ES2188665T3 - Procedimiento para la preparacion de fragmentos de cardiodilatina, fragmentos de cardiodilatina muy purificados y productos intermedios para su preparacion. - Google Patents

Procedimiento para la preparacion de fragmentos de cardiodilatina, fragmentos de cardiodilatina muy purificados y productos intermedios para su preparacion.

Info

Publication number
ES2188665T3
ES2188665T3 ES95921780T ES95921780T ES2188665T3 ES 2188665 T3 ES2188665 T3 ES 2188665T3 ES 95921780 T ES95921780 T ES 95921780T ES 95921780 T ES95921780 T ES 95921780T ES 2188665 T3 ES2188665 T3 ES 2188665T3
Authority
ES
Spain
Prior art keywords
fragments
preparation
cardiodylatin
purified
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95921780T
Other languages
English (en)
Inventor
Hansueli Immer
Wolf-Georg Forssmann
Knut Adermann
Christian Klessen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FORSSMANN WOLF-GEORG PROF DR MED
Original Assignee
FORSSMANN WOLF-GEORG PROF DR MED
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19513784A external-priority patent/DE19513784A1/de
Application filed by FORSSMANN WOLF-GEORG PROF DR MED filed Critical FORSSMANN WOLF-GEORG PROF DR MED
Application granted granted Critical
Publication of ES2188665T3 publication Critical patent/ES2188665T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA INVENCION TRATA DE UN PROCEDIMIENTO PARA LA OBTENCION DE FRAGMENTOS DE CARDIODILATINA, FRAGMENTOS DE CARDIODILATINA MUY PURIFICADOS Y LOS CORRESPONDIENTES PRODUCTOS INTERMEDIOS PARA LA OBTENCION DE ESTOS FRAGMENTOS. ADEMAS TRATA LA INVENCION DE FRAGMENTOS DE CARDIODILATINA MUY PURIFICADOS, QUE ESTAN LIBRES DE IMPUREZAS PEPTIDICAS Y QUE TIENEN UN UNICO MAXIMO DE MIGRACION EN LA ELECTROFORESIS CAPILAR, ASI COMO LOS CORRESPONDIENTES PROCEDIMIENTOS PARA SU OBTENCION
ES95921780T 1994-06-02 1995-05-30 Procedimiento para la preparacion de fragmentos de cardiodilatina, fragmentos de cardiodilatina muy purificados y productos intermedios para su preparacion. Expired - Lifetime ES2188665T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4420381 1994-06-02
DE19513784A DE19513784A1 (de) 1994-06-02 1995-04-10 Hochreines Urodilatin und Verfahren zu seiner Herstellung

Publications (1)

Publication Number Publication Date
ES2188665T3 true ES2188665T3 (es) 2003-07-01

Family

ID=25937342

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95921780T Expired - Lifetime ES2188665T3 (es) 1994-06-02 1995-05-30 Procedimiento para la preparacion de fragmentos de cardiodilatina, fragmentos de cardiodilatina muy purificados y productos intermedios para su preparacion.

Country Status (8)

