DE69637731D1 - Antimikrobielle kationische peptide und methoden zu ihrer identifizierung - Google Patents

Antimikrobielle kationische peptide und methoden zu ihrer identifizierung

Info

Publication number
DE69637731D1
DE69637731D1 DE69637731T DE69637731T DE69637731D1 DE 69637731 D1 DE69637731 D1 DE 69637731D1 DE 69637731 T DE69637731 T DE 69637731T DE 69637731 T DE69637731 T DE 69637731T DE 69637731 D1 DE69637731 D1 DE 69637731D1
Authority
DE
Germany
Prior art keywords
sub
entry
row
seq
tryptophan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69637731T
Other languages
English (en)
Inventor
Timothy J Falla
Robert E Hancock
Monisha Gough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia filed Critical University of British Columbia
Application granted granted Critical
Publication of DE69637731D1 publication Critical patent/DE69637731D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DE69637731T 1995-08-23 1996-08-23 Antimikrobielle kationische peptide und methoden zu ihrer identifizierung Expired - Lifetime DE69637731D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US268795P 1995-08-23 1995-08-23
PCT/IB1996/000996 WO1997008199A2 (en) 1995-08-23 1996-08-23 Antimicrobial cationic peptides and methods of screening for the same

Publications (1)

Publication Number Publication Date
DE69637731D1 true DE69637731D1 (de) 2008-12-11

Family

ID=21701983

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637731T Expired - Lifetime DE69637731D1 (de) 1995-08-23 1996-08-23 Antimikrobielle kationische peptide und methoden zu ihrer identifizierung

Country Status (10)

