HRP20230632T1 - Gla domene kao terapijska sredstva - Google Patents
Gla domene kao terapijska sredstva Download PDFInfo
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- HRP20230632T1 HRP20230632T1 HRP20230632TT HRP20230632T HRP20230632T1 HR P20230632 T1 HRP20230632 T1 HR P20230632T1 HR P20230632T T HRP20230632T T HR P20230632TT HR P20230632 T HRP20230632 T HR P20230632T HR P20230632 T1 HRP20230632 T1 HR P20230632T1
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- Croatia
- Prior art keywords
- virus
- polypeptide according
- polypeptide
- treatment
- disease
- Prior art date
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- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 206010047115 Vasculitis Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 2
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 2
- 229940096437 Protein S Drugs 0.000 claims 2
- 102000029301 Protein S Human genes 0.000 claims 2
- 108010066124 Protein S Proteins 0.000 claims 2
- 206010039710 Scleroderma Diseases 0.000 claims 2
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 2
- UHBYWPGGCSDKFX-VKHMYHEASA-N gamma-carboxy-L-glutamic acid Chemical compound OC(=O)[C@@H](N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-VKHMYHEASA-N 0.000 claims 2
- 201000000306 sarcoidosis Diseases 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- 208000026872 Addison Disease Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 1
- 208000032467 Aplastic anaemia Diseases 0.000 claims 1
- 206010003253 Arthritis enteropathic Diseases 0.000 claims 1
- 206010003267 Arthritis reactive Diseases 0.000 claims 1
- 206010003274 Arthritis viral Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 241000711404 Avian avulavirus 1 Species 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 201000006082 Chickenpox Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 241000709687 Coxsackievirus Species 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 208000000280 Cyclic neutropenia Diseases 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 241001115402 Ebolavirus Species 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 206010016207 Familial Mediterranean fever Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 206010018498 Goitre Diseases 0.000 claims 1
- 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 1
- 241000150562 Hantaan orthohantavirus Species 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 claims 1
- 241000714259 Human T-lymphotropic virus 2 Species 0.000 claims 1
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 241000701806 Human papillomavirus Species 0.000 claims 1
- 206010020608 Hypercoagulation Diseases 0.000 claims 1
- 208000004575 Infectious Arthritis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 241001115401 Marburgvirus Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000150452 Orthohantavirus Species 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 241000711798 Rabies lyssavirus Species 0.000 claims 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 241000702670 Rotavirus Species 0.000 claims 1
- 241000710799 Rubella virus Species 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000006045 Spondylarthropathies Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 206010046980 Varicella Diseases 0.000 claims 1
- 241000700647 Variola virus Species 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 241000710772 Yellow fever virus Species 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 201000005000 autoimmune gastritis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 1
- 238000002648 combination therapy Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 201000003872 goiter Diseases 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 208000005252 hepatitis A Diseases 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 201000010284 hepatitis E Diseases 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 230000003027 hypercoagulation Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
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- 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 201000003068 rheumatic fever Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000005671 spondyloarthropathy Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229940051021 yellow-fever virus Drugs 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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Claims (15)
1. Proba i/ili terapeutski polipeptid prikladan za ciljanje ekspresije fosfatidilserina na površini stanice i in vitro i in vivo navedeni polipeptid koji sadrži:
domena proteina S gama-karboksiglutaminske kiseline (Gla), i
EGF domena,
pri čemu je navedeni polipeptid fuzioniran na proteinsku sekvencu; i
pri čemu navedenom polipeptidu nedostaje domena proteaze i također nedostaje domena za vezanje hormona.
2. Polipeptid prema zahtjevu 1, naznačen time što sadrži EGF domenu iz proteina S.
3. Polipeptid prema zahtjevu 2, naznačen time, da GLA domena ima sekvencu prikazanu u SEQ ID NO: 1.
4. Polipeptid prema bilo kojem od zahtjeva 1 do 3, naznačen time, da se polipeptid sastoji od 300 aminokiselina ili manje.
5. Polipeptid prema bilo kojem od zahtjeva 1 do 3, naznačen time što sadrži SEQ ID NO: 6.
6. Polipeptid prema bilo kojem od zahtjeva 1 do 5, naznačen time, da polipeptid dalje sadrži antitijelo Fc regija.
7. Polipeptid prema bilo kojem od zahtjeva 1 do 6, naznačen time, da se koristi u liječenju.
8. Polipeptid prema zahtjevu 7, naznačen time, da se koristi u liječenju u kombiniranoj terapiji.
9. Polipeptid prema bilo kojem od zahtjeva 1 do 6, naznačen time, da se koristi u liječenju raka.
10. Polipeptid prema bilo kojem od zahtjeva 1 do 6, naznačen time, da se koristi u liječenju virusne infekcije.
11. Polipeptid prema zahtjevu 10, naznačen time, da se koristi u liječenju virusne infekcije odabrane iz skupine koju čine gripe, virusa humane imunodeficijencije, virusa denge, virusa zapadnog Nila, virusa velikih boginja, respiratornog sincicijalni virus, virus korejske hemoragijske groznice, vodene kozice, virus varicella zoster, herpes simplex virus 1 ili 2, Epstein-Barr virus, Marburg virus, hantavirus, virus žute groznice, hepatitis A, B, C ili E, virus ebole, humani papiloma virus, rinovirus, Coxsackie virus, polio virus, virus ospica, virus rubeole, virus bjesnoće, virus newcastleske bolesti, rotavirus, HTLV-1 i -2.
