MA49684A - Arnm modifié codant une glucose-6-phosphatase et utilisations associées - Google Patents

Arnm modifié codant une glucose-6-phosphatase et utilisations associées

Info

Publication number
MA49684A
MA49684A MA049684A MA49684A MA49684A MA 49684 A MA49684 A MA 49684A MA 049684 A MA049684 A MA 049684A MA 49684 A MA49684 A MA 49684A MA 49684 A MA49684 A MA 49684A
Authority
MA
Morocco
Prior art keywords
glucose
modified rna
associated uses
phosphatase
phosphatase modified
Prior art date
Application number
MA049684A
Other languages
English (en)
Inventor
Jeremiah Farelli
Daniel Roseman
Romesh R Subramanian
Original Assignee
Modernatx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modernatx Inc filed Critical Modernatx Inc
Publication of MA49684A publication Critical patent/MA49684A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03009—Glucose-6-phosphatase (3.1.3.9)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA049684A 2017-07-24 2018-07-24 Arnm modifié codant une glucose-6-phosphatase et utilisations associées MA49684A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762536000P 2017-07-24 2017-07-24

Publications (1)

Publication Number Publication Date
MA49684A true MA49684A (fr) 2020-06-03

Family

ID=63143416

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049684A MA49684A (fr) 2017-07-24 2018-07-24 Arnm modifié codant une glucose-6-phosphatase et utilisations associées

Country Status (4)

Country Link
US (1) US20200179494A1 (fr)
EP (1) EP3658672A1 (fr)
MA (1) MA49684A (fr)
WO (1) WO2019023179A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021003015A (es) * 2018-09-13 2021-07-15 Modernatx Inc Polinucleotidos que codifican glucosa-6-fosfatasa para el tratamiento de la glucogenosis.
EP4157217A1 (fr) * 2020-06-01 2023-04-05 Modernatx, Inc. Nanoparticules lipidiques contenant des polynucléotides codant pour la glucose-6-phosphatase et leurs utilisations
CN111972355A (zh) * 2020-08-31 2020-11-24 中国医学科学院北京协和医院 GSDIa型糖原累积症小鼠模型及其构建方法
WO2022204371A1 (fr) * 2021-03-24 2022-09-29 Modernatx, Inc. Nanoparticules lipidiques contenant des polynucléotides codant pour la glucose-6-phosphatase et leurs utilisations
WO2025165616A1 (fr) * 2024-01-31 2025-08-07 The Johns Hopkins University Compositions et méthodes de traitement et de prévention du cancer

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
RS63964B1 (sr) * 2005-08-23 2023-03-31 Univ Pennsylvania Rnk koja sadrži modifikovane nukleozide i postupci za njenu upotrebu
CN101378782A (zh) 2005-12-21 2009-03-04 惠氏公司 粘度降低的蛋白质制剂及其用途
ME03091B (fr) 2009-12-01 2019-01-20 Translate Bio Inc Administration d'arnm pour l'augmentation des protéines et des enzymes dans des maladies génétiques humaines
US8853377B2 (en) 2010-11-30 2014-10-07 Shire Human Genetic Therapies, Inc. mRNA for use in treatment of human genetic diseases
WO2012129648A1 (fr) 2011-03-25 2012-10-04 University Of Guelph Activation d'expression de protéines de vecteurs de virus adéno-associés
US8916696B2 (en) * 2011-06-12 2014-12-23 City Of Hope Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
EP2834259A4 (fr) 2012-04-02 2016-08-24 Moderna Therapeutics Inc Polynucléotides modifiés
BR112014030677A2 (pt) 2012-06-08 2022-07-19 Shire Human Genetic Therapies distribuição pulmonar de mrna para células-alvo não-pulmonares
US9597380B2 (en) 2012-11-26 2017-03-21 Modernatx, Inc. Terminally modified RNA
WO2015061467A1 (fr) * 2013-10-22 2015-04-30 Shire Human Genetic Therapies, Inc. Formulations de lipide pour l'administration d'arn messager
ES2806575T3 (es) * 2013-11-01 2021-02-18 Curevac Ag ARN modificado con propiedades inmunoestimuladoras disminuidas
KR102739894B1 (ko) * 2014-04-25 2024-12-05 샤이어 휴먼 지네틱 테라피즈 인크. 메신저 rna 의 정제 방법

Also Published As

Publication number Publication date
WO2019023179A1 (fr) 2019-01-31
US20200179494A1 (en) 2020-06-11
EP3658672A1 (fr) 2020-06-03

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