Country Link
US (5) US5767239A (es)
EP (1) EP0763061B1 (es)
JP (2) JPH10500969A (es)
AT (1) ATE226960T1 (es)
AU (1) AU2671795A (es)
ES (1) ES2188665T3 (es)
IL (1) IL113979A0 (es)
WO (1) WO1995033769A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
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AU2671795A (en) * 1994-06-02 1996-01-04 Boehringer Mannheim Gmbh Process and intermediate products for preparing cardiodilatin fragments, and highly purified cardiodilatin fragments
KR100691545B1 (ko) * 1998-09-28 2007-03-09 산텐 세이야꾸 가부시키가이샤 나트륨 이뇨 펩티드를 유효 성분으로하는 누액 분비 촉진또는 각결막 장해 치료용 점안제
UA71608C2 (en) * 1999-03-11 2004-12-15 Merck Patent Gmbh A method for producing the cyclic pentapeptide
EP1759001B1 (en) 2004-04-21 2011-04-13 Enobia Pharma Inc. Bone delivery conjugates and method of using same to target proteins to bone
CA2582083A1 (en) * 2004-10-04 2006-04-20 Novetide, Ltd. A counterion exchange process for peptides
EP1865976B1 (en) 2005-04-07 2012-05-23 Cardiopep Pharma GmbH Use of natriuretic peptide for treating heart failure
CN101541957B (zh) * 2007-07-20 2013-08-14 梅约医学教育与研究基金会 利尿钠多肽
US20090163421A1 (en) * 2007-12-19 2009-06-25 Ekr Therapeutics, Inc. Room Temperature Stable, Lyophilized Natriuretic Peptide Formulations
CA2823066A1 (en) 2010-12-27 2012-07-05 Alexion Pharma International Sarl Compositions comprising natriuretic peptides and methods of use thereof
US9611305B2 (en) 2012-01-06 2017-04-04 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases
JP6108858B2 (ja) 2012-02-17 2017-04-05 株式会社半導体エネルギー研究所 ｐ型半導体材料および半導体装置
US10052366B2 (en) 2012-05-21 2018-08-21 Alexion Pharmaceuticsl, Inc. Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
CA2898571A1 (en) 2013-01-25 2014-07-31 Cardiorentis Ltd. Methods of treating cardiovascular indications
CN103145827A (zh) * 2013-03-04 2013-06-12 吉尔生化（上海）有限公司 一种乌拉力肽的固相合成方法
US10822596B2 (en) 2014-07-11 2020-11-03 Alexion Pharmaceuticals, Inc. Compositions and methods for treating craniosynostosis
MX2017007392A (es) 2014-12-05 2019-01-24 Alexion Pharma Inc Tratamiento de convulsiones con fosfatasa alcalina recombinante.
JP6868561B2 (ja) 2015-01-28 2021-05-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼ欠損を有する被験者を治療する方法
WO2016131943A1 (en) 2015-02-20 2016-08-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of obesity and complications arising therefrom including type 2 diabetes
AU2016308624B2 (en) 2015-08-17 2022-06-23 Alexion Pharmaceuticals, Inc. Manufacturing of alkaline phosphatases
JP6868617B2 (ja) 2015-09-28 2021-05-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド 低ホスファターゼ血症の組織非特異的アルカリホスファターゼ（ｔｎｓａｌｐ）酵素補充療法に有効な投薬計画の特定
EP3368062A4 (en) 2015-10-30 2019-07-03 Alexion Pharmaceuticals, Inc. METHODS OF TREATING CRANIOSYNOSTOSIS IN A PATIENT
CN106928342B (zh) * 2015-12-31 2020-10-16 深圳翰宇药业股份有限公司 一种乌拉立肽的制备方法
US11065306B2 (en) 2016-03-08 2021-07-20 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children
EP3436020A4 (en) 2016-04-01 2019-12-25 Alexion Pharmaceuticals, Inc. METHOD FOR TREATING HYPOPHOSPHATASIE IN TEENS AND ADULTS
EP3436052A4 (en) 2016-04-01 2019-10-09 Alexion Pharmaceuticals, Inc. TREATMENT OF MUSCLE WEAKNESS USING ALKALINE PHOSPHATASES
US10988744B2 (en) 2016-06-06 2021-04-27 Alexion Pharmaceuticals, Inc. Method of producing alkaline phosphatase
US11116821B2 (en) 2016-08-18 2021-09-14 Alexion Pharmaceuticals, Inc. Methods for treating tracheobronchomalacia
EP3600383A4 (en) 2017-03-31 2020-10-28 Alexion Pharmaceuticals, Inc. METHODS FOR TREATMENT OF HYPOPHOSPHATASIA (HPP) IN ADULTS AND ADOLESCENTS
EP3773684A1 (en) 2018-03-30 2021-02-17 Alexion Pharmaceuticals, Inc. Manufacturing of glycoproteins
US11312744B2 (en) * 2018-05-30 2022-04-26 Hybio Pharmaceutical Co., Ltd. Method for purifying long chain polypeptide
CN110845599B (zh) * 2018-08-21 2022-10-14 鲁南制药集团股份有限公司 一种多肽的制备纯化方法
WO2022029499A1 (en) 2020-08-06 2022-02-10 Ads Aiphia Development Services Ag Methods of treating refractory ascites
WO2022029497A1 (en) 2020-08-06 2022-02-10 Ads Aiphia Development Services Ag Ularitide for use in methods of treating refractory ascites
EP4291224A1 (en) 2021-02-12 2023-12-20 Alexion Pharmaceuticals, Inc. Alkaline phosphatase polypeptides and methods of use thereof
CA3217598A1 (en) 2021-05-06 2022-11-10 Par Ingemar Johansson Diagnosing and treating critically ill subjects

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU572173B2 (en) * 1983-08-29 1988-05-05 Institut De Recherches Cliniques De Montreal Natriuretic factors
DE3346953A1 (de) * 1983-12-24 1985-08-14 Organogen Medizinisch-Molekularbiologische Forschungsgesellschaft mbH, 6900 Heidelberg Cardiodilatin, ein neues peptidhormon und verfahren zu seiner herstellung
WO1985004870A1 (en) * 1984-04-19 1985-11-07 Biotechnology Research Partners, Ltd. Novel atrial natriuretic/vasodilator polypeptides
JPH0672157B2 (ja) * 1984-08-29 1994-09-14 味の素株式会社 新規ペプチド
US5057603A (en) * 1986-01-31 1991-10-15 Merck & Co., Inc. Peptides having ANF activity
JP2819467B2 (ja) * 1987-03-02 1998-10-30 ファーマ・ビッセンドルフ・ペプタイド・ゲーエムベーハー 新規なカルジオジラチン断片およびその製造方法
US5449751A (en) * 1987-03-02 1995-09-12 Pharma Bissendorf Peptide Gmbh Cardiodilatin fragment, process for preparing same and use thereof
US5204327A (en) * 1988-11-18 1993-04-20 Ashi Kasei Kogyo Kabushiki Kaisha Treatment of cerebral edema with anp pharmaceutical compositions
AU2671795A (en) * 1994-06-02 1996-01-04 Boehringer Mannheim Gmbh Process and intermediate products for preparing cardiodilatin fragments, and highly purified cardiodilatin fragments

Also Published As

Publication number Publication date
US20030171536A1 (en) 2003-09-11
IL113979A0 (en) 1995-10-31
US20060122371A1 (en) 2006-06-08
US20100317600A1 (en) 2010-12-16
ATE226960T1 (de) 2002-11-15
US20090240031A1 (en) 2009-09-24
EP0763061B1 (de) 2002-10-30
US5767239A (en) 1998-06-16
WO1995033769A1 (de) 1995-12-14
JPH10500969A (ja) 1998-01-27
EP0763061A1 (de) 1997-03-19
AU2671795A (en) 1996-01-04
JP2005298526A (ja) 2005-10-27
JP4130671B2 (ja) 2008-08-06

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