DE69633234D1 - Reinigung von dalbeheptide-antibiotika mittels isoelektrofokussierung - Google Patents

Reinigung von dalbeheptide-antibiotika mittels isoelektrofokussierung

Info

Publication number
DE69633234D1
DE69633234D1 DE69633234T DE69633234T DE69633234D1 DE 69633234 D1 DE69633234 D1 DE 69633234D1 DE 69633234 T DE69633234 T DE 69633234T DE 69633234 T DE69633234 T DE 69633234T DE 69633234 D1 DE69633234 D1 DE 69633234D1
Authority
DE
Germany
Prior art keywords
pct
sec
dalbeheptide
isoelectrofocusing
antibiotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69633234T
Other languages
English (en)
Other versions
DE69633234T2 (de
Inventor
Maria Bossi
Giorgio Righetti
Ernesto Riva
Franco Zerilli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis SpA
Original Assignee
Aventis Bulk SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Bulk SpA filed Critical Aventis Bulk SpA
Publication of DE69633234D1 publication Critical patent/DE69633234D1/de
Application granted granted Critical
Publication of DE69633234T2 publication Critical patent/DE69633234T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
DE69633234T 1995-07-05 1996-06-25 Reinigung von dalbeheptide-antibiotika mittels isoelektrofokussierung Expired - Lifetime DE69633234T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP95110467 1995-07-05
EP95110467 1995-07-05
EP95111583 1995-07-24
EP95111583 1995-07-24
PCT/EP1996/002769 WO1997002288A1 (en) 1995-07-05 1996-06-25 Purification of dalbaheptide antibiotics by isoelectric focusing

Publications (2)

Publication Number Publication Date
DE69633234D1 true DE69633234D1 (de) 2004-09-30
DE69633234T2 DE69633234T2 (de) 2005-09-15

Family

ID=26138707

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69633234T Expired - Lifetime DE69633234T2 (de) 1995-07-05 1996-06-25 Reinigung von dalbeheptide-antibiotika mittels isoelektrofokussierung

Country Status (13)

Country Link
US (1) US5939523A (de)
EP (1) EP0836619B1 (de)
JP (1) JP4051421B2 (de)
KR (1) KR100430202B1 (de)
AT (1) ATE274524T1 (de)
AU (1) AU701463B2 (de)
CA (1) CA2226142C (de)
DE (1) DE69633234T2 (de)
DK (1) DK0836619T3 (de)
ES (1) ES2224173T3 (de)
IL (1) IL122151A (de)
PT (1) PT836619E (de)
WO (1) WO1997002288A1 (de)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
DK0912604T3 (da) * 1996-04-23 2002-03-25 Biosearch Italia Spa Forbedret kemisk fremgangsmåde til fremstilling af amidderivater af A 40926 antibiotikum
US6699836B2 (en) 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
AU4054900A (en) 1999-04-02 2000-10-23 Advanced Medicine East, Inc. Desleucyl glycopeptide antibiotics and methods of making same
US6713448B2 (en) 2001-04-25 2004-03-30 Wyeth Holdings Corporation Substantially pure glycopeptide antibiotics AC-98-1; AC-98-2; AC-98-3; AC-98-4 and AC-98-5
ATE489962T1 (de) * 2001-04-25 2010-12-15 Wyeth Corp Im wesentlichen reine glycopeptid-antibiotika ac- 98-1; ac-98-2; ac-98-3; ac-98-4 und ac-98-5
US20050004011A1 (en) * 2002-11-18 2005-01-06 Marco Cavaleri Compositions and methods for treating bacterial infections with protein-dalbavancin complexes
US20070105757A1 (en) * 2005-10-31 2007-05-10 May Thomas B Vancomycin formulations having reduced amount of histamine
CN101851277B (zh) * 2009-03-12 2012-10-03 成都雅途生物技术有限公司 一种道古霉素关键中间体a40926 bo组分的纯化制备方法
CN105671110B (zh) * 2015-05-05 2019-02-01 重庆乾泰生物医药有限公司 一种生产达巴万星前体a40926的方法

Family Cites Families (48)

