2022-06-21 | Yale University | Mutant FGF21 polypeptide compositions |
AU2018378802A1 (en) * | 2017-12-06 | 2020-07-23 | Klotho Therapeutics, Inc. | Products and methods for assessing and increasing Klotho protein levels |
EP3724230A4 (fr) * | 2017-12-13 | 2022-01-19 | Yale University | Compositions et méthodes de traitement ou de prévention de maladies liées au fgf endocrinien |
CN108434441A (zh) * | 2018-04-17 | 2018-08-24 | 哈尔滨博翱生物医药技术开发有限公司 | 新型成纤维细胞生长因子-21类似物在治疗弥漫性间质性肺脏疾病中的应用 |
CN109722480B (zh) * | 2018-05-17 | 2022-04-26 | 上海交通大学 | 一种非小细胞肺癌检测试剂盒及其应用 |
WO2019236603A1 (fr) | 2018-06-08 | 2019-12-12 | Saint Louis University | Procédés et compositions pour traiter une réduction de capacité cognitive |
US11891615B2 (en) | 2020-06-10 | 2024-02-06 | Gail Marion Humble | Process to produce Klotho protein in vitro |
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-
2009
- 2009-01-22 TW TW098102662A patent/TW200936156A/zh unknown
- 2009-01-26 KR KR1020107019047A patent/KR20100118126A/ko not_active Application Discontinuation
- 2009-01-26 EP EP09706624.5A patent/EP2247614B1/fr active Active
- 2009-01-26 BR BRPI0906722-1A patent/BRPI0906722A2/pt not_active IP Right Cessation
- 2009-01-26 EA EA201001204A patent/EA201001204A1/ru unknown
- 2009-01-26 ES ES09706624.5T patent/ES2479417T3/es active Active
- 2009-01-26 CA CA2712634A patent/CA2712634C/fr not_active Expired - Fee Related
- 2009-01-26 WO PCT/EP2009/050850 patent/WO2009095372A1/fr active Application Filing
- 2009-01-26 CN CN200980111072.0A patent/CN102015760B/zh not_active Expired - Fee Related
- 2009-01-26 JP JP2010543520A patent/JP5627469B2/ja not_active Expired - Fee Related
- 2009-01-26 AU AU2009209696A patent/AU2009209696B2/en not_active Ceased
- 2009-01-26 MX MX2010008206A patent/MX2010008206A/es active IP Right Grant
- 2009-01-26 CA CA2854933A patent/CA2854933A1/fr not_active Abandoned
- 2009-01-27 PE PE2009000108A patent/PE20091405A1/es not_active Application Discontinuation
- 2009-01-27 AR ARP090100247A patent/AR070690A1/es unknown
- 2009-01-27 CL CL2009000166A patent/CL2009000166A1/es unknown
- 2009-01-28 US US12/360,970 patent/US8481031B2/en not_active Expired - Fee Related
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2010
- 2010-07-19 MA MA33039A patent/MA32031B1/fr unknown
- 2010-07-21 CR CR11580A patent/CR11580A/es not_active Application Discontinuation
- 2010-07-22 IL IL207161A patent/IL207161A0/en unknown
- 2010-07-28 EC EC2010010372A patent/ECSP10010372A/es unknown
- 2010-07-28 CO CO10092102A patent/CO6300826A2/es not_active Application Discontinuation
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2013
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Also Published As
Publication number | Publication date |
---|---|
CA2712634C (fr) | 2014-09-16 |
CA2854933A1 (fr) | 2009-08-06 |
CN102015760A (zh) | 2011-04-13 |
KR20100118126A (ko) | 2010-11-04 |
WO2009095372A1 (fr) | 2009-08-06 |
AU2009209696B2 (en) | 2012-04-19 |
TW200936156A (en) | 2009-09-01 |
MX2010008206A (es) | 2010-08-10 |
CR11580A (es) | 2010-10-05 |
US8481031B2 (en) | 2013-07-09 |
JP5627469B2 (ja) | 2014-11-19 |
AU2009209696A1 (en) | 2009-08-06 |
EP2247614A1 (fr) | 2010-11-10 |
ECSP10010372A (es) | 2010-08-31 |
JP2011510620A (ja) | 2011-04-07 |
CO6300826A2 (es) | 2011-07-21 |
EA201001204A1 (ru) | 2011-02-28 |
US20130324458A1 (en) | 2013-12-05 |
AR070690A1 (es) | 2010-04-28 |
BRPI0906722A2 (pt) | 2015-07-07 |
IL207161A0 (en) | 2010-12-30 |
PE20091405A1 (es) | 2009-10-07 |
US9458209B2 (en) | 2016-10-04 |
CA2712634A1 (fr) | 2009-08-06 |
EP2247614B1 (fr) | 2014-04-09 |
CL2009000166A1 (es) | 2010-12-24 |
CN102015760B (zh) | 2014-06-11 |
US20090192087A1 (en) | 2009-07-30 |
ES2479417T3 (es) | 2014-07-24 |
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