Country Link
US (2) US6191254B1 (de)
EP (1) EP0846128B1 (de)
JP (1) JP3860838B2 (de)
AT (1) ATE412668T1 (de)
AU (1) AU6940796A (de)
CA (1) CA2230160A1 (de)
DE (1) DE69637731D1 (de)
ES (1) ES2316154T3 (de)
HK (1) HK1011867A1 (de)
WO (1) WO1997008199A2 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503881B2 (en) 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6180604B1 (en) 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
EP1174439B1 (de) * 1996-08-21 2008-10-08 Migenix Inc. Zusammensetzungen und Methoden zur Behandlung von Infektionen unter Verwendung von Indolicidinanalogen
US6303575B1 (en) 1998-05-12 2001-10-16 The Regents Of The University Of California Indolicidin analogs and methods of using same
US6444645B1 (en) * 1998-06-18 2002-09-03 The Regents Of The University Of California Crosslink-stabilized indolicidin analogs
US6288212B1 (en) * 1998-08-28 2001-09-11 The University Of British Columbia Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor
BR9914922A (pt) * 1998-10-30 2001-07-10 Interlink Biotechnologies Llc Métodos para reduzir a extensão de degradação de protease de uma proteìna aplicada a ou produzida por uma planta, para inibir o crescimento de um patógeno vegetal e para produzir uma planta, peptìdeo, molécula de ácido nucleico, segmento de ácido nucleico, construção de ácido nucleico, planta transgênica, semente, célula vegetal, e, composição para o uso na proteção de um peptìdeo, polipeptìdeo ou proteìna da degradação da protease.
US6946261B1 (en) * 1998-11-20 2005-09-20 Migenix Inc. Efficient methods for producing anti-microbial cationic peptides in host cells
US6335318B1 (en) 1999-05-10 2002-01-01 The Regents Of The University Of California Antimicrobial theta defensins and methods of using same
US6497676B1 (en) 2000-02-10 2002-12-24 Baxter International Method and apparatus for monitoring and controlling peritoneal dialysis therapy
US6337317B1 (en) 2000-06-27 2002-01-08 The University Of British Columbia Antimicrobial peptides and methods of use thereof
US6835536B2 (en) 2001-08-21 2004-12-28 Micrologix Biotech Inc. Antimicrobial cationic peptides and formulations thereof
WO2003018619A2 (en) 2001-08-24 2003-03-06 Micrologix Biotech Inc. Antimicrobial and anti-inflammatory peptides
KR100438416B1 (ko) * 2001-09-19 2004-07-02 학교법인조선대학교 Ｃａ－ｍａ 펩타이드의 아미노산 중 하나 또는 그 이상을치환하여 ＋ 전극과 소수성 영역이 증가된 신규한펩타이드 및 그를 포함하는 약학적 조성물
US7507787B2 (en) * 2001-12-03 2009-03-24 The University Of British Columbia Effectors of innate immunity
US20030125662A1 (en) * 2002-01-03 2003-07-03 Tuan Bui Method and apparatus for providing medical treatment therapy based on calculated demand
US20030219854A1 (en) * 2002-03-21 2003-11-27 Micrologix Biotech Inc. Methods for producing modified anti-infective peptides
WO2003091429A1 (fr) * 2002-04-25 2003-11-06 Toagosei Co.,Ltd. Polypeptide microbicide et ses utilisations
US7119070B2 (en) 2002-04-30 2006-10-10 The Regents Of The University Of California Antimicrobial theta defensins, analogs thereof, and methods of use
US7033769B2 (en) * 2002-05-23 2006-04-25 The United States Of America As Represented By The Secretary Of The Army Method for discovering one or more peptides adapted for specific binding to a microorganism of interest
US7238164B2 (en) * 2002-07-19 2007-07-03 Baxter International Inc. Systems, methods and apparatuses for pumping cassette-based therapies
WO2005019241A2 (en) * 2003-08-18 2005-03-03 E.I. Dupont De Nemours And Company Cationic antimicrobial peptides and compositions thereof
WO2005049819A1 (ja) * 2003-10-29 2005-06-02 Toagosei Co., Ltd. 抗菌ペプチド及びその利用
US20050209563A1 (en) * 2004-03-19 2005-09-22 Peter Hopping Cassette-based dialysis medical fluid therapy systems, apparatuses and methods
JP4507080B2 (ja) * 2004-07-30 2010-07-21 東亞合成株式会社 抗菌ペプチド及びその利用
JP4730584B2 (ja) 2004-12-06 2011-07-20 東亞合成株式会社 抗菌ペプチド及びその利用
US8252737B2 (en) * 2004-12-15 2012-08-28 The Regents Of The University Of Colorado Antimicrobial peptides and methods of use
US20090030179A1 (en) * 2005-02-15 2009-01-29 Toagosei Co., Ltd Antimicrobial peptide and use thereof
US7998115B2 (en) * 2007-02-15 2011-08-16 Baxter International Inc. Dialysis system having optical flowrate detection
US8558964B2 (en) 2007-02-15 2013-10-15 Baxter International Inc. Dialysis system having display with electromagnetic compliance (“EMC”) seal
US8870812B2 (en) * 2007-02-15 2014-10-28 Baxter International Inc. Dialysis system having video display with ambient light adjustment
US7731689B2 (en) 2007-02-15 2010-06-08 Baxter International Inc. Dialysis system having inductive heating
US8361023B2 (en) * 2007-02-15 2013-01-29 Baxter International Inc. Dialysis system with efficient battery back-up
ES2805225T3 (es) * 2007-07-26 2021-02-11 Revance Therapeutics Inc Péptidos antimicrobianos y composiciones de los mismos
WO2010042534A1 (en) * 2008-10-06 2010-04-15 The Regents Of The University Of Colorado, A Body Corporate Peptides and methods of use
GB0821616D0 (en) * 2008-11-26 2008-12-31 Lytix Biopharma As Compounds
WO2010141760A2 (en) * 2009-06-05 2010-12-09 The Regents Of The University Of Colorado, A Body Corporate Antimicrobial peptides
US9134323B2 (en) 2009-12-01 2015-09-15 The Rockefeller University Antibody that specifically binds to an epitope in the tureet region of a human Kir channel
US11225655B2 (en) 2010-04-16 2022-01-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
WO2013039861A2 (en) 2011-09-12 2013-03-21 modeRNA Therapeutics Engineered nucleic acids and methods of use thereof
AU2013243949A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
CA2868398A1 (en) 2012-04-02 2013-10-10 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
WO2013158773A2 (en) * 2012-04-17 2013-10-24 The Research Institute At Nationwide Children's Hospital Rnase 7 antimicrobial peptides
MY151307A (en) * 2012-06-18 2014-05-05 Univ Malaya Peptides having antimicrobial activity
GB201401877D0 (en) 2014-02-04 2014-03-19 Univ Tromsoe Peptides
EP3067608A1 (de) * 2015-03-10 2016-09-14 Abu Dhabi Polymers Co. Ltd (Borouge) LLC. Exzentrisches Polyolefinrohr
CA3004790A1 (en) 2015-11-10 2017-05-18 Visterra, Inc. Lipopolysaccharide binding antibody-antimicrobial peptide conjugates and uses thereof
AU2018209940A1 (en) 2017-01-18 2019-07-11 Visterra, Inc. Antibody molecule-drug conjugates and uses thereof
US11021529B2 (en) 2017-03-03 2021-06-01 Massachusetts Institute Of Technology Antimicrobial constructs and uses thereof
US10934943B2 (en) 2017-04-27 2021-03-02 General Electric Company Compressor apparatus with bleed slot and supplemental flange
US11179516B2 (en) 2017-06-22 2021-11-23 Baxter International Inc. Systems and methods for incorporating patient pressure into medical fluid delivery
EP4126064A1 (de) 2020-04-03 2023-02-08 Visterra, Inc. Antikörpermolekül-wirkstoff-konjugate und verwendungen davon
CU20200086A7 (es) * 2020-11-19 2022-06-06 Centro De Investig Y Desarrollo De Medicamentos Cidem Entidades peptídicas con actividad antimicrobiana frente a patógenos multi-drogoresistentes

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206154A (en) 1985-01-28 1993-04-27 Xoma Corporation Method of producing cecropins by microbiological techniques
US5166321A (en) 1985-01-28 1992-11-24 International Genetic Engineering, Inc. Cecropin polypetides with activity against Gram-positive and Gram-negative bacteria
US5028530A (en) 1985-01-28 1991-07-02 Xoma Corporation AraB promoters and method of producing polypeptides, including cecropins, by microbiological techniques
US4810777A (en) 1987-03-04 1989-03-07 The United States Of America As Represented By The Department Of Health And Human Services Antimicrobial compounds
US4822608A (en) 1987-09-14 1989-04-18 Vespa Laboratories, Inc. Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof
IL90356A0 (en) 1988-05-27 1989-12-15 Magainin Sciences Inc Amphiphilic peptides and pharmaceutical compositions containing them
SE8802939D0 (sv) 1988-08-19 1988-08-19 Kabigen Ab A method for the production and isolation of a fusion protein in eukaryotic cells
WO1990004408A1 (en) 1988-10-21 1990-05-03 Magainin Sciences, Inc. Composition and treatment with biologically active peptides and certain anions
WO1990004407A1 (en) 1988-10-21 1990-05-03 Magainin Sciences, Inc. Cpf peptide compositions and uses
US5217956A (en) 1988-10-21 1993-06-08 The Children's Hospital Of Philadelphia Composition and treatment with biologically active peptides and certain anions
CA2007913A1 (en) 1989-01-30 1990-07-30 Michael Zasloff Composition and treatment with peptide combinations
US5254535A (en) 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
FR2646777B1 (fr) 1989-05-12 1993-09-03 Bio Serae Lab Procede de preparation d'un produit particulaire antimicrobien, produit antimicrobien obtenu et applications
US5073542A (en) 1989-06-07 1991-12-17 Magainin Sciences Inc. CPF peptide compositions and their use in inhibiting growth of target cells or a virus
US5045531A (en) 1989-12-18 1991-09-03 Magainin Sciences Inc. Wound treatment employing biologically active ion channel forming peptides and proteins
EP0514464A4 (en) 1990-02-08 1993-04-28 Magainin Sciences, Inc. Biologically active amphiphilic peptides and method of inhibiting growth of target cells, virus or virally-infected cell
US5227469A (en) 1990-02-14 1993-07-13 Genentech, Inc. Platelet aggregation inhibitors from the leech
JPH05509295A (ja) 1990-04-23 1993-12-22 マゲイニン　サイエンセズ　インコーポレーテッド 生物学的に活性なペプチドおよび毒性陽イオンを有する組成物およびこれらを使用する治療法
JPH05507077A (ja) 1990-04-27 1993-10-14 マゲイニン　サイエンセズ　インコーポレーテッド 生物活性ペプチドおよび駆虫剤もしくは抗真菌剤を使う組成物および治療法
WO1991017760A1 (en) 1990-05-14 1991-11-28 Magainin Sciences Inc. Composition of and treatment with biologically active peptides having d-amino acid residues
US5208220A (en) 1990-06-27 1993-05-04 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
US5202420A (en) 1990-10-25 1993-04-13 The Children's Hospital Of Philadelphia Tracheal antimicrobial peptides, dna sequences and methods for the production and use thereof
US5235038A (en) 1991-01-22 1993-08-10 Torry Pines Institute For Molecular Studies Deletion and substitution analogues of melittin peptide
EP0579763A4 (de) 1991-04-08 1994-12-21 Magainin Pharma Neuartige peptidzusammensetzungen und ihre verwendungen.
AU667479B2 (en) 1991-06-12 1996-03-28 Magainin Pharmaceuticals, Inc. Treating the oral cavity with ion-channel forming peptides
EP0590044A4 (en) 1991-06-12 1996-06-12 Magainin Pharma Composition and treatment with biologically active peptides having c-terminal substitutions
US5547939A (en) * 1991-06-14 1996-08-20 The Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5324716A (en) * 1991-06-14 1994-06-28 Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
EP0667871A1 (de) 1991-09-13 1995-08-23 Magainin Pharmaceuticals Inc. Biologisch aktive amphiphile peptidzusammensetzungen und ihre verwendungen
CA2125494A1 (en) 1991-12-09 1993-06-24 Barry Berkowitz Composition and treatment with biologically active peptides and chelating agents
CA2137087A1 (en) 1992-06-01 1993-12-09 U. Prasad Kari Biologically active peptides having n-terminal substitutions
JPH08501213A (ja) * 1992-08-21 1996-02-13 ザ ユニバーシティー オブ ブリティッシュ コロンビア カチオン性ペプチド及びその製造方法
CA2106720C (en) 1992-09-23 1997-12-16 Charles L. Deschenes Needle for use as part of a plastic fastener dispensing tool
US5635594A (en) * 1994-03-11 1997-06-03 University Of California, Los Angeles Gallinacins - antibiotic peptides
US5877274A (en) * 1995-06-02 1999-03-02 University Of British Columbia Antimicrobial cationic peptides