* Cited by examiner, † Cited by third party
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US2951766A (en) * 1957-07-15 1960-09-06 Le Roy A White Antiseptic plastic
US4322343A (en) * 1980-12-18 1982-03-30 Eli Lilly And Company Pseudo-aglycone of actaplanin
US4521335A (en) * 1983-07-13 1985-06-04 Smithkline Beckman Corporation Aglycone and pseudo-aglycones of the AAD 216 antibiotics
US4563442A (en) * 1983-10-21 1986-01-07 Eli Lilly And Company Glycopeptide bioconversion products
US4504467A (en) * 1983-10-21 1985-03-12 Eli Lilly And Company Glycopeptide derivatives
EP0159180B1 (de) * 1984-04-16 1989-08-09 Eli Lilly And Company Antibiotika M43A, M43B, M43C und M43D
US4552701A (en) * 1984-04-16 1985-11-12 Eli Lilly And Company Glycopeptide antibiotics and process of preparation
GB8415092D0 (en) * 1984-06-13 1984-07-18 Lepetit Spa Ester derivatives
GB8425685D0 (en) * 1984-10-11 1984-11-14 Lepetit Spa Antibiotic a 40926 complex
IL78597A0 (en) * 1985-04-25 1986-08-31 Lilly Co Eli Novel glycopeptide derivatives
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
GB8522574D0 (en) * 1985-09-12 1985-10-16 Lepetit Spa Amides of teicoplanin compounds
GB8531846D0 (en) * 1985-12-30 1986-02-05 Lepetit Spa Antibiotic a 40926 mannosyl aglycon
US4946941A (en) * 1986-01-24 1990-08-07 Shionogi & Co., Ltd. Novel glycopeptide antibiotics
GB8608809D0 (en) * 1986-04-11 1986-05-14 Lepetit Spa Antibiotic
JP2516202B2 (ja) * 1986-07-10 1996-07-24 三共株式会社 グリコペプチド系抗生物質
GB8618445D0 (en) * 1986-07-29 1986-09-03 Lepetit Spa Antibiotic a 42867
DK363587A (da) * 1986-07-30 1988-01-31 Smithkline Beckman Corp Antibiotika og fremstilling heraf under anvendelseaf actinomadura parvosata
US4742045A (en) * 1986-07-30 1988-05-03 Smithkline Beckman Corporation Glycopeptide antibiotics
GB8621912D0 (en) * 1986-09-11 1986-10-15 Lepetit Spa Increasing ratio of components of anti-biotic complex
GR871488B (en) * 1986-10-10 1987-11-12 Lepetit Spa New antibiotics
GB8624806D0 (en) * 1986-10-16 1986-11-19 Pfizer Ltd Glycopeptide antibiotic
IE873523L (en) * 1986-12-30 1988-06-30 Memorex Corp Glycosylated glycopeptides
GB8701872D0 (en) * 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
EP0287513B1 (de) * 1987-04-11 1992-12-02 Ciba-Geigy Ag Isoelektrisches Fokussierverfahren sowie Einrichtung zur Durchführung dieses Verfahrens
GB8711066D0 (en) * 1987-05-11 1987-06-17 Lepetit Spa Teicoplanin derivatives
GB8715735D0 (en) * 1987-07-03 1987-08-12 Lepetit Spa De-mannosyl teicoplanin derivatives
US4882313A (en) * 1987-07-31 1989-11-21 Smithkline Beckman Corporation Carboxamide derivatives of glycopeptides
PT88523B (pt) * 1987-09-19 1992-11-30 Beecham Group Plc Processo para a producao de um antibiotico glicopeptidico
GB8802211D0 (en) * 1988-02-02 1988-03-02 Lepetit Spa Teicoplanin hydrazides
EP0368949A1 (de) * 1988-02-10 1990-05-23 Beecham Group Plc Antibiotika-verbindungen
EP0339982A1 (de) * 1988-04-28 1989-11-02 Beecham Group Plc Antibiotika-Verbindungen
GB8817053D0 (en) * 1988-07-18 1988-08-24 Lepetit Spa Process for preparing n15 n15-dialkyl derivatives of teicoplanin compounds
GB8817052D0 (en) * 1988-07-18 1988-08-24 Lepetit Spa Process for preparing n15-alkyl derivatives of teicoplanin compounds
GB8817397D0 (en) * 1988-07-21 1988-08-24 Lepetit Spa N15-alkyl & n15 n15-di-alkyl derivatives of teicoplanin antibiotics carrying functional groups on alkyl side chain
GB8817736D0 (en) * 1988-07-26 1988-09-01 Lepetit Spa New teicoplanin antibiotics
IN167068B (de) * 1988-08-27 1990-08-25 Hoechst India
CA1339808C (en) * 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
GB8827202D0 (en) * 1988-11-22 1988-12-29 Lepetit Spa Process for preparing 63-carboxyamides of teicoplanin antibiotics
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
IE64155B1 (en) * 1989-03-29 1995-07-12 Lepetit Spa New substituted alkylamide derivatives of teicoplanin
US5185320A (en) * 1989-04-03 1993-02-09 Gruppo Lepetit S.P.A. O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin
ES2106738T3 (es) * 1990-03-28 1997-11-16 Lepetit Spa Procedimiento de preparacion de derivados de manosil-teicoplanina y de aglicona de manosil-teicoplanina.
ATE134379T1 (de) * 1990-12-05 1996-03-15 Lepetit Spa 38-decarboxy-38-hydroxymethylderivate von teicoplaninantibiotika, und verfahren zu deren herstellung
ATE145921T1 (de) * 1991-03-27 1996-12-15 Lepetit Spa Esterderivate von antibiotikum-a 40926
ATE125551T1 (de) * 1991-07-29 1995-08-15 Lepetit Spa Amidderivate vom antibiotikum a 40926.

Also Published As

Publication number Publication date
AU701463B2 (en) 1999-01-28
DK0836619T3 (da) 2004-12-06
CA2226142C (en) 2007-11-13
IL122151A (en) 2001-08-26
US5939523A (en) 1999-08-17
KR19990028712A (ko) 1999-04-15
ATE274524T1 (de) 2004-09-15
JP4051421B2 (ja) 2008-02-27
KR100430202B1 (ko) 2004-09-18
IL122151A0 (en) 1998-04-05
EP0836619A1 (de) 1998-04-22
WO1997002288A1 (en) 1997-01-23
JPH11508572A (ja) 1999-07-27
ES2224173T3 (es) 2005-03-01
PT836619E (pt) 2004-11-30
AU6416196A (en) 1997-02-05
DE69633234T2 (de) 2005-09-15
CA2226142A1 (en) 1997-01-23
EP0836619B1 (de) 2004-08-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS S.P.A., MILANO, IT

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC