MA43415A - Arnm modifié codant pour une uridine diphosphate glucuronosyltransférase et utilisations associées - Google Patents
Arnm modifié codant pour une uridine diphosphate glucuronosyltransférase et utilisations associéesInfo
- Publication number
- MA43415A MA43415A MA043415A MA43415A MA43415A MA 43415 A MA43415 A MA 43415A MA 043415 A MA043415 A MA 043415A MA 43415 A MA43415 A MA 43415A MA 43415 A MA43415 A MA 43415A
- Authority
- MA
- Morocco
- Prior art keywords
- modified rna
- uridine diphosphate
- rna coding
- associated uses
- diphosphate glucuronosyltransferase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562265174P | 2015-12-09 | 2015-12-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA43415A true MA43415A (fr) | 2018-10-17 |
Family
ID=57758709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA043415A MA43415A (fr) | 2015-12-09 | 2016-12-09 | Arnm modifié codant pour une uridine diphosphate glucuronosyltransférase et utilisations associées |
Country Status (4)
Country | Link |
---|---|
US (1) | US20190307857A1 (fr) |
EP (1) | EP3386533A1 (fr) |
MA (1) | MA43415A (fr) |
WO (1) | WO2017100562A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020056239A1 (fr) * | 2018-09-14 | 2020-03-19 | Modernatx, Inc. | Polynucléotides codant pour le polypeptide a1, de la famille de l'uridine diphosphate glycosyltransférase 1, pour le traitement du syndrome de crigler-najjar |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
LT2578685T (lt) * | 2005-08-23 | 2019-06-10 | The Trustees Of The University Of Pennsylvania | Rnr, apimančios modifikuotus nukleozidus ir jų panaudojimo būdai |
AU2006330858A1 (en) | 2005-12-21 | 2007-07-05 | Wyeth | Protein formulations with reduced viscosity and uses thereof |
PT2506857T (pt) | 2009-12-01 | 2018-05-14 | Translate Bio Inc | Entrega de arnm para o acréscimo de proteínas e enzimas em doenças genéticas humanas |
WO2012075040A2 (fr) | 2010-11-30 | 2012-06-07 | Shire Human Genetic Therapies, Inc. | Arnm pour l'utilisation dans le traitement de maladies génétiques humaines |
WO2012129648A1 (fr) | 2011-03-25 | 2012-10-04 | University Of Guelph | Activation d'expression de protéines de vecteurs de virus adéno-associés |
RS63244B1 (sr) | 2011-12-16 | 2022-06-30 | Modernatx Inc | Kompozicije modifikovane mrna |
CN108949772A (zh) * | 2012-04-02 | 2018-12-07 | 现代泰克斯公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
EP2833892A4 (fr) | 2012-04-02 | 2016-07-20 | Moderna Therapeutics Inc | Polynucléotides modifiés destinés à la production de protéines et de peptides associés à l'oncologie |
JP6561378B2 (ja) | 2012-06-08 | 2019-08-21 | トランスレイト バイオ, インコーポレイテッド | 非肺標的細胞へのmRNAの経肺送達 |
ES2921623T3 (es) | 2012-11-26 | 2022-08-30 | Modernatx Inc | ARN modificado terminalmente |
CN114395559A (zh) * | 2014-04-25 | 2022-04-26 | 吉尼松公司 | 高胆红素血症的治疗 |
-
2016
- 2016-12-09 MA MA043415A patent/MA43415A/fr unknown
- 2016-12-09 WO PCT/US2016/065814 patent/WO2017100562A1/fr active Application Filing
- 2016-12-09 US US15/781,881 patent/US20190307857A1/en not_active Abandoned
- 2016-12-09 EP EP16823387.2A patent/EP3386533A1/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP3386533A1 (fr) | 2018-10-17 |
WO2017100562A1 (fr) | 2017-06-15 |
WO2017100562A9 (fr) | 2017-08-03 |
US20190307857A1 (en) | 2019-10-10 |
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