12. Polipeptid prema bilo kojem od zahtjeva 1 do 6, naznačen time, da se koristi u liječenju poremećaja hiperkoagulacije.
13. Polipeptid prema bilo kojem od zahtjeva 1 do 6, naznačen time, da se koristi u liječenju autoimunih i/ili upalnih bolesnih stanja.
14. Polipeptid za upotrebu prema zahtjevu 13, naznačen time što je bolesno stanje odabrano iz skupine koja se sastoji od spondiloartropatija, ankilozantni spondilitis, psorijatični artritis, reaktivni artritis, enteropatski artritis, ulcerozni kolitis, Crohnova bolest, bolest iritabilnog crijeva, upalna bolest crijeva, reumatoidni artritis, juvenilni reumatoidni artritis, obiteljska mediteranska groznica, amiotrofična lateralna skleroza, Sjogren' s sindrom, rani artritis, virusno artritis, multipla skleroza, sistemski eritematozni lupus, psorijaza, vaskulitis, Wegenerova granulomatoza, Addisonova bolest, alopecija, antifosfolipidni sindrom, Behcetova bolest, celijakija, sindrom kroničnog umora, ulcerozni kolitis, dijabetes tipa I, fibromijalgija, autoimuni gastritis, Goodpastureov sindrom , Gušavost, idiopatska trombocitopenična purpura (ITP), miastenija gravis, pemfigus vulgaris, primarna bilijarna ciroza, reumatska groznica, sarkoidoza, sklerodermija, vitiligo, vaskulitis, vaskulitis malih krvnih žila, hepatitis, primarna bilijarna ciroza, sarkoidoza, sklerodermija, reakcija presatka protiv domaćina (akutna i kronična), aplastična anemija i ciklička neutropenija.
15. Polipeptid prema bilo kojem od zahtjeva 1 do 6, naznačen time, da se koristi u liječenju sepse.
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| WO2015170778A1 (ja) * | 2014-05-08 | 2015-11-12 | 学校法人日本大学 | ホスファチジルセリンの細胞表面への表出促進剤又は表出抑制剤、及び脂質ラフトのクラスター形成抑制剤 |
| CN104745649B (zh) * | 2015-02-28 | 2018-03-09 | 苏州汉酶生物技术有限公司 | 一种福沙那韦中间体的生物制备方法 |
| CN104784179A (zh) * | 2015-04-01 | 2015-07-22 | 重庆理工大学 | 替拉那韦在抗乳腺癌药物中的应用及抗乳腺癌药物 |
| US11820833B2 (en) * | 2016-06-05 | 2023-11-21 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Peptides that inhibit binding of EPCR to its ligand to treat inflammation |
| US11352404B2 (en) | 2017-07-24 | 2022-06-07 | Rutgers, The State University Of New Jersey | Phosphatidylserine targeting fusion molecules and methods for their use |
| CN111051500A (zh) * | 2017-09-05 | 2020-04-21 | 角斗士生物科学公司 | 有效载荷递送至干细胞 |
| CN108159421B (zh) * | 2018-02-05 | 2021-05-18 | 苏州大学 | 磷脂酰丝氨酸阻断剂在制备治疗血小板数量减少相关疾病药物中的用途 |
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| CA3177374A1 (en) * | 2018-10-22 | 2020-04-30 | Asahi Kasei Pharma Corporation | Medicament for therapeutic treatment and/or improvement of sepsis accompanied by coagulopathy |
| CN113061169B (zh) * | 2020-03-24 | 2022-09-27 | 江南大学 | 一种转录调控蛋白及其在共轭亚油酸生产中的应用 |
| CN112057623A (zh) * | 2020-06-03 | 2020-12-11 | 江苏靶标生物医药研究所有限公司 | 一种磷脂酰丝氨酸在制备治疗炎症性肠病药物中的应用 |
| RU2768194C1 (ru) * | 2021-08-02 | 2022-03-23 | федеральное государственное бюджетное образовательное учреждение высшего образования "Нижегородский государственный технический университет им. Р.Е. Алексеева" (НГТУ) | Способ оценки степени экстернализации фосфатидилсерина на поверхность мембран эритроцитов |
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