Also Published As

Publication number Publication date
HK1011867A1 (en) 1999-07-23
WO1997008199A3 (en) 1997-09-12
AU6940796A (en) 1997-03-19
JPH11511971A (ja) 1999-10-19
US20040019181A1 (en) 2004-01-29
US6191254B1 (en) 2001-02-20
WO1997008199A2 (en) 1997-03-06
CA2230160A1 (en) 1997-03-06
JP3860838B2 (ja) 2006-12-20
ATE412668T1 (de) 2008-11-15
ES2316154T3 (es) 2009-04-01
EP0846128A2 (de) 1998-06-10
EP0846128B1 (de) 2008-10-29
US7390873B2 (en) 2008-06-24

Similar Documents

Publication Publication Date Title
DE69637731D1 (de) Antimikrobielle kationische peptide und methoden zu ihrer identifizierung
TW281675B (de)
DE69739035D1 (de) Zusammensetzungen und Methoden zur Behandlung von Infektionen unter Verwendung von Indolicidinanalogen
ATE176241T1 (de) 3-amino-2-oxo-piperidinessigsäurederivate, die eine argininnachahmende verbindung, mit enzyminhibitorischen wirkung enthalten
AU5249898A (en) N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
DE69030100D1 (de) Peptidderivat, verfahren zu dessen herstellung, sowie dieses enthaltende pharmazeutische zusammensetzung
AU1383297A (en) Novel n-(arylsulphonyl)amino acid derivatives having bradykinin receptor affinity
ES2192620T3 (es) Polipeptido receptor de il-13.
PT866691E (pt) Administracao sublingual e bucal de selegilina
DE69530404D1 (de) Analogen des keratinozytenwachstumfaktors
CA2094347A1 (en) A method of producing a factor viii preparation
BR9609847A (pt) Derivados de N-(4-Benzila-substituída)-2-aminolactam
IL122606A (en) (S)-hydroxa-nitrile-lyase
AU579593B2 (en) Novel peptides which are active on the central nervous system and have an action on the cholinergic system
PT635025E (pt) Processo para preparar proteinas modificadas
BR9609337A (pt) Preparação de derivado de biciclohexano
CA2136103A1 (en) Antibiotic cryptdin peptides and methods of their use
DE69633234D1 (de) Reinigung von dalbeheptide-antibiotika mittels isoelektrofokussierung
GR3021408T3 (en) Cloning of a new member of the fibroblast growth factor (fgf) receptor family
CA2033730A1 (en) Heparin-binding growth factor
DK0382268T3 (da) Aminocarboxylsyrederivater
FR2654430B1 (fr) Nouveaux derives de peptides, utilisables comme inhibiteurs des collagenases bacteriennes.
ES2088000T3 (es) Procedimiento para la obtencion de (2s,3s)-3-etilasparaginatos de dialquilo n-protegidos.
AU2001277717A1 (en) Novel proteins and dnas thereof
NZ331432A (en) Process for the preparation of N-methyl-D-phenylalanyl-N-[1-[3-[(aminoiminomethyl)amino]propyl]-3,3 -difluoro-2-oxohexyl]-l-prolinamide

Legal Events

Date Code Title Description
8364 No opposition during term of opposition